HAMP2 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	HAMP2
Entrez Gene ID	66438
Full Name	hepcidin antimicrobial peptide 2
Synonyms	1810073K19Rik,HEPC2
General protein information	Preferred Names hepcidin antimicrobial peptide 2 Names hepcidin-2
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 7 Map Location: 7 B1\|7 19.27 cM
Summary	This gene encodes a peptide hormone that functions in the regulation of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Transgenic mice overexpressing the encoded protein develop normally with hematologic parameters similar to the non-transgenic mice. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_183257.4	NP_899080.2	hepcidin-2 preproprotein
NM_183257.3	NP_899080.1	hepcidin-2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Hamp2	NP_899080.1
Mus musculus (house mouse)	Hamp	NP_115930.1

Gene Ontology
Bibliography

Related articles in PubMed

Hepcidin-2 in mouse urine as a candidate radiation-responsive molecule.
Iizuka D, Yoshioka S, Kawai H, Okazaki E, Kiriyama K, Izumi S, Nishimura M, Shimada Y, Kamiya K, Suzuki F
Journal of radiation research57(2)142-9(2016 Mar)

Inductively coupled mass spectrometry analysis of biometals in conditional Hamp1 and Hamp1 and Hamp2 transgenic mouse models.
Lu S, Seravalli J, Harrison-Findik D
Transgenic research24(4)765-73(2015 Aug)

A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates.
Cooke KS, Hinkle B, Salimi-Moosavi H, Foltz I, King C, Rathanaswami P, Winters A, Steavenson S, Begley CG, Molineux G, Sasu BJ
Blood122(17)3054-61(2013 Oct)

Transcriptional ontogeny of the developing liver.
Lee JS, Ward WO, Knapp G, Ren H, Vallanat B, Abbott B, Ho K, Karp SJ, Corton JC
BMC genomics1333(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

radiation exposure directly or indirectly induces urinary excretion of hepcidin-2 at least in part by the upregulation of Hamp2 mRNA in the liver.
Title: Hepcidin-2 in mouse urine as a candidate radiation-responsive molecule.

Hep-1 and Hep-2 peptide responses in experimental mouse agree with the known biology of hepcidin mRNA regulators.
Title: Mass spectrometry analysis of hepcidin peptides in experimental mouse models.

regulatory variation in hepcidin expression may be just as important as structural variation or mutations within its coding sequence.
Title: Regulatory variation in hepcidin expression as a heritable quantitative trait.

alcohol loading down-regulates hepatic hepcidin expression and leads to the increase of iron absorption from the intestine
Title: Hepcidin is down-regulated in alcohol loading.

Hepatic Hamp2 expression displays considerable strain- and sex-dependent variation in mice.
Title: Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice.

The following HAMP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HAMP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu83505	NM_183257.4 Latest version!	Mus musculus hepcidin antimicrobial peptide 2 (Hamp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu16527	NM_183257.3 Latest version!	Mus musculus hepcidin antimicrobial peptide 2 (Hamp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HAMP2 ( NM_183257.4 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_899080.2 Mus musculus hepcidin antimicrobial peptide 2 (Hamp2), mRNA.

Price & Availability↑

CloneID	OMu83505
Clone ID Related Accession (Same CDS sequence)	NM_183257.4
Accession Version	NM_183257.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 252bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	hepcidin-2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK008993.1 and D17962.1. On Aug 12, 2016 this sequence version replaced NM_183257.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC086895.1, AK008993.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END##

ATGGCACTCA GCACTCGGAC CCAGGCTGCC TGTCTCCTGC TTCTCCTCCT TGCCAGCCTG 
AGCAGCACCA CCTATCTCCA GCAACAGATG AGACAGACTA CAGAGCTGCA GCCTTTGCAC 
GGGGAAGAAA GCAGGGCAGA CATTGCGATC CCAATGCAGA AGAGAAGGAA GAGAGACATC 
AACTTCCCCA TCTGCAGATT CTGCTGTCAG TGCTGTAACA AACCCTCCTG TGGTATCTGT 
TGTGAAGAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_899080.2
CDS	50..301
Translation	MALSTRTQAACLLLLLLASLSSTTYLQQQMRQTTELQPLHGEESRADIAIPMQKRRKRDINFPICRFCCQCCNKPSCGICCEE

