PDCD1LG2 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	PDCD1LG2
Entrez Gene ID	58205
Full Name	programmed cell death 1 ligand 2
Synonyms	B7-DC,Btdc,F730015O22Rik,PD-L2
General protein information	Preferred Names programmed cell death 1 ligand 2 Names programmed cell death 1 ligand 2 PD-1 ligand 2 PDCD1 ligand 2 butyrophilin B7-DC butyrophilin-like protein programmed death ligand 2
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 19 Map Location: 19\|19 C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_021396.2	NP_067371.1	programmed cell death 1 ligand 2 precursor
XM_011247309.1	XP_011245611.1	programmed cell death 1 ligand 2 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PDCD1LG2	NP_079515.2
Canis lupus familiaris (dog)	PDCD1LG2	XP_852105.2
Pan troglodytes (chimpanzee)	PDCD1LG2	XP_001140776.1
Bos taurus (cattle)	PDCD1LG2	XP_002689648.1
Mus musculus (house mouse)	Pdcd1lg2	NP_067371.1
Rattus norvegicus (Norway rat)	Pdcd1lg2	NP_001101052.2
	PDCD1LG2	NP_001077068.1
Gallus gallus (chicken)	PDCD1LG2	XP_424812.4

Gene Ontology
Bibliography

Related articles in PubMed

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M
Nature551(7680)340-345(2017 Nov)

PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients.
Hossain MS, Kunter GM, El-Najjar VF, Jaye DL, Al-Kadhimi Z, Taofeek OK, Li JM, Waller EK
PloS one12(9)e0184254(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PD-L1 and PD-L2 in dermal fibroblasts is up-regulated by activated T cells in alopecia areata-affected skin.
Title: Increased expression of PD-L1 and PD-L2 in dermal fibroblasts from alopecia areata mice.

this study demonstrates that PD-L2 regulates the production of natural Abs against phosphorylcholine
Title: PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism.

findings indicate that the PerC B cells, including PD-L1/PD-L2 B-1a cells, may suppress T cells responding to allostimulation, and thus may be optimal for donor lymphocyte injection
Title: PD-L1/PD-L2-expressing B-1 cells inhibit alloreactive T cells in mice.

this study shows that PD-L2 is essential for effective CD4+ T cell immunity and determines the severity of malarial infections
Title: Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity.

injection of gene knockdown-dendritic cells induces intra-tumor T cell infiltration and release of inflammatory cytokines
Title: PDL-1/PDL-2 blockade in mice dendritic cells by RNAi techniques to induce antitumor immunity.

The following PDCD1LG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDCD1LG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22691	NM_021396.2 Latest version!	Mus musculus programmed cell death 1 ligand 2 (Pdcd1lg2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu22691	XM_011247309.1 Latest version!	Mus musculus programmed cell death 1 ligand 2 (Pdcd1lg2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PDCD1LG2 ( NM_021396.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_067371.1 Mus musculus programmed cell death 1 ligand 2 (Pdcd1lg2), mRNA.

