Mmp19 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp19
Entrez Gene ID	58223
Full Name	matrix metallopeptidase 19
General protein information	Preferred Names matrix metallopeptidase 19 Names matrix metalloproteinase-19 matrix metalloproteinase RASI
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 D3\|10 77.16 cM
Summary	This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein develop a diet-induced obesity due to adipocyte hypertophy, exhibit decreased susceptibility to chemical carcinogen-induced skin tumors and early onset of tumoral angiogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001164197.2	NP_001157669.1	matrix metalloproteinase-19 isoform 2
NM_021412.3	NP_067387.1	matrix metalloproteinase-19 isoform 1 preproprotein

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC100536874	XP_003199461.2
Pan troglodytes (chimpanzee)	MMP19	XP_001154045.2
	MMP19	XP_001111542.1
Bos taurus (cattle)	MMP19	NP_001069451.1
Mus musculus (house mouse)	Mmp19	NP_067387.1
Canis lupus familiaris (dog)	MMP19	XP_848410.2
Homo sapiens (human)	MMP19	NP_002420.1
Rattus norvegicus (Norway rat)	Mmp19	NP_001100629.1
Xenopus tropicalis (tropical clawed frog)	mmp19	XP_002934557.2

Gene Ontology
Bibliography

Related articles in PubMed

MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function.
Brauer R, Tureckova J, Kanchev I, Khoylou M, Skarda J, Prochazka J, Spoutil F, Beck IM, Zbodakova O, Kasparek P, Korinek V, Chalupsky K, Karhu T, Herzig KH, Hajduch M, Gregor M, Sedlacek R
Mucosal immunology9(4)974-85(2016 07)

Estrogen receptor ? controls MMP-19 expression in mouse ovaries during ovulation.
Nalvarte I, T?h?nen V, Lindeberg M, Varshney M, Gustafsson J?, Inzunza J
Reproduction (Cambridge, England)151(3)253-9(2016 Mar)

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.
Vanden Berghe T, Hulpiau P, Martens L, Vandenbroucke RE, Van Wonterghem E, Perry SW, Bruggeman I, Divert T, Choi SM, Vuylsteke M, Shestopalov VI, Libert C, Vandenabeele P
Immunity43(1)200-9(2015 Jul)

Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation.
Newby AC
Matrix biology : journal of the International Society for Matrix Biology44-46157-66(2015 May-Jul)

Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.
Kobielak A, Fuchs E
Proceedings of the National Academy of Sciences of the United States of America103(7)2322-7(2006 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function
Title: MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function.

Estrogen receptor beta target gene, where ERbeta requires a specific Sp1 site on the MMP-19 promoter to mediate ligand dependent transcription
Title: Estrogen receptor ? controls MMP-19 expression in mouse ovaries during ovulation.

These findings suggest that, in lung fibroblasts, MMP-19 has strong regulatory effects on the synthesis of key ECM components, on fibroblast to myofibroblast differentiation, and in migration and proliferation.
Title: Matrix metalloproteinase (MMP)-19-deficient fibroblasts display a profibrotic phenotype.

In WT mice, PTGS2 was significantly increased in bronchoalveolar lavage and lung tissues after bleomycin-induced fibrosis, but not in Mmp19-/- mice. Inhibition of Mmp-19 by siRNA resulted in inhibition of Ptgs2 at mRNA and protein levels.
Title: Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans.

MMP-19-deficiency improves the development of hepatic fibrosis through the diminished replacement of physiological extracellular matrix with fibrotic deposits in the beginning of the injury
Title: Hepatoprotective effect of MMP-19 deficiency in a mouse model of chronic liver fibrosis.

