Eri1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eri1
Entrez Gene ID	67276
Full Name	exoribonuclease 1
Synonyms	3'hexo,3110010F15Rik,Thex1,eri-1
General protein information	Preferred Names exoribonuclease 1 Names 3'-5' exoribonuclease 1 3'-5' exonuclease ERI1 enhanced RNAi protein 1 eri-1 homolog histone mRNA 3' end-specific exonuclease histone mRNA 3'-exonuclease 1 three prime histone mRNA exonuclease 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 A4

mRNA and Protein(s)

mRNA	Protein	Name
NM_026067.3	NP_080343.4	3'-5' exoribonuclease 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ERI1	XP_002699843.1
Schizosaccharomyces pombe (fission yeast)	eri1	XP_001713129.1
	LOC699381	XP_002805307.1
Canis lupus familiaris (dog)	ERI1	XP_539997.2
Gallus gallus (chicken)	ERI1	NP_001006450.1
Danio rerio (zebrafish)	eri1	NP_001018450.1
Caenorhabditis elegans (roundworm)	eri-1	NP_741293.1
Pan troglodytes (chimpanzee)	ERI1	XP_001136735.1
Mus musculus (house mouse)	Eri1	NP_080343.4
Rattus norvegicus (Norway rat)	Eri1	NP_001014165.1
Xenopus tropicalis (tropical clawed frog)	eri1	NP_001016146.1
Homo sapiens (human)	ERI1	NP_699163.2

Gene Ontology
Bibliography

Related articles in PubMed

Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay.
Hoefig KP, Rath N, Heinz GA, Wolf C, Dameris J, Schepers A, Kremmer E, Ansel KM, Heissmeyer V
Nature structural & molecular biology20(1)73-81(2013 Jan)

Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function.
Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier LL, Heissmeyer V, Ansel KM
Blood120(1)130-42(2012 Jul)

High-dose siRNAs upregulate mouse Eri-1 at both transcription and posttranscription levels.
Bian Y, Zhou W, Zhao Y, Li X, Geng W, Hao R, Yang Q, Huang W
PloS one6(10)e26466(2011)

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Developmental cell18(4)675-85(2010 Apr)

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Developmental cell17(6)836-48(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data demonstrate how degradation of histone mRNAs is initiated when 3' oligouridylation creates a cis element that enables Eri1 to process the double-stranded stem-loop structure
Title: Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay.

Mouse Eri1 regulates miRNA homeostasis in lymphocytes and is required for normal NK-cell development and antiviral immunity.
Title: Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function.

Findings indicate that Eri1 catalyzes the final trimming step in 5.8S rRNA processing, functionally and spatially connecting this regulator of RNAi with the basal translation machinery.
Title: Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing.

The roles of meri-1 (mouse enhanced RNAi) and adar1 in the regulation of RNA interference are reported.
Title: High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse.

The following Eri1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eri1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01509	NM_026067.3 Latest version!	Mus musculus exoribonuclease 1 (Eri1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eri1 ( NM_026067.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080343.4 Mus musculus exoribonuclease 1 (Eri1), mRNA.

Price & Availability↑

CloneID	OMu01509
Clone ID Related Accession (Same CDS sequence)	NM_026067.3
Accession Version	NM_026067.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Mus musculus(house mouse)
Product	3'-5' exoribonuclease 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK014410.1, AK165026.1, AK161031.1 and AK050230.1. On Jan 17, 2008 this sequence version replaced NM_026067.2. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.248668.1, AK144223.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGACG AGCGGGGCCG GGAGCGTGGC GGCGACGCGG CGCAGCAGAA GACGCCGCGG 
CCGGAGTGTG AGGAGTCCCG GCCGCTGAGC GTGGAGAAAA AGCAGCGATG CAGACTTGAT 
GGCAAAGAGA CAGATGGATC GAAGTTCATT TCCTCCAATG GCAGTGACTT CAGTGACCCG 
GTTTACAAAG AGATCGCAAT GACAAACGGT TGTATCAACC GGATGAGTAA GGAGGAACTC 
AGAGCTAAAC TTTCAGAATT TAAGCTTGAA ACAAGAGGAG TCAAGGATGT TCTAAAGAAG 
AGACTGAAAA ACTATTACAA GAAGCAGAAG TTGATGCTGA AAGAGAGCTC CGCTGGGGAC 
AGTTACTATG ACTACATTTG TATCATTGAC TTTGAGGCTA CTTGTGAAGA GGGGAACCCA 
GCTGAGTTCC TACATGAAAT CATTGAGTTT CCTGTTGTCC TGTTGAATAC ACACACCTTA 
GAAATCGAAG ATACGTTTCA GCAGTATGTG AGGCCAGAAG TCAATGATCA GCTTTCAGAG 
TTCTGCATCG GTCTTACTGG AATCACTCAG GATCAGGTAG ACAGAGCCGA TGCTTTCCCT 
CAGGTCCTGA AAAAAGTGAT TGAGTGGATG AAGTCAAAGG AGTTGGGAAC TAAGTACAAG 
TACTGTATAC TAACAGATGG CTCCTGGGAT ATGAGTAAGT TCCTGAGCAT CCAGTGCCGG 
CTCAGCAGAC TCAAACACCC GGCCTTCGCT AAGAAGTGGA TCAATATCCG GAAGTCATAC 
GGAAACTTCT ATAAGGTTCC CAGAAGCCAG ACCAAACTAA CAATAATGCT TGAAAAATTA 
GGAATGGATT ATGATGGACG GCCTCACAGC GGTCTCGATG ACTCTAAGAA CATTGCTAGA 
ATAGCTATTC GGATGCTTCA GGATGGATGT GAACTTCGAA TCAATGAAAA AATACTTGGA 
GGGCAGTTGA TGAGTGTGTC CTCATCCTTA CCAGTAGAGG GCGCTCCAGC TCCACAGATG 
CCACATAGTA GAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080343.4
CDS	167..1204
Translation	MEDERGRERGGDAAQQKTPRPECEESRPLSVEKKQRCRLDGKETDGSKFISSNGSDFSDPVYKEIAMTNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRLKNYYKKQKLMLKESSAGDSYYDYICIIDFEATCEEGNPAEFLHEIIEFPVVLLNTHTLEIEDTFQQYVRPEVNDQLSEFCIGLTGITQDQVDRADAFPQVLKKVIEWMKSKELGTKYKYCILTDGSWDMSKFLSIQCRLSRLKHPAFAKKWINIRKSYGNFYKVPRSQTKLTIMLEKLGMDYDGRPHSGLDDSKNIARIAIRMLQDGCELRINEKILGGQLMSVSSSLPVEGAPAPQMPHSRK

Target ORF information:

RefSeq Version	NM_026067.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus exoribonuclease 1 (Eri1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026067.3

ORF Insert Sequence:

ATGGAGGACG AGCGGGGCCG GGAGCGTGGC GGCGACGCGG CGCAGCAGAA GACGCCGCGG 
CCGGAGTGTG AGGAGTCCCG GCCGCTGAGC GTGGAGAAAA AGCAGCGATG CAGACTTGAT 
GGCAAAGAGA CAGATGGATC GAAGTTCATT TCCTCCAATG GCAGTGACTT CAGTGACCCG 
GTTTACAAAG AGATCGCAAT GACAAACGGT TGTATCAACC GGATGAGTAA GGAGGAACTC 
AGAGCTAAAC TTTCAGAATT TAAGCTTGAA ACAAGAGGAG TCAAGGATGT TCTAAAGAAG 
AGACTGAAAA ACTATTACAA GAAGCAGAAG TTGATGCTGA AAGAGAGCTC CGCTGGGGAC 
AGTTACTATG ACTACATTTG TATCATTGAC TTTGAGGCTA CTTGTGAAGA GGGGAACCCA 
GCTGAGTTCC TACATGAAAT CATTGAGTTT CCTGTTGTCC TGTTGAATAC ACACACCTTA 
GAAATCGAAG ATACGTTTCA GCAGTATGTG AGGCCAGAAG TCAATGATCA GCTTTCAGAG 
TTCTGCATCG GTCTTACTGG AATCACTCAG GATCAGGTAG ACAGAGCCGA TGCTTTCCCT 
CAGGTCCTGA AAAAAGTGAT TGAGTGGATG AAGTCAAAGG AGTTGGGAAC TAAGTACAAG 
TACTGTATAC TAACAGATGG CTCCTGGGAT ATGAGTAAGT TCCTGAGCAT CCAGTGCCGG 
CTCAGCAGAC TCAAACACCC GGCCTTCGCT AAGAAGTGGA TCAATATCCG GAAGTCATAC 
GGAAACTTCT ATAAGGTTCC CAGAAGCCAG ACCAAACTAA CAATAATGCT TGAAAAATTA 
GGAATGGATT ATGATGGACG GCCTCACAGC GGTCTCGATG ACTCTAAGAA CATTGCTAGA 
ATAGCTATTC GGATGCTTCA GGATGGATGT GAACTTCGAA TCAATGAAAA AATACTTGGA 
GGGCAGTTGA TGAGTGTGTC CTCATCCTTA CCAGTAGAGG GCGCTCCAGC TCCACAGATG 
CCACATAGTA GAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay.
Nature structural & molecular biology20(1)73-81(2013 Jan)
Hoefig KP,Rath N,Heinz GA,Wolf C,Dameris J,Schepers A,Kremmer E,Ansel KM,Heissmeyer V

Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function.
Blood120(1)130-42(2012 Jul)
Thomas MF,Abdul-Wajid S,Panduro M,Babiarz JE,Rajaram M,Woodruff P,Lanier LL,Heissmeyer V,Ansel KM

High-dose siRNAs upregulate mouse Eri-1 at both transcription and posttranscription levels.
PloS one6(10)e26466(2011)
Bian Y,Zhou W,Zhao Y,Li X,Geng W,Hao R,Yang Q,Huang W

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Developmental cell18(4)675-85(2010 Apr)
Guo G,Huss M,Tong GQ,Wang C,Li Sun L,Clarke ND,Robson P

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Developmental cell17(6)836-48(2009 Dec)
Yokoyama S,Ito Y,Ueno-Kudoh H,Shimizu H,Uchibe K,Albini S,Mitsuoka K,Miyaki S,Kiso M,Nagai A,Hikata T,Osada T,Fukuda N,Yamashita S,Harada D,Mezzano V,Kasai M,Puri PL,Hayashizaki Y,Okado H,Hashimoto M,Asahara H

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Eri1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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