Nrarp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nrarp
Entrez Gene ID	67122
Full Name	Notch-regulated ankyrin repeat protein
Synonyms	2700054M22Rik
General protein information	Preferred Names Notch-regulated ankyrin repeat protein Names notch-regulated ankyrin repeat-containing protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_025980.2	NP_080256.2	notch-regulated ankyrin repeat-containing protein

Pathways from BioSystems

Homologies

	LOC720929	XP_001116892.1
Rattus norvegicus (Norway rat)	Nrarp	NP_001137222.1
Danio rerio (zebrafish)	nrarpa	NP_852472.1
Homo sapiens (human)	NRARP	NP_001004354.1
Pan troglodytes (chimpanzee)	NRARP	XP_528519.1
Gallus gallus (chicken)	NRARP	XP_428951.2
Canis lupus familiaris (dog)	NRARP	XP_005625115.1
Bos taurus (cattle)	NRARP	XP_005213553.1
Mus musculus (house mouse)	Nrarp	NP_080256.2

Gene Ontology
Bibliography

Related articles in PubMed

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.
Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J
Nature545(7654)360-364(2017 05)

Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis.
Lee S, Rho SS, Park H, Park JA, Kim J, Lee IK, Koh GY, Mochizuki N, Kim YM, Kwon YG
The Journal of clinical investigation127(2)457-471(2017 Feb)

Disruption of somitogenesis by a novel dominant allele of Lfng suggests important roles for protein processing and secretion.
Williams DR, Shifley ET, Braunreiter KM, Cole SE
Development (Cambridge, England)143(5)822-30(2016 Mar)

Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA
Developmental biology406(1)92-103(2015 Oct)

Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes.
Hoyle NP, Ish-Horowicz D
Proceedings of the National Academy of Sciences of the United States of America110(46)E4316-24(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated in the mouse testis
Title: Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.

Nrarp is essential for forming the proper number and morphology of axial skeleton components
Title: The period of the somite segmentation clock is sensitive to Notch activity.

Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.
Title: Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.

Results show that the Notch-regulated ankyrin repeat protein (Nrarp) acts as a molecular link between Notch- and Lef1-dependent Wnt signaling in endothelial cells to control stability of new vessel connections in mouse and zebrafish.
Title: Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis.

Different effects of Nrarp overexpression suggest that alternate Notch signaling pathways mediate T- versus B-cell lineage commitment and thymocyte maturation.
Title: Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development.

The following Nrarp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nrarp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16656	NM_025980.2 Latest version!	Mus musculus Notch-regulated ankyrin repeat protein (Nrarp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nrarp ( NM_025980.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080256.2 Mus musculus Notch-regulated ankyrin repeat protein (Nrarp), mRNA.

Price & Availability↑

CloneID	OMu16656
Clone ID Related Accession (Same CDS sequence)	NM_025980.2
Accession Version	NM_025980.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Mus musculus(house mouse)
Product	notch-regulated ankyrin repeat-containing protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY046077.1. On Jul 28, 2006 this sequence version replaced NM_025980.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AY046077.1 [ECO:0000345] ##Evidence-Data-END##

ATGAGCCAAG CCGAGCTGTC CACCTGCTCG GCGCCACAGA CGCAGCGCAT CTTCCAGGAA 
GCGGTGCGCA AGGGCAACAC GCAGGAGCTG CAGTCGCTGC TGCAGAACAT GACTAACTGC 
GAATTCAACG TGAACTCGTT CGGGCCGGAG GGCCAGACAG CACTACACCA GTCAGTCATC 
GACGGCAACC TGGAGCTGGT GAAGCTGTTG GTCAAGTTCG GAGCCGACAT CCGCCTAGCT 
AACCGCGACG GCTGGAGCGC GCTACACATC GCCGCTTTCG GGGGCCACCA GGACATCGTG 
CTCTATCTCA TCACCAAGGC CAAGTACGCG GCCAGCGGCC GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080256.2
CDS	354..698
Translation	MSQAELSTCSAPQTQRIFQEAVRKGNTQELQSLLQNMTNCEFNVNSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANRDGWSALHIAAFGGHQDIVLYLITKAKYAASGR

Target ORF information:

RefSeq Version	NM_025980.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Notch-regulated ankyrin repeat protein (Nrarp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025980.2

ORF Insert Sequence:

ATGAGCCAAG CCGAGCTGTC CACCTGCTCG GCGCCACAGA CGCAGCGCAT CTTCCAGGAA 
GCGGTGCGCA AGGGCAACAC GCAGGAGCTG CAGTCGCTGC TGCAGAACAT GACTAACTGC 
GAATTCAACG TGAACTCGTT CGGGCCGGAG GGCCAGACAG CACTACACCA GTCAGTCATC 
GACGGCAACC TGGAGCTGGT GAAGCTGTTG GTCAAGTTCG GAGCCGACAT CCGCCTAGCT 
AACCGCGACG GCTGGAGCGC GCTACACATC GCCGCTTTCG GGGGCCACCA GGACATCGTG 
CTCTATCTCA TCACCAAGGC CAAGTACGCG GCCAGCGGCC GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.
Nature545(7654)360-364(2017 05)
Lim JS,Ibaseta A,Fischer MM,Cancilla B,O'Young G,Cristea S,Luca VC,Yang D,Jahchan NS,Hamard C,Antoine M,Wislez M,Kong C,Cain J,Liu YW,Kapoun AM,Garcia KC,Hoey T,Murriel CL,Sage J

Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis.
The Journal of clinical investigation127(2)457-471(2017 Feb)
Lee S,Rho SS,Park H,Park JA,Kim J,Lee IK,Koh GY,Mochizuki N,Kim YM,Kwon YG

Disruption of somitogenesis by a novel dominant allele of Lfng suggests important roles for protein processing and secretion.
Development (Cambridge, England)143(5)822-30(2016 Mar)
Williams DR,Shifley ET,Braunreiter KM,Cole SE

Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Developmental biology406(1)92-103(2015 Oct)
Lewandowski JP,Du F,Zhang S,Powell MB,Falkenstein KN,Ji H,Vokes SA

Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes.
Proceedings of the National Academy of Sciences of the United States of America110(46)E4316-24(2013 Nov)
Hoyle NP,Ish-Horowicz D

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Nrarp cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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