Slc4a8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc4a8
Entrez Gene ID	59033
Full Name	solute carrier family 4 (anion exchanger), member 8
Synonyms	AW493845,C230026C11,NDCBE,kNBC-3
General protein information	Preferred Names solute carrier family 4 (anion exchanger), member 8 Names electroneutral sodium bicarbonate exchanger 1 electroneutral Na+-driven Cl-HCO3 exchanger k-NBC3 slc4a8 sodium bicarbonate cotransporter isoform 3 kNBC-3 solute carrier family 4 member 8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 F1

mRNA and Protein(s)

mRNA	Protein	Name
XM_017316718.1	XP_017172207.1	electroneutral sodium bicarbonate exchanger 1 isoform X1
NM_001347102.1	NP_001334031.1	electroneutral sodium bicarbonate exchanger 1 isoform 2
NM_021530.2	NP_067505.2	electroneutral sodium bicarbonate exchanger 1 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC4A8	XP_005636865.1
Mus musculus (house mouse)	Slc4a8	NP_067505.2
Danio rerio (zebrafish)	slc4a8	XP_685666.5
Homo sapiens (human)	SLC4A8	NP_001035049.1
	SLC4A8	XP_001090180.1
Bos taurus (cattle)	SLC4A8	XP_002687339.3
Gallus gallus (chicken)	LOC425441	XP_004949806.1
Rattus norvegicus (Norway rat)	Slc4a8	NP_001257723.1
Xenopus tropicalis (tropical clawed frog)	slc4a8	XP_002933752.2

Gene Ontology
Bibliography

Related articles in PubMed

Double Knockout of the Na+-Driven Cl-/HCO3- Exchanger and Na+/Cl- Cotransporter Induces Hypokalemia and Volume Depletion.
Sinning A, Radionov N, Trepiccione F, L?pez-Cayuqueo KI, Jayat M, Baron S, Corni?re N, Alexander RT, Hadchouel J, Eladari D, H?bner CA, Chambrey R
Journal of the American Society of Nephrology : JASN28(1)130-139(2017 Jan)

Immunocytochemical identification of electroneutral Na?-coupled HCO?? transporters in freshly dissociated mouse medullary raph? neurons.
Coley AA, Ruffin VA, Moss FJ, Hopfer U, Boron WF
Neuroscience246451-67(2013 Aug)

NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos.
Siyanov V, Baltz JM
Biology of reproduction88(6)157(2013 Jun)

Renal intercalated cells are rather energized by a proton than a sodium pump.
Chambrey R, Kurth I, Peti-Peterdi J, Houillier P, Purkerson JM, Leviel F, Hentschke M, Zdebik AA, Schwartz GJ, H?bner CA, Eladari D
Proceedings of the National Academy of Sciences of the United States of America110(19)7928-33(2013 May)

Synaptic glutamate release is modulated by the Na+ -driven Cl-/HCO?? exchanger Slc4a8.
Sinning A, Liebmann L, Kougioumtzes A, Westermann M, Bruehl C, H?bner CA
The Journal of neuroscience : the official journal of the Society for Neuroscience31(20)7300-11(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Slc4a8 localizes to presynaptic nerve endings and modulates glutamate release in a pH-dependent manner.
Title: Synaptic glutamate release is modulated by the Na+ -driven Cl-/HCO?? exchanger Slc4a8.

SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice
Title: The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice.

mouse brain exhibits marked developmental differences in the response of NDCBE protein expression to chronic continuous hypoxia
Title: Effects of chronic continuous hypoxia on the expression of SLC4A8 (NDCBE) in neonatal versus adult mouse brain.

Thus, SLC4A8 is in a position to contribute substantially to pH(i) regulation in multiple CNS neurons.
Title: Expression and localization of Na-driven Cl-HCO(3)(-) exchanger (SLC4A8) in rodent CNS.

The following Slc4a8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc4a8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu51474	NM_001347102.1 Latest version!	Mus musculus solute carrier family 4 (anion exchanger), member 8 (Slc4a8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$559.30 $799.00
OMu51474	XM_017316718.1 Latest version!	Mus musculus solute carrier family 4 (anion exchanger), member 8 (Slc4a8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$559.30 $799.00
OMu17670	NM_021530.2 Latest version!	Mus musculus solute carrier family 4 (anion exchanger), member 8 (Slc4a8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$643.30 $919.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc4a8 ( NM_001347102.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001334031.1 Mus musculus solute carrier family 4 (anion exchanger), member 8 (Slc4a8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu51474
Clone ID Related Accession (Same CDS sequence)	XM_017316718.1 , NM_001347102.1
Accession Version	NM_001347102.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3114bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	electroneutral sodium bicarbonate exchanger 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK171610.1, AC113587.16, AK141910.1 and BP759706.1. On Nov 15, 2016 this sequence version replaced XM_006521225.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK171610.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849385 [ECO:0000348] ##Evidence-Data-END##

