Noc3l cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Noc3l
Entrez Gene ID	57753
Full Name	NOC3 like DNA replication regulator
Synonyms	AF233884,Fad24
General protein information	Preferred Names NOC3 like DNA replication regulator Names nucleolar complex protein 3 homolog NOC3 protein homolog NOC3-like protein factor for adipocyte differentiation 24 nucleolar complex associated 3 homolog nucleolar complex-associated protein 3-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_021315.2	NP_067290.2	nucleolar complex protein 3 homolog

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	noc3	NP_596477.1
Arabidopsis thaliana (thale cress)	AT1G79150	NP_178036.2
Oryza sativa (rice)	Os06g0498500	NP_001057700.1
Bos taurus (cattle)	NOC3L	NP_001091477.1
Mus musculus (house mouse)	Noc3l	NP_067290.2
Caenorhabditis elegans (roundworm)	C37H5.5	NP_504292.2
Neurospora crassa	NCU00337	XP_957808.1
Pan troglodytes (chimpanzee)	NOC3L	XP_507934.2
Canis lupus familiaris (dog)	NOC3L	XP_003640035.1
Rattus norvegicus (Norway rat)	Noc3l	NP_001101993.1
Danio rerio (zebrafish)	noc3l	NP_001002863.1
Eremothecium gossypii	AGOS_ACR032C	NP_983435.1
Magnaporthe oryzae (rice blast fungus)	MGG_04996	XP_003712496.1
Xenopus tropicalis (tropical clawed frog)	noc3l	XP_002937223.2
Homo sapiens (human)	NOC3L	NP_071896.8
Gallus gallus (chicken)	NOC3L	XP_421670.4
Drosophila melanogaster (fruit fly)	CG1234	NP_649710.1
Saccharomyces cerevisiae (baker's yeast)	NOC3	NP_013102.1
Kluyveromyces lactis	KLLA0D09735g	XP_453496.1
	NOC3L	XP_002805824.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010308	XP_314636.3

Gene Ontology
Bibliography

Related articles in PubMed

Fad24, a Positive Regulator of Adipogenesis, Is Required for S Phase Re-entry of C2C12 Myoblasts Arrested in G0 Phase and Involved in p27(Kip1) Expression at the Protein Level.
Ochiai N, Nishizuka M, Osada S, Imagawa M
Biological & pharmaceutical bulletin39(5)807-14(2016 May)

[Molecular Mechanisms of Early-stage Adipocyte Differentiation and Multi-functional Roles of Newly Isolated Adipogenic Factors].
Imagawa M
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan136(4)649-58(2016)

Targeted disruption of fad24, a regulator of adipogenesis, causes pre-implantation embryonic lethality due to the growth defect at the blastocyst stage.
Ochiai N, Nishizuka M, Miyamoto T, Miyoshi I, Ikawa M, Osada S, Imagawa M
Biochemical and biophysical research communications438(2)301-5(2013 Aug)

FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation.
Johmura Y, Osada S, Nishizuka M, Imagawa M
Biological & pharmaceutical bulletin31(6)1092-5(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

fad24 may have an important role in the S phase re-entry of quiescent C2C12 cells through the regulation of p27(Kip1) at the protein level
Title: Fad24, a Positive Regulator of Adipogenesis, Is Required for S Phase Re-entry of C2C12 Myoblasts Arrested in G0 Phase and Involved in p27(Kip1) Expression at the Protein Level.

It contributes not only to adipogenesis but also to other physiological events like pre-implantation in embryonic developments.
Title: [Molecular Mechanisms of Early-stage Adipocyte Differentiation and Multi-functional Roles of Newly Isolated Adipogenic Factors].

fad24 is essential for pre-implantation in embryonic development, particularly for the progression to the blastocyst stage
Title: Targeted disruption of fad24, a regulator of adipogenesis, causes pre-implantation embryonic lethality due to the growth defect at the blastocyst stage.

fad24 plays positive roles in the proliferation of pre-confluent cells as well as adipogenesis
Title: FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation.

