Angptl4 cDNA ORF clone, Mus musculus(house mouse)

Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase.
Yoshida K, Shimizugawa T, Ono M, Furukawa H
Journal of lipid research43(11)1770-2(2002 Nov)

1) ANGPTL4 is not involved in the triglyceride-lowering effect ofbile acids ; 2) ANGPTL4 promotes bile acids absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota.
Title: ANGPTL4 promotes bile acid absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota.

This study shows that TNF-alpha, by a Foxo1 dependent pathway, increases the transcription of ANGPTL4 which is secreted by the cells and causes inactivation of LPL.
Title: TNF-? decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4.

Angptl4-deficient mice show impaired insulin secretion and dysmorphic pancreatic islets.
Title: Angiopoietin-like peptide 4 regulates insulin secretion and islet morphology.

Angptl4 induces obesity-associated metabolic disorders. The present study suggested that Angptl4 promotes liver steatosis and lipolysis, in addition to impairing liver function; while Angptl4 improves glucose tolerance and insulin resistance, in addition to causing the downregulation of various insulin signaling pathway-associated genes.
Title: Angiopoietin-like protein?4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice.

physiological changes in adipose tissue ANGPTL4 expression during fasting and cold resulted in inverse changes in the amount of mature-glycosylated LPL in wild-type mice, but not Angptl4(-/-) mice. We conclude that ANGPTL4 promotes loss of intracellular LPL by stimulating LPL degradation after LPL processing in the endoplasmic reticulum (ER).
Title: Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes.