Dnajc10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dnajc10
Entrez Gene ID	66861
Full Name	DnaJ heat shock protein family (Hsp40) member C10
Synonyms	1200006L06Rik,D2Ertd706e,ERdj5,JPDI
General protein information	Preferred Names DnaJ heat shock protein family (Hsp40) member C10 Names dnaJ homolog subfamily C member 10 DnaJ (Hsp40) homolog, subfamily C, member 10 ER-resident protein ERdj5 endoplasmic reticulum DNA J domain-containing protein 5 endoplasmic reticulum DnaJ-PDI fusion protein 1 j domain-containing PDI-like protein j domain-containing protein disulfide isomerase-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_024181.2	NP_077143.2	dnaJ homolog subfamily C member 10 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DNAJC10	XP_001159905.1
Canis lupus familiaris (dog)	DNAJC10	XP_005640437.1
Homo sapiens (human)	DNAJC10	NP_061854.1
Rattus norvegicus (Norway rat)	Dnajc10	NP_001099956.2
Caenorhabditis elegans (roundworm)	dnj-27	NP_001040704.1
Gallus gallus (chicken)	DNAJC10	XP_421968.2
Xenopus tropicalis (tropical clawed frog)	dnajc10	XP_004917970.1
Bos taurus (cattle)	DNAJC10	NP_001092591.1
Mus musculus (house mouse)	Dnajc10	NP_077143.2
	DNAJC10	XP_001102300.1
Danio rerio (zebrafish)	dnajc10	NP_001077016.1

Gene Ontology
Bibliography

Related articles in PubMed

Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5.
Ushioda R, Miyamoto A, Inoue M, Watanabe S, Okumura M, Maegawa KI, Uegaki K, Fujii S, Fukuda Y, Umitsu M, Takagi J, Inaba K, Mikoshiba K, Nagata K
Proceedings of the National Academy of Sciences of the United States of America113(41)E6055-E6063(2016 10)

Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue.
Kadokura H, Saito M, Tsuru A, Hosoda A, Iwawaki T, Inaba K, Kohno K
Biochemical and biophysical research communications440(2)245-50(2013 Oct)

Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5.
Hagiwara M, Maegawa K, Suzuki M, Ushioda R, Araki K, Matsumoto Y, Hoseki J, Nagata K, Inaba K
Molecular cell41(4)432-44(2011 Feb)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study identified the redox partners of ERdj5 from the mouse epididymis; findings show that ERdj5 interacted with two of the identified proteins via formation of intermolecular disulfide bond
Title: Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue.

Data suggest that ERdj5 contributes to ER protein quality control in the salivary gland.
Title: Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland.

study found that an endoplasmic reticulum (ER) protein ERdj5 had a reductase activity, cleaved the disulfide bonds of misfolded proteins & accelerated ER-associated degradation through its physical and functional associations with EDEM & BiP
Title: ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER.

JPDI may have roles in folding of some proteins in the ER, chaperoning by BiP and formation of proper disulfide bonds
Title: JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs.

The following Dnajc10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dnajc10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01057	NM_024181.2 Latest version!	Mus musculus DnaJ heat shock protein family (Hsp40) member C10 (Dnajc10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$468.30 $669.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dnajc10 ( NM_024181.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_077143.2 Mus musculus DnaJ heat shock protein family (Hsp40) member C10 (Dnajc10), mRNA.

