Larp6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Larp6
Entrez Gene ID	67557
Full Name	La ribonucleoprotein domain family, member 6
Synonyms	5430431G03Rik,AI552438,Achn
General protein information	Preferred Names La ribonucleoprotein domain family, member 6 Names la-related protein 6 acheron
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 B

mRNA and Protein(s)

mRNA	Protein	Name
NM_026235.4	NP_080511.2	la-related protein 6

Pathways from BioSystems

Homologies

Homo sapiens (human)	LARP6	NP_060827.2
Pan troglodytes (chimpanzee)	LARP6	NP_001233506.1
Gallus gallus (chicken)	LARP6	XP_413777.3
Danio rerio (zebrafish)	larp6	NP_956197.1
Bos taurus (cattle)	LARP6	NP_001092675.1
Rattus norvegicus (Norway rat)	Larp6	NP_001101624.1
	LARP6	XP_001088126.1
Mus musculus (house mouse)	Larp6	NP_080511.2
Canis lupus familiaris (dog)	LARP6	XP_005638605.1
Xenopus tropicalis (tropical clawed frog)	larp6	NP_001008144.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic Dissection of a QTL Affecting Bone Geometry.
Sabik OL, Medrano JF, Farber CR
G3 (Bethesda, Md.)7(3)865-870(2017 Mar)

Insulin-like growth factor-1 promotes osteogenic differentiation and collagen I alpha 2 synthesis via induction of mRNA-binding protein LARP6 expression.
Guo Y, Tang CY, Man XF, Tang HN, Tang J, Zhou CL, Tan SW, Wang M, Feng YZ, Zhou HD
Development, growth & differentiation59(2)94-103(2017 Feb)

Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA.
Blackstock CD, Higashi Y, Sukhanov S, Shai SY, Stefanovic B, Tabony AM, Yoshida T, Delafontaine P
The Journal of biological chemistry289(11)7264-74(2014 Mar)

Serine-threonine kinase receptor-associated protein (STRAP) regulates translation of type I collagen mRNAs.
Vukmirovic M, Manojlovic Z, Stefanovic B
Molecular and cellular biology33(19)3893-906(2013 Oct)

Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
Sun R, Chen W, Zhao X, Li T, Song Q
Cell biochemistry and function29(8)636-40(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that insulin-like growth factor 1 (IGF1) could promote collagen I alpha 2 (COL1A2) expression and osteoblast differentiation in primary pre-osteoblasts by increasing La ribonucleoprotein domain family member 6 (Larp6) expression via a posttranscriptional mechanism.
Title: Insulin-like growth factor-1 promotes osteogenic differentiation and collagen I alpha 2 synthesis via induction of mRNA-binding protein LARP6 expression.

LARP6 is a critical mediator by which IGF-1 augments synthesis of collagen type I in vascular smooth muscle
Title: Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA.

Achn enhances human breast tumor growth and vascularization and that this activity is dependent on nuclear localization.
Title: The novel lupus antigen related protein acheron enhances the development of human breast cancer.

Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
Title: Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.

achn plays key roles in the processes of differentiation and self-renewal
Title: Regulation of muscle differentiation and survival by Acheron.

The following Larp6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Larp6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22726	NM_026235.4 Latest version!	Mus musculus La ribonucleoprotein domain family, member 6 (Larp6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Larp6 ( NM_026235.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080511.2 Mus musculus La ribonucleoprotein domain family, member 6 (Larp6), mRNA.