ATGCCGCTGG GGAGGCAGAG CCATCGGCAC CACCGCACTC ATGGCCAGAA GCACCGGAGA 
CGAGGAGGGC GGGGCAAAGG AGCCAGCCAG GGCGAGGAGG GCTTGGAAGC CTTGGCCCAC 
GACACCCCGT CTCAGCGTGT TCAGTTCATT CTTGGCACTG AGGAAGATGA AGAACATGTG 
CCTCATGAGC TCTTCACAGA GCTGGACGAG ATCTGTATGA AAGAGGGGGA AGATGCTGAG 
TGGAAGGAGA CGGCCAGGTG GCTGAAGTTT GAAGAGGATG TGGAGGACGG GGGAGAGCGC 
TGGAGCAAGC CTTACGTGGC CACGCTCTCT CTGCACAGCC TGTTTGAGCT GAGGAGCTGC 
CTCATCAACG GCTCTGTGCT TCTGGACATG CGTGCAAGTA GCATAGAGGA GATCTCAGAC 
CTGATCCTGG ACCAGCAGGA GCTGCTCCGA GACCTGAGCG ACAGCGTGAG GGTTAAAGTG 
CGGGAAGCCC TGCTGAAGAA GCACCACCAC CAGAACGAGA GGAGGAGGAA CAACCTCATC 
CCCATCGTCC GCTCCTTCGC TGAGGTTGGC AAGAAGCAGT CTGACCCGCA CTCCATGGAC 
AGAGATGGGC AAACGGTGTC TCCTCAGTCA GCTACAAACC TTGAAGTGAA GAATGGTGTG 
AACTGTGAGC ACAGCCCTGT GGATCTAAGC AAGGTGGATC TTCACTTCAT GAAAAAAATT 
CCCACGGGGG CAGAGGCCTC CAATGTCCTG GTGGGAGAGG TGGATACGCT GGACCGGCCC 
ATCGTGGCCT TCGTGAGGCT CTCCCCGGCT GTGCTGCTCT CTGGCCTGAC GGAAGTGCCC 
ATCCCAACGA GGTTTTTGTT TATCTTACTG GGCCCAGTGG GAAAAGGGCA GCAGTACCAT 
GAGATTGGCA GGTCCATGGC CACCATCATG ACGGACGAGA TTTTTCATGA TGTGGCATAT 
AAAGCAAAGG AACGCGATGA CCTCCTGGCA GGGATTGACG AGTTCCTGGA CCAGGTGACG 
GTGCTTCCGC CAGGGGAGTG GGACCCATCT ATTAGAATTG AGCCACCCAA GAATGTCCCT 
TCCCAGGAAA AAAGGAAAAT GCCCGGTGTT CCAAACGGAA ACGTTTGCCA CATAGAACCA 
GAGCCACATG GGGGGCACAG TGGGCCAGAA CTGGAGCGGA CTGGGCGGCT GTTTGGGGGC 
TTGGTGCTGG ATGTCAAGCG GAAGGCTCCC TGGTACTGGA GTGACTACCG GGATGCTCTC 
AGCTTACAGT GTCTGGCCTC CTTCCTGTTC CTGTACTGTG CCTGCATGTC GCCCGTTATC 
ACCTTCGGGG GACTGCTGGG AGAAGCCACT GAAGGACGCA TAAGTGCGAT TGAGTCGTTG 
TTTGGAGCGT CCATGACGGG GATTGCCTAC TCTCTGTTTG CTGGGCAGCC TCTCACCATC 
CTGGGAAGCA CGGGGCCCGT GCTGGTGTTT GAAAAGATTT TGTTCAAATT CTGCAAGGAC 
TATGCCCTTT CGTACCTGTC CCTGCGGGCT CTCATCGGGC TGTGGACTGC CTTCCTGTGC 
ATCGTCCTGG TGGCCACGGA TGCCAGCTCC CTCGTCTGCT ACATTACCCG CTTCACCGAG 
GAAGCGTTTG CCTCCCTGAT TTGTATCATC TTCATCTATG AAGCCATAGA AAAGCTGATC 
CACCTGGCAG AGACCTACCC CATCCACATG CACAGCCAGC TGGACCACCT GAGCCTCTAT 
TACTGCAGGT GTGTGCTCCC GGAGAATCCA AACAACCACA CCTTACAGTA TTGGAAGGAC 
CACAACATCC TGGCTGCCGA AGTGAACTGG GCAAACCTGA CAGTCAGCGA ATGCCAGGAG 
ATGCACGGGG AGTTCATGGG ATCTGCCTGC GGTCACCACG GACCCTACAC GCCCGACGTG 
CTCTTTTGGT CCTGCATTCT GTTCTTCGCC ACCTTCATCG TCTCCAGCAC CTTAAAGACA 
TTTAAGACAA GCCGCTACTT CCCGACCAGG GTCCGCTCCA TGGTGAGTGA CTTCGCCGTG 
TTCCTCACCA TCTTCACCAT GGTGGTCCTT GACTTTCTGA TTGGCGTCCC GTCGCCAAAG 
CTTCAGGTTC CCAATGTGTT CAAGCCAACA AGGGACGATC GAGGATGGTT TATTAATCCC 
ATTGGCCCCA ATCCCTGGTG GACTGTGATA GCCGCAATTA TCCCAGCTCT CCTGTGCACT 
ATCCTGATAT TCATGGACCA GCAGATCACC GCTGTCATCA TTAACAGGAA GGAACACAAG 
CTCAAGAAAG GCTGTGGCTA CCACCTGGAC CTGCTCATGG TGGCCGTCAT GCTGGGAGTT 
TGCTCCATCA TGGGCCTGCC TTGGTTTGTG GCCGCGACCG TCCTGTCCAT TACCCATGTG 
AACAGCCTCA AGCTGGAATC CGAATGCTCT GCCCCCGGGG AGCAGCCCAA GTTCTTGGGC 
ATCCGGGAAC AGAGAGTCAC AGGGCTTATG ATCTTCGTGC TGATGGGCTG CTCAGTCTTC 
ATGACAGCTG TCTTAAAGTT TATCCCGATG CCAGTGCTCT ACGGAGTTTT CCTCTACATG 
GGAGTCTCTT CGCTACAAGG AATCCAGTTC TTCGACCGTC TGAAGCTTTT CGGGATGCCT 
GCAAAACACC AGCCAGACTT CATCTACCTG CGGCACGTGC CGCTGCGCAA GGTGCACCTG 
TTCACGCTAG TGCAGCTCAC CTGCCTCGTC CTGCTCTGGG TCATCAAGGC ATCGCCGGCC 
GCCATTGTTT TCCCAATGAT GGTGCTGGCC TTGGTCTTCG TCAGGAAAGT CATGGATCTC 
TGCTTCTCCA AGCGTGAGCT AAGCTGGCTG GACGACCTCA TGCCTGAGAG CAAAAAGAAG 
AAGCTGGACG ATGCGAAGAA GAAGGAGGAG GAGGAGGCCG AGAAGATGTT GGACATTGGG 
GGTGACAAGT TTCCCCTGGA AAGCAGGAAG CTGCTAAGTA GTCCTGGCAA GAGCAGCAGC 
TTCAGATGTG ACCCTTCTGA GATTAATATA TCAGATGAAA TGCCTAAAAC CACGGTCTGG 
AAGGCTCTCA GCATAAATTC CGGAAATACA AAAGAAAAAA GCCCCTTCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334031.1
CDS	115..3228
Translation	MPLGRQSHRHHRTHGQKHRRRGGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGSVLLDMRASSIEEISDLILDQQELLRDLSDSVRVKVREALLKKHHHQNERRRNNLIPIVRSFAEVGKKQSDPHSMDRDGQTVSPQSATNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDTLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEPEPHGGHSGPELERTGRLFGGLVLDVKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYALSYLSLRALIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCVLPENPNNHTLQYWKDHNILAAEVNWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFATFIVSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVVLDFLIGVPSPKLQVPNVFKPTRDDRGWFINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKEEEEAEKMLDIGGDKFPLESRKLLSSPGKSSSFRCDPSEINISDEMPKTTVWKALSINSGNTKEKSPFN

Target ORF information:

RefSeq Version	NM_001347102.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 4 (anion exchanger), member 8 (Slc4a8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347102.1

ORF Insert Sequence:

ATGCCGCTGG GGAGGCAGAG CCATCGGCAC CACCGCACTC ATGGCCAGAA GCACCGGAGA 
CGAGGAGGGC GGGGCAAAGG AGCCAGCCAG GGCGAGGAGG GCTTGGAAGC CTTGGCCCAC 
GACACCCCGT CTCAGCGTGT TCAGTTCATT CTTGGCACTG AGGAAGATGA AGAACATGTG 
CCTCATGAGC TCTTCACAGA GCTGGACGAG ATCTGTATGA AAGAGGGGGA AGATGCTGAG 
TGGAAGGAGA CGGCCAGGTG GCTGAAGTTT GAAGAGGATG TGGAGGACGG GGGAGAGCGC 
TGGAGCAAGC CTTACGTGGC CACGCTCTCT CTGCACAGCC TGTTTGAGCT GAGGAGCTGC 
CTCATCAACG GCTCTGTGCT TCTGGACATG CGTGCAAGTA GCATAGAGGA GATCTCAGAC 
CTGATCCTGG ACCAGCAGGA GCTGCTCCGA GACCTGAGCG ACAGCGTGAG GGTTAAAGTG 
CGGGAAGCCC TGCTGAAGAA GCACCACCAC CAGAACGAGA GGAGGAGGAA CAACCTCATC 
CCCATCGTCC GCTCCTTCGC TGAGGTTGGC AAGAAGCAGT CTGACCCGCA CTCCATGGAC 
AGAGATGGGC AAACGGTGTC TCCTCAGTCA GCTACAAACC TTGAAGTGAA GAATGGTGTG 
AACTGTGAGC ACAGCCCTGT GGATCTAAGC AAGGTGGATC TTCACTTCAT GAAAAAAATT 
CCCACGGGGG CAGAGGCCTC CAATGTCCTG GTGGGAGAGG TGGATACGCT GGACCGGCCC 
ATCGTGGCCT TCGTGAGGCT CTCCCCGGCT GTGCTGCTCT CTGGCCTGAC GGAAGTGCCC 
ATCCCAACGA GGTTTTTGTT TATCTTACTG GGCCCAGTGG GAAAAGGGCA GCAGTACCAT 
GAGATTGGCA GGTCCATGGC CACCATCATG ACGGACGAGA TTTTTCATGA TGTGGCATAT 
AAAGCAAAGG AACGCGATGA CCTCCTGGCA GGGATTGACG AGTTCCTGGA CCAGGTGACG 
GTGCTTCCGC CAGGGGAGTG GGACCCATCT ATTAGAATTG AGCCACCCAA GAATGTCCCT 
TCCCAGGAAA AAAGGAAAAT GCCCGGTGTT CCAAACGGAA ACGTTTGCCA CATAGAACCA 
GAGCCACATG GGGGGCACAG TGGGCCAGAA CTGGAGCGGA CTGGGCGGCT GTTTGGGGGC 
TTGGTGCTGG ATGTCAAGCG GAAGGCTCCC TGGTACTGGA GTGACTACCG GGATGCTCTC 
AGCTTACAGT GTCTGGCCTC CTTCCTGTTC CTGTACTGTG CCTGCATGTC GCCCGTTATC 
ACCTTCGGGG GACTGCTGGG AGAAGCCACT GAAGGACGCA TAAGTGCGAT TGAGTCGTTG 
TTTGGAGCGT CCATGACGGG GATTGCCTAC TCTCTGTTTG CTGGGCAGCC TCTCACCATC 
CTGGGAAGCA CGGGGCCCGT GCTGGTGTTT GAAAAGATTT TGTTCAAATT CTGCAAGGAC 
TATGCCCTTT CGTACCTGTC CCTGCGGGCT CTCATCGGGC TGTGGACTGC CTTCCTGTGC 
ATCGTCCTGG TGGCCACGGA TGCCAGCTCC CTCGTCTGCT ACATTACCCG CTTCACCGAG 
GAAGCGTTTG CCTCCCTGAT TTGTATCATC TTCATCTATG AAGCCATAGA AAAGCTGATC 
CACCTGGCAG AGACCTACCC CATCCACATG CACAGCCAGC TGGACCACCT GAGCCTCTAT 
TACTGCAGGT GTGTGCTCCC GGAGAATCCA AACAACCACA CCTTACAGTA TTGGAAGGAC 
CACAACATCC TGGCTGCCGA AGTGAACTGG GCAAACCTGA CAGTCAGCGA ATGCCAGGAG 
ATGCACGGGG AGTTCATGGG ATCTGCCTGC GGTCACCACG GACCCTACAC GCCCGACGTG 
CTCTTTTGGT CCTGCATTCT GTTCTTCGCC ACCTTCATCG TCTCCAGCAC CTTAAAGACA 
TTTAAGACAA GCCGCTACTT CCCGACCAGG GTCCGCTCCA TGGTGAGTGA CTTCGCCGTG 
TTCCTCACCA TCTTCACCAT GGTGGTCCTT GACTTTCTGA TTGGCGTCCC GTCGCCAAAG 
CTTCAGGTTC CCAATGTGTT CAAGCCAACA AGGGACGATC GAGGATGGTT TATTAATCCC 
ATTGGCCCCA ATCCCTGGTG GACTGTGATA GCCGCAATTA TCCCAGCTCT CCTGTGCACT 
ATCCTGATAT TCATGGACCA GCAGATCACC GCTGTCATCA TTAACAGGAA GGAACACAAG 
CTCAAGAAAG GCTGTGGCTA CCACCTGGAC CTGCTCATGG TGGCCGTCAT GCTGGGAGTT 
TGCTCCATCA TGGGCCTGCC TTGGTTTGTG GCCGCGACCG TCCTGTCCAT TACCCATGTG 
AACAGCCTCA AGCTGGAATC CGAATGCTCT GCCCCCGGGG AGCAGCCCAA GTTCTTGGGC 
ATCCGGGAAC AGAGAGTCAC AGGGCTTATG ATCTTCGTGC TGATGGGCTG CTCAGTCTTC 
ATGACAGCTG TCTTAAAGTT TATCCCGATG CCAGTGCTCT ACGGAGTTTT CCTCTACATG 
GGAGTCTCTT CGCTACAAGG AATCCAGTTC TTCGACCGTC TGAAGCTTTT CGGGATGCCT 
GCAAAACACC AGCCAGACTT CATCTACCTG CGGCACGTGC CGCTGCGCAA GGTGCACCTG 
TTCACGCTAG TGCAGCTCAC CTGCCTCGTC CTGCTCTGGG TCATCAAGGC ATCGCCGGCC 
GCCATTGTTT TCCCAATGAT GGTGCTGGCC TTGGTCTTCG TCAGGAAAGT CATGGATCTC 
TGCTTCTCCA AGCGTGAGCT AAGCTGGCTG GACGACCTCA TGCCTGAGAG CAAAAAGAAG 
AAGCTGGACG ATGCGAAGAA GAAGGAGGAG GAGGAGGCCG AGAAGATGTT GGACATTGGG 
GGTGACAAGT TTCCCCTGGA AAGCAGGAAG CTGCTAAGTA GTCCTGGCAA GAGCAGCAGC 
TTCAGATGTG ACCCTTCTGA GATTAATATA TCAGATGAAA TGCCTAAAAC CACGGTCTGG 
AAGGCTCTCA GCATAAATTC CGGAAATACA AAAGAAAAAA GCCCCTTCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc4a8 ( XM_017316718.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017172207.1 Mus musculus solute carrier family 4 (anion exchanger), member 8 (Slc4a8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu51474
Clone ID Related Accession (Same CDS sequence)	XM_017316718.1 , NM_001347102.1
Accession Version	XM_017316718.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3114bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	electroneutral sodium bicarbonate exchanger 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000081.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGCTGG GGAGGCAGAG CCATCGGCAC CACCGCACTC ATGGCCAGAA GCACCGGAGA 
