Ctnnbip1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ctnnbip1
Entrez Gene ID	67087
Full Name	catenin beta interacting protein 1
Synonyms	1110008O09Rik,2310001I19Rik,AW457332,Catnbip1,Icat
General protein information	Preferred Names catenin beta interacting protein 1 Names beta-catenin-interacting protein 1 inhibitor of beta-catenin and Tcf-4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001141930.1	NP_001135402.1	beta-catenin-interacting protein 1
NM_023465.4	NP_075954.1	beta-catenin-interacting protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CTNNBIP1	XP_001168482.1
Rattus norvegicus (Norway rat)	Ctnnbip1	NP_001166859.1
Canis lupus familiaris (dog)	CTNNBIP1	XP_005620575.1
Mus musculus (house mouse)	Ctnnbip1	NP_001135402.1
Bos taurus (cattle)	CTNNBIP1	NP_001032219.1
	CTNNBIP1	XP_001100001.1
Xenopus tropicalis (tropical clawed frog)	ctnnbip1	NP_001008103.1
Homo sapiens (human)	CTNNBIP1	NP_064633.1
Gallus gallus (chicken)	CTNNBIP1	XP_001233910.1
Danio rerio (zebrafish)	ctnnbip1	NP_571669.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-215 impairs adipocyte differentiation and co-represses FNDC3B and CTNNBIP1.
Peng Y, Li H, Li X, Yu S, Xiang H, Peng J, Jiang S
The international journal of biochemistry & cell biology79104-112(2016 10)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/?-catenin signaling.
Shin J, Shin Y, Oh SM, Yang H, Yu WJ, Lee JP, Huh SO, Lee SH, Suh YH, Chung S, Kim HS
Cell death & disease5e1473(2014 Oct)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-215-5p is a negative regulator of adipocyte differentiation through post-transcriptional regulation of FNDC3B and CTNNBIP1 during early adipogenesis
Title: MicroRNA-215 impairs adipocyte differentiation and co-represses FNDC3B and CTNNBIP1.

miR-29b plays a pivotal role in fetal mouse neurogenesis by regulating ICAT-mediated Wnt/beta-catenin signaling.
Title: MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/?-catenin signaling.

Mechanistic studies revealed that CTNNBIP1 suppresses Wnt/beta-catenin signaling and that miR-215 promotes beta-catenin activation and upregulates alpha-SMA and fibronectin expression in TGF-beta1-treated MMCs by targeting CTNNBIP1
Title: Functional implications of microRNA-215 in TGF-?1-induced phenotypic transition of mesangial cells by targeting CTNNBIP1.

Inhibition of beta-catenin signaling in articular chondrocytes causes increased cell apoptosis and articular cartilage destruction in Col2a1-ICAT- transgenic mice.
Title: Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction.

These results suggest that the loss of ICAT gene function causes the arrest of UB branching and the apoptotic death of MM cells, resulting in renal agenesis.
Title: Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesis.

The following Ctnnbip1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ctnnbip1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02935	NM_001141930.1 Latest version!	Mus musculus catenin beta interacting protein 1 (Ctnnbip1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu02935	NM_023465.4 Latest version!	Mus musculus catenin beta interacting protein 1 (Ctnnbip1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ctnnbip1 ( NM_001141930.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001135402.1 Mus musculus catenin beta interacting protein 1 (Ctnnbip1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu02935
Clone ID Related Accession (Same CDS sequence)	NM_001141930.1 , NM_023465.4
Accession Version	NM_001141930.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	beta-catenin-interacting protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK003595.1, BQ043263.1, AK048258.1 and BQ031304.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK003595.1, BY703851.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCGCG AGGGAGCACC CGGGAAGAGT CCGGAGGAGA TGTACATTCA ACAGAAGGTC 
CGCGTGCTGC TCATGCTGAG GAAGATGGGG TCAAACCTGA CCGCCAGTGA GGAGGAATTT 
CTGCGCACCT ATGCTGGGGT CGTCAGCAGC CAGCTCAGCC AGCTGCCACA GCACTCCATC 
GACCAGGGTG CAGAGGACGT GGTGATGGCG TTTTCCAGAT CGGAGACGGA AGACCGGAGG 
CAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135402.1
CDS	144..389
Translation	MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVSSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ

Target ORF information:

RefSeq Version	NM_001141930.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus catenin beta interacting protein 1 (Ctnnbip1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001141930.1

ORF Insert Sequence:

ATGAACCGCG AGGGAGCACC CGGGAAGAGT CCGGAGGAGA TGTACATTCA ACAGAAGGTC 
CGCGTGCTGC TCATGCTGAG GAAGATGGGG TCAAACCTGA CCGCCAGTGA GGAGGAATTT 
CTGCGCACCT ATGCTGGGGT CGTCAGCAGC CAGCTCAGCC AGCTGCCACA GCACTCCATC 
GACCAGGGTG CAGAGGACGT GGTGATGGCG TTTTCCAGAT CGGAGACGGA AGACCGGAGG 
CAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ctnnbip1 ( NM_023465.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075954.1 Mus musculus catenin beta interacting protein 1 (Ctnnbip1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu02935
Clone ID Related Accession (Same CDS sequence)	NM_001141930.1 , NM_023465.4
Accession Version	NM_023465.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Mus musculus(house mouse)
Product	beta-catenin-interacting protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK036181.1 and BQ031304.1. On Nov 20, 2008 this sequence version replaced NM_023465.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036181.1, AB021261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCGCG AGGGAGCACC CGGGAAGAGT CCGGAGGAGA TGTACATTCA ACAGAAGGTC 
CGCGTGCTGC TCATGCTGAG GAAGATGGGG TCAAACCTGA CCGCCAGTGA GGAGGAATTT 
CTGCGCACCT ATGCTGGGGT CGTCAGCAGC CAGCTCAGCC AGCTGCCACA GCACTCCATC 
GACCAGGGTG CAGAGGACGT GGTGATGGCG TTTTCCAGAT CGGAGACGGA AGACCGGAGG 
CAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075954.1
CDS	250..495
Translation	MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVSSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ

Target ORF information:

RefSeq Version	NM_023465.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus catenin beta interacting protein 1 (Ctnnbip1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023465.4

ORF Insert Sequence:

ATGAACCGCG AGGGAGCACC CGGGAAGAGT CCGGAGGAGA TGTACATTCA ACAGAAGGTC 
CGCGTGCTGC TCATGCTGAG GAAGATGGGG TCAAACCTGA CCGCCAGTGA GGAGGAATTT 
CTGCGCACCT ATGCTGGGGT CGTCAGCAGC CAGCTCAGCC AGCTGCCACA GCACTCCATC 
GACCAGGGTG CAGAGGACGT GGTGATGGCG TTTTCCAGAT CGGAGACGGA AGACCGGAGG 
CAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-215 impairs adipocyte differentiation and co-represses FNDC3B and CTNNBIP1.
The international journal of biochemistry & cell biology79104-112(2016 10)
Peng Y,Li H,Li X,Yu S,Xiang H,Peng J,Jiang S

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/?-catenin signaling.
Cell death & disease5e1473(2014 Oct)
Shin J,Shin Y,Oh SM,Yang H,Yu WJ,Lee JP,Huh SO,Lee SH,Suh YH,Chung S,Kim HS

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

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Ctnnbip1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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