Price & Availability↑

CloneID	OMu22691
Clone ID Related Accession (Same CDS sequence)	NM_021396.2 , XM_011247309.1
Accession Version	NM_021396.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	programmed cell death 1 ligand 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY749628.1, BC104138.1 and AC093339.17. On Aug 14, 2009 this sequence version replaced NM_021396.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK155002.1, AK089369.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCTCC TGCTGCCGAT ACTGAACCTG AGCTTACAAC TTCATCCTGT AGCAGCTTTA 
TTCACCGTGA CAGCCCCTAA AGAAGTGTAC ACCGTAGACG TCGGCAGCAG TGTGAGCCTG 
GAGTGCGATT TTGACCGCAG AGAATGCACT GAACTGGAAG GGATAAGAGC CAGTTTGCAG 
AAGGTAGAAA ATGATACGTC TCTGCAAAGT GAAAGAGCCA CCCTGCTGGA GGAGCAGCTG 
CCCCTGGGAA AGGCTTTGTT CCACATCCCT AGTGTCCAAG TGAGAGATTC CGGGCAGTAC 
CGTTGCCTGG TCATCTGCGG GGCCGCCTGG GACTACAAGT ACCTGACGGT GAAAGTCAAA 
GCTTCTTACA TGAGGATAGA CACTAGGATC CTGGAGGTTC CAGGTACAGG GGAGGTGCAG 
CTTACCTGCC AGGCTAGAGG TTATCCCCTA GCAGAAGTGT CCTGGCAAAA TGTCAGTGTT 
CCTGCCAACA CCAGCCACAT CAGGACCCCC GAAGGCCTCT ACCAGGTCAC CAGTGTTCTG 
CGCCTCAAGC CTCAGCCTAG CAGAAACTTC AGCTGCATGT TCTGGAATGC TCACATGAAG 
GAGCTGACTT CAGCCATCAT TGACCCTCTG AGTCGGATGG AACCCAAAGT CCCCAGAACG 
TGGCCACTTC ATGTTTTCAT CCCGGCCTGC ACCATCGCTT TGATCTTCCT GGCCATAGTG 
ATAATCCAGA GAAAGAGGAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067371.1
CDS	237..980
Translation	MLLLLPILNLSLQLHPVAALFTVTAPKEVYTVDVGSSVSLECDFDRRECTELEGIRASLQKVENDTSLQSERATLLEEQLPLGKALFHIPSVQVRDSGQYRCLVICGAAWDYKYLTVKVKASYMRIDTRILEVPGTGEVQLTCQARGYPLAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPSRNFSCMFWNAHMKELTSAIIDPLSRMEPKVPRTWPLHVFIPACTIALIFLAIVIIQRKRI

Target ORF information:

RefSeq Version	NM_021396.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus programmed cell death 1 ligand 2 (Pdcd1lg2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021396.2

ORF Insert Sequence:

ATGCTGCTCC TGCTGCCGAT ACTGAACCTG AGCTTACAAC TTCATCCTGT AGCAGCTTTA 
TTCACCGTGA CAGCCCCTAA AGAAGTGTAC ACCGTAGACG TCGGCAGCAG TGTGAGCCTG 
GAGTGCGATT TTGACCGCAG AGAATGCACT GAACTGGAAG GGATAAGAGC CAGTTTGCAG 
AAGGTAGAAA ATGATACGTC TCTGCAAAGT GAAAGAGCCA CCCTGCTGGA GGAGCAGCTG 
CCCCTGGGAA AGGCTTTGTT CCACATCCCT AGTGTCCAAG TGAGAGATTC CGGGCAGTAC 
CGTTGCCTGG TCATCTGCGG GGCCGCCTGG GACTACAAGT ACCTGACGGT GAAAGTCAAA 
GCTTCTTACA TGAGGATAGA CACTAGGATC CTGGAGGTTC CAGGTACAGG GGAGGTGCAG 
CTTACCTGCC AGGCTAGAGG TTATCCCCTA GCAGAAGTGT CCTGGCAAAA TGTCAGTGTT 
CCTGCCAACA CCAGCCACAT CAGGACCCCC GAAGGCCTCT ACCAGGTCAC CAGTGTTCTG 
CGCCTCAAGC CTCAGCCTAG CAGAAACTTC AGCTGCATGT TCTGGAATGC TCACATGAAG 
GAGCTGACTT CAGCCATCAT TGACCCTCTG AGTCGGATGG AACCCAAAGT CCCCAGAACG 
TGGCCACTTC ATGTTTTCAT CCCGGCCTGC ACCATCGCTT TGATCTTCCT GGCCATAGTG 
ATAATCCAGA GAAAGAGGAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDCD1LG2 ( XM_011247309.1 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_011245611.1 Mus musculus programmed cell death 1 ligand 2 (Pdcd1lg2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu22691
Clone ID Related Accession (Same CDS sequence)	NM_021396.2 , XM_011247309.1
Accession Version	XM_011247309.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	programmed cell death 1 ligand 2 isoform X1
Comment

