Dnajc15 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dnajc15
Entrez Gene ID	66148
Full Name	DnaJ heat shock protein family (Hsp40) member C15
Synonyms	1110003P16Rik,Dnajd1
General protein information	Preferred Names DnaJ heat shock protein family (Hsp40) member C15 Names dnaJ homolog subfamily C member 15 DnaJ (Hsp40) homolog, subfamily C, member 15 DnaJ (Hsp40) homolog, subfamily D, member 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 D3

mRNA and Protein(s)

mRNA	Protein	Name
NM_025384.3	NP_079660.1	dnaJ homolog subfamily C member 15

Pathways from BioSystems

Homologies

Homo sapiens (human)	DNAJC15	NP_037370.2
Bos taurus (cattle)	DNAJC15	NP_001073801.1
Oryza sativa (rice)	Os03g0776900	NP_001051437.1
Canis lupus familiaris (dog)	DNAJC15	XP_534131.1
Mus musculus (house mouse)	Dnajc15	NP_079660.1
Rattus norvegicus (Norway rat)	Dnajc15	NP_001099520.1
Pan troglodytes (chimpanzee)	DNAJC15	XP_509654.1
	DNAJC15	XP_001092902.1
Xenopus tropicalis (tropical clawed frog)	dnajc15	NP_001005145.1
Gallus gallus (chicken)	DNAJC15	NP_001264705.1
Danio rerio (zebrafish)	dnajc15	NP_001003476.1

Gene Ontology
Bibliography

Related articles in PubMed

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
Barbier-Torres L, Iruzubieta P, Fern?ndez-Ramos D, Delgado TC, Taibo D, Guiti?rrez-de-Juan V, Varela-Rey M, Azkargorta M, Navasa N, Fern?ndez-Tussy P, Zubiete-Franco I, Simon J, Lopitz-Otsoa F, Lachiondo-Ortega S, Crespo J, Masson S, McCain MV, Villa E, Reeves H, Elortza F, Lucena MI, Hern?ndez-Alvarez MI, Zorzano A, Andrade RJ, Lu SC, Mato JM, Anguita J, Rinc?n M, Mart?nez-Chantar ML
Nature communications8(1)2068(2017 Dec)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus.
Champagne DP, Hatle KM, Fortner KA, D'Alessandro A, Thornton TM, Yang R, Torralba D, Tom?s-Cort?zar J, Jun YW, Ahn KH, Hansen KC, Haynes L, Anguita J, Rincon M
Immunity44(6)1299-311(2016 06)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations.
Hatle KM, Gummadidala P, Navasa N, Bernardo E, Dodge J, Silverstrim B, Fortner K, Burg E, Suratt BT, Hammer J, Radermacher M, Taatjes DJ, Thornton T, Anguita J, Rincon M
Molecular and cellular biology33(11)2302-14(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DNAJC15 localizes at the mitochondrial inner membrane, where it interacts preferentially with complex I of the electron transfer chain.DnaJC15 functions as a negative regulator of mitochondrial membrane potential and ATP production.
Title: MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations.

The following Dnajc15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dnajc15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00379	NM_025384.3 Latest version!	Mus musculus DnaJ heat shock protein family (Hsp40) member C15 (Dnajc15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dnajc15 ( NM_025384.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079660.1 Mus musculus DnaJ heat shock protein family (Hsp40) member C15 (Dnajc15), mRNA.

Price & Availability↑

CloneID	OMu00379
Clone ID Related Accession (Same CDS sequence)	NM_025384.3
Accession Version	NM_025384.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	dnaJ homolog subfamily C member 15
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC027509.1. On Jun 19, 2003 this sequence version replaced NM_025384.2. ##Evidence-Data-START## Transcript exon combination :: BC027509.1, BY707836.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164143 [ECO:0000348] ##Evidence-Data-END##