Taken together, these results reveal a novel role for fad24 in the repression of NF-kappaB activity and H-ras-mediated transformation.
Title: FAD24, a regulator of adipogenesis and DNA replication, inhibits H-RAS-mediated transformation by repressing NF-kappaB activity.

The following Noc3l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Noc3l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21478	NM_021315.2 Latest version!	Mus musculus NOC3 like DNA replication regulator (Noc3l), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Noc3l ( NM_021315.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067290.2 Mus musculus NOC3 like DNA replication regulator (Noc3l), mRNA.

Price & Availability↑

CloneID	OMu21478
Clone ID Related Accession (Same CDS sequence)	NM_021315.2
Accession Version	NM_021315.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2424bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	nucleolar complex protein 3 homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC101775.10, AC158131.4 and AC111023.12. On May 16, 2008 this sequence version replaced NM_021315.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK168944.1, BC031132.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGAAGGCGA GAAGAAATAA AAAGCAGGTC CCAAGCTTTC GCAAGTTGAT AAAAACTAGT 
AAAGTGAAAC TTGAAAACAA ATTGAAAAAT AAGCAATTTA AACAACAAAG TACCATCAAG 
AAGTACCGAA AAGAGCAGAG GAAACTAAGG CAAGCTGTAA AAGATGCTGT GTCTAAAAAA 
CCCATTCCGC TGGAGGACCC AAAGAGCAAA CGGCCAGTTA AAAGGATGGA GAGGGAGGAG 
GACGAGGAGG AAGAAGCCCT GCCTTTGGAT ATGATGGACG AGGATGACCT ACAGCTGATG 
AAGGATTTAG GACAAAAGGC ATCTTTTCTC ACAAGAGATC TCTCTTCTAG TGAACCAGTC 
CATATCAAGA AACGAAAGCA TGAGAGTGTG ATAGAGAAAT ATGAAAAAGT GCCAAGAACT 
CTGCAAACCG CACCGGAGAA GGAGTTGATT CACCTGCTCC CTATCAAGGA CAAGAGTGGC 
ATCATCCCTC AGGCTCGGGA GAAGCCGGTC ACTGACGTGC AGCAAGAAGA GGAGGCTGAG 
GAAGAGCTGG AAGATGAGGA AGAGGTCATT GAAGACCCCA GGAAGGAGCT GACCATAGAA 
GAGCATGTGA TCGAGAGAAA GAAGAAACTG CAGGACAAGA AAATACAGAT TGCAGCCTTA 
GCATCTGCTA TTCTGTCAGA TCCAGAAAGT CATATTAAAA AACTGAAAGA GTTGCGTTCC 
ATGCTGATGG AGCAGGACCC TGATGTGGCT GTCACTGTCC GGAAGTTGGT TATCATCTCA 
CTGATGGAGC TGTTTAAGGA CATCACTCCC TCGTATAAAA TCCGGCCTCT AACCGAAGCA 
GAAAAATCTA CCAAGATTCG TAAAGAAACC CAGAAGTTAA GAGAATTTGA AGAAGGCCTG 
GTTAGCCAAT ACAAATTTTA TTTGGAAAAT CTGGAGCAAA TAGTTAAAGA CTGGAAGCAA 
AGGAAGCTGA AGAAGAGCAA TGTGGTGTCC TTAAAGGCCT ACAAAGGGCT GGCTGAAGTG 
GCAGTGAAGA GCCTGTGTGA GCTGTTGGTG GCCCTGCCCC ATTTTAACTT TCACAACAAC 
ATCATTGTAC TGATTGTCCC TCTGATGAAC GATGGGTCAA AACCGGTATC TGAAATGTGT 
TGCGAAGCAG TAAAGAAACT CTTTAAACAA GATAAATTAG GCCAAGCTTC TCTGGGTGTC 
ATTAAAGTCA TCTCTGGTTT TGTAAAGGGC AGAAATTACG AAGTTAGGCC AGAGATGTTA 
AAAACATTTT TATGCCTGCG GATCAAGGAG GTAGAAGTGA AAAAAGATAC AGAGGACATT 
AACAAGCCCA AAAGGTTCAT GACTTTCAAG GAGAAGAGAA AAACTCTATC AAGAATGCAA 
AGAAAGTGGA AGAAAGCAGA AGAGAAACTA GAGCGGGAAC TTCGGGAGGC CGAAGCTTCG 
GAAAGCACTG AGAAAAAGCT GAAACTGCAC ACCGAGACTC TGAATATTGT GTTTGTGACC 
TACTTCAGAA TACTGAAGAA GGCCCAGAAG TCACCTCTTC TGCCAGCGGT TCTAGAAGGC 
CTTGCCAAGT TTGCACATCT TATAAATGTG GAGTTTTTTG ATGATTTATT AGTGGTTCTT 
CATACCCTCA TTGAGTCTGG GGAGCTAAGT TATCAAGAAA GTCTCCACTG TGTTCAAACT 
GCTTTTCATA TTCTTTCTGG ACAAGGTGAT GTTTTAAATA TTGACCCGAT GAAATTCTAT 
ACACATCTCT ACAAGACACT GTTCACATTA CATGCAGGTG CCACCAACGA CGGCATTGAG 
ATTGTGCTCC ACTGCCTCGA TGTCATGCTA AGCAAGCGCA GAAAGCAGGT TTCTCATCAG 
CGAGCTCTTG CCTTCATCAA ACGCCTTTGT ACACTTGCTC TGCAGGTTCT TCCAAATTCA 
AGCATTGGCC TTTTAGCAAC TACCAGGATA TTGATGCATA CTTTTCCCAG AACAGATCTC 
TTGCTTGATA ACGAGTCTCA GGGCAGCGGG GTGTTTCTAC CTGAGCTGGA GGAGCCAGAG 
TACTGTAATG CACAGAACAC CGCACTGTGG GAGCTGCACA CGCTTCGGAG ACATTACCAT 
CCCATTGTGC GAAGGTTTGC AGCACATCTG CTTGCTGGGG CACCATCCGA AGGCTCTGAG 
GCCCTCAAGC CCGAGCTGAG CCGAAGATCT GCAGTTGAAC TTTTTGAGAC TTACAGCATG 
GCAGCAATGA CATTCAATCC GCCTGTTGAA TCTTCACACT CCAAAAGGAA GGATAAATTT 
TTACCAGGAG ACTCATTTTT GAATGAAGAT TTAAATCAAC TAATCAAAAG ATACTGTAAT 
GAAGCTGCTC CTGAGACACC GCTGGATTTC GCCAAGTGTT TGGAAAGCTC ATCCCGGCAG 
TACAGAGTGA ATGGACTGTC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067290.2
CDS	137..2560
Translation	MKARRNKKQVPSFRKLIKTSKVKLENKLKNKQFKQQSTIKKYRKEQRKLRQAVKDAVSKKPIPLEDPKSKRPVKRMEREEDEEEEALPLDMMDEDDLQLMKDLGQKASFLTRDLSSSEPVHIKKRKHESVIEKYEKVPRTLQTAPEKELIHLLPIKDKSGIIPQAREKPVTDVQQEEEAEEELEDEEEVIEDPRKELTIEEHVIERKKKLQDKKIQIAALASAILSDPESHIKKLKELRSMLMEQDPDVAVTVRKLVIISLMELFKDITPSYKIRPLTEAEKSTKIRKETQKLREFEEGLVSQYKFYLENLEQIVKDWKQRKLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFHNNIIVLIVPLMNDGSKPVSEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTFLCLRIKEVEVKKDTEDINKPKRFMTFKEKRKTLSRMQRKWKKAEEKLERELREAEASESTEKKLKLHTETLNIVFVTYFRILKKAQKSPLLPAVLEGLAKFAHLINVEFFDDLLVVLHTLIESGELSYQESLHCVQTAFHILSGQGDVLNIDPMKFYTHLYKTLFTLHAGATNDGIEIVLHCLDVMLSKRRKQVSHQRALAFIKRLCTLALQVLPNSSIGLLATTRILMHTFPRTDLLLDNESQGSGVFLPELEEPEYCNAQNTALWELHTLRRHYHPIVRRFAAHLLAGAPSEGSEALKPELSRRSAVELFETYSMAAMTFNPPVESSHSKRKDKFLPGDSFLNEDLNQLIKRYCNEAAPETPLDFAKCLESSSRQYRVNGLS