CGAGGAGGGC GGGGCAAAGG AGCCAGCCAG GGCGAGGAGG GCTTGGAAGC CTTGGCCCAC 
GACACCCCGT CTCAGCGTGT TCAGTTCATT CTTGGCACTG AGGAAGATGA AGAACATGTG 
CCTCATGAGC TCTTCACAGA GCTGGACGAG ATCTGTATGA AAGAGGGGGA AGATGCTGAG 
TGGAAGGAGA CGGCCAGGTG GCTGAAGTTT GAAGAGGATG TGGAGGACGG GGGAGAGCGC 
TGGAGCAAGC CTTACGTGGC CACGCTCTCT CTGCACAGCC TGTTTGAGCT GAGGAGCTGC 
CTCATCAACG GCTCTGTGCT TCTGGACATG CGTGCAAGTA GCATAGAGGA GATCTCAGAC 
CTGATCCTGG ACCAGCAGGA GCTGCTCCGA GACCTGAGCG ACAGCGTGAG GGTTAAAGTG 
CGGGAAGCCC TGCTGAAGAA GCACCACCAC CAGAACGAGA GGAGGAGGAA CAACCTCATC 
CCCATCGTCC GCTCCTTCGC TGAGGTTGGC AAGAAGCAGT CTGACCCGCA CTCCATGGAC 
AGAGATGGGC AAACGGTGTC TCCTCAGTCA GCTACAAACC TTGAAGTGAA GAATGGTGTG 
AACTGTGAGC ACAGCCCTGT GGATCTAAGC AAGGTGGATC TTCACTTCAT GAAAAAAATT 
CCCACGGGGG CAGAGGCCTC CAATGTCCTG GTGGGAGAGG TGGATACGCT GGACCGGCCC 
ATCGTGGCCT TCGTGAGGCT CTCCCCGGCT GTGCTGCTCT CTGGCCTGAC GGAAGTGCCC 
ATCCCAACGA GGTTTTTGTT TATCTTACTG GGCCCAGTGG GAAAAGGGCA GCAGTACCAT 
GAGATTGGCA GGTCCATGGC CACCATCATG ACGGACGAGA TTTTTCATGA TGTGGCATAT 
AAAGCAAAGG AACGCGATGA CCTCCTGGCA GGGATTGACG AGTTCCTGGA CCAGGTGACG 
GTGCTTCCGC CAGGGGAGTG GGACCCATCT ATTAGAATTG AGCCACCCAA GAATGTCCCT 
TCCCAGGAAA AAAGGAAAAT GCCCGGTGTT CCAAACGGAA ACGTTTGCCA CATAGAACCA 
GAGCCACATG GGGGGCACAG TGGGCCAGAA CTGGAGCGGA CTGGGCGGCT GTTTGGGGGC 
TTGGTGCTGG ATGTCAAGCG GAAGGCTCCC TGGTACTGGA GTGACTACCG GGATGCTCTC 
AGCTTACAGT GTCTGGCCTC CTTCCTGTTC CTGTACTGTG CCTGCATGTC GCCCGTTATC 
ACCTTCGGGG GACTGCTGGG AGAAGCCACT GAAGGACGCA TAAGTGCGAT TGAGTCGTTG 
TTTGGAGCGT CCATGACGGG GATTGCCTAC TCTCTGTTTG CTGGGCAGCC TCTCACCATC 
CTGGGAAGCA CGGGGCCCGT GCTGGTGTTT GAAAAGATTT TGTTCAAATT CTGCAAGGAC 
TATGCCCTTT CGTACCTGTC CCTGCGGGCT CTCATCGGGC TGTGGACTGC CTTCCTGTGC 
ATCGTCCTGG TGGCCACGGA TGCCAGCTCC CTCGTCTGCT ACATTACCCG CTTCACCGAG 
GAAGCGTTTG CCTCCCTGAT TTGTATCATC TTCATCTATG AAGCCATAGA AAAGCTGATC 
CACCTGGCAG AGACCTACCC CATCCACATG CACAGCCAGC TGGACCACCT GAGCCTCTAT 
TACTGCAGGT GTGTGCTCCC GGAGAATCCA AACAACCACA CCTTACAGTA TTGGAAGGAC 
CACAACATCC TGGCTGCCGA AGTGAACTGG GCAAACCTGA CAGTCAGCGA ATGCCAGGAG 
ATGCACGGGG AGTTCATGGG ATCTGCCTGC GGTCACCACG GACCCTACAC GCCCGACGTG 
CTCTTTTGGT CCTGCATTCT GTTCTTCGCC ACCTTCATCG TCTCCAGCAC CTTAAAGACA 
TTTAAGACAA GCCGCTACTT CCCGACCAGG GTCCGCTCCA TGGTGAGTGA CTTCGCCGTG 
TTCCTCACCA TCTTCACCAT GGTGGTCCTT GACTTTCTGA TTGGCGTCCC GTCGCCAAAG 
CTTCAGGTTC CCAATGTGTT CAAGCCAACA AGGGACGATC GAGGATGGTT TATTAATCCC 
ATTGGCCCCA ATCCCTGGTG GACTGTGATA GCCGCAATTA TCCCAGCTCT CCTGTGCACT 
ATCCTGATAT TCATGGACCA GCAGATCACC GCTGTCATCA TTAACAGGAA GGAACACAAG 
CTCAAGAAAG GCTGTGGCTA CCACCTGGAC CTGCTCATGG TGGCCGTCAT GCTGGGAGTT 
TGCTCCATCA TGGGCCTGCC TTGGTTTGTG GCCGCGACCG TCCTGTCCAT TACCCATGTG 
AACAGCCTCA AGCTGGAATC CGAATGCTCT GCCCCCGGGG AGCAGCCCAA GTTCTTGGGC 
ATCCGGGAAC AGAGAGTCAC AGGGCTTATG ATCTTCGTGC TGATGGGCTG CTCAGTCTTC 
ATGACAGCTG TCTTAAAGTT TATCCCGATG CCAGTGCTCT ACGGAGTTTT CCTCTACATG 
GGAGTCTCTT CGCTACAAGG AATCCAGTTC TTCGACCGTC TGAAGCTTTT CGGGATGCCT 
GCAAAACACC AGCCAGACTT CATCTACCTG CGGCACGTGC CGCTGCGCAA GGTGCACCTG 
TTCACGCTAG TGCAGCTCAC CTGCCTCGTC CTGCTCTGGG TCATCAAGGC ATCGCCGGCC 
GCCATTGTTT TCCCAATGAT GGTGCTGGCC TTGGTCTTCG TCAGGAAAGT CATGGATCTC 
TGCTTCTCCA AGCGTGAGCT AAGCTGGCTG GACGACCTCA TGCCTGAGAG CAAAAAGAAG 
AAGCTGGACG ATGCGAAGAA GAAGGAGGAG GAGGAGGCCG AGAAGATGTT GGACATTGGG 
GGTGACAAGT TTCCCCTGGA AAGCAGGAAG CTGCTAAGTA GTCCTGGCAA GAGCAGCAGC 
TTCAGATGTG ACCCTTCTGA GATTAATATA TCAGATGAAA TGCCTAAAAC CACGGTCTGG 
AAGGCTCTCA GCATAAATTC CGGAAATACA AAAGAAAAAA GCCCCTTCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017172207.1
CDS	106..3219
Translation	MPLGRQSHRHHRTHGQKHRRRGGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGSVLLDMRASSIEEISDLILDQQELLRDLSDSVRVKVREALLKKHHHQNERRRNNLIPIVRSFAEVGKKQSDPHSMDRDGQTVSPQSATNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDTLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEPEPHGGHSGPELERTGRLFGGLVLDVKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYALSYLSLRALIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCVLPENPNNHTLQYWKDHNILAAEVNWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFATFIVSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVVLDFLIGVPSPKLQVPNVFKPTRDDRGWFINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKEEEEAEKMLDIGGDKFPLESRKLLSSPGKSSSFRCDPSEINISDEMPKTTVWKALSINSGNTKEKSPFN

