Dnase1l2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dnase1l2
Entrez Gene ID	66705
Full Name	deoxyribonuclease 1-like 2
Synonyms	4733401H14Rik
General protein information	Preferred Names deoxyribonuclease 1-like 2 Names deoxyribonuclease-1-like 2 DNase I-like 2 deoxyribonuclease I-like 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 A3.3

mRNA and Protein(s)

mRNA	Protein	Name
XM_006524799.4	XP_006524862.1	deoxyribonuclease-1-like 2 isoform X2
NM_025718.3	NP_079994.2	deoxyribonuclease-1-like 2 precursor
XM_006524799.3	XP_006524862.1	deoxyribonuclease-1-like 2 isoform X2
XM_006524798.3	XP_006524861.1	deoxyribonuclease-1-like 2 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DNASE1L2	NP_001098489.1
Rattus norvegicus (Norway rat)	Dnase1l2	XP_001057412.4
Pan troglodytes (chimpanzee)	DNASE1L2	XP_003952812.1
Homo sapiens (human)	DNASE1L2	NP_001365.1
Mus musculus (house mouse)	Dnase1l2	NP_079994.2

Gene Ontology
Bibliography

Related articles in PubMed

Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.
Manils J, Fischer H, Climent J, Casas E, Garc?a-Mart?nez C, Bas J, Sukseree S, Vavouri T, Ciruela F, de Anta JM, Tschachler E, Eckhart L, Soler C
Scientific reports7(1)11902(2017 Sep)

Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis.
Fischer H, Buchberger M, Napirei M, Tschachler E, Eckhart L
Scientific reports7(1)6433(2017 Jul)

Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death.
Fischer H, Fumicz J, Rossiter H, Napirei M, Buchberger M, Tschachler E, Eckhart L
The Journal of investigative dermatology137(3)587-594(2017 Mar)

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH
PloS one12(7)e0180682(2017)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DNase1L2 as an essential and specific regulator of programmed cell death in skin appendages, and demonstrate that the breakdown of nuclear DNA is crucial for establishing the full mechanical stability of hair.
Title: Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails.

The following Dnase1l2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dnase1l2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13103	NM_025718.3 Latest version!	Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu53929	XM_006524798.3 Latest version!	Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu53930	XM_006524799.4 Latest version!	Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu53930	XM_006524799.3	Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dnase1l2 ( NM_025718.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079994.2 Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), mRNA.

Price & Availability↑

CloneID	OMu13103
Clone ID Related Accession (Same CDS sequence)	NM_025718.3
Accession Version	NM_025718.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 837bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Mus musculus(house mouse)
Product	deoxyribonuclease-1-like 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK003619.1. On Jun 3, 2007 this sequence version replaced NM_025718.2. ##Evidence-Data-START## Transcript exon combination :: AK003619.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGGTTGGC CCTGGGCCCC GCTGACAGCA GTTTGGGCAC TGGGGGTCAT GGGAGCCACA 
GCGCTGCGGA TTGGAGCCTT CAATGTTCAG AGCTTTGGAG ACAACAAAGT GTCAGATCCA 
GACTGTGGCA GTGTCATAGC ACAGATCCTG GCCGGCTATG ATATCGCCCT GGTGCAAGAG 
GTACGAGACC CAGACCTAAG TGCAGTGTCC TTGCTCATGG AGCAAATTAA CAGAGTGTCC 
AAGCACGAGT ACGGCTTTGT GAGCAGCAAG CCACTCGGAC GTGACCAGTA CAAGGAAATG 
TACCTGTTTG TTTACAGGAA AGATGTAGCG TCAGTGGTGA GCACGTACCA GTATCCAGAC 
CCAGAGGACG CTTTCAGCCG GGAGCCTTTT GTGGTCAAAT TCTCAGTTCC TAGCTGTGCC 
ACCAAGGAGC TGGTGCTGAT CCCCCTCCAT GCAGCACCAC ACCAGGCGGT GGCAGAGATC 
GACGCGCTCT ACGATGTGTA CCTTGATGTC ATTGACAAGT GGAACACTGA TGACATGCTG 
TTTCTGGGTG ACTTTAATGC CGATTGCAAG TACGTGAAGG CGCATGACTG GCCATCGATC 
CGCCTTCGAA GCAGTGAGGT GTTTAAATGG CTCATCCCAG ACAGTGCGGA CACCACAGTG 
GGCAACTCAG ACTGTGCCTA TGACCGGATT GTAGTGAGTG GCGCCCATCT GCGCAGGAGC 
CTGAAGCCCC ACTCAGCCTC AGTTCACAAC TTTCAGGAGG AATTTGACCT AGATCAGACC 
CAGGCTCTTG CCATCAGTGA CCATTTTCCT GTGGAAGTGA CTTTCAAGAC TCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079994.2
CDS	112..948
Translation	MGWPWAPLTAVWALGVMGATALRIGAFNVQSFGDNKVSDPDCGSVIAQILAGYDIALVQEVRDPDLSAVSLLMEQINRVSKHEYGFVSSKPLGRDQYKEMYLFVYRKDVASVVSTYQYPDPEDAFSREPFVVKFSVPSCATKELVLIPLHAAPHQAVAEIDALYDVYLDVIDKWNTDDMLFLGDFNADCKYVKAHDWPSIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVVSGAHLRRSLKPHSASVHNFQEEFDLDQTQALAISDHFPVEVTFKTH

