Dspp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dspp
Entrez Gene ID	666279
Full Name	dentin sialophosphoprotein
Synonyms	Dmp2,Dmp3,Dpp,Dsp
General protein information	Preferred Names dentin sialophosphoprotein Names dentin sialophosphoprotein DMP-3 dentin matrix protein 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 E5\|5 50.59 cM
Summary	This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mice lacking the encoded protein exhibit hypomineralization defects in dentin, similar to human dentinogenesis imperfecta. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010080.3	NP_034210.2	dentin sialophosphoprotein preproprotein

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Hey1 and Hey2 are differently expressed during mouse tooth development.
Kibe K, Nakatomi M, Kataoka S, Toyono T, Seta Y
Gene expression patterns : GEP2799-105(2017 Nov)

Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis.
Zhu Q, Gibson MP, Liu Q, Liu Y, Lu Y, Wang X, Feng JQ, Qin C
The Journal of biological chemistry287(36)30426-35(2012 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

no significant dentin malformation was observed in Mep1b (-/-) or Mep1a (-/-) deficient mice.
Title: Deficiency of the DSPP-cleaving enzymes meprin ? and meprin ? does not result in dentin malformation in mice.

Results show that transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice and suggest that DSPP and DMP1 may function synergistically within the complex milieu of bone matrices.
Title: Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice.

Data show provide evidence that DSPP is important for normal mineralization of both dentin and enamel.
Title: Accelerated enamel mineralization in Dspp mutant mice.

overexpressing DPP inhibited skeletal development, suggesting that the balanced actions between the NH2- and COOH-terminal fragments of DSPP may be required for normal skeletal development.
Title: Transgenic expression of dentin phosphoprotein inhibits skeletal development.

Klf10 is involved in tooth development and promotes odontoblastic differentiation via the up-regulation of Dmp1 and Dspp transcription.
Title: Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes.

The following Dspp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dspp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16703	NM_010080.3 Latest version!	Mus musculus dentin sialophosphoprotein (Dspp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dspp ( NM_010080.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034210.2 Mus musculus dentin sialophosphoprotein (Dspp), mRNA.