Price & Availability↑

CloneID	OMu01057
Clone ID Related Accession (Same CDS sequence)	NM_024181.2
Accession Version	NM_024181.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2382bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	dnaJ homolog subfamily C member 10 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK016269.1, AK004617.1, CN460590.1 and AW546442.1. On Dec 16, 2006 this sequence version replaced NM_024181.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128945.1, SRR1660815.242753.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGGAGTCT GGTTAAACAA AGATGACTTT ATCAGAGACT TGAAGAGGAT CAGTCTCTGT 
CTTCTGATAC TGTACGTGGT CGTTGTGGTG GGCACAGATC AGAATTTTTA CAGTTTACTT 
GGAGTGTCGA AAACTGCAAG CAGTAGAGAA ATAAGACAAG CCTTTAAGAA ATTAGCACTG 
AAGTTACATC CTGATAAAAA CCCGAATAAC CCAAATGCAC ATGGTGATTT TTTAAAAATA 
AATAGAGCAT ATGAAGTACT CAAAGATGAA GATCTACGGA AAAAGTATGA CAAATATGGA 
GAAAAGGGAC TTGAAGATAA TCAAGGAGGC CAGTATGAGA GCTGGAGCTA CTACCGTTAC 
GATTTCGGTA TTTACGATGA TGATCCTGAA ATCATAACAT TAGAAAGAAG AGAATTTGAT 
GCTGCTGTCA ACTCTGGAGA ACTGTGGTTT GTAAACTTTT ACTCCCCAGG ATGTTCGCAT 
TGCCATGATT TAGCCCCCAC TTGGAGAGAA TTTGCTAAAG AAGTGGATGG GTTGCTTCGA 
ATCGGAGCTG TCAACTGTGG TGATGATCGG ATGCTCTGCC GAATGAAAGG AGTTAACAGC 
TACCCCAGCC TCTTCATCTT TAGGTCTGGA ATGGCTGCAG TGAAGTACAA TGGAGATCGG 
TCAAAGGAGA GCTTAGTGGC CTTCGCCATG CAGCACGTCA GGAGCACAGT GACAGAGCTG 
TCAACAGGAA ATTTTGTTAA TGCCATAGAA ACTGCTTTTG CTGCTGGTGT TGGCTGGCTG 
ATCACATTCT GCTCTAAAGG AGAAGATTGT TTGACATCAC AGACCCGACT CAGGCTTAGT 
GGCATGTTGG ACGGCCTTGT TAACGTGGGA TGGGTGGACT GTGACGCCCA GGACAGCCTC 
TGCAAGAGCC TGGATACCAC AGCCAGCACC ACGGCTTATT TCCCTCCTGG AGCCACTTTG 
AATGACAGGG AAAAATCCAG TGTGTTGTTT CTTAATTCAT TGGATGCTAA GGAAATATAC 
ATGGAAATCA TACATAATCT TCCAGACTTT GAACTGCTTT CAGCAAATCA ACTAGAGGAT 
CGTTTGGCAC ATCATCGCTG GCTTGTATTT TTTCATTTTG GAAAAAATGA AAACGCAAAT 
GATCCTGAGT TGAAAAAACT GAAAACTCTA CTTAAAAATG AGCATATTCA AGTTGGAAGG 
TTTGATTGCT CTTCTGCACC GGGCATCTGC TCTGATCTTT ATGTCTTCCA GCCCTGCCTA 
GCAGTGTTTA AAGGACAAGG AACCAAAGAA TATGAAATTC ATCATGGAAA GAAGATTCTA 
