Pgp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pgp
Entrez Gene ID	67078
Full Name	phosphoglycolate phosphatase
Synonyms	1700012G19Rik,AI481330,AUM,G3PP
General protein information	Preferred Names phosphoglycolate phosphatase Names glycerol-3-phosphate phosphatase PGPase aspartate-based ubiquitous Mg(2+)-dependent phosphatase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 A3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_025954.4	NP_080230.2	glycerol-3-phosphate phosphatase
NM_025954.3	NP_080230.2	glycerol-3-phosphate phosphatase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PGP	XP_001162359.2
	LOC695591	XP_001084229.2
Canis lupus familiaris (dog)	PGP	XP_005622146.1
Rattus norvegicus (Norway rat)	Pgp	NP_001162623.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011350	XP_309300.4
Caenorhabditis elegans (roundworm)	C53A3.2	NP_504511.1
Caenorhabditis elegans (roundworm)	CELE_K09H11.7	NP_504509.1
Caenorhabditis elegans (roundworm)	C45E5.1	NP_500857.2
Saccharomyces cerevisiae (baker's yeast)	PHO13	NP_010045.1
Kluyveromyces lactis	KLLA0D19382g	XP_453922.1
Schizosaccharomyces pombe (fission yeast)	pho2	NP_596255.1
Neurospora crassa	NCU00088	XP_957212.1
Bos taurus (cattle)	PGP	NP_001033261.1
Caenorhabditis elegans (roundworm)	F44E7.2	NP_504512.1
Magnaporthe oryzae (rice blast fungus)	MGG_10149	XP_003713787.1
Arabidopsis thaliana (thale cress)	PGLP2	NP_199587.1
Gallus gallus (chicken)	PGP	NP_001025809.1
Caenorhabditis elegans (roundworm)	K02D10.1	NP_001122707.1
Oryza sativa (rice)	Os09g0261300	NP_001062708.2
Xenopus tropicalis (tropical clawed frog)	pgp	XP_002932481.1
Homo sapiens (human)	PGP	NP_001035830.1
Mus musculus (house mouse)	Pgp	NP_080230.2
Danio rerio (zebrafish)	pgp	NP_997891.2
Drosophila melanogaster (fruit fly)	CG5567	NP_649015.2
Eremothecium gossypii	AGOS_ABL184W	NP_982763.1

Gene Ontology
Bibliography

Related articles in PubMed

An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation.
Segerer G, Hadamek K, Zundler M, Fekete A, Seifried A, Mueller MJ, Koentgen F, Gessler M, Jeanclos E, Gohla A
Scientific reports635160(2016 Oct)

Reversible oxidation controls the activity and oligomeric state of the mammalian phosphoglycolate phosphatase AUM.
Seifried A, Bergeron A, Boivin B, Gohla A
Free radical biology & medicine9775-84(2016 08)

Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes.
Mugabo Y, Zhao S, Seifried A, Gezzar S, Al-Mass A, Zhang D, Lamontagne J, Attane C, Poursharifi P, Iglesias J, Joly E, Peyot ML, Gohla A, Madiraju SR, Prentki M
Proceedings of the National Academy of Sciences of the United States of America113(4)E430-9(2016 Jan)

Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
Seifried A, Knobloch G, Duraphe PS, Segerer G, Manhard J, Schindelin H, Schultz J, Gohla A
The Journal of biological chemistry289(6)3416-31(2014 Feb)

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic acids research31(1)278-81(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our findings establish that PGP, an aspartate-dependent HAD phosphatase, is transiently inactivated by reversible oxidation in cells
Title: Reversible oxidation controls the activity and oligomeric state of the mammalian phosphoglycolate phosphatase AUM.

A previously known phosphoglycolate phosphatase (PGP) with an uncertain function acts as a specific glycerol-3-phosphate phosphatase and plays a role in the glucose and lipid metabolism and signaling, and the response to metabolic stress.
Title: Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes.

Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
Title: Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.

The following Pgp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pgp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17793	NM_025954.4 Latest version!	Mus musculus phosphoglycolate phosphatase (Pgp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OMu17793	NM_025954.3	Mus musculus phosphoglycolate phosphatase (Pgp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pgp ( NM_025954.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080230.2 Mus musculus phosphoglycolate phosphatase (Pgp), mRNA.

