Asb2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Asb2
Entrez Gene ID	65256
Full Name	ankyrin repeat and SOCS box-containing 2
Synonyms	1110008E15Rik
General protein information	Preferred Names ankyrin repeat and SOCS box-containing 2 Names ankyrin repeat and SOCS box protein 2 ASB-2 ankyrin repeat and SOCS box-containing protein 2 ankyrin repeat-containing SOCS box protein 2 asb2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 E\|12 52.9 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_023049.1	NP_075536.1	ankyrin repeat and SOCS box protein 2 isoform 1
NM_001374764.1	NP_001361693.1	ankyrin repeat and SOCS box protein 2 isoform 2

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	asb2	XP_002933276.2
Pan troglodytes (chimpanzee)	ASB2	XP_001151280.2
Canis lupus familiaris (dog)	ASB2	XP_854471.1
Mus musculus (house mouse)	Asb2	NP_075536.1
Gallus gallus (chicken)	ASB2	XP_421337.1
Danio rerio (zebrafish)	asb2a.1	XP_696390.3
	ASB2	XP_001095689.2
Rattus norvegicus (Norway rat)	Asb2	NP_001011984.1
Homo sapiens (human)	ASB2	NP_001189358.1
Bos taurus (cattle)	ASB2	NP_001029841.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteolysis regulates cardiomyocyte maturation and tissue integration.
Fukuda R, Gunawan F, Beisaw A, Jimenez-Amilburu V, Maischein HM, Kostin S, Kawakami K, Stainier DY
Nature communications814495(2017 Feb)

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N
Li Z, Weng H, Su R, Weng X, Zuo Z, Li C, Huang H, Nachtergaele S, Dong L, Hu C, Qin X, Tang L, Wang Y, Hong GM, Huang H, Wang X, Chen P, Gurbuxani S, Arnovitz S, Li Y, Li S, Strong J, Neilly MB, Larson RA, Jiang X, Zhang P, Jin J, He C, Chen J
Cancer cell31(1)127-141(2017 Jan)

Substrates of the ASB2? E3 ubiquitin ligase in dendritic cells.
Spinner CA, Uttenweiler-Joseph S, Metais A, Stella A, Burlet-Schiltz O, Moog-Lutz C, Lamsoul I, Lutz PG
Scientific reports516269(2015 Nov)

The E3 ubiquitin ligase Asb2? is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation.
Thottakara T, Friedrich FW, Reischmann S, Braumann S, Schlossarek S, Kr?mer E, Juhr D, Schl?ter H, van der Velden J, M?nch J, Patten M, Eschenhagen T, Moog-Lutz C, Carrier L
Journal of molecular and cellular cardiology87214-24(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study identifies desmin as a new Asb2b target for proteasomal degradation in cardiomyocytes and suggests that accumulation of desmin could contribute to UPS impairment in Hypertrophic cardiomyopathy mice and patients
Title: The E3 ubiquitin ligase Asb2? is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation.

ASB2(-/-) immature dendritic cells exhibit reduced matrix-degrading function leading to defective migration.
Title: ASB2? regulates migration of immature dendritic cells.

ASB2alpha is a novel regulator of integrin-dependent adhesion of hematopoietic cells
Title: Functional and structural insights into ASB2alpha, a novel regulator of integrin-dependent adhesion of hematopoietic cells.

ASB2beta is part of an active E3 ubiquitin ligase complex and targets the actin-binding protein filamin B for proteasomal degradation.
Title: The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation.

