Nmnat1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nmnat1
Entrez Gene ID	66454
Full Name	nicotinamide nucleotide adenylyltransferase 1
Synonyms	2610529L11Rik,5730441G13Rik,D4Cole1e,nmnat
General protein information	Preferred Names nicotinamide nucleotide adenylyltransferase 1 Names nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 NMN adenylyltransferase 1 NMN/NaMN adenylyltransferase 1 naMN adenylyltransferase 1 nicotinamide mononucleotide adenylyl transferase nicotinamide mononucleotide adenylyltransferase 1 nicotinamide/nicotinate mononucleotide adenylyltransferase 1 nicotinate-nucleotide adenylyltransferase 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_133435.1	NP_597679.1	nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
XM_006539105.2	XP_006539168.1	nicotinamide mononucleotide adenylyltransferase 1 isoform X1
NM_133435.2	NP_597679.1	nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
XM_006539105.3	XP_006539168.1	nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X1
NM_001356357.1	NP_001343286.1	nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0C18051g	XP_453005.1
Schizosaccharomyces pombe (fission yeast)	SPAC806.06c	NP_592856.2
Bos taurus (cattle)	NMNAT1	NP_001069302.1
Mus musculus (house mouse)	Nmnat1	NP_597679.1
Saccharomyces cerevisiae (baker's yeast)	NMA1	NP_013432.1
Eremothecium gossypii	AGOS_AGR022C	NP_986687.2
Pan troglodytes (chimpanzee)	NMNAT1	XP_003949340.1
Xenopus tropicalis (tropical clawed frog)	nmnat1	NP_001016772.1
Canis lupus familiaris (dog)	NMNAT1	XP_003639109.1
Saccharomyces cerevisiae (baker's yeast)	NMA2	NP_011524.1
Homo sapiens (human)	NMNAT1	NP_073624.2
Rattus norvegicus (Norway rat)	Nmnat1	NP_001032645.2
Gallus gallus (chicken)	NMNAT1	XP_004947508.1

Gene Ontology
Bibliography

Related articles in PubMed

NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy.
Rossi F, Geiszler PC, Meng W, Barron MR, Prior M, Herd-Smith A, Loreto A, Lopez MY, Faas H, Pardon MC, Conforti L
Behavioural brain research339140-152(2018 Feb)

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD
Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J
eLife5(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Using steady-state and flux analysis of NAD(+) metabolites in healthy and injured mouse dorsal root ganglion axons, we find that rather than altering NAD(+) synthesis, NMNAT1 instead blocks the injury-induced, SARM1-dependent NAD(+) consumption that is central to axon degeneration.
Title: NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD

Mouse-non nuclear-nicotinamide mononucleotide adenylyltransferase type 1 maintains mitochondrial nicotinamide levels and thereby supports mitochondrial unfolded protein response function and mitochondrial proteostasis in injured neurons.
Title: Nicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response.

NMNAT1 overexpression enhanced AMPK activity in oxygen-glucose deprivation treated cortical neurons
Title: Nicotinamide Mononucleotide Adenylyltransferase 1 Protects Neural Cells Against Ischemic Injury in Primary Cultured Neuronal Cells and Mouse Brain with Ischemic Stroke Through AMP-Activated Protein Kinase Activation.

Overexpression of Nmnat1 in the cytoplasm and axons of RGCs robustly protected against both ischemic and glaucomatous loss of RGC axonal integrity, as well as loss of RGC soma.
Title: Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.

An increased level of Nmnat protein in hiw mutants is both required and sufficient to inhibit axonal degeneration.
Title: The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein.

The following Nmnat1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nmnat1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17664	NM_133435.2 Latest version!	Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu17664	NM_001356357.1 Latest version!	Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu17664	XM_006539105.3 Latest version!	Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OMu17664	NM_133435.1	Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu17664	XM_006539105.2	Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nmnat1 ( NM_133435.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_597679.1 Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), mRNA.