Price & Availability↑

CloneID	OMu17793
Clone ID Related Accession (Same CDS sequence)	NM_025954.4 , NM_025954.3
Accession Version	NM_025954.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-01
Organism	Mus musculus(house mouse)
Product	glycerol-3-phosphate phosphatase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154237.1. On Feb 9, 2019 this sequence version replaced NM_025954.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.4017591.1, SRR7345562.3948949.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGG CGGAAGCCGG TGGCGACGAA GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG 
GCCAAGTTGC TGCTGGCCGA GGTGGACACG CTGCTGTTCG ACTGCGATGG CGTGCTGTGG 
CGCGGTGAGA CGGCCGTGCC GGGCGCGCCG GAGACTCTGC GGGCTCTGCG GGCCCGCGGC 
AAGCGACTGG GCTTCATCAC CAACAACAGC AGCAAGACTC GCACGGCCTA CGCGGAGAAG 
CTAAGGCGCT TGGGTTTCGG CGGCCCGGTG GGGCCCGAAG CTGGCCTCGA GGTGTTCGGC 
ACGGCCTATT GCAGCGCGCT CTATCTGCGC CAACGCCTGG CCGGCGTGCC GGACCCCAAG 
GCCTACGTGC TGGGCAGCCC GGCCTTAGCA GCCGAGCTGG AGGCCGTGGG TGTCACTAGC 
GTGGGCGTGG GCCCGGACGT GCTTCACGGC GATGGCCCCA GCGACTGGCT AGCCGTGCCG 
CTCGAACCCG ACGTGCGCGC GGTAGTGGTG GGCTTCGACC CACACTTCAG CTACATGAAG 
CTCACCAAGG CCGTGCGGTA CCTGCAGCAG CCCGACTGTC TGCTCGTGGG CACCAACATG 
GACAACCGGC TCCCGCTAGA GAACGGCCGT TTCATTGCGG GTACCGGCTG TCTGGTGCGA 
GCCGTGGAGA TGGCCGCCCA GCGCCAGGCG GACATCATCG GGAAGCCTAG CCGCTTCATC 
TTCGACTGCG TGTCCCAGGA GTATGGTATC AACCCGGAGC GCACCGTCAT GGTGGGAGAC 
CGCCTGGACA CAGACATCCT CCTGGGCTCC ACCTGTAGCC TGAAGACTAT CCTGACCCTC 
ACCGGAGTCT CCAGTCTTGA GGATGTGAAG AGCAATCAGG AAAGTGACTG CATGTTCAAG 
AAGAAAATGG TCCCTGACTT CTATGTTGAC AGCATTGCCG ACCTCTTGCC TGCCCTTCAA 
GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080230.2
CDS	85..1050
Translation	MAEAEAGGDEARCVRLSAERAKLLLAEVDTLLFDCDGVLWRGETAVPGAPETLRALRARGKRLGFITNNSSKTRTAYAEKLRRLGFGGPVGPEAGLEVFGTAYCSALYLRQRLAGVPDPKAYVLGSPALAAELEAVGVTSVGVGPDVLHGDGPSDWLAVPLEPDVRAVVVGFDPHFSYMKLTKAVRYLQQPDCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGSTCSLKTILTLTGVSSLEDVKSNQESDCMFKKKMVPDFYVDSIADLLPALQG

Target ORF information:

RefSeq Version	NM_025954.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus phosphoglycolate phosphatase (Pgp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025954.4

ORF Insert Sequence:

