Ctsz cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ctsz
Entrez Gene ID	64138
Full Name	cathepsin Z
Synonyms	AI787083,AU019819,CTSX,D2Wsu143e
General protein information	Preferred Names cathepsin Z Names cathepsin Z cathepsin X
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 H4\|2 97.94 cM
Summary	This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate a mature enzyme with carboxypeptidase activity. An enzymatically inactive form of the protein, that is associated with the propeptide, may be involved in cancer cell invasion and proliferation. Homozygous knockout mice for this gene exhibit impaired cancer cell invasion in a breast cancer model. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022325.5	NP_071720.1	cathepsin Z preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CTSZ	XP_005635417.1
Bos taurus (cattle)	CTSZ	NP_001071303.1
Caenorhabditis elegans (roundworm)	cpz-1	NP_491023.2
Pan troglodytes (chimpanzee)	CTSZ	XP_001140086.1
Xenopus tropicalis (tropical clawed frog)	ctsz	NP_001106427.1
Danio rerio (zebrafish)	ctsz	NP_001006043.1
Homo sapiens (human)	CTSZ	NP_001327.2
Mus musculus (house mouse)	Ctsz	NP_071720.1
Rattus norvegicus (Norway rat)	Ctsz	NP_899159.1
Gallus gallus (chicken)	CTSZ	XP_417483.3

Gene Ontology
Bibliography

Related articles in PubMed

Lysosomal processing of progranulin.
Zhou X, Paushter DH, Feng T, Sun L, Reinheckel T, Hu F
Molecular neurodegeneration12(1)62(2017 08)

Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1? activation.
Orlowski GM, Sharma S, Colbert JD, Bogyo M, Robertson SA, Kataoka H, Chan FK, Rock KL
Journal of leukocyte biology102(1)7-17(2017 Jul)

A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis.
Allan ERO, Campden RI, Ewanchuk BW, Tailor P, Balce DR, McKenna NT, Greene CJ, Warren AL, Reinheckel T, Yates RM
Journal of neuroinflammation14(1)103(2017 May)

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1? Activation.
Yan D, Wang HW, Bowman RL, Joyce JA
Cell reports16(11)2914-2927(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

nigericin-induced cell death depended partly on a single cathepsin, cathepsin X.
Title: Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1? activation.

tumor proliferation was exclusively regulated by cancer cell-intrinsic functions of CtsZ, whereas tumor invasion required contributions from both macrophages and cancer cell
Title: Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.

Plaque-associated microglial cells express gamma-enolase and cathepsin X.
Title: Neuroprotective role of ?-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X.

Our data show an active role for Ctsz in chronic inflammation and the development of gastric metaplasia.
Title: Induction of premalignant host responses by cathepsin x/z-deficiency in Helicobacter pylori-infected mice.

Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.
Title: Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.

The following Ctsz gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ctsz cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16648	NM_022325.5 Latest version!	Mus musculus cathepsin Z (Ctsz), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ctsz ( NM_022325.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_071720.1 Mus musculus cathepsin Z (Ctsz), mRNA.

Price & Availability↑

CloneID	OMu16648
Clone ID Related Accession (Same CDS sequence)	NM_022325.5
Accession Version	NM_022325.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Mus musculus(house mouse)
Product	cathepsin Z preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL844534.4, BY319344.1, AK159618.1 and AI834947.1. On Aug 14, 2015 this sequence version replaced NM_022325.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008619.1, AK159618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTCGT CGGGGTCGGT GCAGCAGCTG CCCCTGGTGC TGCTGATGTT GCTGTTGGCG 
AGTGCGGCAC GGGCCAGACT CTACTTCCGC TCGGGCCAGA CTTGCTACCA TCCCATTCGC 
GGGGACCAGC TGGCTCTGCT GGGGCGCAGG ACTTATCCTC GGCCGCATGA GTACCTGTCC 
CCAGCGGATC TCCCCAAGAA TTGGGACTGG AGAAATGTGA ACGGTGTCAA CTATGCCAGC 
GTCACCAGGA ACCAGCACAT CCCACAGTAC TGTGGTTCCT GCTGGGCCCA CGGCAGCACC 
AGTGCCATGG CAGACCGAAT CAACATCAAG AGGAAAGGTG CATGGCCCTC CATCCTGCTG 
TCCGTACAGA ATGTCATTGA CTGTGGCAAT GCTGGCTCTT GTGAAGGGGG CAATGACCTT 
CCGGTGTGGG AGTATGCCCA CAAGCATGGC ATCCCCGATG AGACCTGCAA CAACTACCAG 
GCCAAGGACC AAGACTGTGA CAAGTTTAAC CAGTGTGGGA CCTGCACTGA ATTCAAAGAG 
TGTCACACCA TCCAGAATTA CACCCTCTGG AGAGTGGGTG ATTACGGCTC CCTGTCCGGG 
AGGGAGAAGA TGATGGCCGA GATCTATGCC AATGGTCCCA TCAGCTGCGG GATAATGGCA 
ACAGAGATGA TGTCTAACTA CACTGGGGGC ATCTATGCTG AGCACCAGGA CCAGGCCGTT 
ATCAACCACA TCATCTCTGT AGCTGGCTGG GGTGTCAGCA ACGATGGCAT CGAGTACTGG 
ATTGTCCGAA ATTCATGGGG CGAACCCTGG GGTGAGAAAG GCTGGATGAG GATCGTGACC 
AGCACCTACA AGGGAGGCAC AGGTGACAGC TACAACCTTG CCATCGAGAG TGCCTGCACA 
TTTGGGGACC CCATTGTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071720.1
CDS	142..1062
Translation	MASSGSVQQLPLVLLMLLLASAARARLYFRSGQTCYHPIRGDQLALLGRRTYPRPHEYLSPADLPKNWDWRNVNGVNYASVTRNQHIPQYCGSCWAHGSTSAMADRINIKRKGAWPSILLSVQNVIDCGNAGSCEGGNDLPVWEYAHKHGIPDETCNNYQAKDQDCDKFNQCGTCTEFKECHTIQNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATEMMSNYTGGIYAEHQDQAVINHIISVAGWGVSNDGIEYWIVRNSWGEPWGEKGWMRIVTSTYKGGTGDSYNLAIESACTFGDPIV