Price & Availability↑

CloneID	OMu17664
Clone ID Related Accession (Same CDS sequence)	NM_133435.1 , XM_006539105.2 , NM_133435.2 , XM_006539105.3 , NM_001356357.1
Accession Version	NM_133435.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-04-24
Organism	Mus musculus(House mouse)
Product	nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY679721.1. On or before Jan 14, 2005 this sequence version replaced XM_207858.3, XM_359223.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY679721.1, BC138500.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END##

ATGGACTCAT CCAAGAAGAC AGAGGTGGTT CTCCTGGCCT GTGGCTCTTT TAACCCCATC 
ACCAACATGC ACCTCAGGCT GTTCGAGCTG GCCAAGGACT ATATGCATGC TACAGGAAAA 
TACAGTGTTA TCAAAGGCAT TATCTCACCG GTCGGTGATG CGTACAAGAA GAAAGGGCTC 
ATCCCAGCCC ACCACCGAAT CATCATGGCA GAACTTGCCA CCAAGAACTC ACACTGGGTG 
GAAGTGGATA CGTGGGAAAG TCTTCAGAAG GAGTGGGTGG AGACTGTGAA GGTGCTCAGA 
TACCATCAGG AGAAGCTGGC AACTGGCAGC TGCAGTTACC CACAAAGCTC ACCTGCACTG 
GAAAAGCCTG GGCGGAAGAG GAAGTGGGCT GATCAAAAGC AAGATTCTAG CCCACAGAAG 
CCCCAAGAGC CCAAACCAAC AGGTGTGCCC AAGGTGAAAT TGCTGTGTGG GGCAGATTTA 
CTGGAGTCCT TCAGCGTGCC CAACTTGTGG AAGATGGAGG ACATCACGCA AATCGTGGCC 
AACTTTGGGC TCATCTGTAT CACTCGGGCT GGCAGTGACG CTCAGAAATT CATCTACGAG 
TCCGATGTGC TGTGGAGACA TCAGAGCAAC ATCCACCTGG TGAACGAGTG GATCACCAAT 
GACATCTCGT CCACCAAGAT CCGGAGGGCG CTCAGGAGGG GCCAGAGCAT CCGCTACTTG 
GTACCGGACC TGGTCCAAGA GTACATTGAG AAGCATGAGC TGTACAACAC GGAGAGCGAA 
GGCAGGAATG CTGGGGTCAC CCTGGCTCCT CTGCAGAGGA ACGCCGCAGA GGCCAAGCAC 
AACCATTCCA CTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_597679.1
CDS	88..945
Translation	MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGRKRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNTESEGRNAGVTLAPLQRNAAEAKHNHSTL

Target ORF information:

RefSeq Version	NM_133435.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133435.1

ORF Insert Sequence:

ATGGACTCAT CCAAGAAGAC AGAGGTGGTT CTCCTGGCCT GTGGCTCTTT TAACCCCATC 
ACCAACATGC ACCTCAGGCT GTTCGAGCTG GCCAAGGACT ATATGCATGC TACAGGAAAA 
TACAGTGTTA TCAAAGGCAT TATCTCACCG GTCGGTGATG CGTACAAGAA GAAAGGGCTC 
ATCCCAGCCC ACCACCGAAT CATCATGGCA GAACTTGCCA CCAAGAACTC ACACTGGGTG 
GAAGTGGATA CGTGGGAAAG TCTTCAGAAG GAGTGGGTGG AGACTGTGAA GGTGCTCAGA 
TACCATCAGG AGAAGCTGGC AACTGGCAGC TGCAGTTACC CACAAAGCTC ACCTGCACTG 
GAAAAGCCTG GGCGGAAGAG GAAGTGGGCT GATCAAAAGC AAGATTCTAG CCCACAGAAG 
CCCCAAGAGC CCAAACCAAC AGGTGTGCCC AAGGTGAAAT TGCTGTGTGG GGCAGATTTA 
CTGGAGTCCT TCAGCGTGCC CAACTTGTGG AAGATGGAGG ACATCACGCA AATCGTGGCC 
AACTTTGGGC TCATCTGTAT CACTCGGGCT GGCAGTGACG CTCAGAAATT CATCTACGAG 
TCCGATGTGC TGTGGAGACA TCAGAGCAAC ATCCACCTGG TGAACGAGTG GATCACCAAT 
GACATCTCGT CCACCAAGAT CCGGAGGGCG CTCAGGAGGG GCCAGAGCAT CCGCTACTTG 
GTACCGGACC TGGTCCAAGA GTACATTGAG AAGCATGAGC TGTACAACAC GGAGAGCGAA 
GGCAGGAATG CTGGGGTCAC CCTGGCTCCT CTGCAGAGGA ACGCCGCAGA GGCCAAGCAC 
AACCATTCCA CTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nmnat1 ( NM_133435.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_597679.1 Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu17664
Clone ID Related Accession (Same CDS sequence)	NM_133435.1 , XM_006539105.2 , NM_133435.2 , XM_006539105.3 , NM_001356357.1
Accession Version	NM_133435.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL606973.29, AK152407.1, AK011137.1, AK012194.1 and BY516711.1. On Oct 3, 2017 this sequence version replaced NM_133435.1. Transcript Variant: This variant (1) represents the shorter transcripts. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC138500.1, SRR1660811.67587.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTCAT CCAAGAAGAC AGAGGTGGTT CTCCTGGCCT GTGGCTCTTT TAACCCCATC 
ACCAACATGC ACCTCAGGCT GTTCGAGCTG GCCAAGGACT ATATGCATGC TACAGGAAAA 
TACAGTGTTA TCAAAGGCAT TATCTCACCG GTCGGTGATG CGTACAAGAA GAAAGGGCTC 
ATCCCAGCCC ACCACCGAAT CATCATGGCA GAACTTGCCA CCAAGAACTC ACACTGGGTG 
GAAGTGGATA CGTGGGAAAG TCTTCAGAAG GAGTGGGTGG AGACTGTGAA GGTGCTCAGA 
TACCATCAGG AGAAGCTGGC AACTGGCAGC TGCAGTTACC CACAAAGCTC ACCTGCACTG 
GAAAAGCCTG GGCGGAAGAG GAAGTGGGCT GATCAAAAGC AAGATTCTAG CCCACAGAAG 
CCCCAAGAGC CCAAACCAAC AGGTGTGCCC AAGGTGAAAT TGCTGTGTGG GGCAGATTTA 
CTGGAGTCCT TCAGCGTGCC CAACTTGTGG AAGATGGAGG ACATCACGCA AATCGTGGCC 
AACTTTGGGC TCATCTGTAT CACTCGGGCT GGCAGTGACG CTCAGAAATT CATCTACGAG 
TCCGATGTGC TGTGGAGACA TCAGAGCAAC ATCCACCTGG TGAACGAGTG GATCACCAAT 
GACATCTCGT CCACCAAGAT CCGGAGGGCG CTCAGGAGGG GCCAGAGCAT CCGCTACTTG 
GTACCGGACC TGGTCCAAGA GTACATTGAG AAGCATGAGC TGTACAACAC GGAGAGCGAA 
GGCAGGAATG CTGGGGTCAC CCTGGCTCCT CTGCAGAGGA ACGCCGCAGA GGCCAAGCAC 
AACCATTCCA CTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_597679.1
CDS	156..1013
Translation	MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGRKRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNTESEGRNAGVTLAPLQRNAAEAKHNHSTL

Target ORF information:

RefSeq Version	NM_133435.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133435.2

ORF Insert Sequence:

ATGGACTCAT CCAAGAAGAC AGAGGTGGTT CTCCTGGCCT GTGGCTCTTT TAACCCCATC 
ACCAACATGC ACCTCAGGCT GTTCGAGCTG GCCAAGGACT ATATGCATGC TACAGGAAAA 
TACAGTGTTA TCAAAGGCAT TATCTCACCG GTCGGTGATG CGTACAAGAA GAAAGGGCTC 
ATCCCAGCCC ACCACCGAAT CATCATGGCA GAACTTGCCA CCAAGAACTC ACACTGGGTG 
GAAGTGGATA CGTGGGAAAG TCTTCAGAAG GAGTGGGTGG AGACTGTGAA GGTGCTCAGA 
TACCATCAGG AGAAGCTGGC AACTGGCAGC TGCAGTTACC CACAAAGCTC ACCTGCACTG 
GAAAAGCCTG GGCGGAAGAG GAAGTGGGCT GATCAAAAGC AAGATTCTAG CCCACAGAAG 
CCCCAAGAGC CCAAACCAAC AGGTGTGCCC AAGGTGAAAT TGCTGTGTGG GGCAGATTTA 
CTGGAGTCCT TCAGCGTGCC CAACTTGTGG AAGATGGAGG ACATCACGCA AATCGTGGCC 
AACTTTGGGC TCATCTGTAT CACTCGGGCT GGCAGTGACG CTCAGAAATT CATCTACGAG 
TCCGATGTGC TGTGGAGACA TCAGAGCAAC ATCCACCTGG TGAACGAGTG GATCACCAAT 
GACATCTCGT CCACCAAGAT CCGGAGGGCG CTCAGGAGGG GCCAGAGCAT CCGCTACTTG 
GTACCGGACC TGGTCCAAGA GTACATTGAG AAGCATGAGC TGTACAACAC GGAGAGCGAA 
GGCAGGAATG CTGGGGTCAC CCTGGCTCCT CTGCAGAGGA ACGCCGCAGA GGCCAAGCAC 
AACCATTCCA CTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nmnat1 ( NM_001356357.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001343286.1 Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu17664
Clone ID Related Accession (Same CDS sequence)	NM_133435.1 , XM_006539105.2 , NM_133435.2 , XM_006539105.3 , NM_001356357.1
Accession Version	NM_001356357.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK012194.1, BY250040.1, AL606973.29 and BY516711.1. On Sep 30, 2017 this sequence version replaced XM_006539105.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK012194.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164133 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTCAT CCAAGAAGAC AGAGGTGGTT CTCCTGGCCT GTGGCTCTTT TAACCCCATC 
ACCAACATGC ACCTCAGGCT GTTCGAGCTG GCCAAGGACT ATATGCATGC TACAGGAAAA 
TACAGTGTTA TCAAAGGCAT TATCTCACCG GTCGGTGATG CGTACAAGAA GAAAGGGCTC 
ATCCCAGCCC ACCACCGAAT CATCATGGCA GAACTTGCCA CCAAGAACTC ACACTGGGTG 
GAAGTGGATA CGTGGGAAAG TCTTCAGAAG GAGTGGGTGG AGACTGTGAA GGTGCTCAGA 
TACCATCAGG AGAAGCTGGC AACTGGCAGC TGCAGTTACC CACAAAGCTC ACCTGCACTG 
GAAAAGCCTG GGCGGAAGAG GAAGTGGGCT GATCAAAAGC AAGATTCTAG CCCACAGAAG 
CCCCAAGAGC CCAAACCAAC AGGTGTGCCC AAGGTGAAAT TGCTGTGTGG GGCAGATTTA 
CTGGAGTCCT TCAGCGTGCC CAACTTGTGG AAGATGGAGG ACATCACGCA AATCGTGGCC 
AACTTTGGGC TCATCTGTAT CACTCGGGCT GGCAGTGACG CTCAGAAATT CATCTACGAG 
TCCGATGTGC TGTGGAGACA TCAGAGCAAC ATCCACCTGG TGAACGAGTG GATCACCAAT 
GACATCTCGT CCACCAAGAT CCGGAGGGCG CTCAGGAGGG GCCAGAGCAT CCGCTACTTG 
GTACCGGACC TGGTCCAAGA GTACATTGAG AAGCATGAGC TGTACAACAC GGAGAGCGAA 
GGCAGGAATG CTGGGGTCAC CCTGGCTCCT CTGCAGAGGA ACGCCGCAGA GGCCAAGCAC 
AACCATTCCA CTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001343286.1
CDS	324..1181
Translation	MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGRKRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNTESEGRNAGVTLAPLQRNAAEAKHNHSTL

