Jph3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Jph3
Entrez Gene ID	57340
Full Name	junctophilin 3
Synonyms	JP-3,Jp3
General protein information	Preferred Names junctophilin 3 Names junctophilin-3 junctophilin type 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_020605.3	NP_065630.1	junctophilin-3

Pathways from BioSystems

Homologies

Homo sapiens (human)	JPH3	NP_065706.2
Pan troglodytes (chimpanzee)	JPH3	XP_001153256.2
Canis lupus familiaris (dog)	JPH3	XP_546789.2
Mus musculus (house mouse)	Jph3	NP_065630.1
Rattus norvegicus (Norway rat)	Jph3	NP_001100907.1
Gallus gallus (chicken)	JPH3	XP_414192.1
Danio rerio (zebrafish)	LOC569861	NP_001116174.1
	LOC704611	XP_001092976.2
Bos taurus (cattle)	JPH3	NP_001192548.1
Xenopus tropicalis (tropical clawed frog)	jph3	XP_002936140.2

Gene Ontology
Bibliography

Related articles in PubMed

Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion.
Li L, Pan ZF, Huang X, Wu BW, Li T, Kang MX, Ge RS, Hu XY, Zhang YH, Ge LJ, Zhu DY, Wu YL, Lou YJ
Cell death & disease7(6)e2275(2016 Jun)

Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.
Ikeda A, Miyazaki T, Kakizawa S, Okuno Y, Tsuchiya S, Myomoto A, Saito SY, Yamamoto T, Yamazaki T, Iino M, Tsujimoto G, Watanabe M, Takeshima H
Biochemical and biophysical research communications363(3)835-9(2007 Nov)

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM
Molecular & cellular proteomics : MCP6(2)283-93(2007 Feb)

Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.
Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito SY, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H
Proceedings of the National Academy of Sciences of the United States of America103(28)10811-6(2006 Jul)

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL
Molecular & cellular proteomics : MCP5(5)914-22(2006 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression of JPH isoforms was examined in human and mouse pancreatic tissues, and JPH3 expression was found in both the beta cells.
Title: Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion.

Gene expression was slightly altered in the JP-3 and JP-4 Knockout cerebellum.
Title: Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.

Motor discoordination in mutant mice lacking junctophilin type 3
Title: Motor discoordination in mutant mice lacking junctophilin type 3.

The following Jph3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Jph3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12062	NM_020605.3 Latest version!	Mus musculus junctophilin 3 (Jph3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$433.30 $619.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Jph3 ( NM_020605.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_065630.1 Mus musculus junctophilin 3 (Jph3), mRNA.