Target ORF information:

RefSeq Version	XM_017316718.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 4 (anion exchanger), member 8 (Slc4a8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017316718.1

ORF Insert Sequence:

ATGCCGCTGG GGAGGCAGAG CCATCGGCAC CACCGCACTC ATGGCCAGAA GCACCGGAGA 
CGAGGAGGGC GGGGCAAAGG AGCCAGCCAG GGCGAGGAGG GCTTGGAAGC CTTGGCCCAC 
GACACCCCGT CTCAGCGTGT TCAGTTCATT CTTGGCACTG AGGAAGATGA AGAACATGTG 
CCTCATGAGC TCTTCACAGA GCTGGACGAG ATCTGTATGA AAGAGGGGGA AGATGCTGAG 
TGGAAGGAGA CGGCCAGGTG GCTGAAGTTT GAAGAGGATG TGGAGGACGG GGGAGAGCGC 
TGGAGCAAGC CTTACGTGGC CACGCTCTCT CTGCACAGCC TGTTTGAGCT GAGGAGCTGC 
CTCATCAACG GCTCTGTGCT TCTGGACATG CGTGCAAGTA GCATAGAGGA GATCTCAGAC 
CTGATCCTGG ACCAGCAGGA GCTGCTCCGA GACCTGAGCG ACAGCGTGAG GGTTAAAGTG 
CGGGAAGCCC TGCTGAAGAA GCACCACCAC CAGAACGAGA GGAGGAGGAA CAACCTCATC 
CCCATCGTCC GCTCCTTCGC TGAGGTTGGC AAGAAGCAGT CTGACCCGCA CTCCATGGAC 
AGAGATGGGC AAACGGTGTC TCCTCAGTCA GCTACAAACC TTGAAGTGAA GAATGGTGTG 
AACTGTGAGC ACAGCCCTGT GGATCTAAGC AAGGTGGATC TTCACTTCAT GAAAAAAATT 
CCCACGGGGG CAGAGGCCTC CAATGTCCTG GTGGGAGAGG TGGATACGCT GGACCGGCCC 
ATCGTGGCCT TCGTGAGGCT CTCCCCGGCT GTGCTGCTCT CTGGCCTGAC GGAAGTGCCC 
ATCCCAACGA GGTTTTTGTT TATCTTACTG GGCCCAGTGG GAAAAGGGCA GCAGTACCAT 
GAGATTGGCA GGTCCATGGC CACCATCATG ACGGACGAGA TTTTTCATGA TGTGGCATAT 
AAAGCAAAGG AACGCGATGA CCTCCTGGCA GGGATTGACG AGTTCCTGGA CCAGGTGACG 
GTGCTTCCGC CAGGGGAGTG GGACCCATCT ATTAGAATTG AGCCACCCAA GAATGTCCCT 
TCCCAGGAAA AAAGGAAAAT GCCCGGTGTT CCAAACGGAA ACGTTTGCCA CATAGAACCA 
GAGCCACATG GGGGGCACAG TGGGCCAGAA CTGGAGCGGA CTGGGCGGCT GTTTGGGGGC 
TTGGTGCTGG ATGTCAAGCG GAAGGCTCCC TGGTACTGGA GTGACTACCG GGATGCTCTC 
AGCTTACAGT GTCTGGCCTC CTTCCTGTTC CTGTACTGTG CCTGCATGTC GCCCGTTATC 
ACCTTCGGGG GACTGCTGGG AGAAGCCACT GAAGGACGCA TAAGTGCGAT TGAGTCGTTG 
TTTGGAGCGT CCATGACGGG GATTGCCTAC TCTCTGTTTG CTGGGCAGCC TCTCACCATC 
CTGGGAAGCA CGGGGCCCGT GCTGGTGTTT GAAAAGATTT TGTTCAAATT CTGCAAGGAC 
TATGCCCTTT CGTACCTGTC CCTGCGGGCT CTCATCGGGC TGTGGACTGC CTTCCTGTGC 
ATCGTCCTGG TGGCCACGGA TGCCAGCTCC CTCGTCTGCT ACATTACCCG CTTCACCGAG 
GAAGCGTTTG CCTCCCTGAT TTGTATCATC TTCATCTATG AAGCCATAGA AAAGCTGATC 
CACCTGGCAG AGACCTACCC CATCCACATG CACAGCCAGC TGGACCACCT GAGCCTCTAT 
TACTGCAGGT GTGTGCTCCC GGAGAATCCA AACAACCACA CCTTACAGTA TTGGAAGGAC 
CACAACATCC TGGCTGCCGA AGTGAACTGG GCAAACCTGA CAGTCAGCGA ATGCCAGGAG 
ATGCACGGGG AGTTCATGGG ATCTGCCTGC GGTCACCACG GACCCTACAC GCCCGACGTG 
CTCTTTTGGT CCTGCATTCT GTTCTTCGCC ACCTTCATCG TCTCCAGCAC CTTAAAGACA 
TTTAAGACAA GCCGCTACTT CCCGACCAGG GTCCGCTCCA TGGTGAGTGA CTTCGCCGTG 
TTCCTCACCA TCTTCACCAT GGTGGTCCTT GACTTTCTGA TTGGCGTCCC GTCGCCAAAG 
CTTCAGGTTC CCAATGTGTT CAAGCCAACA AGGGACGATC GAGGATGGTT TATTAATCCC 
ATTGGCCCCA ATCCCTGGTG GACTGTGATA GCCGCAATTA TCCCAGCTCT CCTGTGCACT 
ATCCTGATAT TCATGGACCA GCAGATCACC GCTGTCATCA TTAACAGGAA GGAACACAAG 
CTCAAGAAAG GCTGTGGCTA CCACCTGGAC CTGCTCATGG TGGCCGTCAT GCTGGGAGTT 
TGCTCCATCA TGGGCCTGCC TTGGTTTGTG GCCGCGACCG TCCTGTCCAT TACCCATGTG 
AACAGCCTCA AGCTGGAATC CGAATGCTCT GCCCCCGGGG AGCAGCCCAA GTTCTTGGGC 
ATCCGGGAAC AGAGAGTCAC AGGGCTTATG ATCTTCGTGC TGATGGGCTG CTCAGTCTTC 
ATGACAGCTG TCTTAAAGTT TATCCCGATG CCAGTGCTCT ACGGAGTTTT CCTCTACATG 
GGAGTCTCTT CGCTACAAGG AATCCAGTTC TTCGACCGTC TGAAGCTTTT CGGGATGCCT 
GCAAAACACC AGCCAGACTT CATCTACCTG CGGCACGTGC CGCTGCGCAA GGTGCACCTG 
TTCACGCTAG TGCAGCTCAC CTGCCTCGTC CTGCTCTGGG TCATCAAGGC ATCGCCGGCC 
GCCATTGTTT TCCCAATGAT GGTGCTGGCC TTGGTCTTCG TCAGGAAAGT CATGGATCTC 
TGCTTCTCCA AGCGTGAGCT AAGCTGGCTG GACGACCTCA TGCCTGAGAG CAAAAAGAAG 
AAGCTGGACG ATGCGAAGAA GAAGGAGGAG GAGGAGGCCG AGAAGATGTT GGACATTGGG 
GGTGACAAGT TTCCCCTGGA AAGCAGGAAG CTGCTAAGTA GTCCTGGCAA GAGCAGCAGC 
TTCAGATGTG ACCCTTCTGA GATTAATATA TCAGATGAAA TGCCTAAAAC CACGGTCTGG 
AAGGCTCTCA GCATAAATTC CGGAAATACA AAAGAAAAAA GCCCCTTCAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc4a8 ( NM_021530.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067505.2 Mus musculus solute carrier family 4 (anion exchanger), member 8 (Slc4a8), transcript variant 1, mRNA.