Target ORF information:

RefSeq Version	NM_025718.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025718.3

ORF Insert Sequence:

ATGGGTTGGC CCTGGGCCCC GCTGACAGCA GTTTGGGCAC TGGGGGTCAT GGGAGCCACA 
GCGCTGCGGA TTGGAGCCTT CAATGTTCAG AGCTTTGGAG ACAACAAAGT GTCAGATCCA 
GACTGTGGCA GTGTCATAGC ACAGATCCTG GCCGGCTATG ATATCGCCCT GGTGCAAGAG 
GTACGAGACC CAGACCTAAG TGCAGTGTCC TTGCTCATGG AGCAAATTAA CAGAGTGTCC 
AAGCACGAGT ACGGCTTTGT GAGCAGCAAG CCACTCGGAC GTGACCAGTA CAAGGAAATG 
TACCTGTTTG TTTACAGGAA AGATGTAGCG TCAGTGGTGA GCACGTACCA GTATCCAGAC 
CCAGAGGACG CTTTCAGCCG GGAGCCTTTT GTGGTCAAAT TCTCAGTTCC TAGCTGTGCC 
ACCAAGGAGC TGGTGCTGAT CCCCCTCCAT GCAGCACCAC ACCAGGCGGT GGCAGAGATC 
GACGCGCTCT ACGATGTGTA CCTTGATGTC ATTGACAAGT GGAACACTGA TGACATGCTG 
TTTCTGGGTG ACTTTAATGC CGATTGCAAG TACGTGAAGG CGCATGACTG GCCATCGATC 
CGCCTTCGAA GCAGTGAGGT GTTTAAATGG CTCATCCCAG ACAGTGCGGA CACCACAGTG 
GGCAACTCAG ACTGTGCCTA TGACCGGATT GTAGTGAGTG GCGCCCATCT GCGCAGGAGC 
CTGAAGCCCC ACTCAGCCTC AGTTCACAAC TTTCAGGAGG AATTTGACCT AGATCAGACC 
CAGGCTCTTG CCATCAGTGA CCATTTTCCT GTGGAAGTGA CTTTCAAGAC TCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dnase1l2 ( XM_006524798.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006524861.1 Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu53929
Clone ID Related Accession (Same CDS sequence)	XM_006524798.3
Accession Version	XM_006524798.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	deoxyribonuclease-1-like 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006524798.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTTGGC CCTGGGCCCC GCTGACAGCA GTTTGGGCAC TGGGGGTCAT GGGAGCCACA 
GCGCTGCGGA TTGGAGCCTT CAATGTTCAG AGCTTTGGAG ACAACAAAGT GTCAGATCCA 
GACTGTGGCA GTGTCATAGC ACAGATCCTG GCCGGCTATG ATATCGCCCT GGTGCAAGAG 
GTACGAGACC CAGACCTAAG TGCAGTGTCC TTGCTCATGG AGCAAATTAA CAGAGTGTCC 
AAGCACGAGT ACGGCTTTGT GAGCAGCAAG CCACTCGGAC GTGACCAGTA CAAGGAAATG 
TACCTGTTTG TTTACAGGAA AGATGTAGCG TCAGTGGTGA GCACGTACCA GTATCCAGAC 
CCAGAGGACG CTTTCAGCCG GGAGCCTTTT GTGGTCAAAT TCTCAGTTCC TAGCTGTGGT 
GAGTTGATAC TGCCCTCTCC CAGACAAGCC TACCTCTTCC AGGCTTCCCT TGACCCTCAT 
ATCCCCCCAC CTTCCACAGC CACCAAGGAG CTGGTGCTGA TCCCCCTCCA TGCAGCACCA 
CACCAGGCGG TGGCAGAGAT CGACGCGCTC TACGATGTGT ACCTTGATGT CATTGACAAG 
TGGAACACTG ATGACATGCT GTTTCTGGGT GACTTTAATG CCGATTGCAA GTACGTGAAG 
GCGCATGACT GGCCATCGAT CCGCCTTCGA AGCAGTGAGG TGTTTAAATG GCTCATCCCA 
GACAGTGCGG ACACCACAGT GGGCAACTCA GACTGTGCCT ATGACCGGAT TGTAGTGAGT 
GGCGCCCATC TGCGCAGGAG CCTGAAGCCC CACTCAGCCT CAGTTCACAA CTTTCAGGAG 
GAATTTGACC TAGATCAGAC CCAGGCTCTT GCCATCAGTG ACCATTTTCC TGTGGAAGTG 
ACTTTCAAGA CTCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006524861.1
CDS	774..1691
Translation	MGWPWAPLTAVWALGVMGATALRIGAFNVQSFGDNKVSDPDCGSVIAQILAGYDIALVQEVRDPDLSAVSLLMEQINRVSKHEYGFVSSKPLGRDQYKEMYLFVYRKDVASVVSTYQYPDPEDAFSREPFVVKFSVPSCGELILPSPRQAYLFQASLDPHIPPPSTATKELVLIPLHAAPHQAVAEIDALYDVYLDVIDKWNTDDMLFLGDFNADCKYVKAHDWPSIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVVSGAHLRRSLKPHSASVHNFQEEFDLDQTQALAISDHFPVEVTFKTH

