Fancl cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fancl
Entrez Gene ID	67030
Full Name	Fanconi anemia, complementation group L
Synonyms	2010322C19Rik,AW554273,B230118H11Rik,Phf9,Pog,gcd
General protein information	Preferred Names Fanconi anemia, complementation group L Names E3 ubiquitin-protein ligase FANCL PHD finger protein 9 RING-type E3 ubiquitin transferase FANCL fanconi anemia group L protein homolog germ cell deficient proliferation of germ cells protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 A3.3
Summary	This gene encodes the complementation group L subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes. The FA complex is necessary for protection against DNA damage. This gene product, an E3 ubiquitin ligase, catalyzes and is required for the monoubiquitination of the protein encoded by the Fanconi anemia, complementation group D2 gene, a critical step in the FA pathway (PMID: 12973351, 21229326). In mouse, mutations of this E3 ubiquitin ligase gene can lead to infertility in adult males and females, and a deletion of this gene can cause embryonic lethality in some genetic backgrounds. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_025923.3	NP_080199.1	E3 ubiquitin-protein ligase FANCL isoform 1
NM_001277273.1	NP_001264202.1	E3 ubiquitin-protein ligase FANCL isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	FANCL	NP_001108108.1
Pan troglodytes (chimpanzee)	FANCL	XP_001157414.1
Mus musculus (house mouse)	Fancl	NP_080199.1
	LOC717528	XP_001115119.2
Rattus norvegicus (Norway rat)	Fancl	NP_001178613.1
Oryza sativa (rice)	Os03g0726900	NP_001051138.1
Bos taurus (cattle)	FANCL	NP_001069800.1
Xenopus tropicalis (tropical clawed frog)	fancl	NP_001007482.1
Canis lupus familiaris (dog)	FANCL	XP_005626177.1
Gallus gallus (chicken)	FANCL	NP_001029113.1
Danio rerio (zebrafish)	fancl	NP_998147.1
Arabidopsis thaliana (thale cress)	AT5G65740	NP_001032152.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse.
Jamsai D, O'Connor AE, Deboer KD, Clark BJ, Smith SJ, Browne CM, Bensley JG, Merriman JA, Yuen WS, Koopman P, Jones KT, O'Bryan MK
PloS one8(2)e56955(2013)

FANCL ubiquitinates ?-catenin and enhances its nuclear function.
Dao KH, Rotelli MD, Petersen CL, Kaech S, Nelson WD, Yates JE, Hanlon Newell AE, Olson SB, Druker BJ, Bagby GC
Blood120(2)323-34(2012 Jul)

A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.
Nakano Y, Jahan I, Bonde G, Sun X, Hildebrand MS, Engelhardt JF, Smith RJ, Cornell RA, Fritzsch B, B?nfi B
PLoS genetics8(10)e1002966(2012)

A novel ubiquitin ligase is deficient in Fanconi anemia.
Meetei AR, de Winter JP, Medhurst AL, Wallisch M, Waisfisz Q, van de Vrugt HJ, Oostra AB, Yan Z, Ling C, Bishop CE, Hoatlin ME, Joenje H, Wang W
Nature genetics35(2)165-70(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FANCL increases the activity and expression of beta-catenin, a key pluripotency factor in hematopoietic stem cells.
Title: FANCL ubiquitinates ?-catenin and enhances its nuclear function.

The authors report the structure of the human FANCL central domain and show that the RING domain is necessary and sufficient for E2 binding.
Title: Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.

Fancl is associated with acute lung injury
Title: Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.

UBE2W regulates FANCD2 monoubiquitination by mechanisms different from UBE2T and HRR6.
Title: UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2.

expression of a novel splice variant of FA complementation group L (FANCL), named FAVL, can impair the FA pathway in non-FA tumor cells and act as a tumor promoting factor
Title: FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth.