ATGGCAGAGG CGGAAGCCGG TGGCGACGAA GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG 
GCCAAGTTGC TGCTGGCCGA GGTGGACACG CTGCTGTTCG ACTGCGATGG CGTGCTGTGG 
CGCGGTGAGA CGGCCGTGCC GGGCGCGCCG GAGACTCTGC GGGCTCTGCG GGCCCGCGGC 
AAGCGACTGG GCTTCATCAC CAACAACAGC AGCAAGACTC GCACGGCCTA CGCGGAGAAG 
CTAAGGCGCT TGGGTTTCGG CGGCCCGGTG GGGCCCGAAG CTGGCCTCGA GGTGTTCGGC 
ACGGCCTATT GCAGCGCGCT CTATCTGCGC CAACGCCTGG CCGGCGTGCC GGACCCCAAG 
GCCTACGTGC TGGGCAGCCC GGCCTTAGCA GCCGAGCTGG AGGCCGTGGG TGTCACTAGC 
GTGGGCGTGG GCCCGGACGT GCTTCACGGC GATGGCCCCA GCGACTGGCT AGCCGTGCCG 
CTCGAACCCG ACGTGCGCGC GGTAGTGGTG GGCTTCGACC CACACTTCAG CTACATGAAG 
CTCACCAAGG CCGTGCGGTA CCTGCAGCAG CCCGACTGTC TGCTCGTGGG CACCAACATG 
GACAACCGGC TCCCGCTAGA GAACGGCCGT TTCATTGCGG GTACCGGCTG TCTGGTGCGA 
GCCGTGGAGA TGGCCGCCCA GCGCCAGGCG GACATCATCG GGAAGCCTAG CCGCTTCATC 
TTCGACTGCG TGTCCCAGGA GTATGGTATC AACCCGGAGC GCACCGTCAT GGTGGGAGAC 
CGCCTGGACA CAGACATCCT CCTGGGCTCC ACCTGTAGCC TGAAGACTAT CCTGACCCTC 
ACCGGAGTCT CCAGTCTTGA GGATGTGAAG AGCAATCAGG AAAGTGACTG CATGTTCAAG 
AAGAAAATGG TCCCTGACTT CTATGTTGAC AGCATTGCCG ACCTCTTGCC TGCCCTTCAA 
GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pgp ( NM_025954.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080230.2 Mus musculus phosphoglycolate phosphatase (Pgp), mRNA.

Price & Availability↑

CloneID	OMu17793
Clone ID Related Accession (Same CDS sequence)	NM_025954.4 , NM_025954.3
Accession Version	NM_025954.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-22
Organism	Mus musculus(house mouse)
Product	glycerol-3-phosphate phosphatase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC154237.1. On Nov 17, 2006 this sequence version replaced NM_025954.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC040100.1, SRR1660817.40808.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGAGG CGGAAGCCGG TGGCGACGAA GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG 
GCCAAGTTGC TGCTGGCCGA GGTGGACACG CTGCTGTTCG ACTGCGATGG CGTGCTGTGG 
CGCGGTGAGA CGGCCGTGCC GGGCGCGCCG GAGACTCTGC GGGCTCTGCG GGCCCGCGGC 
AAGCGACTGG GCTTCATCAC CAACAACAGC AGCAAGACTC GCACGGCCTA CGCGGAGAAG 
CTAAGGCGCT TGGGTTTCGG CGGCCCGGTG GGGCCCGAAG CTGGCCTCGA GGTGTTCGGC 
ACGGCCTATT GCAGCGCGCT CTATCTGCGC CAACGCCTGG CCGGCGTGCC GGACCCCAAG 
GCCTACGTGC TGGGCAGCCC GGCCTTAGCA GCCGAGCTGG AGGCCGTGGG TGTCACTAGC 
GTGGGCGTGG GCCCGGACGT GCTTCACGGC GATGGCCCCA GCGACTGGCT AGCCGTGCCG 
CTCGAACCCG ACGTGCGCGC GGTAGTGGTG GGCTTCGACC CACACTTCAG CTACATGAAG 
CTCACCAAGG CCGTGCGGTA CCTGCAGCAG CCCGACTGTC TGCTCGTGGG CACCAACATG 
GACAACCGGC TCCCGCTAGA GAACGGCCGT TTCATTGCGG GTACCGGCTG TCTGGTGCGA 
GCCGTGGAGA TGGCCGCCCA GCGCCAGGCG GACATCATCG GGAAGCCTAG CCGCTTCATC 
TTCGACTGCG TGTCCCAGGA GTATGGTATC AACCCGGAGC GCACCGTCAT GGTGGGAGAC 
CGCCTGGACA CAGACATCCT CCTGGGCTCC ACCTGTAGCC TGAAGACTAT CCTGACCCTC 
ACCGGAGTCT CCAGTCTTGA GGATGTGAAG AGCAATCAGG AAAGTGACTG CATGTTCAAG 
AAGAAAATGG TCCCTGACTT CTATGTTGAC AGCATTGCCG ACCTCTTGCC TGCCCTTCAA 
GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080230.2
CDS	38..1003
Translation	MAEAEAGGDEARCVRLSAERAKLLLAEVDTLLFDCDGVLWRGETAVPGAPETLRALRARGKRLGFITNNSSKTRTAYAEKLRRLGFGGPVGPEAGLEVFGTAYCSALYLRQRLAGVPDPKAYVLGSPALAAELEAVGVTSVGVGPDVLHGDGPSDWLAVPLEPDVRAVVVGFDPHFSYMKLTKAVRYLQQPDCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGSTCSLKTILTLTGVSSLEDVKSNQESDCMFKKKMVPDFYVDSIADLLPALQG

