Htra2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Htra2
Entrez Gene ID	64704
Full Name	HtrA serine peptidase 2
Synonyms	AI481710,Omi,Prss25,mnd2
General protein information	Preferred Names HtrA serine peptidase 2 Names serine protease HTRA2, mitochondrial high temperature requirement protein A2 motor neuron degeneration 2 omi stress-regulated endoprotease protease, serine, 25 serine protease 25 serine protease OMI serine proteinase OMI
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 C3\|6 35.94 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_019752.3	NP_062726.3	serine protease HTRA2, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	HTRA2	NP_037379.1
Pan troglodytes (chimpanzee)	HTRA2	XP_003309140.2
Canis lupus familiaris (dog)	HTRA2	XP_532992.3
Danio rerio (zebrafish)	LOC560917	XP_002663637.2
Danio rerio (zebrafish)	zgc:173425	NP_001098612.1
Danio rerio (zebrafish)	si:busm1-sl7.7	XP_003199743.1
Danio rerio (zebrafish)	LOC100003308	NP_001103205.1
Danio rerio (zebrafish)	LOC799006	XP_001339411.5
Danio rerio (zebrafish)	si:dkey-84o3.3	XP_002665896.3
Bos taurus (cattle)	HTRA2	NP_001071424.1
Gallus gallus (chicken)	HTRA2	XP_423666.3
Danio rerio (zebrafish)	LOC100536969	XP_003199752.2
Danio rerio (zebrafish)	si:dkey-84o3.7	XP_001335201.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000240	XP_310886.5
Danio rerio (zebrafish)	zgc:174193	NP_001108178.1
Danio rerio (zebrafish)	si:dkey-33c12.10	XP_003199749.2
Danio rerio (zebrafish)	si:dkey-33c12.2	XP_005172803.1
Danio rerio (zebrafish)	LOC100329860	XP_002664149.3
Danio rerio (zebrafish)	LOC797876	XP_001923767.4
Danio rerio (zebrafish)	LOC100331049	XP_002665901.2
Danio rerio (zebrafish)	LOC799537	NP_001103640.1
Rattus norvegicus (Norway rat)	Htra2	NP_001100069.1
Danio rerio (zebrafish)	LOC100149563	NP_001122292.1
Danio rerio (zebrafish)	LOC797799	NP_001103998.1
Drosophila melanogaster (fruit fly)	HtrA2	NP_001262565.1
	HTRA2	XP_001110803.1
Mus musculus (house mouse)	Htra2	NP_062726.3
Danio rerio (zebrafish)	LOC793110	XP_001332804.5
Danio rerio (zebrafish)	LOC793521	XP_001333305.1
Danio rerio (zebrafish)	LOC100330919	XP_005161042.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart.
Liu X, Lei J, Wang K, Ma L, Liu D, Du Y, Wu Y, Zhang S, Wang W, Ma X, Liu H
Rejuvenation research20(3)183-192(2017 Jun)

Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction.
Wang K, Yuan Y, Liu X, Lau WB, Zuo L, Wang X, Ma L, Jiao K, Shang J, Wang W, Ma X, Liu H
Scientific reports637927(2016 Dec)

HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3.
Lee SH, Moon YM, Seo HB, Kim SY, Kim EK, Yi J, Nam MK, Min JK, Park SH, Rhim H, Cho ML
Scientific reports639393(2016 Dec)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mice overexpressing wild-type or G399S mutant HtrA2 have mitochondrial defects resulting in neurodegeneration.
Title: Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.

Protease Omi impairs mitochondrial function by cleaving Hax-1, which induces apoptosis in oxygen-glucose deprivation and reoxygenation -treated N2a cells and causes reperfusion injury in middle cerebral artery occlusion mice.
Title: Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice.

Protease Omi facilitates neurite outgrowth by cleaving the transcription factor E2F1 in differentiated neuroblastoma cells; E2F1 is a substrate of Omi.
Title: Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1.

The NG2 proteoglycan protects oligodendrocyte precursor cells against oxidative stress via interaction with OMI/HtrA2.
Title: The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2.

Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.
Title: Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.

The following Htra2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Htra2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22610	NM_019752.3 Latest version!	Mus musculus HtrA serine peptidase 2 (Htra2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Htra2 ( NM_019752.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062726.3 Mus musculus HtrA serine peptidase 2 (Htra2), mRNA.

