Socs4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Socs4
Entrez Gene ID	67296
Full Name	suppressor of cytokine signaling 4
Synonyms	3110032M18Rik,A730004F22Rik,AI427843,AU015727,AU015859,Socs7
General protein information	Preferred Names suppressor of cytokine signaling 4 Names suppressor of cytokine signaling 4 SOCS-4 SOCS-7 suppressor of cytokine signaling 7 suppressor of cytokine signalling 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_080843.2	NP_543119.2	suppressor of cytokine signaling 4

Pathways from BioSystems

Homologies

	SOCS4	XP_001087968.1
Mus musculus (house mouse)	Socs4	NP_543119.2
Xenopus tropicalis (tropical clawed frog)	socs4	NP_001017074.1
Danio rerio (zebrafish)	socs9	NP_001107273.1
Homo sapiens (human)	SOCS4	NP_543143.1
Pan troglodytes (chimpanzee)	SOCS4	XP_003952539.1
Rattus norvegicus (Norway rat)	Socs4	NP_001100726.1
Canis lupus familiaris (dog)	SOCS4	XP_003435184.1
Bos taurus (cattle)	SOCS4	NP_001069686.1
Gallus gallus (chicken)	SOCS4	NP_001186037.1

Gene Ontology
Bibliography

Related articles in PubMed

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.
Kedzierski L, Tate MD, Hsu AC, Kolesnik TB, Linossi EM, Dagley L, Dong Z, Freeman S, Infusini G, Starkey MR, Bird NL, Chatfield SM, Babon JJ, Huntington N, Belz G, Webb A, Wark PA, Nicola NA, Xu J, Kedzierska K, Hansbro PM, Nicholson SE
eLife6(2017 02)

SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity.
Kedzierski L, Clemens EB, Bird NL, Kile BT, Belz GT, Nicola NA, Kedzierska K, Nicholson SE
Immunology and cell biology93(10)909-13(2015 Nov)

Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
Kedzierski L, Linossi EM, Kolesnik TB, Day EB, Bird NL, Kile BT, Belz GT, Metcalf D, Nicola NA, Kedzierska K, Nicholson SE
PLoS pathogens10(5)e1004134(2014 May)

Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors.
Sim? S, Cooper JA
Developmental cell27(4)399-411(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

dispensable for immunological memory response to influenza virus infection
Title: SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity.

SOCS4 is a critical regulator of anti-viral immunity.
Title: Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.

Negative regulation of the JAK/STAT pathway is controlled by SOCS4, which target members of negative feedback loops, to suppress follicle growth and development.
Title: Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation.

Identified is a conserved region of about 70 residues in the N-terminal domains of Socs4 and 5 that is predicted to be more ordered than the surrounding sequence.
Title: The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.

Socs4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
Title: ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.

The following Socs4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Socs4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09751	NM_080843.2 Latest version!	Mus musculus suppressor of cytokine signaling 4 (Socs4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Socs4 ( NM_080843.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_543119.2 Mus musculus suppressor of cytokine signaling 4 (Socs4), mRNA.

Price & Availability↑

CloneID	OMu09751
Clone ID Related Accession (Same CDS sequence)	NM_080843.2
Accession Version	NM_080843.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1311bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Mus musculus(house mouse)
Product	suppressor of cytokine signaling 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK014115.1, AW046781.1 and BG083279.2. On Jun 28, 2004 this sequence version replaced NM_080843.1. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.121406.1, AK014115.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGAAA ACAATAGTAA AAATGTAGAT GTACGGCCTA AAACAAGTCG GAGTCGAAGT 
GCTGACAGGA AGGATGGTTA TGTGTGGAGT GGAAAGAAGT TGTCTTGGTC CAAAAAGAGT 
GAGAGTTGTT CTGAATCTGA AGCCATAGGT ACTGTTGAGA ATGTTGAAAT TCCTCTAAGA 
AGCCAAGAAA GGCAGCTTAG CTGTTCGTCC ATTGAGTTGG ACTTAGATCA TTCCTGTGGG 
CATAGATTTT TAGGCCGATC CCTTAAACAG AAACTGCAAG ATGCGGTGGG GCAGTGTTTT 
CCAATAAAGA ATTGTAGTGG CCGACACTCT CCAGGGCTTC CATCTAAAAG AAAGATTCAT 
ATCAGTGAAC TCATGTTAGA TAAGTGCCCT TTCCCACCTC GCTCAGATTT AGCCTTTAGG 
TGGCATTTTA TTAAACGACA CACTGTTCCT ATGAGTCCCA ACTCAGATGA ATGGGTGAGT 
GCAGACCTGT CTGAGAGGAA ACTGAGAGAT GCTCAGCTGA AACGAAGAAA CACAGAAGAT 
GACATACCCT GTTTCTCACA TACCAATGGC CAGCCTTGTG TCATAACTGC CAACAGTGCT 
TCGTGTACAG GTGGTCACAT AACTGGTTCT ATGATGAACT TGGTCACAAA CAACAGCATA 
GAAGACAGTG ACATGGATTC AGAGGATGAA ATTATAACGC TGTGCACAAG CTCCAGAAAA 
AGGAATAAGC CCAGGTGGGA AATGGAAGAG GAGATCCTGC AGTTGGAGGC ACCTCCTAAG 
TTCCACACCC AGATCGACTA CGTCCACTGC CTTGTTCCAG ACCTCCTTCA GATCAGTAAC 
AATCCGTGCT ACTGGGGTGT CATGGACAAA TATGCAGCCG AAGCTCTGCT GGAAGGAAAG 
CCAGAGGGCA CCTTTTTACT TCGAGATTCA GCGCAGGAAG ATTATTTATT CTCTGTTAGT 
TTTAGACGCT ACAGTCGTTC TCTTCATGCT AGAATTGAGC AGTGGAATCA TAACTTTAGC 
TTTGATGCCC ATGATCCTTG TGTCTTCCAT TCTCCTGATA TTACTGGGCT CCTGGAACAC 
TATAAGGACC CCAGTGCCTG TATGTTCTTT GAGCCGCTCT TGTCCACTCC CTTAATCCGG 
ACGTTCCCCT TTTCCTTGCA GCATATTTGC AGAACGGTTA TTTGTAATTG TACGACTTAC 
GATGGCATCG ATGCCCTTCC CATTCCTTCG CCTATGAAAT TGTATCTGAA GGAATACCAT 
TATAAATCAA AAGTTAGGTT ACTCAGGATT GATGTGCCAG AGCAGCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_543119.2
CDS	173..1483
Translation	MAENNSKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESCSESEAIGTVENVEIPLRSQERQLSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSGRHSPGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTVPMSPNSDEWVSADLSERKLRDAQLKRRNTEDDIPCFSHTNGQPCVITANSASCTGGHITGSMMNLVTNNSIEDSDMDSEDEIITLCTSSRKRNKPRWEMEEEILQLEAPPKFHTQIDYVHCLVPDLLQISNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSPMKLYLKEYHYKSKVRLLRIDVPEQQ

