Sln cDNA ORF clone, Mus musculus(house mouse)

Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice.
Voit A, Patel V, Pachon R, Shah V, Bakhutma M, Kohlbrenner E, McArdle JJ, Dell'Italia LJ, Mendell JR, Xie LH, Hajjar RJ, Duan D, Fraidenraich D, Babu GJ
Nature communications8(1)1068(2017 Oct)

Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice.
Bal NC, Singh S, Reis FCG, Maurya SK, Pani S, Rowland LA, Periasamy M
The Journal of biological chemistry292(40)16616-16625(2017 10)

SLN plays an important role in adaptive muscle remodeling potentially through calcineurin stimulation, which could have important implications for other muscle diseases and conditions
Title: Effects of sarcolipin deletion on skeletal muscle adaptive responses to functional overload and unload.

SLN overexpression is associated with severe muscle atrophy and weakness.
Title: Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice.

Cardiac function of Sln(Cre/+) mice was not significantly different from WT mice in all aspects that were examined.
Title: Heterozygous deletion of sarcolipin maintains normal cardiac function.

UCP1 and SLN are required to maintain optimal thermogenesis and loss of both systems compromises survival of mice under cold stress
Title: Uncoupling Protein 1 and Sarcolipin Are Required to Maintain Optimal Thermogenesis, and Loss of Both Systems Compromises Survival of Mice under Cold Stress.

the N termini of SLN and PLB influence their respective unique functions
Title: The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca2+-ATPase (SERCA) ATP Hydrolysis from Ca2+ Transport.