Oxct1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Oxct1
Entrez Gene ID	67041
Full Name	3-oxoacid CoA transferase 1
Synonyms	2610008O03Rik,Oxct,Oxct2a,Scot-s
General protein information	Preferred Names 3-oxoacid CoA transferase 1 Names succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial somatic-type succinyl-CoA:3-oxoacid CoA-transferase succinyl-CoA:3-ketoacid CoA transferase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 A1

mRNA and Protein(s)

mRNA	Protein	Name
NM_024188.6	NP_077150.1	succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor

Pathways from BioSystems

Homologies

	OXCT1	XP_001114587.1
Gallus gallus (chicken)	OXCT1	NP_001006578.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006096	XP_316153.4
Caenorhabditis elegans (roundworm)	C05C10.3	NP_496144.1
Neurospora crassa	NCU06881	XP_959228.1
Xenopus tropicalis (tropical clawed frog)	oxct1	NP_001007927.1
Canis lupus familiaris (dog)	OXCT1	XP_536487.2
Rattus norvegicus (Norway rat)	Oxct1	NP_001121052.1
Magnaporthe oryzae (rice blast fungus)	MGG_11480	XP_003718114.1
Pan troglodytes (chimpanzee)	OXCT1	XP_001137948.1
Homo sapiens (human)	OXCT1	NP_000427.1
Mus musculus (house mouse)	Oxct1	NP_077150.1
Danio rerio (zebrafish)	oxct1b	NP_001070618.1
Drosophila melanogaster (fruit fly)	CG1140	NP_647683.1
Bos taurus (cattle)	OXCT1	NP_001069538.1
Danio rerio (zebrafish)	oxct1a	NP_001007292.1

Gene Ontology
Bibliography

Related articles in PubMed

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.
Sinagoga KL, Stone WJ, Schiesser JV, Schweitzer JI, Sampson L, Zheng Y, Wells JM
Development (Cambridge, England)144(13)2402-2414(2017 07)

CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI
The Journal of cell biology216(3)675-693(2017 Mar)

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.
Schugar RC, Moll AR, Andr? d'Avignon D, Weinheimer CJ, Kovacs A, Crawford PA
Molecular metabolism3(7)754-69(2014 Oct)

Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374).
Cong W, Ma W, Zhao T, Zhu Z, Wang Y, Tan Y, Li X, Jin L, Cai L
American journal of physiology. Endocrinology and metabolism304(8)E826-35(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that MT prevention of diabetes-induced pathological changes in cardiac tissues is most likely mediated by suppression of SCOT nitration at Trp(374).
Title: Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374).

Data suggest that to sustain survival and euglycemia during moderate-duration starvation, ketone body oxidation via Oxct1 is not required for energy transfer in three cell types: neurons, skeletal myocytes, and cardiomyocytes.
Title: Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation.

Although Oxct1(-/-) mice exhibit normal prenatal development, all develop ketoacidosis, hypoglycemia, and reduced plasma lactate concentrations within the first 48 h of birth
Title: Obligate role for ketone body oxidation in neonatal metabolic homeostasis.

The following Oxct1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Oxct1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21357	NM_024188.6 Latest version!	Mus musculus 3-oxoacid CoA transferase 1 (Oxct1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Oxct1 ( NM_024188.6 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_077150.1 Mus musculus 3-oxoacid CoA transferase 1 (Oxct1), mRNA.