The following Mmp19 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp19 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09640	NM_001164197.2 Latest version!	Mus musculus matrix metallopeptidase 19 (Mmp19), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$272.30 $389.00
OMu12308	NM_021412.3 Latest version!	Mus musculus matrix metallopeptidase 19 (Mmp19), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp19 ( NM_001164197.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001157669.1 Mus musculus matrix metallopeptidase 19 (Mmp19), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu09640
Clone ID Related Accession (Same CDS sequence)	NM_001164197.2
Accession Version	NM_001164197.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1368bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Mus musculus(house mouse)
Product	matrix metalloproteinase-19 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK079924.1, AK136517.1 and AC131081.7. On Feb 17, 2016 this sequence version replaced NM_001164197.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK136517.1, AK079924.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGACG CCACAAGGGC CCGTATGAAG CAGCCCCGTT GTGGTCTGGA GGATCCCTTC 
AACCAGAAAT CTCTTAAATA CCTGCTTCTG GGCCACTGGA GAAAGAAGAA CTTGACATTC 
CGCATCTTCA ATGTGCCCTC CACCCTCTCA CTTCCCAGAG TCCGAGCAGC CCTGCATCAA 
GCCTTTAAGT ACTGGAGCAG CGTGGCTCCT CTGACCTTCC GGGAGGTGAA AGCTGGTTGG 
GCTGACATTC GCCTCTCTTT CCATGGCCGC CAAAGCCTGT ACTGCTCCAA TACCTTTGAT 
GGGCCTGGAA AGGTCCTGGC CCATGCTGAC ATCCCAGAAC TTGGGAGTAT ACACTTTGAT 
AAAGATGAAC TCTGGACTGA GGGGACCTAT CAAGGAGTGA ACCTGCGCAT CATTGCGGCC 
CATGAAGTGG GCCATGCCCT AGGACTTGGG CACTCCCGAT ATACCCAGGC ACTCATGGCT 
CCTGTCTATG CTGGCTACCA GCCCTTCTTC AAGCTGCATC CAGATGATGT GGCAGGGATC 
CAGGCTCTCT ATGGCAAGAG GAGCCCAGAG ACAAGAGATG AGGAGGAAGA GACCGAGATG 
CTCACTGTGT CTCCAGTGAC TGCAAAACCT GGTCCCATGC CAAACCCCTG CAGCGGTGAG 
GTGGACGCCA TGGTGCTGGG GCCTCGTGGG AAGACTTATG CTTTCAAGGG CGACTATGTG 
TGGACTGTAA CAGATTCAGG GCCAGGCCCC TTGTTCCAAA TATCTGCCCT TTGGGAGGGG 
CTTCCTGGAA ACCTAGATGC TGCCGTTTAC TCTCCCCGGA CACGACGGAC TCATTTCTTC 
AAGGGAAACA AGGTGTGGCG GTATGTGGAT TTCAAGATGT CTCCTGGCTT TCCCATGAAA 
TTCAACAGAG TAGAGCCCAA CCTGGATGCA GCTCTCTACT GGCCTGTTAA TCAAAAGGTG 
TTCCTGTTTA AGGGCTCAGG ATACTGGCAA TGGGATGAAC TGGCCAGAAC TGACCTTAGC 
CGCTACCCTA AACCAATCAA GGAACTGTTT ACTGGAGTGC CAGACCGACC CTCGGCAGCT 
ATGAGCTGGC AAGATGGCCA AGTCTACTTT TTCAAGGGCA AAGAGTATTG GCGCCTTAAC 
CAGCAACTTC GAGTGGCAAA GGGCTATCCC AGAAATACGA CACACTGGAT GCACTGTGGT 
TCTCAGACTC CAGACACTAA CTCATCAACC GGGGACGTTA CTCCTTCAAC CACAGACACA 
GTCTTGGGTA CCACTCCATC AACCATGGGC TCAACCTTGG ACATTCCCTC AGCTACAGAC 
TCTGCCTCCC TCTCATTCTC TGCTAATGTC ACCCTGCTAG GGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001157669.1
CDS	184..1551
Translation	MDDATRARMKQPRCGLEDPFNQKSLKYLLLGHWRKKNLTFRIFNVPSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAGWADIRLSFHGRQSLYCSNTFDGPGKVLAHADIPELGSIHFDKDELWTEGTYQGVNLRIIAAHEVGHALGLGHSRYTQALMAPVYAGYQPFFKLHPDDVAGIQALYGKRSPETRDEEEETEMLTVSPVTAKPGPMPNPCSGEVDAMVLGPRGKTYAFKGDYVWTVTDSGPGPLFQISALWEGLPGNLDAAVYSPRTRRTHFFKGNKVWRYVDFKMSPGFPMKFNRVEPNLDAALYWPVNQKVFLFKGSGYWQWDELARTDLSRYPKPIKELFTGVPDRPSAAMSWQDGQVYFFKGKEYWRLNQQLRVAKGYPRNTTHWMHCGSQTPDTNSSTGDVTPSTTDTVLGTTPSTMGSTLDIPSATDSASLSFSANVTLLGA

Target ORF information:

RefSeq Version	NM_001164197.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 19 (Mmp19), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164197.2

ORF Insert Sequence:

ATGGATGACG CCACAAGGGC CCGTATGAAG CAGCCCCGTT GTGGTCTGGA GGATCCCTTC 
AACCAGAAAT CTCTTAAATA CCTGCTTCTG GGCCACTGGA GAAAGAAGAA CTTGACATTC 
CGCATCTTCA ATGTGCCCTC CACCCTCTCA CTTCCCAGAG TCCGAGCAGC CCTGCATCAA 
GCCTTTAAGT ACTGGAGCAG CGTGGCTCCT CTGACCTTCC GGGAGGTGAA AGCTGGTTGG 
GCTGACATTC GCCTCTCTTT CCATGGCCGC CAAAGCCTGT ACTGCTCCAA TACCTTTGAT 
GGGCCTGGAA AGGTCCTGGC CCATGCTGAC ATCCCAGAAC TTGGGAGTAT ACACTTTGAT 
AAAGATGAAC TCTGGACTGA GGGGACCTAT CAAGGAGTGA ACCTGCGCAT CATTGCGGCC 
CATGAAGTGG GCCATGCCCT AGGACTTGGG CACTCCCGAT ATACCCAGGC ACTCATGGCT 
CCTGTCTATG CTGGCTACCA GCCCTTCTTC AAGCTGCATC CAGATGATGT GGCAGGGATC 
CAGGCTCTCT ATGGCAAGAG GAGCCCAGAG ACAAGAGATG AGGAGGAAGA GACCGAGATG 
CTCACTGTGT CTCCAGTGAC TGCAAAACCT GGTCCCATGC CAAACCCCTG CAGCGGTGAG 
GTGGACGCCA TGGTGCTGGG GCCTCGTGGG AAGACTTATG CTTTCAAGGG CGACTATGTG 
TGGACTGTAA CAGATTCAGG GCCAGGCCCC TTGTTCCAAA TATCTGCCCT TTGGGAGGGG 
CTTCCTGGAA ACCTAGATGC TGCCGTTTAC TCTCCCCGGA CACGACGGAC TCATTTCTTC 
AAGGGAAACA AGGTGTGGCG GTATGTGGAT TTCAAGATGT CTCCTGGCTT TCCCATGAAA 
TTCAACAGAG TAGAGCCCAA CCTGGATGCA GCTCTCTACT GGCCTGTTAA TCAAAAGGTG 
TTCCTGTTTA AGGGCTCAGG ATACTGGCAA TGGGATGAAC TGGCCAGAAC TGACCTTAGC 
CGCTACCCTA AACCAATCAA GGAACTGTTT ACTGGAGTGC CAGACCGACC CTCGGCAGCT 
ATGAGCTGGC AAGATGGCCA AGTCTACTTT TTCAAGGGCA AAGAGTATTG GCGCCTTAAC 
CAGCAACTTC GAGTGGCAAA GGGCTATCCC AGAAATACGA CACACTGGAT GCACTGTGGT 
TCTCAGACTC CAGACACTAA CTCATCAACC GGGGACGTTA CTCCTTCAAC CACAGACACA 
GTCTTGGGTA CCACTCCATC AACCATGGGC TCAACCTTGG ACATTCCCTC AGCTACAGAC 
TCTGCCTCCC TCTCATTCTC TGCTAATGTC ACCCTGCTAG GGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mmp19 ( NM_021412.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067387.1 Mus musculus matrix metallopeptidase 19 (Mmp19), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu12308
Clone ID Related Accession (Same CDS sequence)	NM_021412.3
Accession Version	NM_021412.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	matrix metalloproteinase-19 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY135344.1, AK086808.1, AC131081.7, AK135651.1, AK003621.1 and AI503640.1. On Feb 17, 2016 this sequence version replaced NM_021412.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK154863.1, AF155221.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTGGC AGCAGCTGTG GCTGGCATTC TTACTTCCCA TGACAGTCTC AGGCCGGGCT 