The following Fancl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fancl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17002	NM_001277273.1 Latest version!	Mus musculus Fanconi anemia, complementation group L (Fancl), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu01279	NM_025923.3 Latest version!	Mus musculus Fanconi anemia, complementation group L (Fancl), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fancl ( NM_001277273.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001264202.1 Mus musculus Fanconi anemia, complementation group L (Fancl), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu17002
Clone ID Related Accession (Same CDS sequence)	NM_001277273.1
Accession Version	NM_001277273.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase FANCL isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF513619.1, AK011903.1, AA476004.1, AW554273.2 and AI854815.1. Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK011903.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGAAG CAGAAGCAAG CCTGTTGCGC CATTTCCCGC TGCTACTTCC TCAGAACCGG 
GAGAAAACTG TGTATGAGGG ATTCATTTCG GCTCAGGGAA GTGACTTTCA CCTCAGAATA 
GTGCTGCCTA AGGACCTGCA GCTCAAGAAG GCAAGATTAC TGTGTAGCCT GCAGCTGAAA 
AATATACTTA ATGAGTACCA TCAAGTAGTC CAACAGAGAA TGAAGCACTC TCCTGATCTA 
ATGAGTTTTA TGATGGAATT GAAGATGATT TTGGAAGTTG CTTTAAAGAA TAAGCAAGAG 
TTGTGTGTAC AACCACCTTC TTGCAGTTTC TGCAAAGACC TTCTTACTGA GATAGGAGCC 
ATTGGTTGGG ATAAACTCGC ATGTGTGGAG AGTTCCTTCA GCACCATCAA GTTAAAAGCA 
GATGATGCTT CTGGTAGGAA GCACCTAATC ACTGTCAAGT TGAAGGCAAA GTATCCTGTA 
GAGCCACCAG ATTGTGTTGT GGACTTTCCT GTCCCATTTT CTGTTTCCTG GACACCACAG 
AGCTCCTTGG TAGATGTTTA TAGTCAGTTC TTGGTGGCAT TAGAGACGCT GAAGGTGTTC 
TGGGATGTTA TGGATGAAAT TGATGAGAAG ACCTGGGTGC TGGAGCCAGA GAAACCTCCC 
CGGAGTGCAA CAGCACGCAG GATTGCATTA GGAAAGAATG TTTCCATAGC CATCGAGGTG 
GACCCCAGGC ACCCTACCAT GCTTCCTGAG TTTTGCTTTC TTGGAGCTGA CCATGTGACA 
AAACCCCTGG GAATGAAGCT GAGTGGTAGC ATTCATTTAT GTCTGTTACA AAATTTGAAA 
GATGTTTTAG AAATTGATTT CCCAGCTCGT AGTATCTTGG AAGAATCTGA CTTTAGCATG 
GACTGTGGAA TCTGTTATGC CCGTCACCTG AATGGTGCCA TTCCTGATCA AGTGTGTAAT 
AATCCCCAGT GTGGACAACC TTTCCATGAA ATATGTCTGT ATGAGTGGCT GAGAGGGTTG 
AGCACCAGCA GACAGAGTTT TAACGTCTTC TTTGGTGACT GTCCCTATTG TAGTAAGCCA 
ATTACCTTGA AAATGTCTGG GAGAAAACCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264202.1
CDS	132..1244
Translation	MDEAEASLLRHFPLLLPQNREKTVYEGFISAQGSDFHLRIVLPKDLQLKKARLLCSLQLKNILNEYHQVVQQRMKHSPDLMSFMMELKMILEVALKNKQELCVQPPSCSFCKDLLTEIGAIGWDKLACVESSFSTIKLKADDASGRKHLITVKLKAKYPVEPPDCVVDFPVPFSVSWTPQSSLVDVYSQFLVALETLKVFWDVMDEIDEKTWVLEPEKPPRSATARRIALGKNVSIAIEVDPRHPTMLPEFCFLGADHVTKPLGMKLSGSIHLCLLQNLKDVLEIDFPARSILEESDFSMDCGICYARHLNGAIPDQVCNNPQCGQPFHEICLYEWLRGLSTSRQSFNVFFGDCPYCSKPITLKMSGRKP

Target ORF information:

RefSeq Version	NM_001277273.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus Fanconi anemia, complementation group L (Fancl), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277273.1

ORF Insert Sequence:

ATGGACGAAG CAGAAGCAAG CCTGTTGCGC CATTTCCCGC TGCTACTTCC TCAGAACCGG 
GAGAAAACTG TGTATGAGGG ATTCATTTCG GCTCAGGGAA GTGACTTTCA CCTCAGAATA 
GTGCTGCCTA AGGACCTGCA GCTCAAGAAG GCAAGATTAC TGTGTAGCCT GCAGCTGAAA 
AATATACTTA ATGAGTACCA TCAAGTAGTC CAACAGAGAA TGAAGCACTC TCCTGATCTA 
ATGAGTTTTA TGATGGAATT GAAGATGATT TTGGAAGTTG CTTTAAAGAA TAAGCAAGAG 
TTGTGTGTAC AACCACCTTC TTGCAGTTTC TGCAAAGACC TTCTTACTGA GATAGGAGCC 
ATTGGTTGGG ATAAACTCGC ATGTGTGGAG AGTTCCTTCA GCACCATCAA GTTAAAAGCA 
GATGATGCTT CTGGTAGGAA GCACCTAATC ACTGTCAAGT TGAAGGCAAA GTATCCTGTA 
GAGCCACCAG ATTGTGTTGT GGACTTTCCT GTCCCATTTT CTGTTTCCTG GACACCACAG 
AGCTCCTTGG TAGATGTTTA TAGTCAGTTC TTGGTGGCAT TAGAGACGCT GAAGGTGTTC 
TGGGATGTTA TGGATGAAAT TGATGAGAAG ACCTGGGTGC TGGAGCCAGA GAAACCTCCC 
CGGAGTGCAA CAGCACGCAG GATTGCATTA GGAAAGAATG TTTCCATAGC CATCGAGGTG 
GACCCCAGGC ACCCTACCAT GCTTCCTGAG TTTTGCTTTC TTGGAGCTGA CCATGTGACA 
AAACCCCTGG GAATGAAGCT GAGTGGTAGC ATTCATTTAT GTCTGTTACA AAATTTGAAA 
GATGTTTTAG AAATTGATTT CCCAGCTCGT AGTATCTTGG AAGAATCTGA CTTTAGCATG 
GACTGTGGAA TCTGTTATGC CCGTCACCTG AATGGTGCCA TTCCTGATCA AGTGTGTAAT 
AATCCCCAGT GTGGACAACC TTTCCATGAA ATATGTCTGT ATGAGTGGCT GAGAGGGTTG 
AGCACCAGCA GACAGAGTTT TAACGTCTTC TTTGGTGACT GTCCCTATTG TAGTAAGCCA 
ATTACCTTGA AAATGTCTGG GAGAAAACCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fancl ( NM_025923.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080199.1 Mus musculus Fanconi anemia, complementation group L (Fancl), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu01279
Clone ID Related Accession (Same CDS sequence)	NM_025923.3
Accession Version	NM_025923.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase FANCL isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF513619.1 and AI854815.1. On Mar 29, 2013 this sequence version replaced NM_025923.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF513619.1, BC032876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGAAG CAGAAGCAAG CCTGTTGCGC CATTTCCCGC TGCTACTTCC TCAGAACCGG 
GAGAAAACTG TGTATGAGGG ATTCATTTCG GCTCAGGGAA GTGACTTTCA CCTCAGAATA 
GTGCTGCCTA AGGACCTGCA GCTCAAGAAG GCAAGATTAC TGTGTAGCCT GCAGCTGAAA 
AATATACTTA ATGAGTACCA TCAAGTAGTC CAACAGAGAA TGAAGCACTC TCCTGATCTA 
ATGAGTTTTA TGATGGAATT GAAGATGATT TTGGAAGTTG CTTTAAAGAA TAAGCAAGAG 
TTGTGTGTAC AACCACCTTC TTGCAGTTTC TGCAAAGACC TTCTTACTGA GATAGGAGCC 
ATTGGTTGGG ATAAACTCGC ATGTGTGGAG AGTTCCTTCA GCACCATCAA GTTAAAAGCA 
GATGATGCTT CTGGTAGGAA GCACCTAATC ACTGTCAAGT TGAAGGCAAA GTATCCTGTA 
GAGCCACCAG ATTGTGTTGT GGACTTTCCT GTCCCATTTT CTGTTTCCTG GACACCACAG 
AGCTCCTTGG TAGATGTTTA TAGTCAGTTC TTGGTGGCAT TAGAGACGCT GAAGGTGTTC 
TGGGATGTTA TGGATGAAAT TGATGAGAAG ACCTGGGTGC TGGAGCCAGA GAAACCTCCC 
CGGAGTGCAA CAGCACGCAG GATTGCATTA GGAAAGAATG TTTCCATAGC CATCGAGGTG 
GACCCCAGGC ACCCTACCAT GCTTCCTGAG TTTTGCTTTC TTGGAGCTGA CCATGTGACA 
AAACCCCTGG GAATGAAGCT GAGTGGTAGC ATTCATTTAT GGGATCCAGA AAATAGTCTG 
TTACAAAATT TGAAAGATGT TTTAGAAATT GATTTCCCAG CTCGTAGTAT CTTGGAAGAA 
TCTGACTTTA GCATGGACTG TGGAATCTGT TATGCCCGTC ACCTGAATGG TGCCATTCCT 
GATCAAGTGT GTAATAATCC CCAGTGTGGA CAACCTTTCC ATGAAATATG TCTGTATGAG 
TGGCTGAGAG GGTTGAGCAC CAGCAGACAG AGTTTTAACG TCTTCTTTGG TGACTGTCCC 
TATTGTAGTA AGCCAATTAC CTTGAAAATG TCTGGGAGAA AACCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080199.1
CDS	132..1259
Translation	MDEAEASLLRHFPLLLPQNREKTVYEGFISAQGSDFHLRIVLPKDLQLKKARLLCSLQLKNILNEYHQVVQQRMKHSPDLMSFMMELKMILEVALKNKQELCVQPPSCSFCKDLLTEIGAIGWDKLACVESSFSTIKLKADDASGRKHLITVKLKAKYPVEPPDCVVDFPVPFSVSWTPQSSLVDVYSQFLVALETLKVFWDVMDEIDEKTWVLEPEKPPRSATARRIALGKNVSIAIEVDPRHPTMLPEFCFLGADHVTKPLGMKLSGSIHLWDPENSLLQNLKDVLEIDFPARSILEESDFSMDCGICYARHLNGAIPDQVCNNPQCGQPFHEICLYEWLRGLSTSRQSFNVFFGDCPYCSKPITLKMSGRKP