TACGATATAC TTGCTTTTGC CAAAGAAAGT GTTAATTCTC ATGTTACCAC ACTTGGACCT 
CAGAACTTCC CTGCAAGTGA CAAGGAACCA TGGCTTGTTG ACTTCTTTGC CCCTTGGTGT 
CCGCCATGTC GTGCGCTTTT GCCAGAGTTA CGGAAAGCAT CAACACTGCT CTACGGTCAA 
CTCAAAGTTG GTACCTTAGA CTGTACAATT CATGAAGGAC TCTGCAACAT GTATAACATC 
CAAGCTTATC CAACGACAGT GGTATTCAAT CAGTCCAGTA TTCATGAGTA TGAAGGACAT 
CACTCTGCGG AACAGATCTT GGAGTTCATA GAGGATCTCA GAAACCCTTC AGTGGTCTCT 
CTTACACCCA GCACTTTCAA TGAGCTGGTT AAACAGAGAA AGCATGATGA AGTCTGGATG 
GTCGATTTCT ATTCTCCATG GTGTCATCCC TGTCAGGTCT TGATGCCAGA ATGGAAACGC 
ATGGCCCGGA CGTTAACTGG ACTGATCAAT GTAGGCAGTG TGGACTGCCA ACAGTATCAT 
TCTTTTTGTA CTCAAGAAAA TGTTCAAAGA TACCCCGAGA TAAGATTTTA TCCCCAAAAG 
TCAAGTAAAG CCTATCAGTA TCATAGTTAC AATGGCTGGA ATAGGGATGC GTATTCCCTG 
AGAAGCTGGG GTCTTGGATT TTTGCCCCAA GCATCCATAG ATTTAACACC TCAGACTTTC 
AATGAAAAAG TTCTACAAGG GAAAACTCAC TGGGTGGTTG ATTTCTATGC TCCTTGGTGT 
GGACCTTGCC AGAATTTTGC TCCTGAGTTT GAACTCTTGG CTAGGATGAT CAAAGGAAAA 
GTGAGAGCCG GGAAAGTGGA CTGTCAGGCT TACCCCCAGA CGTGCCAGAA AGCCGGCATC 
AAAGCCTACC CCAGTGTCAA ACTGTACCAG TACGAGAGAG CAAAGAAAAG TATTTGGGAA 
GAGCAAATAA ATTCCAGAGA TGCAAAAACT ATTGCTGCCT TAATTTATGG AAAATTGGAA 
ACGCTCCAAA GCCAAGTAAA AAGAAATAAG GATGAGCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077143.2
CDS	488..2869
Translation	MGVWLNKDDFIRDLKRISLCLLILYVVVVVGTDQNFYSLLGVSKTASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYDKYGEKGLEDNQGGQYESWSYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWREFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAAVKYNGDRSKESLVAFAMQHVRSTVTELSTGNFVNAIETAFAAGVGWLITFCSKGEDCLTSQTRLRLSGMLDGLVNVGWVDCDAQDSLCKSLDTTASTTAYFPPGATLNDREKSSVLFLNSLDAKEIYMEIIHNLPDFELLSANQLEDRLAHHRWLVFFHFGKNENANDPELKKLKTLLKNEHIQVGRFDCSSAPGICSDLYVFQPCLAVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPASDKEPWLVDFFAPWCPPCRALLPELRKASTLLYGQLKVGTLDCTIHEGLCNMYNIQAYPTTVVFNQSSIHEYEGHHSAEQILEFIEDLRNPSVVSLTPSTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSVDCQQYHSFCTQENVQRYPEIRFYPQKSSKAYQYHSYNGWNRDAYSLRSWGLGFLPQASIDLTPQTFNEKVLQGKTHWVVDFYAPWCGPCQNFAPEFELLARMIKGKVRAGKVDCQAYPQTCQKAGIKAYPSVKLYQYERAKKSIWEEQINSRDAKTIAALIYGKLETLQSQVKRNKDEL