Target ORF information:

RefSeq Version	NM_080843.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus suppressor of cytokine signaling 4 (Socs4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080843.2

ORF Insert Sequence:

ATGGCTGAAA ACAATAGTAA AAATGTAGAT GTACGGCCTA AAACAAGTCG GAGTCGAAGT 
GCTGACAGGA AGGATGGTTA TGTGTGGAGT GGAAAGAAGT TGTCTTGGTC CAAAAAGAGT 
GAGAGTTGTT CTGAATCTGA AGCCATAGGT ACTGTTGAGA ATGTTGAAAT TCCTCTAAGA 
AGCCAAGAAA GGCAGCTTAG CTGTTCGTCC ATTGAGTTGG ACTTAGATCA TTCCTGTGGG 
CATAGATTTT TAGGCCGATC CCTTAAACAG AAACTGCAAG ATGCGGTGGG GCAGTGTTTT 
CCAATAAAGA ATTGTAGTGG CCGACACTCT CCAGGGCTTC CATCTAAAAG AAAGATTCAT 
ATCAGTGAAC TCATGTTAGA TAAGTGCCCT TTCCCACCTC GCTCAGATTT AGCCTTTAGG 
TGGCATTTTA TTAAACGACA CACTGTTCCT ATGAGTCCCA ACTCAGATGA ATGGGTGAGT 
GCAGACCTGT CTGAGAGGAA ACTGAGAGAT GCTCAGCTGA AACGAAGAAA CACAGAAGAT 
GACATACCCT GTTTCTCACA TACCAATGGC CAGCCTTGTG TCATAACTGC CAACAGTGCT 
TCGTGTACAG GTGGTCACAT AACTGGTTCT ATGATGAACT TGGTCACAAA CAACAGCATA 
GAAGACAGTG ACATGGATTC AGAGGATGAA ATTATAACGC TGTGCACAAG CTCCAGAAAA 
AGGAATAAGC CCAGGTGGGA AATGGAAGAG GAGATCCTGC AGTTGGAGGC ACCTCCTAAG 
TTCCACACCC AGATCGACTA CGTCCACTGC CTTGTTCCAG ACCTCCTTCA GATCAGTAAC 
AATCCGTGCT ACTGGGGTGT CATGGACAAA TATGCAGCCG AAGCTCTGCT GGAAGGAAAG 
CCAGAGGGCA CCTTTTTACT TCGAGATTCA GCGCAGGAAG ATTATTTATT CTCTGTTAGT 
TTTAGACGCT ACAGTCGTTC TCTTCATGCT AGAATTGAGC AGTGGAATCA TAACTTTAGC 
TTTGATGCCC ATGATCCTTG TGTCTTCCAT TCTCCTGATA TTACTGGGCT CCTGGAACAC 
TATAAGGACC CCAGTGCCTG TATGTTCTTT GAGCCGCTCT TGTCCACTCC CTTAATCCGG 
ACGTTCCCCT TTTCCTTGCA GCATATTTGC AGAACGGTTA TTTGTAATTG TACGACTTAC 
GATGGCATCG ATGCCCTTCC CATTCCTTCG CCTATGAAAT TGTATCTGAA GGAATACCAT 
TATAAATCAA AAGTTAGGTT ACTCAGGATT GATGTGCCAG AGCAGCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.
eLife6(2017 02)
Kedzierski L,Tate MD,Hsu AC,Kolesnik TB,Linossi EM,Dagley L,Dong Z,Freeman S,Infusini G,Starkey MR,Bird NL,Chatfield SM,Babon JJ,Huntington N,Belz G,Webb A,Wark PA,Nicola NA,Xu J,Kedzierska K,Hansbro PM,Nicholson SE

SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity.
Immunology and cell biology93(10)909-13(2015 Nov)
Kedzierski L,Clemens EB,Bird NL,Kile BT,Belz GT,Nicola NA,Kedzierska K,Nicholson SE

Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
PLoS pathogens10(5)e1004134(2014 May)
Kedzierski L,Linossi EM,Kolesnik TB,Day EB,Bird NL,Kile BT,Belz GT,Metcalf D,Nicola NA,Kedzierska K,Nicholson SE

Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors.
Developmental cell27(4)399-411(2013 Nov)
Sim? S,Cooper JA

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Socs4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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