Target ORF information:

RefSeq Version	XM_006524798.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006524798.3

ORF Insert Sequence:

ATGGGTTGGC CCTGGGCCCC GCTGACAGCA GTTTGGGCAC TGGGGGTCAT GGGAGCCACA 
GCGCTGCGGA TTGGAGCCTT CAATGTTCAG AGCTTTGGAG ACAACAAAGT GTCAGATCCA 
GACTGTGGCA GTGTCATAGC ACAGATCCTG GCCGGCTATG ATATCGCCCT GGTGCAAGAG 
GTACGAGACC CAGACCTAAG TGCAGTGTCC TTGCTCATGG AGCAAATTAA CAGAGTGTCC 
AAGCACGAGT ACGGCTTTGT GAGCAGCAAG CCACTCGGAC GTGACCAGTA CAAGGAAATG 
TACCTGTTTG TTTACAGGAA AGATGTAGCG TCAGTGGTGA GCACGTACCA GTATCCAGAC 
CCAGAGGACG CTTTCAGCCG GGAGCCTTTT GTGGTCAAAT TCTCAGTTCC TAGCTGTGGT 
GAGTTGATAC TGCCCTCTCC CAGACAAGCC TACCTCTTCC AGGCTTCCCT TGACCCTCAT 
ATCCCCCCAC CTTCCACAGC CACCAAGGAG CTGGTGCTGA TCCCCCTCCA TGCAGCACCA 
CACCAGGCGG TGGCAGAGAT CGACGCGCTC TACGATGTGT ACCTTGATGT CATTGACAAG 
TGGAACACTG ATGACATGCT GTTTCTGGGT GACTTTAATG CCGATTGCAA GTACGTGAAG 
GCGCATGACT GGCCATCGAT CCGCCTTCGA AGCAGTGAGG TGTTTAAATG GCTCATCCCA 
GACAGTGCGG ACACCACAGT GGGCAACTCA GACTGTGCCT ATGACCGGAT TGTAGTGAGT 
GGCGCCCATC TGCGCAGGAG CCTGAAGCCC CACTCAGCCT CAGTTCACAA CTTTCAGGAG 
GAATTTGACC TAGATCAGAC CCAGGCTCTT GCCATCAGTG ACCATTTTCC TGTGGAAGTG 
ACTTTCAAGA CTCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dnase1l2 ( XM_006524799.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006524862.1 Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu53930
Clone ID Related Accession (Same CDS sequence)	XM_006524799.4 , XM_006524799.3
Accession Version	XM_006524799.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	deoxyribonuclease-1-like 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006524799.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATATCGC CCTGGTGCAA GAGAGTGTCC AAGCACGAGT ACGGCTTTGT GAGCAGCAAG 
CCACTCGGAC GTGACCAGTA CAAGGAAATG TACCTGTTTG TTTACAGGAA AGATGTAGCG 
TCAGTGGTGA GCACGTACCA GTATCCAGAC CCAGAGGACG CTTTCAGCCG GGAGCCTTTT 
GTGGTCAAAT TCTCAGTTCC TAGCTGTGCC ACCAAGGAGC TGGTGCTGAT CCCCCTCCAT 
GCAGCACCAC ACCAGGCGGT GGCAGAGATC GACGCGCTCT ACGATGTGTA CCTTGATGTC 
ATTGACAAGT GGAACACTGA TGACATGCTG TTTCTGGGTG ACTTTAATGC CGATTGCAAG 
TACGTGAAGG CGCATGACTG GCCATCGATC CGCCTTCGAA GCAGTGAGGT GTTTAAATGG 
CTCATCCCAG ACAGTGCGGA CACCACAGTG GGCAACTCAG ACTGTGCCTA TGACCGGATT 
GTAGTGAGTG GCGCCCATCT GCGCAGGAGC CTGAAGCCCC ACTCAGCCTC AGTTCACAAC 
TTTCAGGAGG AATTTGACCT AGATCAGACC CAGGCTCTTG CCATCAGTGA CCATTTTCCT 
GTGGAAGTGA CTTTCAAGAC TCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006524862.1
CDS	925..1551