The following Asb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Asb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00098	NM_023049.1 Latest version!	Mus musculus ankyrin repeat and SOCS box-containing 2 (Asb2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$370.30 $529.00
OMu90608	NM_001374764.1 Latest version!	Mus musculus ankyrin repeat and SOCS box-containing 2 (Asb2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Asb2 ( NM_023049.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075536.1 Mus musculus ankyrin repeat and SOCS box-containing 2 (Asb2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu00098
Clone ID Related Accession (Same CDS sequence)	NM_023049.1
Accession Version	NM_023049.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1905bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Mus musculus(house mouse)
Product	ankyrin repeat and SOCS box protein 2 isoform 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC031161.1. On or before May 4, 2006 this sequence version replaced XM_977761.1, XM_977732.1, XM_977651.1, XM_977692.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031161.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGCGACTG AGATCTCCAC TCGGGGCAGA CAACGTGCCA TCGGACATGA GGAATACAGC 
CTATACAGCA GCCTGAGCGA GGAGGAGCTG CTCCAGATGG CCATCGAGCA GAGCCTGGCA 
GACAAGACTC GGGGCCCGAC CCCTGCTGAG GCCTCCGCGT CCTCTCAGAC CAACCACCAG 
CCAGGACATT TCCACCCATG GACCAGGTCC CCTTCGTCTC CCGAGAACCC ACCGGCCCGC 
GCACCCCTGG GTCTGTTCCA AGGGGTCATG CAGAAGTATA GCAGCAACCT GTTCAAGACC 
TCCCAGATGG CGGCTATGGA CCCCGTGCTG AAGGCCATCA AGGAAGGGGA TGAAGAGGCC 
TTGAAGATCA TGATCCAGGA TGGGAAGAAT CTTGCAGAGC CCAACAAGGA GGGCTGGCTG 
CCGCTCCACG AGGCTGCCTA CTATGGCCAG CTGGGCTGCC TGAAAGTCCT GCAGCAAGCC 
TACCCAGGGA CCATTGACCA ACGCACACTG CAGGAAGAGA CAGCATTATA CCTGGCCACA 
TGCAGAGAAC ACCTGGATTG CCTCCTGTCG CTGCTCCAGG CGGGGGCAGA GCCTGACATC 
TCTAACAAAT CCAGGGAGAC TCCACTTTAC AAAGCCTGTG AGCGCAAGAA CGCGGAGGCG 