ATGGCTACCG GTGGCGGCGT GACCTCCAGA GAGGGGCTGC GCTACGCCGA ATACCTGCCT 
CCTTCTGCCC AAAGGTCGGA CGCCGACATC GACCACACAG CGGGGAGAAG GTTGCTAGCT 
GTAGGACTAG GTGTTGCAGC TGTTGCATTT GCAGGTCGCT ATGCATTTCA GATCTGGAAA 
CCTCTAGAAC AAGTAATCAC GGCAACAGCA AGGAAGATTT CCTCTCCAAG CTTTTCATCC 
TACTATAAAG GAGGATTCGA GCAGAAAATG AGTAAGCGAG AGGCTAGTCT TATTTTAGGT 
GTAAGCCCAT CTGCTGGCAA GGCCAAGATT AGAACAGCAC ACAAGAGAAT TATGATTTTA 
AACCATCCAG ACAAAGGTGG ATCTCCTTAC TTAGCATCCA AAATAAATGA AGCAAAAGAT 
TTGCTCGAAG CATCCAGCAA AGCTAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079660.1
CDS	19..468
Translation	MATGGGVTSREGLRYAEYLPPSAQRSDADIDHTAGRRLLAVGLGVAAVAFAGRYAFQIWKPLEQVITATARKISSPSFSSYYKGGFEQKMSKREASLILGVSPSAGKAKIRTAHKRIMILNHPDKGGSPYLASKINEAKDLLEASSKAN

Target ORF information:

RefSeq Version	NM_025384.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus DnaJ heat shock protein family (Hsp40) member C15 (Dnajc15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025384.3

ORF Insert Sequence:

ATGGCTACCG GTGGCGGCGT GACCTCCAGA GAGGGGCTGC GCTACGCCGA ATACCTGCCT 
CCTTCTGCCC AAAGGTCGGA CGCCGACATC GACCACACAG CGGGGAGAAG GTTGCTAGCT 
GTAGGACTAG GTGTTGCAGC TGTTGCATTT GCAGGTCGCT ATGCATTTCA GATCTGGAAA 
CCTCTAGAAC AAGTAATCAC GGCAACAGCA AGGAAGATTT CCTCTCCAAG CTTTTCATCC 
TACTATAAAG GAGGATTCGA GCAGAAAATG AGTAAGCGAG AGGCTAGTCT TATTTTAGGT 
GTAAGCCCAT CTGCTGGCAA GGCCAAGATT AGAACAGCAC ACAAGAGAAT TATGATTTTA 
AACCATCCAG ACAAAGGTGG ATCTCCTTAC TTAGCATCCA AAATAAATGA AGCAAAAGAT 
TTGCTCGAAG CATCCAGCAA AGCTAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
Nature communications8(1)2068(2017 Dec)
Barbier-Torres L,Iruzubieta P,Fern?ndez-Ramos D,Delgado TC,Taibo D,Guiti?rrez-de-Juan V,Varela-Rey M,Azkargorta M,Navasa N,Fern?ndez-Tussy P,Zubiete-Franco I,Simon J,Lopitz-Otsoa F,Lachiondo-Ortega S,Crespo J,Masson S,McCain MV,Villa E,Reeves H,Elortza F,Lucena MI,Hern?ndez-Alvarez MI,Zorzano A,Andrade RJ,Lu SC,Mato JM,Anguita J,Rinc?n M,Mart?nez-Chantar ML

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus.
Immunity44(6)1299-311(2016 06)
Champagne DP,Hatle KM,Fortner KA,D'Alessandro A,Thornton TM,Yang R,Torralba D,Tom?s-Cort?zar J,Jun YW,Ahn KH,Hansen KC,Haynes L,Anguita J,Rincon M

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations.
Molecular and cellular biology33(11)2302-14(2013 Jun)
Hatle KM,Gummadidala P,Navasa N,Bernardo E,Dodge J,Silverstrim B,Fortner K,Burg E,Suratt BT,Hammer J,Radermacher M,Taatjes DJ,Thornton T,Anguita J,Rincon M

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Dnajc15 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Services & Products

見積依頼

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FAX

オンラインフォーム