Translation	MISPWCKRVSKHEYGFVSSKPLGRDQYKEMYLFVYRKDVASVVSTYQYPDPEDAFSREPFVVKFSVPSCATKELVLIPLHAAPHQAVAEIDALYDVYLDVIDKWNTDDMLFLGDFNADCKYVKAHDWPSIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVVSGAHLRRSLKPHSASVHNFQEEFDLDQTQALAISDHFPVEVTFKTH

Target ORF information:

RefSeq Version	XM_006524799.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006524799.3

ORF Insert Sequence:

ATGATATCGC CCTGGTGCAA GAGAGTGTCC AAGCACGAGT ACGGCTTTGT GAGCAGCAAG 
CCACTCGGAC GTGACCAGTA CAAGGAAATG TACCTGTTTG TTTACAGGAA AGATGTAGCG 
TCAGTGGTGA GCACGTACCA GTATCCAGAC CCAGAGGACG CTTTCAGCCG GGAGCCTTTT 
GTGGTCAAAT TCTCAGTTCC TAGCTGTGCC ACCAAGGAGC TGGTGCTGAT CCCCCTCCAT 
GCAGCACCAC ACCAGGCGGT GGCAGAGATC GACGCGCTCT ACGATGTGTA CCTTGATGTC 
ATTGACAAGT GGAACACTGA TGACATGCTG TTTCTGGGTG ACTTTAATGC CGATTGCAAG 
TACGTGAAGG CGCATGACTG GCCATCGATC CGCCTTCGAA GCAGTGAGGT GTTTAAATGG 
CTCATCCCAG ACAGTGCGGA CACCACAGTG GGCAACTCAG ACTGTGCCTA TGACCGGATT 
GTAGTGAGTG GCGCCCATCT GCGCAGGAGC CTGAAGCCCC ACTCAGCCTC AGTTCACAAC 
TTTCAGGAGG AATTTGACCT AGATCAGACC CAGGCTCTTG CCATCAGTGA CCATTTTCCT 
GTGGAAGTGA CTTTCAAGAC TCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dnase1l2 ( XM_006524799.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006524862.1 Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu53930
Clone ID Related Accession (Same CDS sequence)	XM_006524799.4 , XM_006524799.3
Accession Version	XM_006524799.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	deoxyribonuclease-1-like 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006524799.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATATCGC CCTGGTGCAA GAGAGTGTCC AAGCACGAGT ACGGCTTTGT GAGCAGCAAG 
CCACTCGGAC GTGACCAGTA CAAGGAAATG TACCTGTTTG TTTACAGGAA AGATGTAGCG 
TCAGTGGTGA GCACGTACCA GTATCCAGAC CCAGAGGACG CTTTCAGCCG GGAGCCTTTT 
GTGGTCAAAT TCTCAGTTCC TAGCTGTGCC ACCAAGGAGC TGGTGCTGAT CCCCCTCCAT 
GCAGCACCAC ACCAGGCGGT GGCAGAGATC GACGCGCTCT ACGATGTGTA CCTTGATGTC 
ATTGACAAGT GGAACACTGA TGACATGCTG TTTCTGGGTG ACTTTAATGC CGATTGCAAG 
TACGTGAAGG CGCATGACTG GCCATCGATC CGCCTTCGAA GCAGTGAGGT GTTTAAATGG 
CTCATCCCAG ACAGTGCGGA CACCACAGTG GGCAACTCAG ACTGTGCCTA TGACCGGATT 
GTAGTGAGTG GCGCCCATCT GCGCAGGAGC CTGAAGCCCC ACTCAGCCTC AGTTCACAAC 
TTTCAGGAGG AATTTGACCT AGATCAGACC CAGGCTCTTG CCATCAGTGA CCATTTTCCT 
GTGGAAGTGA CTTTCAAGAC TCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006524862.1
CDS	840..1466
Translation	MISPWCKRVSKHEYGFVSSKPLGRDQYKEMYLFVYRKDVASVVSTYQYPDPEDAFSREPFVVKFSVPSCATKELVLIPLHAAPHQAVAEIDALYDVYLDVIDKWNTDDMLFLGDFNADCKYVKAHDWPSIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVVSGAHLRRSLKPHSASVHNFQEEFDLDQTQALAISDHFPVEVTFKTH