Price & Availability↑

CloneID	OMu16703
Clone ID Related Accession (Same CDS sequence)	NM_010080.3
Accession Version	NM_010080.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2838bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Mus musculus(house mouse)
Product	dentin sialophosphoprotein preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC164587.5 and BC116173.1. On Feb 4, 2016 this sequence version replaced NM_010080.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U67916.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01164131, SAMN01164132 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAAATGA AGATAATTAT ATATATATGC ATTTGGGCAA CTGCCTGGGC CATTCCGGTT 
CCCCAGTTAG TACCACTGGA AAGAGACATT GTTGAAAACT CTGTGGCTGT GCCTCTTCTA 
ACACATCCAG GAACTGCAGC ACAGAATGAG TTATCTATCA ACAGCACCAC TAGCAACAGC 
AACGACTCCC CAGATGGCAG TGAGATAGGA GAGCAGGTAC TTAGCGAGGA TGGTTACAAA 
AGAGATGGGA ATGGCTCCGA GTCAATACAT GTAGGAGGGA AGGATTTTCC TACTCAGCCC 
ATTTTAGTAA ACGAACAGGG GAACACTGCT GAAGAACACA ATGACATAGA AACATACGGT 
CATGATGGGG TACATGCGAG AGGAGAGAAC AGCACAGCAA ATGGCATCAG GAGCCAGGTA 
GGCATCGTTG AAAATGCGGA GGAAGCAGAG AGCAGTGTCC ACGGACAGGC TGGTCAGAAT 
ACAAAATCTG GAGGTGCTAG TGATGTAAGC CAGAATGGAG ATGCGACCCT TGTCCAGGAA 
AATGAGCCTC CAGAAGCTAG CATCAAGAAT AGCACCAACC ATGAGGCTGG AATACACGGG 
AGTGGGGTTG CTACACATGA AACGACGCCT CAGAGAGAAG GGCTGGGGAG TGAGAACCAG 
GGGACTGAGG TGACACCAAG CATCGGGGAA GATGCAGGTT TGGATGATAC TGATGGGAGT 
CCTAGCGGGA ACGGGGTAGA GGAGGATGAA GATACAGGCT CTGGTGATGG TGAGGGTGCA 
GAAGCAGGAG ATGGAAGGGA GAGCCATGAT GGCACTAAGG GCCAGGGGGG CCAATCTCAT 
GGGGGAAACA CTGACCACAG AGGTCAGAGT TCAGTTAGTA CTGAAGATGA TGATTCTAAA 
GAACAAGAAG GCTTCCCAAA TGGACACAAT GGAGACAACA GCAGTGAGGA AAACGGTGTT 
GAAGAAGGCG ACAGTACCCA GGCAACGCAG GACAACCAAA AGCTCAGCCC CAAAGACACC 
CGAGATGCAG AGGGTGGGAT CATCAGCCAG TCAGAAGCAT GTCCTTCTGG GAAGAGCCAA 
GATCAGGGAA TAGAAACTGA AGGTCCCAAC AAAGGCAACA AAAGTATTAT TACCAAAGAA 
TCTGGGAAAC TCAGTGGAAG TAAAGATAGC AATGGACACC AAGGAGTGGA GCTGGACAAA 
AGGAATAGCC CAAAGCAAGG GGAGTCTGAC AAGCCTCAAG GCACTGCTGA GAAATCAGCT 
GCCCACAGTA ACCTGGGACA CAGCAGGATA GGTAGCAGCA GCAATAGTGA TGGGCATGAC 
AGTTACGAGT TCGATGACGA GTCCATGCAA GGAGATGATC CCAAGAGCAG CGACGAATCT 
AACGGAAGTG ACGAAAGTGA CACTAACTCT GAAAGCGCCA ATGAGAGTGG CAGCCGTGGA 
GATGCTTCTT ACACATCTGA TGAATCAAGT GATGATGACA ATGACAGTGA CTCACATGCG 
GGAGAAGACG ATAGCAGTGA TGACTCATCT GATACAGATG ACAGTGACAG TAATGGTGAT 
GGTGACAGTG ACAGTAATGG TGATGGTGAC AGCGAGAGTG AGGACAAGGA CGAATCTGAC 