CTGGGGCCTA CAGAGAAGGA GGCAGTCTTG GATTACCTGT TGCAGTATGG GTATCTACAG 
AAACCTCTAG AAGGAGCTGA TGACTTCAGG CTGGAAGATA TCACAGAGGC TTTAAGAACT 
TTCCAGGAAG CATCTGGACT GCCCATTTCC GGTCAGATGG ATGACGCCAC AAGGGCCCGT 
ATGAAGCAGC CCCGTTGTGG TCTGGAGGAT CCCTTCAACC AGAAATCTCT TAAATACCTG 
CTTCTGGGCC ACTGGAGAAA GAAGAACTTG ACATTCCGCA TCTTCAATGT GCCCTCCACC 
CTCTCACTTC CCAGAGTCCG AGCAGCCCTG CATCAAGCCT TTAAGTACTG GAGCAGCGTG 
GCTCCTCTGA CCTTCCGGGA GGTGAAAGCT GGTTGGGCTG ACATTCGCCT CTCTTTCCAT 
GGCCGCCAAA GCCTGTACTG CTCCAATACC TTTGATGGGC CTGGAAAGGT CCTGGCCCAT 
GCTGACATCC CAGAACTTGG GAGTATACAC TTTGATAAAG ATGAACTCTG GACTGAGGGG 
ACCTATCAAG GAGTGAACCT GCGCATCATT GCGGCCCATG AAGTGGGCCA TGCCCTAGGA 
CTTGGGCACT CCCGATATAC CCAGGCACTC ATGGCTCCTG TCTATGCTGG CTACCAGCCC 
TTCTTCAAGC TGCATCCAGA TGATGTGGCA GGGATCCAGG CTCTCTATGG CAAGAGGAGC 
CCAGAGACAA GAGATGAGGA GGAAGAGACC GAGATGCTCA CTGTGTCTCC AGTGACTGCA 
AAACCTGGTC CCATGCCAAA CCCCTGCAGC GGTGAGGTGG ACGCCATGGT GCTGGGGCCT 
CGTGGGAAGA CTTATGCTTT CAAGGGCGAC TATGTGTGGA CTGTAACAGA TTCAGGGCCA 
GGCCCCTTGT TCCAAATATC TGCCCTTTGG GAGGGGCTTC CTGGAAACCT AGATGCTGCC 
GTTTACTCTC CCCGGACACG ACGGACTCAT TTCTTCAAGG GAAACAAGGT GTGGCGGTAT 
GTGGATTTCA AGATGTCTCC TGGCTTTCCC ATGAAATTCA ACAGAGTAGA GCCCAACCTG 
GATGCAGCTC TCTACTGGCC TGTTAATCAA AAGGTGTTCC TGTTTAAGGG CTCAGGATAC 
TGGCAATGGG ATGAACTGGC CAGAACTGAC CTTAGCCGCT ACCCTAAACC AATCAAGGAA 
CTGTTTACTG GAGTGCCAGA CCGACCCTCG GCAGCTATGA GCTGGCAAGA TGGCCAAGTC 
TACTTTTTCA AGGGCAAAGA GTATTGGCGC CTTAACCAGC AACTTCGAGT GGCAAAGGGC 
TATCCCAGAA ATACGACACA CTGGATGCAC TGTGGTTCTC AGACTCCAGA CACTAACTCA 
TCAACCGGGG ACGTTACTCC TTCAACCACA GACACAGTCT TGGGTACCAC TCCATCAACC 
ATGGGCTCAA CCTTGGACAT TCCCTCAGCT ACAGACTCTG CCTCCCTCTC ATTCTCTGCT 
AATGTCACCC TGCTAGGGGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067387.1
CDS	101..1684
Translation	MDWQQLWLAFLLPMTVSGRALGPTEKEAVLDYLLQYGYLQKPLEGADDFRLEDITEALRTFQEASGLPISGQMDDATRARMKQPRCGLEDPFNQKSLKYLLLGHWRKKNLTFRIFNVPSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAGWADIRLSFHGRQSLYCSNTFDGPGKVLAHADIPELGSIHFDKDELWTEGTYQGVNLRIIAAHEVGHALGLGHSRYTQALMAPVYAGYQPFFKLHPDDVAGIQALYGKRSPETRDEEEETEMLTVSPVTAKPGPMPNPCSGEVDAMVLGPRGKTYAFKGDYVWTVTDSGPGPLFQISALWEGLPGNLDAAVYSPRTRRTHFFKGNKVWRYVDFKMSPGFPMKFNRVEPNLDAALYWPVNQKVFLFKGSGYWQWDELARTDLSRYPKPIKELFTGVPDRPSAAMSWQDGQVYFFKGKEYWRLNQQLRVAKGYPRNTTHWMHCGSQTPDTNSSTGDVTPSTTDTVLGTTPSTMGSTLDIPSATDSASLSFSANVTLLGA

