Duoxa2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Duoxa2
Entrez Gene ID	66811
Full Name	dual oxidase maturation factor 2
Synonyms	9030623N16Rik,Nip2
General protein information	Preferred Names dual oxidase maturation factor 2 Names dual oxidase maturation factor 2 Numb-interacting protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 E5

mRNA and Protein(s)

mRNA	Protein	Name
NM_025777.2	NP_080053.1	dual oxidase maturation factor 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	DUOXA1	XP_425055.2
	DUOXA2	XP_001111110.1
Mus musculus (house mouse)	Duoxa2	NP_080053.1
Rattus norvegicus (Norway rat)	Duoxa2	NP_001178894.1
Danio rerio (zebrafish)	LOC100330288	XP_002666953.2
Xenopus tropicalis (tropical clawed frog)	LOC101733132	XP_004918326.1
Pan troglodytes (chimpanzee)	DUOXA2	XP_001146826.2
Bos taurus (cattle)	DUOXA2	XP_002690989.1
Gallus gallus (chicken)	DUOXA1L	XP_425054.2
Canis lupus familiaris (dog)	DUOXA2	XP_003640075.2
Homo sapiens (human)	DUOXA2	NP_997464.2

Gene Ontology
Bibliography

Related articles in PubMed

Increased Expression of DUOX2 Is an Epithelial Response to?Mucosal Dysbiosis Required for Immune Homeostasis in?Mouse Intestine.
Grasberger H, Gao J, Nagao-Kitamoto H, Kitamoto S, Zhang M, Kamada N, Eaton KA, El-Zaatari M, Shreiner AB, Merchant JL, Owyang C, Kao JY
Gastroenterology149(7)1849-59(2015 Dec)

Dual oxidase regulates neutrophil recruitment in allergic airways.
Chang S, Linderholm A, Franzi L, Kenyon N, Grasberger H, Harper R
Free radical biology & medicine6538-46(2013 Dec)

Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice.
Grasberger H, El-Zaatari M, Dang DT, Merchant JL
Gastroenterology145(5)1045-54(2013 Nov)

Mice deficient in dual oxidase maturation factors are severely hypothyroid.
Grasberger H, De Deken X, Mayo OB, Raad H, Weiss M, Liao XH, Refetoff S
Molecular endocrinology (Baltimore, Md.)26(3)481-92(2012 Mar)

Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells.
Kennedy KA, Ostrakhovitch EA, Sandiford SD, Dayarathna T, Xie X, Waese EY, Chang WY, Feng Q, Skerjanc IS, Stanford WL, Li SS
The Journal of biological chemistry285(23)17974-85(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Duoxa2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Duoxa2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17950	NM_025777.2 Latest version!	Mus musculus dual oxidase maturation factor 2 (Duoxa2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Duoxa2 ( NM_025777.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080053.1 Mus musculus dual oxidase maturation factor 2 (Duoxa2), mRNA.

Price & Availability↑

CloneID	OMu17950
Clone ID Related Accession (Same CDS sequence)	NM_025777.2
Accession Version	NM_025777.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-06
Organism	Mus musculus(house mouse)
Product	dual oxidase maturation factor 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK018569.1. On Apr 6, 2007 this sequence version replaced NM_025777.1. ##Evidence-Data-START## Transcript exon combination :: AK018569.1, BC031111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGACTGCGT GGGACGGGGT GCTACCCTTT TACCCCCAGC CCAGGCATGC CGCCAGCTTC 
AGCGTACCGC TGCTCATTGT TATCCTGGTG TTCTTGTCTT TGGCTGCTAG CTTCCTGTTC 
ATCTTGCCTG GAATCCGTGG GCACTCGCGC TGGTTCTGGT TGGTGAGAGT CCTTCTTAGC 
CTGTTCATAG GTGCCGAAAT TGTGGCTGTG CACTTCAGTG GAGACTGGTT CGTGGGGAGA 
GTGTGGACCA ACACATCCTA CAAAGCCTTC AGTCCATCCC GTGTTCAAGT CCATGTCGGT 
CTGCACGTGG GGCTGGCGGG CGTTAACATT ACACTCCGAG GAACACCGAG GCAGCAGCTG 
AACGAGACCA TTGACTACAA TGAGCGTTTC ACTTGGCGTC TGAACGAAGA CTACACCAAG 
GAGTATGTCC ATGCCTTGGA GAAGGGACTG CCGGACCCAG TGCTATACCT GGCAGAGAAG 
TTCACACCGA GCAGTCCTTG CGGGCTGTAC CACCAATATC ACCTGGCCGG TCACTATGCC 
GCAGCAACAC TGTGGGTGGC ATTCTGCTTC TGGATCATCG CCAATGCGCT GCTCTCCATG 
CCCGCCCCAC TCTACGGAGG CCTGGCTTTG CTCACCACCG GTGCCTTCAC GCTCTTCGGT 
GTCTTCGCCT TCGCCTCGAT TTCCAGCGTG CCGCTCTGCC ACTTCCGCCT GGGCTCCGCC 
GTCCTCACGC CTTACTACGG CGCCTCCTTT TGGCTCACGC TGGCCACCGG CATCCTGAGC 
CTCCTCCTCG GAGGGGCGGT GGTGATTCTC CACTATACTC GGCCCAGCGC CCTTCGCTCC 
TTTCTGGATC TAAGTGTCAA AGACTGTAGC AACCAGGCTA AAGGAAACTC ACCTCTCACC 
CTCAACAACC CGCAACACGA ACAGTTGAAG AGTCCAGACT TAAATATTAC CACTCTCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080053.1
CDS	142..1104
Translation	MTAWDGVLPFYPQPRHAASFSVPLLIVILVFLSLAASFLFILPGIRGHSRWFWLVRVLLSLFIGAEIVAVHFSGDWFVGRVWTNTSYKAFSPSRVQVHVGLHVGLAGVNITLRGTPRQQLNETIDYNERFTWRLNEDYTKEYVHALEKGLPDPVLYLAEKFTPSSPCGLYHQYHLAGHYAAATLWVAFCFWIIANALLSMPAPLYGGLALLTTGAFTLFGVFAFASISSVPLCHFRLGSAVLTPYYGASFWLTLATGILSLLLGGAVVILHYTRPSALRSFLDLSVKDCSNQAKGNSPLTLNNPQHEQLKSPDLNITTLL