Target ORF information:

RefSeq Version	NM_001356357.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001356357.1

ORF Insert Sequence:

ATGGACTCAT CCAAGAAGAC AGAGGTGGTT CTCCTGGCCT GTGGCTCTTT TAACCCCATC 
ACCAACATGC ACCTCAGGCT GTTCGAGCTG GCCAAGGACT ATATGCATGC TACAGGAAAA 
TACAGTGTTA TCAAAGGCAT TATCTCACCG GTCGGTGATG CGTACAAGAA GAAAGGGCTC 
ATCCCAGCCC ACCACCGAAT CATCATGGCA GAACTTGCCA CCAAGAACTC ACACTGGGTG 
GAAGTGGATA CGTGGGAAAG TCTTCAGAAG GAGTGGGTGG AGACTGTGAA GGTGCTCAGA 
TACCATCAGG AGAAGCTGGC AACTGGCAGC TGCAGTTACC CACAAAGCTC ACCTGCACTG 
GAAAAGCCTG GGCGGAAGAG GAAGTGGGCT GATCAAAAGC AAGATTCTAG CCCACAGAAG 
CCCCAAGAGC CCAAACCAAC AGGTGTGCCC AAGGTGAAAT TGCTGTGTGG GGCAGATTTA 
CTGGAGTCCT TCAGCGTGCC CAACTTGTGG AAGATGGAGG ACATCACGCA AATCGTGGCC 
AACTTTGGGC TCATCTGTAT CACTCGGGCT GGCAGTGACG CTCAGAAATT CATCTACGAG 
TCCGATGTGC TGTGGAGACA TCAGAGCAAC ATCCACCTGG TGAACGAGTG GATCACCAAT 
GACATCTCGT CCACCAAGAT CCGGAGGGCG CTCAGGAGGG GCCAGAGCAT CCGCTACTTG 
GTACCGGACC TGGTCCAAGA GTACATTGAG AAGCATGAGC TGTACAACAC GGAGAGCGAA 
GGCAGGAATG CTGGGGTCAC CCTGGCTCCT CTGCAGAGGA ACGCCGCAGA GGCCAAGCAC 
AACCATTCCA CTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nmnat1 ( XM_006539105.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006539168.1 Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu17664
Clone ID Related Accession (Same CDS sequence)	NM_133435.1 , XM_006539105.2 , NM_133435.2 , XM_006539105.3 , NM_001356357.1
Accession Version	XM_006539105.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	nicotinamide mononucleotide adenylyltransferase 1 isoform X1
Comment

ATGGACTCAT CCAAGAAGAC AGAGGTGGTT CTCCTGGCCT GTGGCTCTTT TAACCCCATC 
ACCAACATGC ACCTCAGGCT GTTCGAGCTG GCCAAGGACT ATATGCATGC TACAGGAAAA 
TACAGTGTTA TCAAAGGCAT TATCTCACCG GTCGGTGATG CGTACAAGAA GAAAGGGCTC 
ATCCCAGCCC ACCACCGAAT CATCATGGCA GAACTTGCCA CCAAGAACTC ACACTGGGTG 
GAAGTGGATA CGTGGGAAAG TCTTCAGAAG GAGTGGGTGG AGACTGTGAA GGTGCTCAGA 
TACCATCAGG AGAAGCTGGC AACTGGCAGC TGCAGTTACC CACAAAGCTC ACCTGCACTG 
GAAAAGCCTG GGCGGAAGAG GAAGTGGGCT GATCAAAAGC AAGATTCTAG CCCACAGAAG 
CCCCAAGAGC CCAAACCAAC AGGTGTGCCC AAGGTGAAAT TGCTGTGTGG GGCAGATTTA 
CTGGAGTCCT TCAGCGTGCC CAACTTGTGG AAGATGGAGG ACATCACGCA AATCGTGGCC 
AACTTTGGGC TCATCTGTAT CACTCGGGCT GGCAGTGACG CTCAGAAATT CATCTACGAG 
TCCGATGTGC TGTGGAGACA TCAGAGCAAC ATCCACCTGG TGAACGAGTG GATCACCAAT 
GACATCTCGT CCACCAAGAT CCGGAGGGCG CTCAGGAGGG GCCAGAGCAT CCGCTACTTG 
GTACCGGACC TGGTCCAAGA GTACATTGAG AAGCATGAGC TGTACAACAC GGAGAGCGAA 
GGCAGGAATG CTGGGGTCAC CCTGGCTCCT CTGCAGAGGA ACGCCGCAGA GGCCAAGCAC 
AACCATTCCA CTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006539168.1
Translation	MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGRKRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNTESEGRNAGVTLAPLQRNAAEAKHNHSTL