Price & Availability↑

CloneID	OMu22610
Clone ID Related Accession (Same CDS sequence)	NM_019752.3
Accession Version	NM_019752.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	serine protease HTRA2, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC104324.21, AF175324.1 and BM899329.1. On Jul 18, 2009 this sequence version replaced NM_019752.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC049880.1, AK146338.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCTGCGC TGAAAGCGGG GCGGGGTGCA AACTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATCT TCTGGAGGAA GCCTCCCCTG TTAGCTCCTG ACCTCCGGGC TCTGCTGACG 
TCAGGAACTC CTGACTCTCA GATCTGGATG ACTTATGGGA CCCCCAGTCT CCCGGCCCAG 
GTGCCTGAGG GGTTCCTTGC ATCACGGGCA GATCTGACGT CTAGGACCCC GGATCTCTGG 
GCACGATTGA ATGTGGGGAC TTCAGGCTCC AGTGACCAGG AGGCCCGCAG GAGCCCTGGA 
AGCCGTCGGC GCGAATGGCT GGCGGTGGCG GTGGGCGCAG GAGGTGCAGT GGTGCTGCTG 
TTGTGGGGTT GGGGTCGGGG TCTTTCCACG GTGCTGGCTG CTGTTCCTGC TCCGCCACCC 
ACTTCTCCCC GGAGCCAGTA CAATTTCATC GCAGATGTGG TGGAGAAGAC AGCCCCTGCT 
GTGGTCTATA TCGAGATCCT AGACCGGCAC CCTTTCTCCG GCCGTGAAGT CCCCATCTCA 
AACGGATCAG GATTCGTAGT GGCTTCAGAT GGGCTCATCG TTACCAACGC CCACGTGGTG 
GCTGATCGGC GCCGAGTACG AGTGAGGCTG CCTAGCGGGG ATACTTATGA GGCCATGGTC 
ACAGCTGTGG ATCCCGTAGC AGACATTGCC ACACTGAGGA TTCAAACCAA GGAGCCTCTT 
CCCACACTGC CCCTCGGCCG CTCTGCTGAT GTCCGGCAAG GGGAGTTTGT TGTTGCCATG 
GGAAGCCCCT TTGCACTGCA GAACACGATC ACATCTGGTA TTGTCAGCTC TGCTCAGCGC 
CCAGCCAGGG ACCTGGGACT CCCTCAAAAC AACGTGGAAT ACATTCAGAC CGATGCAGCT 
ATTGATTTTG GAAATTCTGG TGGTCCCCTG GTTAACCTGG ATGGGGAGGT GATTGGAGTG 
AACACCATGA AGGTGACAGC TGGAATCTCC TTTGCCATCC CTTCTGATCG CCTTAGGGAG 
TTTCTGCATC GCGGGGAAAA GAAAAATTCC TGGTTTGGAA CCAGTGGGTC CCAGCGCCGC 
TACATTGGAG TGATGATGCT GACCCTGACT CCCAGCATCC TTATTGAACT ACAGCTCCGT 
GAGCCAAGCT TCCCTGATGT TCAGCATGGT GTCCTCATTC ATAAAGTTAT CCTGGGCTCC 
CCCGCACACA GGGCTGGTCT GCGGCCTGGT GATGTGATCT TGGCCATTGG GGAGAAATTG 
GCACAAAATG CTGAAGATGT TTATGAAGCT GTTCGAACCC AATCACAGCT GGCAGTGCGG 
ATCCGGCGCG GATCAGAGAC ACTGACCTTA TATGTGACCC CCGAGGTCAC AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062726.3
CDS	146..1522
Translation	MAALKAGRGANWSLRAWRALGGIFWRKPPLLAPDLRALLTSGTPDSQIWMTYGTPSLPAQVPEGFLASRADLTSRTPDLWARLNVGTSGSSDQEARRSPGSRRREWLAVAVGAGGAVVLLLWGWGRGLSTVLAAVPAPPPTSPRSQYNFIADVVEKTAPAVVYIEILDRHPFSGREVPISNGSGFVVASDGLIVTNAHVVADRRRVRVRLPSGDTYEAMVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQNNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSWFGTSGSQRRYIGVMMLTLTPSILIELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEKLAQNAEDVYEAVRTQSQLAVRIRRGSETLTLYVTPEVTE