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CloneID	OMu17670
Clone ID Related Accession (Same CDS sequence)	NM_021530.2
Accession Version	NM_021530.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	electroneutral sodium bicarbonate exchanger 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB626223.1, BB851903.1, AK173014.1, AC113587.16 and BP759706.1. On Aug 8, 2006 this sequence version replaced NM_021530.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK034237.1, AK173014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGCCG GGAGCAACGA GCCGGACGGC GTCCTCAGCT ATCAGAGGCC AGATGAGGAA 
GCTGTGGTGG ATCAGGGTGG GACCAGCACA ATTCTCAACA TTCACTATGA GAAAGAAGAG 
TTGGAAGGTC ATAGAACTCT GTATGTGGGG GTTCGGATGC CGCTGGGGAG GCAGAGCCAT 
CGGCACCACC GCACTCATGG CCAGAAGCAC CGGAGACGAG GAGGGCGGGG CAAAGGAGCC 
AGCCAGGGCG AGGAGGGCTT GGAAGCCTTG GCCCACGACA CCCCGTCTCA GCGTGTTCAG 
TTCATTCTTG GCACTGAGGA AGATGAAGAA CATGTGCCTC ATGAGCTCTT CACAGAGCTG 
GACGAGATCT GTATGAAAGA GGGGGAAGAT GCTGAGTGGA AGGAGACGGC CAGGTGGCTG 
AAGTTTGAAG AGGATGTGGA GGACGGGGGA GAGCGCTGGA GCAAGCCTTA CGTGGCCACG 
CTCTCTCTGC ACAGCCTGTT TGAGCTGAGG AGCTGCCTCA TCAACGGCTC TGTGCTTCTG 
GACATGCGTG CAAGTAGCAT AGAGGAGATC TCAGACCTGA TCCTGGACCA GCAGGAGCTG 
CTCCGAGACC TGAGCGACAG CGTGAGGGTT AAAGTGCGGG AAGCCCTGCT GAAGAAGCAC 
CACCACCAGA ACGAGAGGAG GAGGAACAAC CTCATCCCCA TCGTCCGCTC CTTCGCTGAG 
GTTGGCAAGA AGCAGTCTGA CCCGCACTCC ATGGACAGAG ATGGGCAAAC GGTGTCTCCT 
CAGTCAGCTA CAAACCTTGA AGTGAAGAAT GGTGTGAACT GTGAGCACAG CCCTGTGGAT 
CTAAGCAAGG TGGATCTTCA CTTCATGAAA AAAATTCCCA CGGGGGCAGA GGCCTCCAAT 
GTCCTGGTGG GAGAGGTGGA TACGCTGGAC CGGCCCATCG TGGCCTTCGT GAGGCTCTCC 
CCGGCTGTGC TGCTCTCTGG CCTGACGGAA GTGCCCATCC CAACGAGGTT TTTGTTTATC 
TTACTGGGCC CAGTGGGAAA AGGGCAGCAG TACCATGAGA TTGGCAGGTC CATGGCCACC 
ATCATGACGG ACGAGATTTT TCATGATGTG GCATATAAAG CAAAGGAACG CGATGACCTC 
CTGGCAGGGA TTGACGAGTT CCTGGACCAG GTGACGGTGC TTCCGCCAGG GGAGTGGGAC 
CCATCTATTA GAATTGAGCC ACCCAAGAAT GTCCCTTCCC AGGAAAAAAG GAAAATGCCC 
GGTGTTCCAA ACGGAAACGT TTGCCACATA GAACCAGAGC CACATGGGGG GCACAGTGGG 
CCAGAACTGG AGCGGACTGG GCGGCTGTTT GGGGGCTTGG TGCTGGATGT CAAGCGGAAG 
GCTCCCTGGT ACTGGAGTGA CTACCGGGAT GCTCTCAGCT TACAGTGTCT GGCCTCCTTC 
CTGTTCCTGT ACTGTGCCTG CATGTCGCCC GTTATCACCT TCGGGGGACT GCTGGGAGAA 
GCCACTGAAG GACGCATAAG TGCGATTGAG TCGTTGTTTG GAGCGTCCAT GACGGGGATT 
GCCTACTCTC TGTTTGCTGG GCAGCCTCTC ACCATCCTGG GAAGCACGGG GCCCGTGCTG 
GTGTTTGAAA AGATTTTGTT CAAATTCTGC AAGGACTATG CCCTTTCGTA CCTGTCCCTG 
CGGGCTCTCA TCGGGCTGTG GACTGCCTTC CTGTGCATCG TCCTGGTGGC CACGGATGCC 
AGCTCCCTCG TCTGCTACAT TACCCGCTTC ACCGAGGAAG CGTTTGCCTC CCTGATTTGT 
ATCATCTTCA TCTATGAAGC CATAGAAAAG CTGATCCACC TGGCAGAGAC CTACCCCATC 
CACATGCACA GCCAGCTGGA CCACCTGAGC CTCTATTACT GCAGGTGTGT GCTCCCGGAG 
AATCCAAACA ACCACACCTT ACAGTATTGG AAGGACCACA ACATCCTGGC TGCCGAAGTG 
AACTGGGCAA ACCTGACAGT CAGCGAATGC CAGGAGATGC ACGGGGAGTT CATGGGATCT 
GCCTGCGGTC ACCACGGACC CTACACGCCC GACGTGCTCT TTTGGTCCTG CATTCTGTTC 
TTCGCCACCT TCATCGTCTC CAGCACCTTA AAGACATTTA AGACAAGCCG CTACTTCCCG 
ACCAGGGTCC GCTCCATGGT GAGTGACTTC GCCGTGTTCC TCACCATCTT CACCATGGTG 
GTCCTTGACT TTCTGATTGG CGTCCCGTCG CCAAAGCTTC AGGTTCCCAA TGTGTTCAAG 
CCAACAAGGG ACGATCGAGG ATGGTTTATT AATCCCATTG GCCCCAATCC CTGGTGGACT 
GTGATAGCCG CAATTATCCC AGCTCTCCTG TGCACTATCC TGATATTCAT GGACCAGCAG 
ATCACCGCTG TCATCATTAA CAGGAAGGAA CACAAGCTCA AGAAAGGCTG TGGCTACCAC 
CTGGACCTGC TCATGGTGGC CGTCATGCTG GGAGTTTGCT CCATCATGGG CCTGCCTTGG 
TTTGTGGCCG CGACCGTCCT GTCCATTACC CATGTGAACA GCCTCAAGCT GGAATCCGAA 
TGCTCTGCCC CCGGGGAGCA GCCCAAGTTC TTGGGCATCC GGGAACAGAG AGTCACAGGG 
CTTATGATCT TCGTGCTGAT GGGCTGCTCA GTCTTCATGA CAGCTGTCTT AAAGTTTATC 
CCGATGCCAG TGCTCTACGG AGTTTTCCTC TACATGGGAG TCTCTTCGCT ACAAGGAATC 
CAGTTCTTCG ACCGTCTGAA GCTTTTCGGG ATGCCTGCAA AACACCAGCC AGACTTCATC 
TACCTGCGGC ACGTGCCGCT GCGCAAGGTG CACCTGTTCA CGCTAGTGCA GCTCACCTGC 
CTCGTCCTGC TCTGGGTCAT CAAGGCATCG CCGGCCGCCA TTGTTTTCCC AATGATGGTG 
CTGGCCTTGG TCTTCGTCAG GAAAGTCATG GATCTCTGCT TCTCCAAGCG TGAGCTAAGC 
TGGCTGGACG ACCTCATGCC TGAGAGCAAA AAGAAGAAGC TGGACGATGC GAAGAAGAAG 
GAGGAGGAGG AGGCCGAGAA GATGTTGGAC ATTGGGGGTG ACAAGTTTCC CCTGGAAAGC 
AGGAAGCTGC TAAGTAGTCC TGGCAAGAGC AGCAGCTTCA GATGTGACCC TTCTGAGATT 
AATATATCAG ATGAAATGCC TAAAACCACG GTCTGGAAGG CTCTCAGCAT AAATTCCGGA 
AATACAAAAG AAAAAAGCCC CTTCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067505.2
CDS	184..3453
Translation	MPAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGSVLLDMRASSIEEISDLILDQQELLRDLSDSVRVKVREALLKKHHHQNERRRNNLIPIVRSFAEVGKKQSDPHSMDRDGQTVSPQSATNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDTLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEPEPHGGHSGPELERTGRLFGGLVLDVKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYALSYLSLRALIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCVLPENPNNHTLQYWKDHNILAAEVNWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFATFIVSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVVLDFLIGVPSPKLQVPNVFKPTRDDRGWFINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKEEEEAEKMLDIGGDKFPLESRKLLSSPGKSSSFRCDPSEINISDEMPKTTVWKALSINSGNTKEKSPFN

