Cd274 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd274
Entrez Gene ID	60533
Full Name	CD274 antigen
Synonyms	A530045L16Rik,B7h1,Pdcd1l1,Pdcd1lg1,Pdl1
General protein information	Preferred Names CD274 antigen Names programmed cell death 1 ligand 1 B7 homolog 1 PDCD1 ligand 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 C1
Summary	The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
XM_030251020.1	XP_030106880.1	programmed cell death 1 ligand 1 isoform X1
XM_030251021.1	XP_030106881.1	programmed cell death 1 ligand 1 isoform X2
NM_021893.3	NP_068693.1	programmed cell death 1 ligand 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CD274	NP_054862.1
Canis lupus familiaris (dog)	CD274	XP_005615991.1
Bos taurus (cattle)	CD274	NP_001156884.1
Mus musculus (house mouse)	Cd274	NP_068693.1
Gallus gallus (chicken)	CD274	XP_424811.4
Pan troglodytes (chimpanzee)	CD274	XP_001140705.1
Rattus norvegicus (Norway rat)	Cd274	NP_001178883.1
Danio rerio (zebrafish)	si:ch211-241b2.5	XP_003200855.2
	CD274	NP_001077358.1
Xenopus tropicalis (tropical clawed frog)	cd274	XP_004911464.1

Gene Ontology
Bibliography

Related articles in PubMed

Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.
L?z?r-Moln?r E, Yan Q, Cao E, Ramagopal U, Nathenson SG, Almo SC
Proceedings of the National Academy of Sciences of the United States of America105(30)10483-8(2008 Jul)

A link between PDL1 and T regulatory cells in fetomaternal tolerance.
Habicht A, Dada S, Jurewicz M, Fife BT, Yagita H, Azuma M, Sayegh MH, Guleria I
Journal of immunology (Baltimore, Md. : 1950)179(8)5211-9(2007 Oct)

PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.
Carter LL, Leach MW, Azoitei ML, Cui J, Pelker JW, Jussif J, Benoit S, Ireland G, Luxenberg D, Askew GR, Milarski KL, Groves C, Brown T, Carito BA, Percival K, Carreno BM, Collins M, Marusic S
Journal of neuroimmunology182(1-2)124-34(2007 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PD-L1 and PD-L2 in dermal fibroblasts is up-regulated by activated T cells in alopecia areata-affected skin.
Title: Increased expression of PD-L1 and PD-L2 in dermal fibroblasts from alopecia areata mice.

RAS signaling can upregulate tumor cell PD-L1 expression through a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-binding protein tristetraprolin.
Title: Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.

spleen-derived IFN-gamma induces generation of PD-L1(+)-suppressive neutrophils.
Title: Spleen-derived IFN-? induces generation of PD-L1

Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR-155, Pdcd1, Pdcd1l1, and Ctla4 appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 = programmed cell death 1 protein; Pdcd1l1 = programmed cell death 1 ligand 1 protein; Ctla4 = cytotoxic T-lymphocyte-associated protein 4]
Title: Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade.

mediates an innate checkpoint to control adaptive T helper responses
Title: ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.

The following Cd274 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd274 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu23190	NM_021893.3 Latest version!	Mus musculus CD274 antigen (Cd274), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu23190	XM_030251020.1 Latest version!	Mus musculus CD274 antigen (Cd274), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu55675	XM_030251021.1 Latest version!	Mus musculus CD274 antigen (Cd274), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd274 ( NM_021893.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_068693.1 Mus musculus CD274 antigen (Cd274), mRNA.