Target ORF information:

RefSeq Version	NM_025954.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus phosphoglycolate phosphatase (Pgp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025954.3

ORF Insert Sequence:

ATGGCAGAGG CGGAAGCCGG TGGCGACGAA GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG 
GCCAAGTTGC TGCTGGCCGA GGTGGACACG CTGCTGTTCG ACTGCGATGG CGTGCTGTGG 
CGCGGTGAGA CGGCCGTGCC GGGCGCGCCG GAGACTCTGC GGGCTCTGCG GGCCCGCGGC 
AAGCGACTGG GCTTCATCAC CAACAACAGC AGCAAGACTC GCACGGCCTA CGCGGAGAAG 
CTAAGGCGCT TGGGTTTCGG CGGCCCGGTG GGGCCCGAAG CTGGCCTCGA GGTGTTCGGC 
ACGGCCTATT GCAGCGCGCT CTATCTGCGC CAACGCCTGG CCGGCGTGCC GGACCCCAAG 
GCCTACGTGC TGGGCAGCCC GGCCTTAGCA GCCGAGCTGG AGGCCGTGGG TGTCACTAGC 
GTGGGCGTGG GCCCGGACGT GCTTCACGGC GATGGCCCCA GCGACTGGCT AGCCGTGCCG 
CTCGAACCCG ACGTGCGCGC GGTAGTGGTG GGCTTCGACC CACACTTCAG CTACATGAAG 
CTCACCAAGG CCGTGCGGTA CCTGCAGCAG CCCGACTGTC TGCTCGTGGG CACCAACATG 
GACAACCGGC TCCCGCTAGA GAACGGCCGT TTCATTGCGG GTACCGGCTG TCTGGTGCGA 
GCCGTGGAGA TGGCCGCCCA GCGCCAGGCG GACATCATCG GGAAGCCTAG CCGCTTCATC 
TTCGACTGCG TGTCCCAGGA GTATGGTATC AACCCGGAGC GCACCGTCAT GGTGGGAGAC 
CGCCTGGACA CAGACATCCT CCTGGGCTCC ACCTGTAGCC TGAAGACTAT CCTGACCCTC 
ACCGGAGTCT CCAGTCTTGA GGATGTGAAG AGCAATCAGG AAAGTGACTG CATGTTCAAG 
AAGAAAATGG TCCCTGACTT CTATGTTGAC AGCATTGCCG ACCTCTTGCC TGCCCTTCAA 
GGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation.
Scientific reports635160(2016 Oct)
Segerer G,Hadamek K,Zundler M,Fekete A,Seifried A,Mueller MJ,Koentgen F,Gessler M,Jeanclos E,Gohla A

Reversible oxidation controls the activity and oligomeric state of the mammalian phosphoglycolate phosphatase AUM.
Free radical biology & medicine9775-84(2016 08)
Seifried A,Bergeron A,Boivin B,Gohla A

Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America113(4)E430-9(2016 Jan)
Mugabo Y,Zhao S,Seifried A,Gezzar S,Al-Mass A,Zhang D,Lamontagne J,Attane C,Poursharifi P,Iglesias J,Joly E,Peyot ML,Gohla A,Madiraju SR,Prentki M

Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
The Journal of biological chemistry289(6)3416-31(2014 Feb)
Seifried A,Knobloch G,Duraphe PS,Segerer G,Manhard J,Schindelin H,Schultz J,Gohla A

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Nucleic acids research31(1)278-81(2003 Jan)
Stryke D,Kawamoto M,Huang CC,Johns SJ,King LA,Harper CA,Meng EC,Lee RE,Yee A,L'Italien L,Chuang PT,Young SG,Skarnes WC,Babbitt PC,Ferrin TE

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Pgp cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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