Reg4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Reg4
Entrez Gene ID	67709
Full Name	regenerating islet-derived family, member 4
Synonyms	2010002L15Rik,GISP,RELP
General protein information	Preferred Names regenerating islet-derived family, member 4 Names regenerating islet-derived protein 4 REG-4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 F2.2

mRNA and Protein(s)

mRNA	Protein	Name
XM_017319697.1	XP_017175186.1	regenerating islet-derived protein 4 isoform X1
NM_026328.2	NP_080604.2	regenerating islet-derived protein 4 precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100485321	XP_002934628.1
Pan troglodytes (chimpanzee)	REG4	XP_001139975.1
Mus musculus (house mouse)	Reg4	NP_080604.2
Xenopus tropicalis (tropical clawed frog)	LOC100485485	XP_002934629.1
	REG4	XP_001084133.1
Canis lupus familiaris (dog)	REG4	XP_549728.3
Homo sapiens (human)	REG4	NP_001152824.1
Rattus norvegicus (Norway rat)	Reg4	NP_001004096.1
Canis lupus familiaris (dog)	LOC475818	XP_549465.3
Bos taurus (cattle)	REG4	NP_001070454.1
Gallus gallus (chicken)	REG4	NP_001264456.1

Gene Ontology
Bibliography

Related articles in PubMed

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.
Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, L?pez-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, Clevers H
Proceedings of the National Academy of Sciences of the United States of America113(37)E5399-407(2016 09)

Impact of lactobacilli on orally acquired listeriosis.
Archambaud C, Nahori MA, Soubigou G, B?cavin C, Laval L, Lechat P, Smokvina T, Langella P, Lecuit M, Cossart P
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)

Reg4 protects against acinar cell necrosis in experimental pancreatitis.
Hu G, Shen J, Cheng L, Guo C, Xu X, Wang F, Huang L, Yang L, He M, Xiang D, Zhu S, Wu M, Yu Y, Han W, Wang X
Gut60(6)820-8(2011 Jun)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest that Reg4 may protect against acinar cell necrosis in experimental pancreatitis by enhancing the expression of Bcl-2 and Bcl-xL via activation of the EGFR/Akt signalling pathway.
Title: Reg4 protects against acinar cell necrosis in experimental pancreatitis.

Reg IV as an important modulator of gastrointestinal cell susceptibility to irradiation; hence, it is a potential target for adjunctive treatments for human colorectal cancer and other gastrointestinal malignancies.
Title: Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis.

reg4 is amplified in the early stages of pancreatic cancer development
Title: The reg4 gene, amplified in the early stages of pancreatic cancer development, is a promising therapeutic target.

Cloning and characterization of human REG4/RELP, in addition to cloning of mouse Reg4.
Title: RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa.

The following Reg4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Reg4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02015	NM_026328.2 Latest version!	Mus musculus regenerating islet-derived family, member 4 (Reg4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu80682	XM_017319697.1 Latest version!	Mus musculus regenerating islet-derived family, member 4 (Reg4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Reg4 ( NM_026328.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080604.2 Mus musculus regenerating islet-derived family, member 4 (Reg4), mRNA.

Price & Availability↑

CloneID	OMu02015
Clone ID Related Accession (Same CDS sequence)	NM_026328.2
Accession Version	NM_026328.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Mus musculus(house mouse)
Product	regenerating islet-derived protein 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK162316.1 and AC121771.3. On Jul 2, 2009 this sequence version replaced NM_026328.1. ##Evidence-Data-START## Transcript exon combination :: AK008438.1, AK162316.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCCA AAGGCGTGCG GCTACTCTTA CTGCTGAGCT GGGTAGCTGG CCCCGAAGTC 
CTGAGCGATA TCTTGAGACC CAGCTGTGCC CCAGGATGGT TTTACTATAG GTCCCACTGC 
TATGGGTACT TCCGGAAGCT AAGAAACTGG TCTCATGCTG AGCTGGAGTG TCAGTCATAT 
GGAAATGGAT CCCATCTGGC ATCTGTCTTG AATCAAAAGG AAGCCAGTGT CATATCAAAG 
TACATAACTG GCTATCAGAG AAACCTGCCT GTGTGGATTG GCCTGCATGA CCCACAAAAG 
AAGCAATTAT GGCAGTGGAC TGATGGGTCT ACAAACCTGT ACAGACGCTG GAATCCCAGG 
ACAAAGAGTG AAGCCAGGCA TTGCGCTGAG ATGAACCCCA AGGATAAATT CTTAACTTGG 
AACAAAAATG GATGTGCCAA CCGCCAACAC TTCCTGTGCA AGTATAAGAC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080604.2
CDS	165..638
Translation	MASKGVRLLLLLSWVAGPEVLSDILRPSCAPGWFYYRSHCYGYFRKLRNWSHAELECQSYGNGSHLASVLNQKEASVISKYITGYQRNLPVWIGLHDPQKKQLWQWTDGSTNLYRRWNPRTKSEARHCAEMNPKDKFLTWNKNGCANRQHFLCKYKT