Price & Availability↑

CloneID	OMu23190
Clone ID Related Accession (Same CDS sequence)	XM_030251020.1 , NM_021893.3
Accession Version	NM_021893.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	programmed cell death 1 ligand 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC119228.10, BY193530.1, AF317088.1 and AI645624.1. On Dec 9, 2009 this sequence version replaced NM_021893.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066841.1, AK154403.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGATAT TTGCTGGCAT TATATTCACA GCCTGCTGTC ACTTGCTACG GGCGTTTACT 
ATCACGGCTC CAAAGGACTT GTACGTGGTG GAGTATGGCA GCAACGTCAC GATGGAGTGC 
AGATTCCCTG TAGAACGGGA GCTGGACCTG CTTGCGTTAG TGGTGTACTG GGAAAAGGAA 
GATGAGCAAG TGATTCAGTT TGTGGCAGGA GAGGAGGACC TTAAGCCTCA GCACAGCAAC 
TTCAGGGGGA GAGCCTCGCT GCCAAAGGAC CAGCTTTTGA AGGGAAATGC TGCCCTTCAG 
ATCACAGACG TCAAGCTGCA GGACGCAGGC GTTTACTGCT GCATAATCAG CTACGGTGGT 
GCGGACTACA AGCGAATCAC GCTGAAAGTC AATGCCCCAT ACCGCAAAAT CAACCAGAGA 
ATTTCCGTGG ATCCAGCCAC TTCTGAGCAT GAACTAATAT GTCAGGCCGA GGGTTATCCA 
GAAGCTGAGG TAATCTGGAC AAACAGTGAC CACCAACCCG TGAGTGGGAA GAGAAGTGTC 
ACCACTTCCC GGACAGAGGG GATGCTTCTC AATGTGACCA GCAGTCTGAG GGTCAACGCC 
ACAGCGAATG ATGTTTTCTA CTGTACGTTT TGGAGATCAC AGCCAGGGCA AAACCACACA 
GCGGAGCTGA TCATCCCAGA ACTGCCTGCA ACACATCCTC CACAGAACAG GACTCACTGG 
GTGCTTCTGG GATCCATCCT GTTGTTCCTC ATTGTAGTGT CCACGGTCCT CCTCTTCTTG 
AGAAAACAAG TGAGAATGCT AGATGTGGAG AAATGTGGCG TTGAAGATAC AAGCTCAAAA 
AACCGAAATG ATACACAATT CGAGGAGACG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068693.1
CDS	84..956
Translation	MRIFAGIIFTACCHLLRAFTITAPKDLYVVEYGSNVTMECRFPVERELDLLALVVYWEKEDEQVIQFVAGEEDLKPQHSNFRGRASLPKDQLLKGNAALQITDVKLQDAGVYCCIISYGGADYKRITLKVNAPYRKINQRISVDPATSEHELICQAEGYPEAEVIWTNSDHQPVSGKRSVTTSRTEGMLLNVTSSLRVNATANDVFYCTFWRSQPGQNHTAELIIPELPATHPPQNRTHWVLLGSILLFLIVVSTVLLFLRKQVRMLDVEKCGVEDTSSKNRNDTQFEET

Target ORF information:

RefSeq Version	NM_021893.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD274 antigen (Cd274), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021893.3

ORF Insert Sequence:

ATGAGGATAT TTGCTGGCAT TATATTCACA GCCTGCTGTC ACTTGCTACG GGCGTTTACT 
ATCACGGCTC CAAAGGACTT GTACGTGGTG GAGTATGGCA GCAACGTCAC GATGGAGTGC 
AGATTCCCTG TAGAACGGGA GCTGGACCTG CTTGCGTTAG TGGTGTACTG GGAAAAGGAA 
GATGAGCAAG TGATTCAGTT TGTGGCAGGA GAGGAGGACC TTAAGCCTCA GCACAGCAAC 
TTCAGGGGGA GAGCCTCGCT GCCAAAGGAC CAGCTTTTGA AGGGAAATGC TGCCCTTCAG 
ATCACAGACG TCAAGCTGCA GGACGCAGGC GTTTACTGCT GCATAATCAG CTACGGTGGT 
GCGGACTACA AGCGAATCAC GCTGAAAGTC AATGCCCCAT ACCGCAAAAT CAACCAGAGA 
ATTTCCGTGG ATCCAGCCAC TTCTGAGCAT GAACTAATAT GTCAGGCCGA GGGTTATCCA 
GAAGCTGAGG TAATCTGGAC AAACAGTGAC CACCAACCCG TGAGTGGGAA GAGAAGTGTC 
ACCACTTCCC GGACAGAGGG GATGCTTCTC AATGTGACCA GCAGTCTGAG GGTCAACGCC 
ACAGCGAATG ATGTTTTCTA CTGTACGTTT TGGAGATCAC AGCCAGGGCA AAACCACACA 
GCGGAGCTGA TCATCCCAGA ACTGCCTGCA ACACATCCTC CACAGAACAG GACTCACTGG 
GTGCTTCTGG GATCCATCCT GTTGTTCCTC ATTGTAGTGT CCACGGTCCT CCTCTTCTTG 
AGAAAACAAG TGAGAATGCT AGATGTGGAG AAATGTGGCG TTGAAGATAC AAGCTCAAAA 
AACCGAAATG ATACACAATT CGAGGAGACG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cd274 ( XM_030251020.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030106880.1 Mus musculus CD274 antigen (Cd274), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu23190
Clone ID Related Accession (Same CDS sequence)	XM_030251020.1 , NM_021893.3
Accession Version	XM_030251020.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	programmed cell death 1 ligand 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000085.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGATAT TTGCTGGCAT TATATTCACA GCCTGCTGTC ACTTGCTACG GGCGTTTACT 
ATCACGGCTC CAAAGGACTT GTACGTGGTG GAGTATGGCA GCAACGTCAC GATGGAGTGC 
AGATTCCCTG TAGAACGGGA GCTGGACCTG CTTGCGTTAG TGGTGTACTG GGAAAAGGAA 
GATGAGCAAG TGATTCAGTT TGTGGCAGGA GAGGAGGACC TTAAGCCTCA GCACAGCAAC 
TTCAGGGGGA GAGCCTCGCT GCCAAAGGAC CAGCTTTTGA AGGGAAATGC TGCCCTTCAG 
ATCACAGACG TCAAGCTGCA GGACGCAGGC GTTTACTGCT GCATAATCAG CTACGGTGGT 
GCGGACTACA AGCGAATCAC GCTGAAAGTC AATGCCCCAT ACCGCAAAAT CAACCAGAGA 
ATTTCCGTGG ATCCAGCCAC TTCTGAGCAT GAACTAATAT GTCAGGCCGA GGGTTATCCA 
GAAGCTGAGG TAATCTGGAC AAACAGTGAC CACCAACCCG TGAGTGGGAA GAGAAGTGTC 
ACCACTTCCC GGACAGAGGG GATGCTTCTC AATGTGACCA GCAGTCTGAG GGTCAACGCC 
ACAGCGAATG ATGTTTTCTA CTGTACGTTT TGGAGATCAC AGCCAGGGCA AAACCACACA 
GCGGAGCTGA TCATCCCAGA ACTGCCTGCA ACACATCCTC CACAGAACAG GACTCACTGG 
GTGCTTCTGG GATCCATCCT GTTGTTCCTC ATTGTAGTGT CCACGGTCCT CCTCTTCTTG 
AGAAAACAAG TGAGAATGCT AGATGTGGAG AAATGTGGCG TTGAAGATAC AAGCTCAAAA 
AACCGAAATG ATACACAATT CGAGGAGACG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030106880.1
CDS	458..1330
Translation	MRIFAGIIFTACCHLLRAFTITAPKDLYVVEYGSNVTMECRFPVERELDLLALVVYWEKEDEQVIQFVAGEEDLKPQHSNFRGRASLPKDQLLKGNAALQITDVKLQDAGVYCCIISYGGADYKRITLKVNAPYRKINQRISVDPATSEHELICQAEGYPEAEVIWTNSDHQPVSGKRSVTTSRTEGMLLNVTSSLRVNATANDVFYCTFWRSQPGQNHTAELIIPELPATHPPQNRTHWVLLGSILLFLIVVSTVLLFLRKQVRMLDVEKCGVEDTSSKNRNDTQFEET