Target ORF information:

RefSeq Version	NM_025777.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual oxidase maturation factor 2 (Duoxa2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025777.2

ORF Insert Sequence:

ATGACTGCGT GGGACGGGGT GCTACCCTTT TACCCCCAGC CCAGGCATGC CGCCAGCTTC 
AGCGTACCGC TGCTCATTGT TATCCTGGTG TTCTTGTCTT TGGCTGCTAG CTTCCTGTTC 
ATCTTGCCTG GAATCCGTGG GCACTCGCGC TGGTTCTGGT TGGTGAGAGT CCTTCTTAGC 
CTGTTCATAG GTGCCGAAAT TGTGGCTGTG CACTTCAGTG GAGACTGGTT CGTGGGGAGA 
GTGTGGACCA ACACATCCTA CAAAGCCTTC AGTCCATCCC GTGTTCAAGT CCATGTCGGT 
CTGCACGTGG GGCTGGCGGG CGTTAACATT ACACTCCGAG GAACACCGAG GCAGCAGCTG 
AACGAGACCA TTGACTACAA TGAGCGTTTC ACTTGGCGTC TGAACGAAGA CTACACCAAG 
GAGTATGTCC ATGCCTTGGA GAAGGGACTG CCGGACCCAG TGCTATACCT GGCAGAGAAG 
TTCACACCGA GCAGTCCTTG CGGGCTGTAC CACCAATATC ACCTGGCCGG TCACTATGCC 
GCAGCAACAC TGTGGGTGGC ATTCTGCTTC TGGATCATCG CCAATGCGCT GCTCTCCATG 
CCCGCCCCAC TCTACGGAGG CCTGGCTTTG CTCACCACCG GTGCCTTCAC GCTCTTCGGT 
GTCTTCGCCT TCGCCTCGAT TTCCAGCGTG CCGCTCTGCC ACTTCCGCCT GGGCTCCGCC 
GTCCTCACGC CTTACTACGG CGCCTCCTTT TGGCTCACGC TGGCCACCGG CATCCTGAGC 
CTCCTCCTCG GAGGGGCGGT GGTGATTCTC CACTATACTC GGCCCAGCGC CCTTCGCTCC 
TTTCTGGATC TAAGTGTCAA AGACTGTAGC AACCAGGCTA AAGGAAACTC ACCTCTCACC 
CTCAACAACC CGCAACACGA ACAGTTGAAG AGTCCAGACT TAAATATTAC CACTCTCCTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased Expression of DUOX2 Is an Epithelial Response to?Mucosal Dysbiosis Required for Immune Homeostasis in?Mouse Intestine.
Gastroenterology149(7)1849-59(2015 Dec)
Grasberger H,Gao J,Nagao-Kitamoto H,Kitamoto S,Zhang M,Kamada N,Eaton KA,El-Zaatari M,Shreiner AB,Merchant JL,Owyang C,Kao JY

Dual oxidase regulates neutrophil recruitment in allergic airways.
Free radical biology & medicine6538-46(2013 Dec)
Chang S,Linderholm A,Franzi L,Kenyon N,Grasberger H,Harper R

Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice.
Gastroenterology145(5)1045-54(2013 Nov)
Grasberger H,El-Zaatari M,Dang DT,Merchant JL

Mice deficient in dual oxidase maturation factors are severely hypothyroid.
Molecular endocrinology (Baltimore, Md.)26(3)481-92(2012 Mar)
Grasberger H,De Deken X,Mayo OB,Raad H,Weiss M,Liao XH,Refetoff S

Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells.
The Journal of biological chemistry285(23)17974-85(2010 Jun)
Kennedy KA,Ostrakhovitch EA,Sandiford SD,Dayarathna T,Xie X,Waese EY,Chang WY,Feng Q,Skerjanc IS,Stanford WL,Li SS

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Duoxa2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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