Target ORF information:

RefSeq Version	NM_025923.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus Fanconi anemia, complementation group L (Fancl), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025923.3

ORF Insert Sequence:

ATGGACGAAG CAGAAGCAAG CCTGTTGCGC CATTTCCCGC TGCTACTTCC TCAGAACCGG 
GAGAAAACTG TGTATGAGGG ATTCATTTCG GCTCAGGGAA GTGACTTTCA CCTCAGAATA 
GTGCTGCCTA AGGACCTGCA GCTCAAGAAG GCAAGATTAC TGTGTAGCCT GCAGCTGAAA 
AATATACTTA ATGAGTACCA TCAAGTAGTC CAACAGAGAA TGAAGCACTC TCCTGATCTA 
ATGAGTTTTA TGATGGAATT GAAGATGATT TTGGAAGTTG CTTTAAAGAA TAAGCAAGAG 
TTGTGTGTAC AACCACCTTC TTGCAGTTTC TGCAAAGACC TTCTTACTGA GATAGGAGCC 
ATTGGTTGGG ATAAACTCGC ATGTGTGGAG AGTTCCTTCA GCACCATCAA GTTAAAAGCA 
GATGATGCTT CTGGTAGGAA GCACCTAATC ACTGTCAAGT TGAAGGCAAA GTATCCTGTA 
GAGCCACCAG ATTGTGTTGT GGACTTTCCT GTCCCATTTT CTGTTTCCTG GACACCACAG 
AGCTCCTTGG TAGATGTTTA TAGTCAGTTC TTGGTGGCAT TAGAGACGCT GAAGGTGTTC 
TGGGATGTTA TGGATGAAAT TGATGAGAAG ACCTGGGTGC TGGAGCCAGA GAAACCTCCC 
CGGAGTGCAA CAGCACGCAG GATTGCATTA GGAAAGAATG TTTCCATAGC CATCGAGGTG 
GACCCCAGGC ACCCTACCAT GCTTCCTGAG TTTTGCTTTC TTGGAGCTGA CCATGTGACA 
AAACCCCTGG GAATGAAGCT GAGTGGTAGC ATTCATTTAT GGGATCCAGA AAATAGTCTG 
TTACAAAATT TGAAAGATGT TTTAGAAATT GATTTCCCAG CTCGTAGTAT CTTGGAAGAA 
TCTGACTTTA GCATGGACTG TGGAATCTGT TATGCCCGTC ACCTGAATGG TGCCATTCCT 
GATCAAGTGT GTAATAATCC CCAGTGTGGA CAACCTTTCC ATGAAATATG TCTGTATGAG 
TGGCTGAGAG GGTTGAGCAC CAGCAGACAG AGTTTTAACG TCTTCTTTGG TGACTGTCCC 
TATTGTAGTA AGCCAATTAC CTTGAAAATG TCTGGGAGAA AACCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse.
PloS one8(2)e56955(2013)
Jamsai D,O'Connor AE,Deboer KD,Clark BJ,Smith SJ,Browne CM,Bensley JG,Merriman JA,Yuen WS,Koopman P,Jones KT,O'Bryan MK

FANCL ubiquitinates ?-catenin and enhances its nuclear function.
Blood120(2)323-34(2012 Jul)
Dao KH,Rotelli MD,Petersen CL,Kaech S,Nelson WD,Yates JE,Hanlon Newell AE,Olson SB,Druker BJ,Bagby GC

A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.
PLoS genetics8(10)e1002966(2012)
Nakano Y,Jahan I,Bonde G,Sun X,Hildebrand MS,Engelhardt JF,Smith RJ,Cornell RA,Fritzsch B,B?nfi B

A novel ubiquitin ligase is deficient in Fanconi anemia.
Nature genetics35(2)165-70(2003 Oct)
Meetei AR,de Winter JP,Medhurst AL,Wallisch M,Waisfisz Q,van de Vrugt HJ,Oostra AB,Yan Z,Ling C,Bishop CE,Hoatlin ME,Joenje H,Wang W

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Fancl cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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