AGCAGTGACC ATGACAACAG CAGTGACAGT GAGAGCAAAT CAGACAGCAG TGACAGTAGT 
GACGACAGCA GTGACAGCAG CGACAGTAGT GACAGCAGTG ACAGCAGTGA CAGTAGTGAC 
AGTAGTGACA GCAGCGACAG CAGTGACAGC AGCGACAGCA ACAGTAGTAG TGACAGCAGC 
GACAGCAGCA GTAGTAGTGA CAGCAGCGAC AGCAGTGACA GCAGTGACAG CAGTGACAGC 
AGCGATAGCA GTGACAGCAG TGACAGCAGT GACAGCAGCG ATAGCAGTGA CAGCAGTGAC 
AGTAGTGACA GCAGTGACAG CAGCGACAGC AGCAGTAGTA GTGACAGCAG CGACAGCAGC 
AGTAGTAGTG ACAGCAGCGA CAGCAGTGAC AGCAGTGACA GCAGCGATAG CAGTGACAGC 
AGTGACAGCA GCAGCAGCGA CAGCAGCAGC AGTAGCAACA GCAGTGACAG TAGTGACAGC 
AGTGACAGCA GCAGCAGCAG CGACAGCAGC AACAGCAGCG ACAGCAGTGA CAGTAGTGAC 
AGCAGTGACA GTAGTGACAG CAGTGACAGC AGCAACAGTA GTGACAGCAG CGACAGCAGC 
AGTAGTAGTG ACAGCAGCGA CAGCAGCAGT AGTAGTGACA GCAGTGACAG TAGTGACAGT 
AGTGACAGCA GTGAGAGCAG TGAGAGCAGC GACAGCAGCA ACAGCAGTGA CAGCAGCGAC 
AGTAGTGACA GCAGTGACAG TAGCGACAGC AGCGACAGTA GTGACAGTAG CGACAGCAGT 
GACAGTAGCA ACAGTAGCGA CAGCAGTGAC AGCAGTGACA GCAGCGACAG TAGTGACAGC 
AGCAACAGTA GTGACAGCAG TGACAGTAGC GACAGTAGTG ACAGCAGTGA CAGCAGTGAC 
AGCAGCGACA GTAGTGACAG CAGTGACAGT AGTGACAGCA GCGACAGTAG TGACAGCAGT 
GACAGCAGTG ACAGCAGTGA CAGCAGCGAC AGCAGCGACA GCAGTGACAG CAGCGACAGC 
AGCGACAGCA GTGACAGCAG CGACAGCAGC AACAGCAGTG ACAGCAGTGA CAGTGACAGC 
AAGGATAGCA GTTCTGACAG CAGTGATGGT GACAGCAAGT CTGGTAATGG CAACAGTGAC 
AGCAACAGTG ACAGCAACAG TGACAGTGAC AGTGACAGTG AAGGCAGTGA CAGTAACCAC 
TCAACCAGTG ATGATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034210.2
CDS	86..2923
Translation	MKMKIIIYICIWATAWAIPVPQLVPLERDIVENSVAVPLLTHPGTAAQNELSINSTTSNSNDSPDGSEIGEQVLSEDGYKRDGNGSESIHVGGKDFPTQPILVNEQGNTAEEHNDIETYGHDGVHARGENSTANGIRSQVGIVENAEEAESSVHGQAGQNTKSGGASDVSQNGDATLVQENEPPEASIKNSTNHEAGIHGSGVATHETTPQREGLGSENQGTEVTPSIGEDAGLDDTDGSPSGNGVEEDEDTGSGDGEGAEAGDGRESHDGTKGQGGQSHGGNTDHRGQSSVSTEDDDSKEQEGFPNGHNGDNSSEENGVEEGDSTQATQDNQKLSPKDTRDAEGGIISQSEACPSGKSQDQGIETEGPNKGNKSIITKESGKLSGSKDSNGHQGVELDKRNSPKQGESDKPQGTAEKSAAHSNLGHSRIGSSSNSDGHDSYEFDDESMQGDDPKSSDESNGSDESDTNSESANESGSRGDASYTSDESSDDDNDSDSHAGEDDSSDDSSDTDDSDSNGDGDSDSNGDGDSESEDKDESDSSDHDNSSDSESKSDSSDSSDDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNSSSDSSDSSSSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSSSSDSSDSSSSSDSSDSSDSSDSSDSSDSSDSSSSDSSSSSNSSDSSDSSDSSSSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSSSSDSSDSSSSSDSSDSSDSSDSSESSESSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSDSKDSSSDSSDGDSKSGNGNSDSNSDSNSDSDSDSEGSDSNHSTSDD

Target ORF information:

RefSeq Version	NM_010080.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus dentin sialophosphoprotein (Dspp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010080.3

ORF Insert Sequence:

ATGAAAATGA AGATAATTAT ATATATATGC ATTTGGGCAA CTGCCTGGGC CATTCCGGTT 
CCCCAGTTAG TACCACTGGA AAGAGACATT GTTGAAAACT CTGTGGCTGT GCCTCTTCTA 
ACACATCCAG GAACTGCAGC ACAGAATGAG TTATCTATCA ACAGCACCAC TAGCAACAGC 
AACGACTCCC CAGATGGCAG TGAGATAGGA GAGCAGGTAC TTAGCGAGGA TGGTTACAAA 
AGAGATGGGA ATGGCTCCGA GTCAATACAT GTAGGAGGGA AGGATTTTCC TACTCAGCCC 
ATTTTAGTAA ACGAACAGGG GAACACTGCT GAAGAACACA ATGACATAGA AACATACGGT 
CATGATGGGG TACATGCGAG AGGAGAGAAC AGCACAGCAA ATGGCATCAG GAGCCAGGTA 
GGCATCGTTG AAAATGCGGA GGAAGCAGAG AGCAGTGTCC ACGGACAGGC TGGTCAGAAT 
ACAAAATCTG GAGGTGCTAG TGATGTAAGC CAGAATGGAG ATGCGACCCT TGTCCAGGAA 
AATGAGCCTC CAGAAGCTAG CATCAAGAAT AGCACCAACC ATGAGGCTGG AATACACGGG 
AGTGGGGTTG CTACACATGA AACGACGCCT CAGAGAGAAG GGCTGGGGAG TGAGAACCAG 
GGGACTGAGG TGACACCAAG CATCGGGGAA GATGCAGGTT TGGATGATAC TGATGGGAGT 
CCTAGCGGGA ACGGGGTAGA GGAGGATGAA GATACAGGCT CTGGTGATGG TGAGGGTGCA 
GAAGCAGGAG ATGGAAGGGA GAGCCATGAT GGCACTAAGG GCCAGGGGGG CCAATCTCAT 
GGGGGAAACA CTGACCACAG AGGTCAGAGT TCAGTTAGTA CTGAAGATGA TGATTCTAAA 
GAACAAGAAG GCTTCCCAAA TGGACACAAT GGAGACAACA GCAGTGAGGA AAACGGTGTT 
GAAGAAGGCG ACAGTACCCA GGCAACGCAG GACAACCAAA AGCTCAGCCC CAAAGACACC 
CGAGATGCAG AGGGTGGGAT CATCAGCCAG TCAGAAGCAT GTCCTTCTGG GAAGAGCCAA 
GATCAGGGAA TAGAAACTGA AGGTCCCAAC AAAGGCAACA AAAGTATTAT TACCAAAGAA 
TCTGGGAAAC TCAGTGGAAG TAAAGATAGC AATGGACACC AAGGAGTGGA GCTGGACAAA 
AGGAATAGCC CAAAGCAAGG GGAGTCTGAC AAGCCTCAAG GCACTGCTGA GAAATCAGCT 
GCCCACAGTA ACCTGGGACA CAGCAGGATA GGTAGCAGCA GCAATAGTGA TGGGCATGAC 
AGTTACGAGT TCGATGACGA GTCCATGCAA GGAGATGATC CCAAGAGCAG CGACGAATCT 
AACGGAAGTG ACGAAAGTGA CACTAACTCT GAAAGCGCCA ATGAGAGTGG CAGCCGTGGA 
GATGCTTCTT ACACATCTGA TGAATCAAGT GATGATGACA ATGACAGTGA CTCACATGCG 
GGAGAAGACG ATAGCAGTGA TGACTCATCT GATACAGATG ACAGTGACAG TAATGGTGAT 
GGTGACAGTG ACAGTAATGG TGATGGTGAC AGCGAGAGTG AGGACAAGGA CGAATCTGAC 
AGCAGTGACC ATGACAACAG CAGTGACAGT GAGAGCAAAT CAGACAGCAG TGACAGTAGT 
GACGACAGCA GTGACAGCAG CGACAGTAGT GACAGCAGTG ACAGCAGTGA CAGTAGTGAC 
AGTAGTGACA GCAGCGACAG CAGTGACAGC AGCGACAGCA ACAGTAGTAG TGACAGCAGC 
GACAGCAGCA GTAGTAGTGA CAGCAGCGAC AGCAGTGACA GCAGTGACAG CAGTGACAGC 
AGCGATAGCA GTGACAGCAG TGACAGCAGT GACAGCAGCG ATAGCAGTGA CAGCAGTGAC 
AGTAGTGACA GCAGTGACAG CAGCGACAGC AGCAGTAGTA GTGACAGCAG CGACAGCAGC 
AGTAGTAGTG ACAGCAGCGA CAGCAGTGAC AGCAGTGACA GCAGCGATAG CAGTGACAGC 
AGTGACAGCA GCAGCAGCGA CAGCAGCAGC AGTAGCAACA GCAGTGACAG TAGTGACAGC 
AGTGACAGCA GCAGCAGCAG CGACAGCAGC AACAGCAGCG ACAGCAGTGA CAGTAGTGAC 
AGCAGTGACA GTAGTGACAG CAGTGACAGC AGCAACAGTA GTGACAGCAG CGACAGCAGC 
AGTAGTAGTG ACAGCAGCGA CAGCAGCAGT AGTAGTGACA GCAGTGACAG TAGTGACAGT 
AGTGACAGCA GTGAGAGCAG TGAGAGCAGC GACAGCAGCA ACAGCAGTGA CAGCAGCGAC 
AGTAGTGACA GCAGTGACAG TAGCGACAGC AGCGACAGTA GTGACAGTAG CGACAGCAGT 
GACAGTAGCA ACAGTAGCGA CAGCAGTGAC AGCAGTGACA GCAGCGACAG TAGTGACAGC 
AGCAACAGTA GTGACAGCAG TGACAGTAGC GACAGTAGTG ACAGCAGTGA CAGCAGTGAC 
AGCAGCGACA GTAGTGACAG CAGTGACAGT AGTGACAGCA GCGACAGTAG TGACAGCAGT 
GACAGCAGTG ACAGCAGTGA CAGCAGCGAC AGCAGCGACA GCAGTGACAG CAGCGACAGC 
AGCGACAGCA GTGACAGCAG CGACAGCAGC AACAGCAGTG ACAGCAGTGA CAGTGACAGC 
AAGGATAGCA GTTCTGACAG CAGTGATGGT GACAGCAAGT CTGGTAATGG CAACAGTGAC 
AGCAACAGTG ACAGCAACAG TGACAGTGAC AGTGACAGTG AAGGCAGTGA CAGTAACCAC 
TCAACCAGTG ATGATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hey1 and Hey2 are differently expressed during mouse tooth development.
Gene expression patterns : GEP2799-105(2017 Nov)
Kibe K,Nakatomi M,Kataoka S,Toyono T,Seta Y

Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis.
The Journal of biological chemistry287(36)30426-35(2012 Aug)
Zhu Q,Gibson MP,Liu Q,Liu Y,Lu Y,Wang X,Feng JQ,Qin C

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Dspp cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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