Price & Availability↑

CloneID	OMu21357
Clone ID Related Accession (Same CDS sequence)	NM_024188.6
Accession Version	NM_024188.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1563bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-28
Organism	Mus musculus(house mouse)
Product	succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK078086.1, AK167681.1, AK151662.1 and BE952161.1. On Feb 22, 2008 this sequence version replaced NM_024188.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146158.1, AK151662.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCGGCTC TCAAACTCCT GTCCTCTGGG CTTCGGCTCG GCGCCTCAGC CCGCAGCTCG 
CGGGGCGCCC TGCATAAGGG GTGTGTCTGC TACTTCTCTG TCAGTACTCG TCACCACACC 
AAATTTTACA CAGATCCCGT GGAAGCTGTA AAAGATATTC CTAATGGTGC AACCTTGCTG 
GTTGGTGGTT TTGGGCTGTG TGGTATTCCA GAGAATCTTA TAGGAGCTTT ACTGAAGACT 
GGAGTAAAAG ATCTAACTGC AGTCAGCAAC AATGCAGGGG TTGACAACTT CGGCCTGGGC 
CTTTTACTTC GATCCAAGCA GATAAAACGA ATGATCTCCT CATATGTGGG AGAAAATGCA 
GAATTTGAGC GACAGTTCCT TTCTGGTGAA TTAGAAGTAG AGCTGACACC TCAGGGCACA 
CTTGCCGAGA GGATCCGTGC CGGTGGAGCT GGAGTCCCTG CCTTCTACAC CAGCACAGGG 
TATGGGACTC TGGTACAGGA AGGAGGATCA CCCATCAAAT ATAACAAAGA TGGCAGTGTT 
GCCATTGCCA GCAAGCCACG AGAGGTGAGG GAGTTTAACG GTCAGCACTT CATTTTGGAG 
GAAGCCATCA CGGGAGATTT TGCTCTGGTG AAAGCATGGA AAGCAGACCG GGCAGGCAAT 
GTGATTTTCA GGAAAAGTGC AAGAAACTTC AATCTGCCAA TGTGCAAAGC TGCAGGAACT 
ACCGTGGTGG AGGTTGAAGA AATTGTAGAC ATTGGCTCAT TTGCCCCAGA AGATATCCAC 
ATTCCAAAGA TTTATGTGCA CCGCCTCATA AAGGGAGAGA AATATGAGAA GAGAATTGAG 
CGTTTATCAC TCCGAAAGGA AGGAGATGGA AAAGGCAAAT CCGGTAAGCC TGGAGGCGAT 
GTGAGGGAAC GGATCATCAA GCGAGCCGCC CTGGAGTTTG AGGACGGCAT GTACGCTAAC 
TTGGGTATTG GGATTCCTCT TCTGGCCAGC AACTTCATCA GTCCCAACAT GACTGTTCAT 
CTTCAAAGTG AAAATGGAGT CTTGGGCCTG GGCCCATACC CACTGAAAGA CGAAGCTGAT 
GCGGATCTCA TCAATGCAGG AAAGGAAACA GTTACTGTTC TCCCAGGAGC CTCTTTCTTC 
TCCAGCGATG AGTCATTCGC CATGATTAGA GGGGGACATG TCAATCTAAC AATGTTAGGA 
GCCATGCAGG TTTCTAAGTA TGGTGACCTG GCCAACTGGA TGATACCTGG AAAAATGGTG 
AAAGGAATGG GAGGAGCTAT GGATTTGGTG TCCAGTTCCA AAACCAAAGT GGTGGTCACC 
ATGGAGCACT CTGCGAAGGG AAATGCTCAT AAAATCATGG AGAAATGTAC ACTACCACTG 
ACGGGCAAAC AGTGTGTCAA CCGCATCATT ACAGAAAAGG GTGTGTTTGA CGTGGACAAG 
AAAAATGGTT TGACACTGAT TGAGCTCTGG GAAGGCCTGA CTGTTGATGA CATCAAGAAG 
AGCACAGGCT GTGACTTTGC AGTTTCACCA AACCTCATGC CAATGCAGCA GATTTCAACT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077150.1
CDS	345..1907
Translation	MAALKLLSSGLRLGASARSSRGALHKGCVCYFSVSTRHHTKFYTDPVEAVKDIPNGATLLVGGFGLCGIPENLIGALLKTGVKDLTAVSNNAGVDNFGLGLLLRSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGVPAFYTSTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAGTTVVEVEEIVDIGSFAPEDIHIPKIYVHRLIKGEKYEKRIERLSLRKEGDGKGKSGKPGGDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNMTVHLQSENGVLGLGPYPLKDEADADLINAGKETVTVLPGASFFSSDESFAMIRGGHVNLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSSKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKGVFDVDKKNGLTLIELWEGLTVDDIKKSTGCDFAVSPNLMPMQQIST

Target ORF information:

RefSeq Version	NM_024188.6
Organism	Mus musculus(house mouse)
Definition	Mus musculus 3-oxoacid CoA transferase 1 (Oxct1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024188.6

ORF Insert Sequence:

ATGGCGGCTC TCAAACTCCT GTCCTCTGGG CTTCGGCTCG GCGCCTCAGC CCGCAGCTCG 
CGGGGCGCCC TGCATAAGGG GTGTGTCTGC TACTTCTCTG TCAGTACTCG TCACCACACC 
AAATTTTACA CAGATCCCGT GGAAGCTGTA AAAGATATTC CTAATGGTGC AACCTTGCTG 
GTTGGTGGTT TTGGGCTGTG TGGTATTCCA GAGAATCTTA TAGGAGCTTT ACTGAAGACT 
GGAGTAAAAG ATCTAACTGC AGTCAGCAAC AATGCAGGGG TTGACAACTT CGGCCTGGGC 
CTTTTACTTC GATCCAAGCA GATAAAACGA ATGATCTCCT CATATGTGGG AGAAAATGCA 
GAATTTGAGC GACAGTTCCT TTCTGGTGAA TTAGAAGTAG AGCTGACACC TCAGGGCACA 
CTTGCCGAGA GGATCCGTGC CGGTGGAGCT GGAGTCCCTG CCTTCTACAC CAGCACAGGG 
TATGGGACTC TGGTACAGGA AGGAGGATCA CCCATCAAAT ATAACAAAGA TGGCAGTGTT 
GCCATTGCCA GCAAGCCACG AGAGGTGAGG GAGTTTAACG GTCAGCACTT CATTTTGGAG 
GAAGCCATCA CGGGAGATTT TGCTCTGGTG AAAGCATGGA AAGCAGACCG GGCAGGCAAT 
GTGATTTTCA GGAAAAGTGC AAGAAACTTC AATCTGCCAA TGTGCAAAGC TGCAGGAACT 
ACCGTGGTGG AGGTTGAAGA AATTGTAGAC ATTGGCTCAT TTGCCCCAGA AGATATCCAC 
ATTCCAAAGA TTTATGTGCA CCGCCTCATA AAGGGAGAGA AATATGAGAA GAGAATTGAG 
CGTTTATCAC TCCGAAAGGA AGGAGATGGA AAAGGCAAAT CCGGTAAGCC TGGAGGCGAT 
GTGAGGGAAC GGATCATCAA GCGAGCCGCC CTGGAGTTTG AGGACGGCAT GTACGCTAAC 
TTGGGTATTG GGATTCCTCT TCTGGCCAGC AACTTCATCA GTCCCAACAT GACTGTTCAT 
CTTCAAAGTG AAAATGGAGT CTTGGGCCTG GGCCCATACC CACTGAAAGA CGAAGCTGAT 
GCGGATCTCA TCAATGCAGG AAAGGAAACA GTTACTGTTC TCCCAGGAGC CTCTTTCTTC 
TCCAGCGATG AGTCATTCGC CATGATTAGA GGGGGACATG TCAATCTAAC AATGTTAGGA 
GCCATGCAGG TTTCTAAGTA TGGTGACCTG GCCAACTGGA TGATACCTGG AAAAATGGTG 
AAAGGAATGG GAGGAGCTAT GGATTTGGTG TCCAGTTCCA AAACCAAAGT GGTGGTCACC 
ATGGAGCACT CTGCGAAGGG AAATGCTCAT AAAATCATGG AGAAATGTAC ACTACCACTG 
ACGGGCAAAC AGTGTGTCAA CCGCATCATT ACAGAAAAGG GTGTGTTTGA CGTGGACAAG 
AAAAATGGTT TGACACTGAT TGAGCTCTGG GAAGGCCTGA CTGTTGATGA CATCAAGAAG 
AGCACAGGCT GTGACTTTGC AGTTTCACCA AACCTCATGC CAATGCAGCA GATTTCAACT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.
Development (Cambridge, England)144(13)2402-2414(2017 07)
Sinagoga KL,Stone WJ,Schiesser JV,Schweitzer JI,Sampson L,Zheng Y,Wells JM

CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
The Journal of cell biology216(3)675-693(2017 Mar)
Schatton D,Pla-Martin D,Marx MC,Hansen H,Mourier A,Nemazanyy I,Pessia A,Zentis P,Corona T,Kondylis V,Barth E,Schauss AC,Velagapudi V,Rugarli EI

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.
Molecular metabolism3(7)754-69(2014 Oct)
Schugar RC,Moll AR,Andr? d'Avignon D,Weinheimer CJ,Kovacs A,Crawford PA

Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374).
American journal of physiology. Endocrinology and metabolism304(8)E826-35(2013 Apr)
Cong W,Ma W,Zhao T,Zhu Z,Wang Y,Tan Y,Li X,Jin L,Cai L

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Oxct1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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