Target ORF information:

RefSeq Version	XM_006524799.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006524799.4

ORF Insert Sequence:

ATGATATCGC CCTGGTGCAA GAGAGTGTCC AAGCACGAGT ACGGCTTTGT GAGCAGCAAG 
CCACTCGGAC GTGACCAGTA CAAGGAAATG TACCTGTTTG TTTACAGGAA AGATGTAGCG 
TCAGTGGTGA GCACGTACCA GTATCCAGAC CCAGAGGACG CTTTCAGCCG GGAGCCTTTT 
GTGGTCAAAT TCTCAGTTCC TAGCTGTGCC ACCAAGGAGC TGGTGCTGAT CCCCCTCCAT 
GCAGCACCAC ACCAGGCGGT GGCAGAGATC GACGCGCTCT ACGATGTGTA CCTTGATGTC 
ATTGACAAGT GGAACACTGA TGACATGCTG TTTCTGGGTG ACTTTAATGC CGATTGCAAG 
TACGTGAAGG CGCATGACTG GCCATCGATC CGCCTTCGAA GCAGTGAGGT GTTTAAATGG 
CTCATCCCAG ACAGTGCGGA CACCACAGTG GGCAACTCAG ACTGTGCCTA TGACCGGATT 
GTAGTGAGTG GCGCCCATCT GCGCAGGAGC CTGAAGCCCC ACTCAGCCTC AGTTCACAAC 
TTTCAGGAGG AATTTGACCT AGATCAGACC CAGGCTCTTG CCATCAGTGA CCATTTTCCT 
GTGGAAGTGA CTTTCAAGAC TCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.
Scientific reports7(1)11902(2017 Sep)
Manils J,Fischer H,Climent J,Casas E,Garc?a-Mart?nez C,Bas J,Sukseree S,Vavouri T,Ciruela F,de Anta JM,Tschachler E,Eckhart L,Soler C

Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis.
Scientific reports7(1)6433(2017 Jul)
Fischer H,Buchberger M,Napirei M,Tschachler E,Eckhart L

Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death.
The Journal of investigative dermatology137(3)587-594(2017 Mar)
Fischer H,Fumicz J,Rossiter H,Napirei M,Buchberger M,Tschachler E,Eckhart L

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
PloS one12(7)e0180682(2017)
Sundberg JP,Dadras SS,Silva KA,Kennedy VE,Garland G,Murray SA,Sundberg BA,Schofield PN,Pratt CH

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

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Dnase1l2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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