Target ORF information:

RefSeq Version	XM_030251020.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD274 antigen (Cd274), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030251020.1

ORF Insert Sequence:

ATGAGGATAT TTGCTGGCAT TATATTCACA GCCTGCTGTC ACTTGCTACG GGCGTTTACT 
ATCACGGCTC CAAAGGACTT GTACGTGGTG GAGTATGGCA GCAACGTCAC GATGGAGTGC 
AGATTCCCTG TAGAACGGGA GCTGGACCTG CTTGCGTTAG TGGTGTACTG GGAAAAGGAA 
GATGAGCAAG TGATTCAGTT TGTGGCAGGA GAGGAGGACC TTAAGCCTCA GCACAGCAAC 
TTCAGGGGGA GAGCCTCGCT GCCAAAGGAC CAGCTTTTGA AGGGAAATGC TGCCCTTCAG 
ATCACAGACG TCAAGCTGCA GGACGCAGGC GTTTACTGCT GCATAATCAG CTACGGTGGT 
GCGGACTACA AGCGAATCAC GCTGAAAGTC AATGCCCCAT ACCGCAAAAT CAACCAGAGA 
ATTTCCGTGG ATCCAGCCAC TTCTGAGCAT GAACTAATAT GTCAGGCCGA GGGTTATCCA 
GAAGCTGAGG TAATCTGGAC AAACAGTGAC CACCAACCCG TGAGTGGGAA GAGAAGTGTC 
ACCACTTCCC GGACAGAGGG GATGCTTCTC AATGTGACCA GCAGTCTGAG GGTCAACGCC 
ACAGCGAATG ATGTTTTCTA CTGTACGTTT TGGAGATCAC AGCCAGGGCA AAACCACACA 
GCGGAGCTGA TCATCCCAGA ACTGCCTGCA ACACATCCTC CACAGAACAG GACTCACTGG 
GTGCTTCTGG GATCCATCCT GTTGTTCCTC ATTGTAGTGT CCACGGTCCT CCTCTTCTTG 
AGAAAACAAG TGAGAATGCT AGATGTGGAG AAATGTGGCG TTGAAGATAC AAGCTCAAAA 
AACCGAAATG ATACACAATT CGAGGAGACG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cd274 ( XM_030251021.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030106881.1 Mus musculus CD274 antigen (Cd274), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu55675
Clone ID Related Accession (Same CDS sequence)	XM_030251021.1
Accession Version	XM_030251021.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	programmed cell death 1 ligand 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000085.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTGCA GATTCCCTGT AGAACGGGAG CTGGACCTGC TTGCGTTAGT GGTGTACTGG 
GAAAAGGAAG ATGAGCAAGT GATTCAGTTT GTGGCAGGAG AGGAGGACCT TAAGCCTCAG 
CACAGCAACT TCAGGGGGAG AGCCTCGCTG CCAAAGGACC AGCTTTTGAA GGGAAATGCT 
GCCCTTCAGA TCACAGACGT CAAGCTGCAG GACGCAGGCG TTTACTGCTG CATAATCAGC 
TACGGTGGTG CGGACTACAA GCGAATCACG CTGAAAGTCA ATGCCCCATA CCGCAAAATC 
AACCAGAGAA TTTCCGTGGA TCCAGCCACT TCTGAGCATG AACTAATATG TCAGGCCGAG 
GGTTATCCAG AAGCTGAGGT AATCTGGACA AACAGTGACC ACCAACCCGT GAGTGGGAAG 
AGAAGTGTCA CCACTTCCCG GACAGAGGGG ATGCTTCTCA ATGTGACCAG CAGTCTGAGG 
GTCAACGCCA CAGCGAATGA TGTTTTCTAC TGTACGTTTT GGAGATCACA GCCAGGGCAA 
AACCACACAG CGGAGCTGAT CATCCCAGAA CTGCCTGCAA CACATCCTCC ACAGAACAGG 
ACTCACTGGG TGCTTCTGGG ATCCATCCTG TTGTTCCTCA TTGTAGTGTC CACGGTCCTC 
CTCTTCTTGA GAAAACAAGT GAGAATGCTA GATGTGGAGA AATGTGGCGT TGAAGATACA 
AGCTCAAAAA ACCGAAATGA TACACAATTC GAGGAGACGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030106881.1
CDS	154..915
Translation	MECRFPVERELDLLALVVYWEKEDEQVIQFVAGEEDLKPQHSNFRGRASLPKDQLLKGNAALQITDVKLQDAGVYCCIISYGGADYKRITLKVNAPYRKINQRISVDPATSEHELICQAEGYPEAEVIWTNSDHQPVSGKRSVTTSRTEGMLLNVTSSLRVNATANDVFYCTFWRSQPGQNHTAELIIPELPATHPPQNRTHWVLLGSILLFLIVVSTVLLFLRKQVRMLDVEKCGVEDTSSKNRNDTQFEET