GTGAGGATAT TGGTGCGATA CAACGCAGAC GCCAACCACC GCTGTAACAG GGGCTGGACC 
GCACTGCACG AGTCTGTCTC CCGCAATGAC CTGGAGGTCA TGGAGATCCT AGTGAGTGGC 
GGGGCCAAGG TGGAGGCCAA GAATGTCTAC AGCATCACCC CTTTGTTTGT GGCTGCCCAG 
AGTGGGCAGC TGGAGGCCCT GAGGTTCCTG GCCAAGCATG GTGCAGACAT CAACACGCAG 
GCCAGTGACA GTGCATCAGC CCTCTACGAG GCCAGCAAGA ATGAGCATGA AGACGTGGTA 
GAGTTTCTTC TCTCTCAGGG CGCCGATGCT AACAAAGCCA ACAAGGACGG CCTGCTCCCC 
CTGCATGTTG CCTCCAAGAA GGGCAACTAT AGAATAGTGC AGATGCTGCT GCCTGTGACC 
AGCCGCACGC GCGTGCGCCG TAGCGGCATC AGCCCGCTGC ACCTAGCGGC CGAGCGCAAC 
CACGACGCGG TGCTGGAGGC GCTGCTGGCC GCGCGCTTCG ACGTGAACGC ACCTCTGGCT 
CCCGAGCGCG CCCGCCTCTA CGAGGACCGC CGCAGTTCTG CGCTCTACTT CGCTGTGGTC 
AACAACAATG TGTACGCCAC CGAGCTGTTG CTGCTGGCGG GCGCGGACCC CAACCGCGAT 
GTCATCAGCC CTCTGCTCGT GGCCATCCGC CACGGCTGCC TGCGCACCAT GCAGCTGCTG 
TTGGACCATG GCGCCAACAT CGACGCCTAC ATCGCCACTC ACCCCACCGC CTTTCCAGCC 
ACCATCATGT TTGCCATGAA GTGCCTGTCG TTACTCAAGT TCCTTATGGA CCTCGGCTGC 
GATGGCGAGC CCTGCTTCTC CTGCCTGTAC GGCAACGGGC CGCACCCACC CGCCCCGCGA 
CCTGGCCGCT TCCACGACGC ACCCGTGGAC GACAAGGCAC CTAGCGTGGT GCAGTTCTGT 
GAGTTCCTGT CGGCCCCGGA AGTGAGCCGC TGGGCGGGAC CCATCATCGA TGTCCTCCTG 
GACTATGTGG GCAACGTGCA GCTGTGCTCC CGGCTGAAGG AGCACATCGA CAGCTTTGAG 
GACTGGGCTG TCATCAAGGA GAAGGCAGAA CCTCCGAGAC CTCTGGCTCA CCTCTGCCGG 
CTGCGGGTTC GGAAGGCCAT AGGAAAATAC CGGATAAAAC TCCTGGACAC ACTGCCGCTT 
CCCGGCAGGC TAATCAGATA CCTGAAATAT GAGAATACAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075536.1
CDS	390..2294
Translation	MATEISTRGRQRAIGHEEYSLYSSLSEEELLQMAIEQSLADKTRGPTPAEASASSQTNHQPGHFHPWTRSPSSPENPPARAPLGLFQGVMQKYSSNLFKTSQMAAMDPVLKAIKEGDEEALKIMIQDGKNLAEPNKEGWLPLHEAAYYGQLGCLKVLQQAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVRYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEASKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNHDAVLEALLAARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPRPGRFHDAPVDDKAPSVVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ

Target ORF information:

RefSeq Version	NM_023049.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ankyrin repeat and SOCS box-containing 2 (Asb2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023049.1

ORF Insert Sequence:

ATGGCGACTG AGATCTCCAC TCGGGGCAGA CAACGTGCCA TCGGACATGA GGAATACAGC 
CTATACAGCA GCCTGAGCGA GGAGGAGCTG CTCCAGATGG CCATCGAGCA GAGCCTGGCA 
GACAAGACTC GGGGCCCGAC CCCTGCTGAG GCCTCCGCGT CCTCTCAGAC CAACCACCAG 
CCAGGACATT TCCACCCATG GACCAGGTCC CCTTCGTCTC CCGAGAACCC ACCGGCCCGC 
GCACCCCTGG GTCTGTTCCA AGGGGTCATG CAGAAGTATA GCAGCAACCT GTTCAAGACC 
TCCCAGATGG CGGCTATGGA CCCCGTGCTG AAGGCCATCA AGGAAGGGGA TGAAGAGGCC 
TTGAAGATCA TGATCCAGGA TGGGAAGAAT CTTGCAGAGC CCAACAAGGA GGGCTGGCTG 
CCGCTCCACG AGGCTGCCTA CTATGGCCAG CTGGGCTGCC TGAAAGTCCT GCAGCAAGCC 
TACCCAGGGA CCATTGACCA ACGCACACTG CAGGAAGAGA CAGCATTATA CCTGGCCACA 
TGCAGAGAAC ACCTGGATTG CCTCCTGTCG CTGCTCCAGG CGGGGGCAGA GCCTGACATC 
TCTAACAAAT CCAGGGAGAC TCCACTTTAC AAAGCCTGTG AGCGCAAGAA CGCGGAGGCG 
GTGAGGATAT TGGTGCGATA CAACGCAGAC GCCAACCACC GCTGTAACAG GGGCTGGACC 
GCACTGCACG AGTCTGTCTC CCGCAATGAC CTGGAGGTCA TGGAGATCCT AGTGAGTGGC 
GGGGCCAAGG TGGAGGCCAA GAATGTCTAC AGCATCACCC CTTTGTTTGT GGCTGCCCAG 
AGTGGGCAGC TGGAGGCCCT GAGGTTCCTG GCCAAGCATG GTGCAGACAT CAACACGCAG 
GCCAGTGACA GTGCATCAGC CCTCTACGAG GCCAGCAAGA ATGAGCATGA AGACGTGGTA 
GAGTTTCTTC TCTCTCAGGG CGCCGATGCT AACAAAGCCA ACAAGGACGG CCTGCTCCCC 
CTGCATGTTG CCTCCAAGAA GGGCAACTAT AGAATAGTGC AGATGCTGCT GCCTGTGACC 
AGCCGCACGC GCGTGCGCCG TAGCGGCATC AGCCCGCTGC ACCTAGCGGC CGAGCGCAAC 
CACGACGCGG TGCTGGAGGC GCTGCTGGCC GCGCGCTTCG ACGTGAACGC ACCTCTGGCT 
CCCGAGCGCG CCCGCCTCTA CGAGGACCGC CGCAGTTCTG CGCTCTACTT CGCTGTGGTC 
AACAACAATG TGTACGCCAC CGAGCTGTTG CTGCTGGCGG GCGCGGACCC CAACCGCGAT 
GTCATCAGCC CTCTGCTCGT GGCCATCCGC CACGGCTGCC TGCGCACCAT GCAGCTGCTG 
TTGGACCATG GCGCCAACAT CGACGCCTAC ATCGCCACTC ACCCCACCGC CTTTCCAGCC 
ACCATCATGT TTGCCATGAA GTGCCTGTCG TTACTCAAGT TCCTTATGGA CCTCGGCTGC 
GATGGCGAGC CCTGCTTCTC CTGCCTGTAC GGCAACGGGC CGCACCCACC CGCCCCGCGA 
CCTGGCCGCT TCCACGACGC ACCCGTGGAC GACAAGGCAC CTAGCGTGGT GCAGTTCTGT 
GAGTTCCTGT CGGCCCCGGA AGTGAGCCGC TGGGCGGGAC CCATCATCGA TGTCCTCCTG 
GACTATGTGG GCAACGTGCA GCTGTGCTCC CGGCTGAAGG AGCACATCGA CAGCTTTGAG 
GACTGGGCTG TCATCAAGGA GAAGGCAGAA CCTCCGAGAC CTCTGGCTCA CCTCTGCCGG 
CTGCGGGTTC GGAAGGCCAT AGGAAAATAC CGGATAAAAC TCCTGGACAC ACTGCCGCTT 
CCCGGCAGGC TAATCAGATA CCTGAAATAT GAGAATACAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Asb2 ( NM_001374764.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001361693.1 Mus musculus ankyrin repeat and SOCS box-containing 2 (Asb2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu90608
Clone ID Related Accession (Same CDS sequence)	NM_001374764.1
Accession Version	NM_001374764.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1761bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Mus musculus(house mouse)