Target ORF information:

RefSeq Version	NM_026328.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus regenerating islet-derived family, member 4 (Reg4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026328.2

ORF Insert Sequence:

ATGGCTTCCA AAGGCGTGCG GCTACTCTTA CTGCTGAGCT GGGTAGCTGG CCCCGAAGTC 
CTGAGCGATA TCTTGAGACC CAGCTGTGCC CCAGGATGGT TTTACTATAG GTCCCACTGC 
TATGGGTACT TCCGGAAGCT AAGAAACTGG TCTCATGCTG AGCTGGAGTG TCAGTCATAT 
GGAAATGGAT CCCATCTGGC ATCTGTCTTG AATCAAAAGG AAGCCAGTGT CATATCAAAG 
TACATAACTG GCTATCAGAG AAACCTGCCT GTGTGGATTG GCCTGCATGA CCCACAAAAG 
AAGCAATTAT GGCAGTGGAC TGATGGGTCT ACAAACCTGT ACAGACGCTG GAATCCCAGG 
ACAAAGAGTG AAGCCAGGCA TTGCGCTGAG ATGAACCCCA AGGATAAATT CTTAACTTGG 
AACAAAAATG GATGTGCCAA CCGCCAACAC TTCCTGTGCA AGTATAAGAC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Reg4 ( XM_017319697.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017175186.1 Mus musculus regenerating islet-derived family, member 4 (Reg4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu80682
Clone ID Related Accession (Same CDS sequence)	XM_017319697.1
Accession Version	XM_017319697.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	regenerating islet-derived protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTCCA AAGGCGTGCG GCTACTCTTA CTGCTGAGCT GGGTAGCTGG CCCCGAAGTC 
CTGAGCGATA TCTTGAGACC CAGCTGTGCC CCAGGATGGT TTTACTATAG GTCCCACTGC 
TATGGGTACT TCCGGAAGCT AAGAAACTGG TCTCATGCTG AGAAGCAATT ATGGCAGTGG 
ACTGATGGGT CTACAAACCT GTACAGACGC TGGAATCCCA GGACAAAGAG TGAAGCCAGG 
CATTGCGCTG AGATGAACCC CAAGGATAAA TTCTTAACTT GGAACAAAAA TGGATGTGCC 
AACCGCCAAC ACTTCCTGTG CAAGTATAAG ACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017175186.1
CDS	183..518
Translation	MASKGVRLLLLLSWVAGPEVLSDILRPSCAPGWFYYRSHCYGYFRKLRNWSHAEKQLWQWTDGSTNLYRRWNPRTKSEARHCAEMNPKDKFLTWNKNGCANRQHFLCKYKT

Target ORF information:

RefSeq Version	XM_017319697.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus regenerating islet-derived family, member 4 (Reg4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017319697.1

ORF Insert Sequence:

ATGGCTTCCA AAGGCGTGCG GCTACTCTTA CTGCTGAGCT GGGTAGCTGG CCCCGAAGTC 
CTGAGCGATA TCTTGAGACC CAGCTGTGCC CCAGGATGGT TTTACTATAG GTCCCACTGC 
TATGGGTACT TCCGGAAGCT AAGAAACTGG TCTCATGCTG AGAAGCAATT ATGGCAGTGG 
ACTGATGGGT CTACAAACCT GTACAGACGC TGGAATCCCA GGACAAAGAG TGAAGCCAGG 
CATTGCGCTG AGATGAACCC CAAGGATAAA TTCTTAACTT GGAACAAAAA TGGATGTGCC 
AACCGCCAAC ACTTCCTGTG CAAGTATAAG ACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.
Proceedings of the National Academy of Sciences of the United States of America113(37)E5399-407(2016 09)
Sasaki N,Sachs N,Wiebrands K,Ellenbroek SI,Fumagalli A,Lyubimova A,Begthel H,van den Born M,van Es JH,Karthaus WR,Li VS,L?pez-Iglesias C,Peters PJ,van Rheenen J,van Oudenaarden A,Clevers H

Impact of lactobacilli on orally acquired listeriosis.
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)
Archambaud C,Nahori MA,Soubigou G,B?cavin C,Laval L,Lechat P,Smokvina T,Langella P,Lecuit M,Cossart P

Reg4 protects against acinar cell necrosis in experimental pancreatitis.
Gut60(6)820-8(2011 Jun)
Hu G,Shen J,Cheng L,Guo C,Xu X,Wang F,Huang L,Yang L,He M,Xiang D,Zhu S,Wu M,Yu Y,Han W,Wang X

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

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Reg4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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