Target ORF information:

RefSeq Version	NM_024181.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus DnaJ heat shock protein family (Hsp40) member C10 (Dnajc10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024181.2

ORF Insert Sequence:

ATGGGAGTCT GGTTAAACAA AGATGACTTT ATCAGAGACT TGAAGAGGAT CAGTCTCTGT 
CTTCTGATAC TGTACGTGGT CGTTGTGGTG GGCACAGATC AGAATTTTTA CAGTTTACTT 
GGAGTGTCGA AAACTGCAAG CAGTAGAGAA ATAAGACAAG CCTTTAAGAA ATTAGCACTG 
AAGTTACATC CTGATAAAAA CCCGAATAAC CCAAATGCAC ATGGTGATTT TTTAAAAATA 
AATAGAGCAT ATGAAGTACT CAAAGATGAA GATCTACGGA AAAAGTATGA CAAATATGGA 
GAAAAGGGAC TTGAAGATAA TCAAGGAGGC CAGTATGAGA GCTGGAGCTA CTACCGTTAC 
GATTTCGGTA TTTACGATGA TGATCCTGAA ATCATAACAT TAGAAAGAAG AGAATTTGAT 
GCTGCTGTCA ACTCTGGAGA ACTGTGGTTT GTAAACTTTT ACTCCCCAGG ATGTTCGCAT 
TGCCATGATT TAGCCCCCAC TTGGAGAGAA TTTGCTAAAG AAGTGGATGG GTTGCTTCGA 
ATCGGAGCTG TCAACTGTGG TGATGATCGG ATGCTCTGCC GAATGAAAGG AGTTAACAGC 
TACCCCAGCC TCTTCATCTT TAGGTCTGGA ATGGCTGCAG TGAAGTACAA TGGAGATCGG 
TCAAAGGAGA GCTTAGTGGC CTTCGCCATG CAGCACGTCA GGAGCACAGT GACAGAGCTG 
TCAACAGGAA ATTTTGTTAA TGCCATAGAA ACTGCTTTTG CTGCTGGTGT TGGCTGGCTG 
ATCACATTCT GCTCTAAAGG AGAAGATTGT TTGACATCAC AGACCCGACT CAGGCTTAGT 
GGCATGTTGG ACGGCCTTGT TAACGTGGGA TGGGTGGACT GTGACGCCCA GGACAGCCTC 
TGCAAGAGCC TGGATACCAC AGCCAGCACC ACGGCTTATT TCCCTCCTGG AGCCACTTTG 
AATGACAGGG AAAAATCCAG TGTGTTGTTT CTTAATTCAT TGGATGCTAA GGAAATATAC 
ATGGAAATCA TACATAATCT TCCAGACTTT GAACTGCTTT CAGCAAATCA ACTAGAGGAT 
CGTTTGGCAC ATCATCGCTG GCTTGTATTT TTTCATTTTG GAAAAAATGA AAACGCAAAT 
GATCCTGAGT TGAAAAAACT GAAAACTCTA CTTAAAAATG AGCATATTCA AGTTGGAAGG 
TTTGATTGCT CTTCTGCACC GGGCATCTGC TCTGATCTTT ATGTCTTCCA GCCCTGCCTA 
GCAGTGTTTA AAGGACAAGG AACCAAAGAA TATGAAATTC ATCATGGAAA GAAGATTCTA 
TACGATATAC TTGCTTTTGC CAAAGAAAGT GTTAATTCTC ATGTTACCAC ACTTGGACCT 
CAGAACTTCC CTGCAAGTGA CAAGGAACCA TGGCTTGTTG ACTTCTTTGC CCCTTGGTGT 
CCGCCATGTC GTGCGCTTTT GCCAGAGTTA CGGAAAGCAT CAACACTGCT CTACGGTCAA 
CTCAAAGTTG GTACCTTAGA CTGTACAATT CATGAAGGAC TCTGCAACAT GTATAACATC 
CAAGCTTATC CAACGACAGT GGTATTCAAT CAGTCCAGTA TTCATGAGTA TGAAGGACAT 
CACTCTGCGG AACAGATCTT GGAGTTCATA GAGGATCTCA GAAACCCTTC AGTGGTCTCT 
CTTACACCCA GCACTTTCAA TGAGCTGGTT AAACAGAGAA AGCATGATGA AGTCTGGATG 
GTCGATTTCT ATTCTCCATG GTGTCATCCC TGTCAGGTCT TGATGCCAGA ATGGAAACGC 
ATGGCCCGGA CGTTAACTGG ACTGATCAAT GTAGGCAGTG TGGACTGCCA ACAGTATCAT 
TCTTTTTGTA CTCAAGAAAA TGTTCAAAGA TACCCCGAGA TAAGATTTTA TCCCCAAAAG 
TCAAGTAAAG CCTATCAGTA TCATAGTTAC AATGGCTGGA ATAGGGATGC GTATTCCCTG 
AGAAGCTGGG GTCTTGGATT TTTGCCCCAA GCATCCATAG ATTTAACACC TCAGACTTTC 
AATGAAAAAG TTCTACAAGG GAAAACTCAC TGGGTGGTTG ATTTCTATGC TCCTTGGTGT 
GGACCTTGCC AGAATTTTGC TCCTGAGTTT GAACTCTTGG CTAGGATGAT CAAAGGAAAA 
GTGAGAGCCG GGAAAGTGGA CTGTCAGGCT TACCCCCAGA CGTGCCAGAA AGCCGGCATC 
AAAGCCTACC CCAGTGTCAA ACTGTACCAG TACGAGAGAG CAAAGAAAAG TATTTGGGAA 
GAGCAAATAA ATTCCAGAGA TGCAAAAACT ATTGCTGCCT TAATTTATGG AAAATTGGAA 
ACGCTCCAAA GCCAAGTAAA AAGAAATAAG GATGAGCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by disulfide reductase ERdj5.
Proceedings of the National Academy of Sciences of the United States of America113(41)E6055-E6063(2016 10)
Ushioda R,Miyamoto A,Inoue M,Watanabe S,Okumura M,Maegawa KI,Uegaki K,Fujii S,Fukuda Y,Umitsu M,Takagi J,Inaba K,Mikoshiba K,Nagata K

Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue.
Biochemical and biophysical research communications440(2)245-50(2013 Oct)
Kadokura H,Saito M,Tsuru A,Hosoda A,Iwawaki T,Inaba K,Kohno K

Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5.
Molecular cell41(4)432-44(2011 Feb)
Hagiwara M,Maegawa K,Suzuki M,Ushioda R,Araki K,Matsumoto Y,Hoseki J,Nagata K,Inaba K

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

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Dnajc10 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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