Target ORF information:

RefSeq Version	NM_183257.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus hepcidin antimicrobial peptide 2 (Hamp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_183257.4

ORF Insert Sequence:

ATGGCACTCA GCACTCGGAC CCAGGCTGCC TGTCTCCTGC TTCTCCTCCT TGCCAGCCTG 
AGCAGCACCA CCTATCTCCA GCAACAGATG AGACAGACTA CAGAGCTGCA GCCTTTGCAC 
GGGGAAGAAA GCAGGGCAGA CATTGCGATC CCAATGCAGA AGAGAAGGAA GAGAGACATC 
AACTTCCCCA TCTGCAGATT CTGCTGTCAG TGCTGTAACA AACCCTCCTG TGGTATCTGT 
TGTGAAGAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HAMP2 ( NM_183257.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_899080.1 Mus musculus hepcidin antimicrobial peptide 2 (Hamp2), mRNA.

Price & Availability↑

CloneID	OMu16527
Clone ID Related Accession (Same CDS sequence)	NM_183257.3
Accession Version	NM_183257.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 255bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	hepcidin-2 precursor
Comment

ATGATGGCAC TCAGCACTCG GACCCAGGCT GCCTGTCTCC TGCTTCTCCT CCTTGCCAGC 
CTGAGCAGCA CCACCTATCT CCAGCAACAG ATGAGACAGA CTACAGAGCT GCAGCCTTTG 
CACGGGGAAG AAAGCAGGGC AGACATTGCG ATCCCAATGC AGAAGAGAAG GAAGAGAGAC 
ATCAACTTCC CCATCTGCAG ATTCTGCTGT CAGTGCTGTA ACAAACCCTC CTGTGGTATC 
TGTTGTGAAG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_899080.1
Translation	MMALSTRTQAACLLLLLLASLSSTTYLQQQMRQTTELQPLHGEESRADIAIPMQKRRKRDINFPICRFCCQCCNKPSCGICCEE

Target ORF information:

RefSeq Version	NM_183257.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus hepcidin antimicrobial peptide 2 (Hamp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_183257.3

ORF Insert Sequence:

ATGATGGCAC TCAGCACTCG GACCCAGGCT GCCTGTCTCC TGCTTCTCCT CCTTGCCAGC 
CTGAGCAGCA CCACCTATCT CCAGCAACAG ATGAGACAGA CTACAGAGCT GCAGCCTTTG 
CACGGGGAAG AAAGCAGGGC AGACATTGCG ATCCCAATGC AGAAGAGAAG GAAGAGAGAC 
ATCAACTTCC CCATCTGCAG ATTCTGCTGT CAGTGCTGTA ACAAACCCTC CTGTGGTATC 
TGTTGTGAAG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepcidin-2 in mouse urine as a candidate radiation-responsive molecule.
Journal of radiation research57(2)142-9(2016 Mar)
Iizuka D,Yoshioka S,Kawai H,Okazaki E,Kiriyama K,Izumi S,Nishimura M,Shimada Y,Kamiya K,Suzuki F

Inductively coupled mass spectrometry analysis of biometals in conditional Hamp1 and Hamp1 and Hamp2 transgenic mouse models.
Transgenic research24(4)765-73(2015 Aug)
Lu S,Seravalli J,Harrison-Findik D

A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates.
Blood122(17)3054-61(2013 Oct)
Cooke KS,Hinkle B,Salimi-Moosavi H,Foltz I,King C,Rathanaswami P,Winters A,Steavenson S,Begley CG,Molineux G,Sasu BJ

Transcriptional ontogeny of the developing liver.
BMC genomics1333(2012 Jan)
Lee JS,Ward WO,Knapp G,Ren H,Vallanat B,Abbott B,Ho K,Karp SJ,Corton JC

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HAMP2 cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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