Target ORF information:

RefSeq Version	XM_030251021.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD274 antigen (Cd274), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030251021.1

ORF Insert Sequence:

ATGGAGTGCA GATTCCCTGT AGAACGGGAG CTGGACCTGC TTGCGTTAGT GGTGTACTGG 
GAAAAGGAAG ATGAGCAAGT GATTCAGTTT GTGGCAGGAG AGGAGGACCT TAAGCCTCAG 
CACAGCAACT TCAGGGGGAG AGCCTCGCTG CCAAAGGACC AGCTTTTGAA GGGAAATGCT 
GCCCTTCAGA TCACAGACGT CAAGCTGCAG GACGCAGGCG TTTACTGCTG CATAATCAGC 
TACGGTGGTG CGGACTACAA GCGAATCACG CTGAAAGTCA ATGCCCCATA CCGCAAAATC 
AACCAGAGAA TTTCCGTGGA TCCAGCCACT TCTGAGCATG AACTAATATG TCAGGCCGAG 
GGTTATCCAG AAGCTGAGGT AATCTGGACA AACAGTGACC ACCAACCCGT GAGTGGGAAG 
AGAAGTGTCA CCACTTCCCG GACAGAGGGG ATGCTTCTCA ATGTGACCAG CAGTCTGAGG 
GTCAACGCCA CAGCGAATGA TGTTTTCTAC TGTACGTTTT GGAGATCACA GCCAGGGCAA 
AACCACACAG CGGAGCTGAT CATCCCAGAA CTGCCTGCAA CACATCCTCC ACAGAACAGG 
ACTCACTGGG TGCTTCTGGG ATCCATCCTG TTGTTCCTCA TTGTAGTGTC CACGGTCCTC 
CTCTTCTTGA GAAAACAAGT GAGAATGCTA GATGTGGAGA AATGTGGCGT TGAAGATACA 
AGCTCAAAAA ACCGAAATGA TACACAATTC GAGGAGACGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.
Proceedings of the National Academy of Sciences of the United States of America105(30)10483-8(2008 Jul)
L?z?r-Moln?r E,Yan Q,Cao E,Ramagopal U,Nathenson SG,Almo SC

A link between PDL1 and T regulatory cells in fetomaternal tolerance.
Journal of immunology (Baltimore, Md. : 1950)179(8)5211-9(2007 Oct)
Habicht A,Dada S,Jurewicz M,Fife BT,Yagita H,Azuma M,Sayegh MH,Guleria I

PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.
Journal of neuroimmunology182(1-2)124-34(2007 Jan)
Carter LL,Leach MW,Azoitei ML,Cui J,Pelker JW,Jussif J,Benoit S,Ireland G,Luxenberg D,Askew GR,Milarski KL,Groves C,Brown T,Carito BA,Percival K,Carreno BM,Collins M,Marusic S

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Cd274 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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