Target ORF information:

RefSeq Version	NM_021530.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 4 (anion exchanger), member 8 (Slc4a8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021530.2

ORF Insert Sequence:

ATGCCCGCCG GGAGCAACGA GCCGGACGGC GTCCTCAGCT ATCAGAGGCC AGATGAGGAA 
GCTGTGGTGG ATCAGGGTGG GACCAGCACA ATTCTCAACA TTCACTATGA GAAAGAAGAG 
TTGGAAGGTC ATAGAACTCT GTATGTGGGG GTTCGGATGC CGCTGGGGAG GCAGAGCCAT 
CGGCACCACC GCACTCATGG CCAGAAGCAC CGGAGACGAG GAGGGCGGGG CAAAGGAGCC 
AGCCAGGGCG AGGAGGGCTT GGAAGCCTTG GCCCACGACA CCCCGTCTCA GCGTGTTCAG 
TTCATTCTTG GCACTGAGGA AGATGAAGAA CATGTGCCTC ATGAGCTCTT CACAGAGCTG 
GACGAGATCT GTATGAAAGA GGGGGAAGAT GCTGAGTGGA AGGAGACGGC CAGGTGGCTG 
AAGTTTGAAG AGGATGTGGA GGACGGGGGA GAGCGCTGGA GCAAGCCTTA CGTGGCCACG 
CTCTCTCTGC ACAGCCTGTT TGAGCTGAGG AGCTGCCTCA TCAACGGCTC TGTGCTTCTG 
GACATGCGTG CAAGTAGCAT AGAGGAGATC TCAGACCTGA TCCTGGACCA GCAGGAGCTG 
CTCCGAGACC TGAGCGACAG CGTGAGGGTT AAAGTGCGGG AAGCCCTGCT GAAGAAGCAC 
CACCACCAGA ACGAGAGGAG GAGGAACAAC CTCATCCCCA TCGTCCGCTC CTTCGCTGAG 
GTTGGCAAGA AGCAGTCTGA CCCGCACTCC ATGGACAGAG ATGGGCAAAC GGTGTCTCCT 
CAGTCAGCTA CAAACCTTGA AGTGAAGAAT GGTGTGAACT GTGAGCACAG CCCTGTGGAT 
CTAAGCAAGG TGGATCTTCA CTTCATGAAA AAAATTCCCA CGGGGGCAGA GGCCTCCAAT 
GTCCTGGTGG GAGAGGTGGA TACGCTGGAC CGGCCCATCG TGGCCTTCGT GAGGCTCTCC 
CCGGCTGTGC TGCTCTCTGG CCTGACGGAA GTGCCCATCC CAACGAGGTT TTTGTTTATC 
TTACTGGGCC CAGTGGGAAA AGGGCAGCAG TACCATGAGA TTGGCAGGTC CATGGCCACC 
ATCATGACGG ACGAGATTTT TCATGATGTG GCATATAAAG CAAAGGAACG CGATGACCTC 
CTGGCAGGGA TTGACGAGTT CCTGGACCAG GTGACGGTGC TTCCGCCAGG GGAGTGGGAC 
CCATCTATTA GAATTGAGCC ACCCAAGAAT GTCCCTTCCC AGGAAAAAAG GAAAATGCCC 
GGTGTTCCAA ACGGAAACGT TTGCCACATA GAACCAGAGC CACATGGGGG GCACAGTGGG 
CCAGAACTGG AGCGGACTGG GCGGCTGTTT GGGGGCTTGG TGCTGGATGT CAAGCGGAAG 
GCTCCCTGGT ACTGGAGTGA CTACCGGGAT GCTCTCAGCT TACAGTGTCT GGCCTCCTTC 
CTGTTCCTGT ACTGTGCCTG CATGTCGCCC GTTATCACCT TCGGGGGACT GCTGGGAGAA 
GCCACTGAAG GACGCATAAG TGCGATTGAG TCGTTGTTTG GAGCGTCCAT GACGGGGATT 
GCCTACTCTC TGTTTGCTGG GCAGCCTCTC ACCATCCTGG GAAGCACGGG GCCCGTGCTG 
GTGTTTGAAA AGATTTTGTT CAAATTCTGC AAGGACTATG CCCTTTCGTA CCTGTCCCTG 
CGGGCTCTCA TCGGGCTGTG GACTGCCTTC CTGTGCATCG TCCTGGTGGC CACGGATGCC 
AGCTCCCTCG TCTGCTACAT TACCCGCTTC ACCGAGGAAG CGTTTGCCTC CCTGATTTGT 
ATCATCTTCA TCTATGAAGC CATAGAAAAG CTGATCCACC TGGCAGAGAC CTACCCCATC 
CACATGCACA GCCAGCTGGA CCACCTGAGC CTCTATTACT GCAGGTGTGT GCTCCCGGAG 
AATCCAAACA ACCACACCTT ACAGTATTGG AAGGACCACA ACATCCTGGC TGCCGAAGTG 
AACTGGGCAA ACCTGACAGT CAGCGAATGC CAGGAGATGC ACGGGGAGTT CATGGGATCT 
GCCTGCGGTC ACCACGGACC CTACACGCCC GACGTGCTCT TTTGGTCCTG CATTCTGTTC 
TTCGCCACCT TCATCGTCTC CAGCACCTTA AAGACATTTA AGACAAGCCG CTACTTCCCG 