Target ORF information:

RefSeq Version	NM_022325.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus cathepsin Z (Ctsz), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022325.5

ORF Insert Sequence:

ATGGCGTCGT CGGGGTCGGT GCAGCAGCTG CCCCTGGTGC TGCTGATGTT GCTGTTGGCG 
AGTGCGGCAC GGGCCAGACT CTACTTCCGC TCGGGCCAGA CTTGCTACCA TCCCATTCGC 
GGGGACCAGC TGGCTCTGCT GGGGCGCAGG ACTTATCCTC GGCCGCATGA GTACCTGTCC 
CCAGCGGATC TCCCCAAGAA TTGGGACTGG AGAAATGTGA ACGGTGTCAA CTATGCCAGC 
GTCACCAGGA ACCAGCACAT CCCACAGTAC TGTGGTTCCT GCTGGGCCCA CGGCAGCACC 
AGTGCCATGG CAGACCGAAT CAACATCAAG AGGAAAGGTG CATGGCCCTC CATCCTGCTG 
TCCGTACAGA ATGTCATTGA CTGTGGCAAT GCTGGCTCTT GTGAAGGGGG CAATGACCTT 
CCGGTGTGGG AGTATGCCCA CAAGCATGGC ATCCCCGATG AGACCTGCAA CAACTACCAG 
GCCAAGGACC AAGACTGTGA CAAGTTTAAC CAGTGTGGGA CCTGCACTGA ATTCAAAGAG 
TGTCACACCA TCCAGAATTA CACCCTCTGG AGAGTGGGTG ATTACGGCTC CCTGTCCGGG 
AGGGAGAAGA TGATGGCCGA GATCTATGCC AATGGTCCCA TCAGCTGCGG GATAATGGCA 
ACAGAGATGA TGTCTAACTA CACTGGGGGC ATCTATGCTG AGCACCAGGA CCAGGCCGTT 
ATCAACCACA TCATCTCTGT AGCTGGCTGG GGTGTCAGCA ACGATGGCAT CGAGTACTGG 
ATTGTCCGAA ATTCATGGGG CGAACCCTGG GGTGAGAAAG GCTGGATGAG GATCGTGACC 
AGCACCTACA AGGGAGGCAC AGGTGACAGC TACAACCTTG CCATCGAGAG TGCCTGCACA 
TTTGGGGACC CCATTGTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lysosomal processing of progranulin.
Molecular neurodegeneration12(1)62(2017 08)
Zhou X,Paushter DH,Feng T,Sun L,Reinheckel T,Hu F

Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1? activation.
Journal of leukocyte biology102(1)7-17(2017 Jul)
Orlowski GM,Sharma S,Colbert JD,Bogyo M,Robertson SA,Kataoka H,Chan FK,Rock KL

A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis.
Journal of neuroinflammation14(1)103(2017 May)
Allan ERO,Campden RI,Ewanchuk BW,Tailor P,Balce DR,McKenna NT,Greene CJ,Warren AL,Reinheckel T,Yates RM

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1? Activation.
Cell reports16(11)2914-2927(2016 09)
Yan D,Wang HW,Bowman RL,Joyce JA

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Ctsz cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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