Product	ankyrin repeat and SOCS box protein 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC160131.2 and AK083400.1. On Oct 11, 2019 this sequence version replaced XM_030246845.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK083400.1, AF155353.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGACTCGCT TCTCTTATGC AGAGTACTTT GCTCTGTTTC ACTCTGGCTC TGCACCTTCC 
AGGTCCCCTT CGTCTCCCGA GAACCCACCG GCCCGCGCAC CCCTGGGTCT GTTCCAAGGG 
GTCATGCAGA AGTATAGCAG CAACCTGTTC AAGACCTCCC AGATGGCGGC TATGGACCCC 
GTGCTGAAGG CCATCAAGGA AGGGGATGAA GAGGCCTTGA AGATCATGAT CCAGGATGGG 
AAGAATCTTG CAGAGCCCAA CAAGGAGGGC TGGCTGCCGC TCCACGAGGC TGCCTACTAT 
GGCCAGCTGG GCTGCCTGAA AGTCCTGCAG CAAGCCTACC CAGGGACCAT TGACCAACGC 
ACACTGCAGG AAGAGACAGC ATTATACCTG GCCACATGCA GAGAACACCT GGATTGCCTC 
CTGTCGCTGC TCCAGGCGGG GGCAGAGCCT GACATCTCTA ACAAATCCAG GGAGACTCCA 
CTTTACAAAG CCTGTGAGCG CAAGAACGCG GAGGCGGTGA GGATATTGGT GCGATACAAC 
GCAGACGCCA ACCACCGCTG TAACAGGGGC TGGACCGCAC TGCACGAGTC TGTCTCCCGC 
AATGACCTGG AGGTCATGGA GATCCTAGTG AGTGGCGGGG CCAAGGTGGA GGCCAAGAAT 
GTCTACAGCA TCACCCCTTT GTTTGTGGCT GCCCAGAGTG GGCAGCTGGA GGCCCTGAGG 
TTCCTGGCCA AGCATGGTGC AGACATCAAC ACGCAGGCCA GTGACAGTGC ATCAGCCCTC 
TACGAGGCCA GCAAGAATGA GCATGAAGAC GTGGTAGAGT TTCTTCTCTC TCAGGGCGCC 
GATGCTAACA AAGCCAACAA GGACGGCCTG CTCCCCCTGC ATGTTGCCTC CAAGAAGGGC 
AACTATAGAA TAGTGCAGAT GCTGCTGCCT GTGACCAGCC GCACGCGCGT GCGCCGTAGC 
GGCATCAGCC CGCTGCACCT AGCGGCCGAG CGCAACCACG ACGCGGTGCT GGAGGCGCTG 
CTGGCCGCGC GCTTCGACGT GAACGCACCT CTGGCTCCCG AGCGCGCCCG CCTCTACGAG 
GACCGCCGCA GTTCTGCGCT CTACTTCGCT GTGGTCAACA ACAATGTGTA CGCCACCGAG 
CTGTTGCTGC TGGCGGGCGC GGACCCCAAC CGCGATGTCA TCAGCCCTCT GCTCGTGGCC 
ATCCGCCACG GCTGCCTGCG CACCATGCAG CTGCTGTTGG ACCATGGCGC CAACATCGAC 
GCCTACATCG CCACTCACCC CACCGCCTTT CCAGCCACCA TCATGTTTGC CATGAAGTGC 
CTGTCGTTAC TCAAGTTCCT TATGGACCTC GGCTGCGATG GCGAGCCCTG CTTCTCCTGC 
CTGTACGGCA ACGGGCCGCA CCCACCCGCC CCGCGACCTG GCCGCTTCCA CGACGCACCC 
GTGGACGACA AGGCACCTAG CGTGGTGCAG TTCTGTGAGT TCCTGTCGGC CCCGGAAGTG 
AGCCGCTGGG CGGGACCCAT CATCGATGTC CTCCTGGACT ATGTGGGCAA CGTGCAGCTG 
TGCTCCCGGC TGAAGGAGCA CATCGACAGC TTTGAGGACT GGGCTGTCAT CAAGGAGAAG 
GCAGAACCTC CGAGACCTCT GGCTCACCTC TGCCGGCTGC GGGTTCGGAA GGCCATAGGA 
AAATACCGGA TAAAACTCCT GGACACACTG CCGCTTCCCG GCAGGCTAAT CAGATACCTG 
AAATATGAGA ATACACAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001361693.1
CDS	148..1908
Translation	MTRFSYAEYFALFHSGSAPSRSPSSPENPPARAPLGLFQGVMQKYSSNLFKTSQMAAMDPVLKAIKEGDEEALKIMIQDGKNLAEPNKEGWLPLHEAAYYGQLGCLKVLQQAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVRYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEASKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNHDAVLEALLAARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPRPGRFHDAPVDDKAPSVVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ

Target ORF information:

RefSeq Version	NM_001374764.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ankyrin repeat and SOCS box-containing 2 (Asb2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001374764.1

ORF Insert Sequence:

ATGACTCGCT TCTCTTATGC AGAGTACTTT GCTCTGTTTC ACTCTGGCTC TGCACCTTCC 
AGGTCCCCTT CGTCTCCCGA GAACCCACCG GCCCGCGCAC CCCTGGGTCT GTTCCAAGGG 
GTCATGCAGA AGTATAGCAG CAACCTGTTC AAGACCTCCC AGATGGCGGC TATGGACCCC 
GTGCTGAAGG CCATCAAGGA AGGGGATGAA GAGGCCTTGA AGATCATGAT CCAGGATGGG 
AAGAATCTTG CAGAGCCCAA CAAGGAGGGC TGGCTGCCGC TCCACGAGGC TGCCTACTAT 
GGCCAGCTGG GCTGCCTGAA AGTCCTGCAG CAAGCCTACC CAGGGACCAT TGACCAACGC 
ACACTGCAGG AAGAGACAGC ATTATACCTG GCCACATGCA GAGAACACCT GGATTGCCTC 
CTGTCGCTGC TCCAGGCGGG GGCAGAGCCT GACATCTCTA ACAAATCCAG GGAGACTCCA 
CTTTACAAAG CCTGTGAGCG CAAGAACGCG GAGGCGGTGA GGATATTGGT GCGATACAAC 
GCAGACGCCA ACCACCGCTG TAACAGGGGC TGGACCGCAC TGCACGAGTC TGTCTCCCGC 
AATGACCTGG AGGTCATGGA GATCCTAGTG AGTGGCGGGG CCAAGGTGGA GGCCAAGAAT 
GTCTACAGCA TCACCCCTTT GTTTGTGGCT GCCCAGAGTG GGCAGCTGGA GGCCCTGAGG 
TTCCTGGCCA AGCATGGTGC AGACATCAAC ACGCAGGCCA GTGACAGTGC ATCAGCCCTC 
TACGAGGCCA GCAAGAATGA GCATGAAGAC GTGGTAGAGT TTCTTCTCTC TCAGGGCGCC 
GATGCTAACA AAGCCAACAA GGACGGCCTG CTCCCCCTGC ATGTTGCCTC CAAGAAGGGC 
AACTATAGAA TAGTGCAGAT GCTGCTGCCT GTGACCAGCC GCACGCGCGT GCGCCGTAGC 
GGCATCAGCC CGCTGCACCT AGCGGCCGAG CGCAACCACG ACGCGGTGCT GGAGGCGCTG 
CTGGCCGCGC GCTTCGACGT GAACGCACCT CTGGCTCCCG AGCGCGCCCG CCTCTACGAG 
GACCGCCGCA GTTCTGCGCT CTACTTCGCT GTGGTCAACA ACAATGTGTA CGCCACCGAG 
CTGTTGCTGC TGGCGGGCGC GGACCCCAAC CGCGATGTCA TCAGCCCTCT GCTCGTGGCC 
ATCCGCCACG GCTGCCTGCG CACCATGCAG CTGCTGTTGG ACCATGGCGC CAACATCGAC 
GCCTACATCG CCACTCACCC CACCGCCTTT CCAGCCACCA TCATGTTTGC CATGAAGTGC 
CTGTCGTTAC TCAAGTTCCT TATGGACCTC GGCTGCGATG GCGAGCCCTG CTTCTCCTGC 
CTGTACGGCA ACGGGCCGCA CCCACCCGCC CCGCGACCTG GCCGCTTCCA CGACGCACCC 
GTGGACGACA AGGCACCTAG CGTGGTGCAG TTCTGTGAGT TCCTGTCGGC CCCGGAAGTG 
AGCCGCTGGG CGGGACCCAT CATCGATGTC CTCCTGGACT ATGTGGGCAA CGTGCAGCTG 
TGCTCCCGGC TGAAGGAGCA CATCGACAGC TTTGAGGACT GGGCTGTCAT CAAGGAGAAG 
GCAGAACCTC CGAGACCTCT GGCTCACCTC TGCCGGCTGC GGGTTCGGAA GGCCATAGGA 
AAATACCGGA TAAAACTCCT GGACACACTG CCGCTTCCCG GCAGGCTAAT CAGATACCTG 
AAATATGAGA ATACACAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteolysis regulates cardiomyocyte maturation and tissue integration.
Nature communications814495(2017 Feb)
Fukuda R,Gunawan F,Beisaw A,Jimenez-Amilburu V,Maischein HM,Kostin S,Kawakami K,Stainier DY

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N
Cancer cell31(1)127-141(2017 Jan)
Li Z,Weng H,Su R,Weng X,Zuo Z,Li C,Huang H,Nachtergaele S,Dong L,Hu C,Qin X,Tang L,Wang Y,Hong GM,Huang H,Wang X,Chen P,Gurbuxani S,Arnovitz S,Li Y,Li S,Strong J,Neilly MB,Larson RA,Jiang X,Zhang P,Jin J,He C,Chen J

Substrates of the ASB2? E3 ubiquitin ligase in dendritic cells.
Scientific reports516269(2015 Nov)
Spinner CA,Uttenweiler-Joseph S,Metais A,Stella A,Burlet-Schiltz O,Moog-Lutz C,Lamsoul I,Lutz PG

The E3 ubiquitin ligase Asb2? is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation.
Journal of molecular and cellular cardiology87214-24(2015 Oct)
Thottakara T,Friedrich FW,Reischmann S,Braumann S,Schlossarek S,Kr?mer E,Juhr D,Schl?ter H,van der Velden J,M?nch J,Patten M,Eschenhagen T,Moog-Lutz C,Carrier L

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Asb2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報