ACCAGGGTCC GCTCCATGGT GAGTGACTTC GCCGTGTTCC TCACCATCTT CACCATGGTG 
GTCCTTGACT TTCTGATTGG CGTCCCGTCG CCAAAGCTTC AGGTTCCCAA TGTGTTCAAG 
CCAACAAGGG ACGATCGAGG ATGGTTTATT AATCCCATTG GCCCCAATCC CTGGTGGACT 
GTGATAGCCG CAATTATCCC AGCTCTCCTG TGCACTATCC TGATATTCAT GGACCAGCAG 
ATCACCGCTG TCATCATTAA CAGGAAGGAA CACAAGCTCA AGAAAGGCTG TGGCTACCAC 
CTGGACCTGC TCATGGTGGC CGTCATGCTG GGAGTTTGCT CCATCATGGG CCTGCCTTGG 
TTTGTGGCCG CGACCGTCCT GTCCATTACC CATGTGAACA GCCTCAAGCT GGAATCCGAA 
TGCTCTGCCC CCGGGGAGCA GCCCAAGTTC TTGGGCATCC GGGAACAGAG AGTCACAGGG 
CTTATGATCT TCGTGCTGAT GGGCTGCTCA GTCTTCATGA CAGCTGTCTT AAAGTTTATC 
CCGATGCCAG TGCTCTACGG AGTTTTCCTC TACATGGGAG TCTCTTCGCT ACAAGGAATC 
CAGTTCTTCG ACCGTCTGAA GCTTTTCGGG ATGCCTGCAA AACACCAGCC AGACTTCATC 
TACCTGCGGC ACGTGCCGCT GCGCAAGGTG CACCTGTTCA CGCTAGTGCA GCTCACCTGC 
CTCGTCCTGC TCTGGGTCAT CAAGGCATCG CCGGCCGCCA TTGTTTTCCC AATGATGGTG 
CTGGCCTTGG TCTTCGTCAG GAAAGTCATG GATCTCTGCT TCTCCAAGCG TGAGCTAAGC 
TGGCTGGACG ACCTCATGCC TGAGAGCAAA AAGAAGAAGC TGGACGATGC GAAGAAGAAG 
GAGGAGGAGG AGGCCGAGAA GATGTTGGAC ATTGGGGGTG ACAAGTTTCC CCTGGAAAGC 
AGGAAGCTGC TAAGTAGTCC TGGCAAGAGC AGCAGCTTCA GATGTGACCC TTCTGAGATT 
AATATATCAG ATGAAATGCC TAAAACCACG GTCTGGAAGG CTCTCAGCAT AAATTCCGGA 
AATACAAAAG AAAAAAGCCC CTTCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Double Knockout of the Na+-Driven Cl-/HCO3- Exchanger and Na+/Cl- Cotransporter Induces Hypokalemia and Volume Depletion.
Journal of the American Society of Nephrology : JASN28(1)130-139(2017 Jan)
Sinning A,Radionov N,Trepiccione F,L?pez-Cayuqueo KI,Jayat M,Baron S,Corni?re N,Alexander RT,Hadchouel J,Eladari D,H?bner CA,Chambrey R

Immunocytochemical identification of electroneutral Na?-coupled HCO?? transporters in freshly dissociated mouse medullary raph? neurons.
Neuroscience246451-67(2013 Aug)
Coley AA,Ruffin VA,Moss FJ,Hopfer U,Boron WF

NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos.
Biology of reproduction88(6)157(2013 Jun)
Siyanov V,Baltz JM

Renal intercalated cells are rather energized by a proton than a sodium pump.
Proceedings of the National Academy of Sciences of the United States of America110(19)7928-33(2013 May)
Chambrey R,Kurth I,Peti-Peterdi J,Houillier P,Purkerson JM,Leviel F,Hentschke M,Zdebik AA,Schwartz GJ,H?bner CA,Eladari D

Synaptic glutamate release is modulated by the Na+ -driven Cl-/HCO?? exchanger Slc4a8.
The Journal of neuroscience : the official journal of the Society for Neuroscience31(20)7300-11(2011 May)
Sinning A,Liebmann L,Kougioumtzes A,Westermann M,Bruehl C,H?bner CA

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Slc4a8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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