Target ORF information:

RefSeq Version	NM_021315.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus NOC3 like DNA replication regulator (Noc3l), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021315.2

ORF Insert Sequence:

ATGAAGGCGA GAAGAAATAA AAAGCAGGTC CCAAGCTTTC GCAAGTTGAT AAAAACTAGT 
AAAGTGAAAC TTGAAAACAA ATTGAAAAAT AAGCAATTTA AACAACAAAG TACCATCAAG 
AAGTACCGAA AAGAGCAGAG GAAACTAAGG CAAGCTGTAA AAGATGCTGT GTCTAAAAAA 
CCCATTCCGC TGGAGGACCC AAAGAGCAAA CGGCCAGTTA AAAGGATGGA GAGGGAGGAG 
GACGAGGAGG AAGAAGCCCT GCCTTTGGAT ATGATGGACG AGGATGACCT ACAGCTGATG 
AAGGATTTAG GACAAAAGGC ATCTTTTCTC ACAAGAGATC TCTCTTCTAG TGAACCAGTC 
CATATCAAGA AACGAAAGCA TGAGAGTGTG ATAGAGAAAT ATGAAAAAGT GCCAAGAACT 
CTGCAAACCG CACCGGAGAA GGAGTTGATT CACCTGCTCC CTATCAAGGA CAAGAGTGGC 
ATCATCCCTC AGGCTCGGGA GAAGCCGGTC ACTGACGTGC AGCAAGAAGA GGAGGCTGAG 
GAAGAGCTGG AAGATGAGGA AGAGGTCATT GAAGACCCCA GGAAGGAGCT GACCATAGAA 
GAGCATGTGA TCGAGAGAAA GAAGAAACTG CAGGACAAGA AAATACAGAT TGCAGCCTTA 
GCATCTGCTA TTCTGTCAGA TCCAGAAAGT CATATTAAAA AACTGAAAGA GTTGCGTTCC 
ATGCTGATGG AGCAGGACCC TGATGTGGCT GTCACTGTCC GGAAGTTGGT TATCATCTCA 
CTGATGGAGC TGTTTAAGGA CATCACTCCC TCGTATAAAA TCCGGCCTCT AACCGAAGCA 
GAAAAATCTA CCAAGATTCG TAAAGAAACC CAGAAGTTAA GAGAATTTGA AGAAGGCCTG 
GTTAGCCAAT ACAAATTTTA TTTGGAAAAT CTGGAGCAAA TAGTTAAAGA CTGGAAGCAA 
AGGAAGCTGA AGAAGAGCAA TGTGGTGTCC TTAAAGGCCT ACAAAGGGCT GGCTGAAGTG 
GCAGTGAAGA GCCTGTGTGA GCTGTTGGTG GCCCTGCCCC ATTTTAACTT TCACAACAAC 
ATCATTGTAC TGATTGTCCC TCTGATGAAC GATGGGTCAA AACCGGTATC TGAAATGTGT 
TGCGAAGCAG TAAAGAAACT CTTTAAACAA GATAAATTAG GCCAAGCTTC TCTGGGTGTC 
ATTAAAGTCA TCTCTGGTTT TGTAAAGGGC AGAAATTACG AAGTTAGGCC AGAGATGTTA 
AAAACATTTT TATGCCTGCG GATCAAGGAG GTAGAAGTGA AAAAAGATAC AGAGGACATT 
AACAAGCCCA AAAGGTTCAT GACTTTCAAG GAGAAGAGAA AAACTCTATC AAGAATGCAA 
AGAAAGTGGA AGAAAGCAGA AGAGAAACTA GAGCGGGAAC TTCGGGAGGC CGAAGCTTCG 
GAAAGCACTG AGAAAAAGCT GAAACTGCAC ACCGAGACTC TGAATATTGT GTTTGTGACC 
TACTTCAGAA TACTGAAGAA GGCCCAGAAG TCACCTCTTC TGCCAGCGGT TCTAGAAGGC 
CTTGCCAAGT TTGCACATCT TATAAATGTG GAGTTTTTTG ATGATTTATT AGTGGTTCTT 