ATGCTGCTCC TGCTGCCGAT ACTGAACCTG AGCTTACAAC TTCATCCTGT AGCAGCTTTA 
TTCACCGTGA CAGCCCCTAA AGAAGTGTAC ACCGTAGACG TCGGCAGCAG TGTGAGCCTG 
GAGTGCGATT TTGACCGCAG AGAATGCACT GAACTGGAAG GGATAAGAGC CAGTTTGCAG 
AAGGTAGAAA ATGATACGTC TCTGCAAAGT GAAAGAGCCA CCCTGCTGGA GGAGCAGCTG 
CCCCTGGGAA AGGCTTTGTT CCACATCCCT AGTGTCCAAG TGAGAGATTC CGGGCAGTAC 
CGTTGCCTGG TCATCTGCGG GGCCGCCTGG GACTACAAGT ACCTGACGGT GAAAGTCAAA 
GCTTCTTACA TGAGGATAGA CACTAGGATC CTGGAGGTTC CAGGTACAGG GGAGGTGCAG 
CTTACCTGCC AGGCTAGAGG TTATCCCCTA GCAGAAGTGT CCTGGCAAAA TGTCAGTGTT 
CCTGCCAACA CCAGCCACAT CAGGACCCCC GAAGGCCTCT ACCAGGTCAC CAGTGTTCTG 
CGCCTCAAGC CTCAGCCTAG CAGAAACTTC AGCTGCATGT TCTGGAATGC TCACATGAAG 
GAGCTGACTT CAGCCATCAT TGACCCTCTG AGTCGGATGG AACCCAAAGT CCCCAGAACG 
TGGCCACTTC ATGTTTTCAT CCCGGCCTGC ACCATCGCTT TGATCTTCCT GGCCATAGTG 
ATAATCCAGA GAAAGAGGAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011245611.1
Translation	MLLLLPILNLSLQLHPVAALFTVTAPKEVYTVDVGSSVSLECDFDRRECTELEGIRASLQKVENDTSLQSERATLLEEQLPLGKALFHIPSVQVRDSGQYRCLVICGAAWDYKYLTVKVKASYMRIDTRILEVPGTGEVQLTCQARGYPLAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPSRNFSCMFWNAHMKELTSAIIDPLSRMEPKVPRTWPLHVFIPACTIALIFLAIVIIQRKRI

Target ORF information:

RefSeq Version	XM_011247309.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus programmed cell death 1 ligand 2 (Pdcd1lg2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011247309.1

ORF Insert Sequence:

ATGCTGCTCC TGCTGCCGAT ACTGAACCTG AGCTTACAAC TTCATCCTGT AGCAGCTTTA 
TTCACCGTGA CAGCCCCTAA AGAAGTGTAC ACCGTAGACG TCGGCAGCAG TGTGAGCCTG 
GAGTGCGATT TTGACCGCAG AGAATGCACT GAACTGGAAG GGATAAGAGC CAGTTTGCAG 
AAGGTAGAAA ATGATACGTC TCTGCAAAGT GAAAGAGCCA CCCTGCTGGA GGAGCAGCTG 
CCCCTGGGAA AGGCTTTGTT CCACATCCCT AGTGTCCAAG TGAGAGATTC CGGGCAGTAC 
CGTTGCCTGG TCATCTGCGG GGCCGCCTGG GACTACAAGT ACCTGACGGT GAAAGTCAAA 
GCTTCTTACA TGAGGATAGA CACTAGGATC CTGGAGGTTC CAGGTACAGG GGAGGTGCAG 
CTTACCTGCC AGGCTAGAGG TTATCCCCTA GCAGAAGTGT CCTGGCAAAA TGTCAGTGTT 
CCTGCCAACA CCAGCCACAT CAGGACCCCC GAAGGCCTCT ACCAGGTCAC CAGTGTTCTG 
CGCCTCAAGC CTCAGCCTAG CAGAAACTTC AGCTGCATGT TCTGGAATGC TCACATGAAG 
GAGCTGACTT CAGCCATCAT TGACCCTCTG AGTCGGATGG AACCCAAAGT CCCCAGAACG 
TGGCCACTTC ATGTTTTCAT CCCGGCCTGC ACCATCGCTT TGATCTTCCT GGCCATAGTG 
ATAATCCAGA GAAAGAGGAT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.
Nature551(7680)340-345(2017 Nov)
Shalapour S,Lin XJ,Bastian IN,Brain J,Burt AD,Aksenov AA,Vrbanac AF,Li W,Perkins A,Matsutani T,Zhong Z,Dhar D,Navas-Molina JA,Xu J,Loomba R,Downes M,Yu RT,Evans RM,Dorrestein PC,Knight R,Benner C,Anstee QM,Karin M

PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients.
PloS one12(9)e0184254(2017)
Hossain MS,Kunter GM,El-Najjar VF,Jaye DL,Al-Kadhimi Z,Taofeek OK,Li JM,Waller EK

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PDCD1LG2 cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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