Price & Availability↑

CloneID	OMu22726
Clone ID Related Accession (Same CDS sequence)	NM_026235.4
Accession Version	NM_026235.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	la-related protein 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC127370.3. On Apr 29, 2007 this sequence version replaced NM_026235.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK087521.1, AK042616.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCAGC TCGGCGAACA GACTCTGCCT GGGCCCGAGA CCACGGTGCA GATCCGTGTC 
GCCATCCAGG AGGCTGAGGA TCTGGAGGAT CTGGAGGAGG AGGACGAGGG GACCTCGGCG 
CGGGCAGCGG GGGACCCAGC CCGGTACCTC AGTCCCGGCT GGGGCAGCGC CAGCGAGGAG 
GAGCCGAGCC GCGGGCACAG TAGTGCCACG ACAAGTGGGG GCGAGAACGA TCGCGAGGAC 
CTGGAGCCTG AGTGGAGGCC CCCGGACGAG GAGCTCATCA GGAAGCTGGT GGATCAGATT 
GAGTTCTACT TTTCGGACGA GAACCTGGAG AAGGACGCCT TCCTGCTGAA GCACGTGCGG 
AGGAACAAGC TGGGCTACGT GAGCGTCAAG CTGCTCACCT CCTTCAAGAA GGTGAAACAC 
CTCACCCGGG ACTGGAGGAC CACAGCACAC GCCTTGAAGT ATTCAGTCAC CCTGGAGTTG 
AACGAGGACC ACCGGAAGGT TAGGAGGACC ACCCCTGTGC CACTGTTCCC CAATGAGAAC 
CTCCCCAGCA AGATGCTGCT GGTCTATGAC CTACACCTGT CCCCTAAGCT CTGGGCCCTG 
GCCACACCCC AGAAGAACGG AAGGGTGCAG GAGAAGGTGA TGGAGCATCT GCTCAAGCTC 
TTTGGGACTT TTGGCGTCAT CTCATCGGTG CGGATCCTAA AACCTGGGAG AGAGCTGCCC 
CCTGACATCC GGAGGATCAG CAGCCGCTAC AGCCAGGTGG GGACCCAAGA GTGCGCCATT 
GTGGAGTTCG AGGAGGTGGA CGCGGCCATT AAAGCCCATG AATTCATGGT CACTGAATCT 
CAGAGCAAAG AGAACATGAA GGCTGTTCTG ATTGGGATGA AGCCGCCCAA AAAGAAACCC 
CTCAAAGATA AGAACCATGA CGATGAGGCC ACAGCAGGTA CCCACCTAAG CAGATCCCTG 
AACAAGAGAG TGGAGGAACT TCAGTACATG GGGGATGAGT CTTCCGCCAA CAGCTCCTCT 
GACCCTGAGA GCAATCCCAC CTCTCCCATG GCCGGCCGGC GGCACGCGGC CAGCAACAAG 
CTCAGCCCTT CGGGCCACCA GAATATTTTT CTGAGCCCCA ATGCCTCCCC GTGCTCAAGC 
CCATGGAGCA GCCCCTTGGC ACAGCGCAAG GGTGTCTCCA GAAAATCCCC GCTGGCTGAA 
GAAGGTAGAC TGAACTTCAG CACCAGCCCT GAGATCTTCC GAAAGTGCAT GGATTATTCT 
TCCGACAGCA GCATCACTCC CTCGGGCAGC CCCTGGGTTC GCAGACGACG CCAGGCTGAG 
ATGGGGACTC AGGAGAAAAG TCCAGGGGCG AGTCCCCTGC TGTCTCGGAG GATGCAGACC 
GCAGATGGGT TACCTGTGGG GGTGCTGAGG CTGCCCAGAG GCCCCGACAA CACCAGGGGC 
TTCCACGGTG GACATGAGAG AGGCAGAGCC TGTGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080511.2
CDS	86..1564
Translation	MAQLGEQTLPGPETTVQIRVAIQEAEDLEDLEEEDEGTSARAAGDPARYLSPGWGSASEEEPSRGHSSATTSGGENDREDLEPEWRPPDEELIRKLVDQIEFYFSDENLEKDAFLLKHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVTLELNEDHRKVRRTTPVPLFPNENLPSKMLLVYDLHLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELPPDIRRISSRYSQVGTQECAIVEFEEVDAAIKAHEFMVTESQSKENMKAVLIGMKPPKKKPLKDKNHDDEATAGTHLSRSLNKRVEELQYMGDESSANSSSDPESNPTSPMAGRRHAASNKLSPSGHQNIFLSPNASPCSSPWSSPLAQRKGVSRKSPLAEEGRLNFSTSPEIFRKCMDYSSDSSITPSGSPWVRRRRQAEMGTQEKSPGASPLLSRRMQTADGLPVGVLRLPRGPDNTRGFHGGHERGRACV

Target ORF information:

RefSeq Version	NM_026235.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus La ribonucleoprotein domain family, member 6 (Larp6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026235.4

ORF Insert Sequence:

ATGGCCCAGC TCGGCGAACA GACTCTGCCT GGGCCCGAGA CCACGGTGCA GATCCGTGTC 
GCCATCCAGG AGGCTGAGGA TCTGGAGGAT CTGGAGGAGG AGGACGAGGG GACCTCGGCG 
CGGGCAGCGG GGGACCCAGC CCGGTACCTC AGTCCCGGCT GGGGCAGCGC CAGCGAGGAG 
GAGCCGAGCC GCGGGCACAG TAGTGCCACG ACAAGTGGGG GCGAGAACGA TCGCGAGGAC 
CTGGAGCCTG AGTGGAGGCC CCCGGACGAG GAGCTCATCA GGAAGCTGGT GGATCAGATT 
GAGTTCTACT TTTCGGACGA GAACCTGGAG AAGGACGCCT TCCTGCTGAA GCACGTGCGG 
AGGAACAAGC TGGGCTACGT GAGCGTCAAG CTGCTCACCT CCTTCAAGAA GGTGAAACAC 
CTCACCCGGG ACTGGAGGAC CACAGCACAC GCCTTGAAGT ATTCAGTCAC CCTGGAGTTG 
AACGAGGACC ACCGGAAGGT TAGGAGGACC ACCCCTGTGC CACTGTTCCC CAATGAGAAC 
CTCCCCAGCA AGATGCTGCT GGTCTATGAC CTACACCTGT CCCCTAAGCT CTGGGCCCTG 
GCCACACCCC AGAAGAACGG AAGGGTGCAG GAGAAGGTGA TGGAGCATCT GCTCAAGCTC 
TTTGGGACTT TTGGCGTCAT CTCATCGGTG CGGATCCTAA AACCTGGGAG AGAGCTGCCC 
CCTGACATCC GGAGGATCAG CAGCCGCTAC AGCCAGGTGG GGACCCAAGA GTGCGCCATT 
GTGGAGTTCG AGGAGGTGGA CGCGGCCATT AAAGCCCATG AATTCATGGT CACTGAATCT 
CAGAGCAAAG AGAACATGAA GGCTGTTCTG ATTGGGATGA AGCCGCCCAA AAAGAAACCC 
CTCAAAGATA AGAACCATGA CGATGAGGCC ACAGCAGGTA CCCACCTAAG CAGATCCCTG 
AACAAGAGAG TGGAGGAACT TCAGTACATG GGGGATGAGT CTTCCGCCAA CAGCTCCTCT 
GACCCTGAGA GCAATCCCAC CTCTCCCATG GCCGGCCGGC GGCACGCGGC CAGCAACAAG 
CTCAGCCCTT CGGGCCACCA GAATATTTTT CTGAGCCCCA ATGCCTCCCC GTGCTCAAGC 
CCATGGAGCA GCCCCTTGGC ACAGCGCAAG GGTGTCTCCA GAAAATCCCC GCTGGCTGAA 
GAAGGTAGAC TGAACTTCAG CACCAGCCCT GAGATCTTCC GAAAGTGCAT GGATTATTCT 
TCCGACAGCA GCATCACTCC CTCGGGCAGC CCCTGGGTTC GCAGACGACG CCAGGCTGAG 
ATGGGGACTC AGGAGAAAAG TCCAGGGGCG AGTCCCCTGC TGTCTCGGAG GATGCAGACC 
GCAGATGGGT TACCTGTGGG GGTGCTGAGG CTGCCCAGAG GCCCCGACAA CACCAGGGGC 
TTCCACGGTG GACATGAGAG AGGCAGAGCC TGTGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic Dissection of a QTL Affecting Bone Geometry.
G3 (Bethesda, Md.)7(3)865-870(2017 Mar)
Sabik OL,Medrano JF,Farber CR

Insulin-like growth factor-1 promotes osteogenic differentiation and collagen I alpha 2 synthesis via induction of mRNA-binding protein LARP6 expression.
Development, growth & differentiation59(2)94-103(2017 Feb)
Guo Y,Tang CY,Man XF,Tang HN,Tang J,Zhou CL,Tan SW,Wang M,Feng YZ,Zhou HD

Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA.
The Journal of biological chemistry289(11)7264-74(2014 Mar)
Blackstock CD,Higashi Y,Sukhanov S,Shai SY,Stefanovic B,Tabony AM,Yoshida T,Delafontaine P

Serine-threonine kinase receptor-associated protein (STRAP) regulates translation of type I collagen mRNAs.
Molecular and cellular biology33(19)3893-906(2013 Oct)
Vukmirovic M,Manojlovic Z,Stefanovic B

Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
Cell biochemistry and function29(8)636-40(2011 Dec)
Sun R,Chen W,Zhao X,Li T,Song Q

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Larp6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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