CATACCCTCA TTGAGTCTGG GGAGCTAAGT TATCAAGAAA GTCTCCACTG TGTTCAAACT 
GCTTTTCATA TTCTTTCTGG ACAAGGTGAT GTTTTAAATA TTGACCCGAT GAAATTCTAT 
ACACATCTCT ACAAGACACT GTTCACATTA CATGCAGGTG CCACCAACGA CGGCATTGAG 
ATTGTGCTCC ACTGCCTCGA TGTCATGCTA AGCAAGCGCA GAAAGCAGGT TTCTCATCAG 
CGAGCTCTTG CCTTCATCAA ACGCCTTTGT ACACTTGCTC TGCAGGTTCT TCCAAATTCA 
AGCATTGGCC TTTTAGCAAC TACCAGGATA TTGATGCATA CTTTTCCCAG AACAGATCTC 
TTGCTTGATA ACGAGTCTCA GGGCAGCGGG GTGTTTCTAC CTGAGCTGGA GGAGCCAGAG 
TACTGTAATG CACAGAACAC CGCACTGTGG GAGCTGCACA CGCTTCGGAG ACATTACCAT 
CCCATTGTGC GAAGGTTTGC AGCACATCTG CTTGCTGGGG CACCATCCGA AGGCTCTGAG 
GCCCTCAAGC CCGAGCTGAG CCGAAGATCT GCAGTTGAAC TTTTTGAGAC TTACAGCATG 
GCAGCAATGA CATTCAATCC GCCTGTTGAA TCTTCACACT CCAAAAGGAA GGATAAATTT 
TTACCAGGAG ACTCATTTTT GAATGAAGAT TTAAATCAAC TAATCAAAAG ATACTGTAAT 
GAAGCTGCTC CTGAGACACC GCTGGATTTC GCCAAGTGTT TGGAAAGCTC ATCCCGGCAG 
TACAGAGTGA ATGGACTGTC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fad24, a Positive Regulator of Adipogenesis, Is Required for S Phase Re-entry of C2C12 Myoblasts Arrested in G0 Phase and Involved in p27(Kip1) Expression at the Protein Level.
Biological & pharmaceutical bulletin39(5)807-14(2016 May)
Ochiai N,Nishizuka M,Osada S,Imagawa M

[Molecular Mechanisms of Early-stage Adipocyte Differentiation and Multi-functional Roles of Newly Isolated Adipogenic Factors].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan136(4)649-58(2016)
Imagawa M

Targeted disruption of fad24, a regulator of adipogenesis, causes pre-implantation embryonic lethality due to the growth defect at the blastocyst stage.
Biochemical and biophysical research communications438(2)301-5(2013 Aug)
Ochiai N,Nishizuka M,Miyamoto T,Miyoshi I,Ikawa M,Osada S,Imagawa M

FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation.
Biological & pharmaceutical bulletin31(6)1092-5(2008 Jun)
Johmura Y,Osada S,Nishizuka M,Imagawa M

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Noc3l cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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