Target ORF information:

RefSeq Version	XM_006539105.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006539105.2

ORF Insert Sequence:

ATGGACTCAT CCAAGAAGAC AGAGGTGGTT CTCCTGGCCT GTGGCTCTTT TAACCCCATC 
ACCAACATGC ACCTCAGGCT GTTCGAGCTG GCCAAGGACT ATATGCATGC TACAGGAAAA 
TACAGTGTTA TCAAAGGCAT TATCTCACCG GTCGGTGATG CGTACAAGAA GAAAGGGCTC 
ATCCCAGCCC ACCACCGAAT CATCATGGCA GAACTTGCCA CCAAGAACTC ACACTGGGTG 
GAAGTGGATA CGTGGGAAAG TCTTCAGAAG GAGTGGGTGG AGACTGTGAA GGTGCTCAGA 
TACCATCAGG AGAAGCTGGC AACTGGCAGC TGCAGTTACC CACAAAGCTC ACCTGCACTG 
GAAAAGCCTG GGCGGAAGAG GAAGTGGGCT GATCAAAAGC AAGATTCTAG CCCACAGAAG 
CCCCAAGAGC CCAAACCAAC AGGTGTGCCC AAGGTGAAAT TGCTGTGTGG GGCAGATTTA 
CTGGAGTCCT TCAGCGTGCC CAACTTGTGG AAGATGGAGG ACATCACGCA AATCGTGGCC 
AACTTTGGGC TCATCTGTAT CACTCGGGCT GGCAGTGACG CTCAGAAATT CATCTACGAG 
TCCGATGTGC TGTGGAGACA TCAGAGCAAC ATCCACCTGG TGAACGAGTG GATCACCAAT 
GACATCTCGT CCACCAAGAT CCGGAGGGCG CTCAGGAGGG GCCAGAGCAT CCGCTACTTG 
GTACCGGACC TGGTCCAAGA GTACATTGAG AAGCATGAGC TGTACAACAC GGAGAGCGAA 
GGCAGGAATG CTGGGGTCAC CCTGGCTCCT CTGCAGAGGA ACGCCGCAGA GGCCAAGCAC 
AACCATTCCA CTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nmnat1 ( XM_006539105.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006539168.1 Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant X1, mRNA.