Target ORF information:

RefSeq Version	NM_021412.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 19 (Mmp19), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021412.3

ORF Insert Sequence:

ATGGACTGGC AGCAGCTGTG GCTGGCATTC TTACTTCCCA TGACAGTCTC AGGCCGGGCT 
CTGGGGCCTA CAGAGAAGGA GGCAGTCTTG GATTACCTGT TGCAGTATGG GTATCTACAG 
AAACCTCTAG AAGGAGCTGA TGACTTCAGG CTGGAAGATA TCACAGAGGC TTTAAGAACT 
TTCCAGGAAG CATCTGGACT GCCCATTTCC GGTCAGATGG ATGACGCCAC AAGGGCCCGT 
ATGAAGCAGC CCCGTTGTGG TCTGGAGGAT CCCTTCAACC AGAAATCTCT TAAATACCTG 
CTTCTGGGCC ACTGGAGAAA GAAGAACTTG ACATTCCGCA TCTTCAATGT GCCCTCCACC 
CTCTCACTTC CCAGAGTCCG AGCAGCCCTG CATCAAGCCT TTAAGTACTG GAGCAGCGTG 
GCTCCTCTGA CCTTCCGGGA GGTGAAAGCT GGTTGGGCTG ACATTCGCCT CTCTTTCCAT 
GGCCGCCAAA GCCTGTACTG CTCCAATACC TTTGATGGGC CTGGAAAGGT CCTGGCCCAT 
GCTGACATCC CAGAACTTGG GAGTATACAC TTTGATAAAG ATGAACTCTG GACTGAGGGG 
ACCTATCAAG GAGTGAACCT GCGCATCATT GCGGCCCATG AAGTGGGCCA TGCCCTAGGA 
CTTGGGCACT CCCGATATAC CCAGGCACTC ATGGCTCCTG TCTATGCTGG CTACCAGCCC 
TTCTTCAAGC TGCATCCAGA TGATGTGGCA GGGATCCAGG CTCTCTATGG CAAGAGGAGC 
CCAGAGACAA GAGATGAGGA GGAAGAGACC GAGATGCTCA CTGTGTCTCC AGTGACTGCA 
AAACCTGGTC CCATGCCAAA CCCCTGCAGC GGTGAGGTGG ACGCCATGGT GCTGGGGCCT 
CGTGGGAAGA CTTATGCTTT CAAGGGCGAC TATGTGTGGA CTGTAACAGA TTCAGGGCCA 
GGCCCCTTGT TCCAAATATC TGCCCTTTGG GAGGGGCTTC CTGGAAACCT AGATGCTGCC 
GTTTACTCTC CCCGGACACG ACGGACTCAT TTCTTCAAGG GAAACAAGGT GTGGCGGTAT 
GTGGATTTCA AGATGTCTCC TGGCTTTCCC ATGAAATTCA ACAGAGTAGA GCCCAACCTG 
GATGCAGCTC TCTACTGGCC TGTTAATCAA AAGGTGTTCC TGTTTAAGGG CTCAGGATAC 
TGGCAATGGG ATGAACTGGC CAGAACTGAC CTTAGCCGCT ACCCTAAACC AATCAAGGAA 
CTGTTTACTG GAGTGCCAGA CCGACCCTCG GCAGCTATGA GCTGGCAAGA TGGCCAAGTC 
TACTTTTTCA AGGGCAAAGA GTATTGGCGC CTTAACCAGC AACTTCGAGT GGCAAAGGGC 
TATCCCAGAA ATACGACACA CTGGATGCAC TGTGGTTCTC AGACTCCAGA CACTAACTCA 
TCAACCGGGG ACGTTACTCC TTCAACCACA GACACAGTCT TGGGTACCAC TCCATCAACC 
ATGGGCTCAA CCTTGGACAT TCCCTCAGCT ACAGACTCTG CCTCCCTCTC ATTCTCTGCT 
AATGTCACCC TGCTAGGGGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function.
Mucosal immunology9(4)974-85(2016 07)
Brauer R,Tureckova J,Kanchev I,Khoylou M,Skarda J,Prochazka J,Spoutil F,Beck IM,Zbodakova O,Kasparek P,Korinek V,Chalupsky K,Karhu T,Herzig KH,Hajduch M,Gregor M,Sedlacek R

Estrogen receptor ? controls MMP-19 expression in mouse ovaries during ovulation.
Reproduction (Cambridge, England)151(3)253-9(2016 Mar)
Nalvarte I,T?h?nen V,Lindeberg M,Varshney M,Gustafsson J?,Inzunza J

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.
Immunity43(1)200-9(2015 Jul)
Vanden Berghe T,Hulpiau P,Martens L,Vandenbroucke RE,Van Wonterghem E,Perry SW,Bruggeman I,Divert T,Choi SM,Vuylsteke M,Shestopalov VI,Libert C,Vandenabeele P

Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation.
Matrix biology : journal of the International Society for Matrix Biology44-46157-66(2015 May-Jul)
Newby AC

Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.
Proceedings of the National Academy of Sciences of the United States of America103(7)2322-7(2006 Feb)
Kobielak A,Fuchs E

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Mmp19 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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