Target ORF information:

RefSeq Version	NM_019752.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus HtrA serine peptidase 2 (Htra2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019752.3

ORF Insert Sequence:

ATGGCTGCGC TGAAAGCGGG GCGGGGTGCA AACTGGAGCC TTCGGGCATG GCGGGCTTTG 
GGGGGCATCT TCTGGAGGAA GCCTCCCCTG TTAGCTCCTG ACCTCCGGGC TCTGCTGACG 
TCAGGAACTC CTGACTCTCA GATCTGGATG ACTTATGGGA CCCCCAGTCT CCCGGCCCAG 
GTGCCTGAGG GGTTCCTTGC ATCACGGGCA GATCTGACGT CTAGGACCCC GGATCTCTGG 
GCACGATTGA ATGTGGGGAC TTCAGGCTCC AGTGACCAGG AGGCCCGCAG GAGCCCTGGA 
AGCCGTCGGC GCGAATGGCT GGCGGTGGCG GTGGGCGCAG GAGGTGCAGT GGTGCTGCTG 
TTGTGGGGTT GGGGTCGGGG TCTTTCCACG GTGCTGGCTG CTGTTCCTGC TCCGCCACCC 
ACTTCTCCCC GGAGCCAGTA CAATTTCATC GCAGATGTGG TGGAGAAGAC AGCCCCTGCT 
GTGGTCTATA TCGAGATCCT AGACCGGCAC CCTTTCTCCG GCCGTGAAGT CCCCATCTCA 
AACGGATCAG GATTCGTAGT GGCTTCAGAT GGGCTCATCG TTACCAACGC CCACGTGGTG 
GCTGATCGGC GCCGAGTACG AGTGAGGCTG CCTAGCGGGG ATACTTATGA GGCCATGGTC 
ACAGCTGTGG ATCCCGTAGC AGACATTGCC ACACTGAGGA TTCAAACCAA GGAGCCTCTT 
CCCACACTGC CCCTCGGCCG CTCTGCTGAT GTCCGGCAAG GGGAGTTTGT TGTTGCCATG 
GGAAGCCCCT TTGCACTGCA GAACACGATC ACATCTGGTA TTGTCAGCTC TGCTCAGCGC 
CCAGCCAGGG ACCTGGGACT CCCTCAAAAC AACGTGGAAT ACATTCAGAC CGATGCAGCT 
ATTGATTTTG GAAATTCTGG TGGTCCCCTG GTTAACCTGG ATGGGGAGGT GATTGGAGTG 
AACACCATGA AGGTGACAGC TGGAATCTCC TTTGCCATCC CTTCTGATCG CCTTAGGGAG 
TTTCTGCATC GCGGGGAAAA GAAAAATTCC TGGTTTGGAA CCAGTGGGTC CCAGCGCCGC 
TACATTGGAG TGATGATGCT GACCCTGACT CCCAGCATCC TTATTGAACT ACAGCTCCGT 
GAGCCAAGCT TCCCTGATGT TCAGCATGGT GTCCTCATTC ATAAAGTTAT CCTGGGCTCC 
CCCGCACACA GGGCTGGTCT GCGGCCTGGT GATGTGATCT TGGCCATTGG GGAGAAATTG 
GCACAAAATG CTGAAGATGT TTATGAAGCT GTTCGAACCC AATCACAGCT GGCAGTGCGG 
ATCCGGCGCG GATCAGAGAC ACTGACCTTA TATGTGACCC CCGAGGTCAC AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart.
Rejuvenation research20(3)183-192(2017 Jun)
Liu X,Lei J,Wang K,Ma L,Liu D,Du Y,Wu Y,Zhang S,Wang W,Ma X,Liu H

Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction.
Scientific reports637927(2016 Dec)
Wang K,Yuan Y,Liu X,Lau WB,Zuo L,Wang X,Ma L,Jiao K,Shang J,Wang W,Ma X,Liu H

HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3.
Scientific reports639393(2016 Dec)
Lee SH,Moon YM,Seo HB,Kim SY,Kim EK,Yi J,Nam MK,Min JK,Park SH,Rhim H,Cho ML

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

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Htra2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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