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CloneID	OMu17664
Clone ID Related Accession (Same CDS sequence)	NM_133435.1 , XM_006539105.2 , NM_133435.2 , XM_006539105.3 , NM_001356357.1
Accession Version	XM_006539105.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(House mouse)
Product	nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006539105.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTCAT CCAAGAAGAC AGAGGTGGTT CTCCTGGCCT GTGGCTCTTT TAACCCCATC 
ACCAACATGC ACCTCAGGCT GTTCGAGCTG GCCAAGGACT ATATGCATGC TACAGGAAAA 
TACAGTGTTA TCAAAGGCAT TATCTCACCG GTCGGTGATG CGTACAAGAA GAAAGGGCTC 
ATCCCAGCCC ACCACCGAAT CATCATGGCA GAACTTGCCA CCAAGAACTC ACACTGGGTG 
GAAGTGGATA CGTGGGAAAG TCTTCAGAAG GAGTGGGTGG AGACTGTGAA GGTGCTCAGA 
TACCATCAGG AGAAGCTGGC AACTGGCAGC TGCAGTTACC CACAAAGCTC ACCTGCACTG 
GAAAAGCCTG GGCGGAAGAG GAAGTGGGCT GATCAAAAGC AAGATTCTAG CCCACAGAAG 
CCCCAAGAGC CCAAACCAAC AGGTGTGCCC AAGGTGAAAT TGCTGTGTGG GGCAGATTTA 
CTGGAGTCCT TCAGCGTGCC CAACTTGTGG AAGATGGAGG ACATCACGCA AATCGTGGCC 
AACTTTGGGC TCATCTGTAT CACTCGGGCT GGCAGTGACG CTCAGAAATT CATCTACGAG 
TCCGATGTGC TGTGGAGACA TCAGAGCAAC ATCCACCTGG TGAACGAGTG GATCACCAAT 
GACATCTCGT CCACCAAGAT CCGGAGGGCG CTCAGGAGGG GCCAGAGCAT CCGCTACTTG 
GTACCGGACC TGGTCCAAGA GTACATTGAG AAGCATGAGC TGTACAACAC GGAGAGCGAA 
GGCAGGAATG CTGGGGTCAC CCTGGCTCCT CTGCAGAGGA ACGCCGCAGA GGCCAAGCAC 
AACCATTCCA CTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006539168.1
CDS	332..1189
Translation	MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGRKRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNTESEGRNAGVTLAPLQRNAAEAKHNHSTL

Target ORF information:

RefSeq Version	XM_006539105.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006539105.3

ORF Insert Sequence:

ATGGACTCAT CCAAGAAGAC AGAGGTGGTT CTCCTGGCCT GTGGCTCTTT TAACCCCATC 
ACCAACATGC ACCTCAGGCT GTTCGAGCTG GCCAAGGACT ATATGCATGC TACAGGAAAA 
TACAGTGTTA TCAAAGGCAT TATCTCACCG GTCGGTGATG CGTACAAGAA GAAAGGGCTC 
ATCCCAGCCC ACCACCGAAT CATCATGGCA GAACTTGCCA CCAAGAACTC ACACTGGGTG 
GAAGTGGATA CGTGGGAAAG TCTTCAGAAG GAGTGGGTGG AGACTGTGAA GGTGCTCAGA 
TACCATCAGG AGAAGCTGGC AACTGGCAGC TGCAGTTACC CACAAAGCTC ACCTGCACTG 
GAAAAGCCTG GGCGGAAGAG GAAGTGGGCT GATCAAAAGC AAGATTCTAG CCCACAGAAG 
CCCCAAGAGC CCAAACCAAC AGGTGTGCCC AAGGTGAAAT TGCTGTGTGG GGCAGATTTA 
CTGGAGTCCT TCAGCGTGCC CAACTTGTGG AAGATGGAGG ACATCACGCA AATCGTGGCC 
AACTTTGGGC TCATCTGTAT CACTCGGGCT GGCAGTGACG CTCAGAAATT CATCTACGAG 
TCCGATGTGC TGTGGAGACA TCAGAGCAAC ATCCACCTGG TGAACGAGTG GATCACCAAT 
GACATCTCGT CCACCAAGAT CCGGAGGGCG CTCAGGAGGG GCCAGAGCAT CCGCTACTTG 
GTACCGGACC TGGTCCAAGA GTACATTGAG AAGCATGAGC TGTACAACAC GGAGAGCGAA 
GGCAGGAATG CTGGGGTCAC CCTGGCTCCT CTGCAGAGGA ACGCCGCAGA GGCCAAGCAC 
AACCATTCCA CTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy.
Behavioural brain research339140-152(2018 Feb)
Rossi F,Geiszler PC,Meng W,Barron MR,Prior M,Herd-Smith A,Loreto A,Lopez MY,Faas H,Pardon MC,Conforti L

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD
eLife5(2016 10)
Sasaki Y,Nakagawa T,Mao X,DiAntonio A,Milbrandt J

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Nmnat1 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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