Price & Availability↑

CloneID	OMu12062
Clone ID Related Accession (Same CDS sequence)	NM_020605.3
Accession Version	NM_020605.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2235bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	junctophilin-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY718602.1, AB024449.1 and AC121975.3. On Mar 24, 2011 this sequence version replaced NM_020605.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.147366.1, SRR1660817.309665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCAGTG GGGGTAGGTT TAATTTTGAC GATGGAGGGT CCTACTGCGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCGA AGGGCCAGGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT TGAGGTGCTG GGCGTCTACA CCTGGCCAAG CGGCAACACG 
TACCAAGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTTAAGGGGC GCTACGGGGT GCGGGAGTGC 
ACGGGCAACG GAGCCAAATA CGAAGGGACC TGGAGCAACG GACTGCAGGA TGGCTACGGC 
ACGGAGACCT ACTCGGATGG AGGAACGTAT CAGGGCCAAT GGGTTGGTGG CATGCGCCAG 
GGCTACGGTG TGCGGCAGAG TGTCCCTTAT GGCATGGCCG CAGTCATCCG TTCGCCCCTG 
AGGACCTCCA TCAACTCCCT GCGCAGCGAG CACACCAACG GGGCGGCACT GCACCCGGAC 
GCCTCCCCGG CAGTGGCCGG CAGTCCGGCC GTGTCCCGTG GTGGCTTCGT GCTGGTGGCC 
CACAGTGACT CGGAGATCCT CAAGAGCAAG AAGAAGGGAC TGTTCCGGCG CTCGCTGCTG 
AGCGGCCTGA AGCTACGCAA GTCTGAGTCC AAGAGCAGCC TGGCCAGCCA GCGCAGCAAG 
CAGAGCTCCT TCCGCAGCGA GGCCGGAATG AGCACCGTGA GCTCCACGGC CAGCGACATC 
CACTCCACCA TCAGCCTGGG CGAGGCCGAG GCTGAGCTGG CGGTCATTGA GGACGACATC 
GACGCCACTA CCACCGAGAC CTACGTGGGT GAATGGAAGA ACGACAAACG CTCGGGCTTC 
GGTGTGAGCC AGCGCTCGGA CGGGCTTAAG TATGAGGGCG AGTGGGTCAG CAACCGCCGG 
CATGGGTACG GGTGCATGAC TTTCCCCGAC GGCACCAAGG AGGAGGGGAA GTACAAGCAG 
AACGTGCTCG TGAGCGGCAA ACGCAAGAAT CTCATCCCGC TGCGTGCCAG CAAGATCCGG 
GAGAAGGTGG ACCGGGCCGT GGAGGCAGCC GAGAGGGCGG CCACCATCGC CAAGCAGAAA 
GCCGAGATCG CTGCGTCCAG GACCTCCCAC TCACGGGCCA AGGCTGAGGC AGCACTTACT 
GCGGCTCAGA AAGCCCAGGA GGAAGCGCGG ATCGCCAGGA TCACTGCCAA AGAGTTCTCT 
CCCTCCTTCC AGCACAGGGA AAACGGGCTT GAGTACCAGA GGCCAAAGCA CCAGATGTCC 
TGCGATGATA TCGAGGTGCT CTCCACCGGG ACACCCCTAC AGCAGGAGAG CCCCGAGCTG 
TACCGAAAGG GCACCACCCC TTCTGATCTG ACCCCTGACG ACAGTCCCCT GCAGAGCTTC 
CCCGCCAGCC CCACATCTAC CCCTCCGCCA GCTCCTGCCT CCAGGACCAA GATGGCCCAC 
TTCTCCAGGC AGGTCTCCGT GGACGAGGAG CGAAGCGGGG ACATCCAGAT GCTCCTCGAG 
GGCCGCGGAG GGGACTATGC CCGCAACAGC TGGGGCGAGG AGAAGGCTGG GGCCTCTAGG 
GGTATCCGCA GCGGTGCCCT ACGCAGCGGC CAGCCCACTG AGGACTTCCG CACCCGGGGC 
TCAGGCCACA AGCAGCCTGG GAACCCCAAG CCCCGGGAGC GGCGGACGGA GTCCCCCACC 
ACGTTCTCAT GGACTTCCCA CCACCGGGCA GGCAATCCCT GTTCTGGGGG CCCCAAGCTG 
CTAGAGCCAG ATGAGGAGCA GCTGAGCAAC TACAAGCTGG AGATGAAGCC CTTACTGAGG 
ATGGATGCCT GTCCACAGGA TACGCACCCA CAGAGACGGC GTCATAGCCG GGGTGCTGGG 
GGGGACAGGG GCTTCGGGCT ACAGAGACTG AGGTCCAAGT CCCAAAACAA GGAGAACCTT 
AGGCCAGCCT CCTCTGCAGA ACCCACGGTG CAGAAACTCG AGAGCCTGCG GCTGGGGGAC 
CGGCCCGAGC CCCGTCTGCT GCGTTGGGAC CTGACCTTCT CCCCACCCCA GAAGTCCCTG 
CCTGTTGCAC TCGAGTCTGA CGAGGAGACT GGAGATGAGC TCAAGTCCAG CACGGGCTCA 
GCTCCCATCT TGGTCGTCAT GGTGATCCTG CTCAACATTG GAGTCGCCAT TTTGTTTATT 
AACTTTTTCA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065630.1
CDS	65..2299
Translation	MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECTGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGAALHPDASPAVAGSPAVSRGGFVLVAHSDSEILKSKKKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWVSNRRHGYGCMTFPDGTKEEGKYKQNVLVSGKRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAASRTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSFQHRENGLEYQRPKHQMSCDDIEVLSTGTPLQQESPELYRKGTTPSDLTPDDSPLQSFPASPTSTPPPAPASRTKMAHFSRQVSVDEERSGDIQMLLEGRGGDYARNSWGEEKAGASRGIRSGALRSGQPTEDFRTRGSGHKQPGNPKPRERRTESPTTFSWTSHHRAGNPCSGGPKLLEPDEEQLSNYKLEMKPLLRMDACPQDTHPQRRRHSRGAGGDRGFGLQRLRSKSQNKENLRPASSAEPTVQKLESLRLGDRPEPRLLRWDLTFSPPQKSLPVALESDEETGDELKSSTGSAPILVVMVILLNIGVAILFINFFI

Target ORF information:

RefSeq Version	NM_020605.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus junctophilin 3 (Jph3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020605.3

ORF Insert Sequence:

ATGTCCAGTG GGGGTAGGTT TAATTTTGAC GATGGAGGGT CCTACTGCGG AGGCTGGGAG 
GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCGA AGGGCCAGGG CGAATACACC 
GGCTCGTGGA GCCACGGCTT TGAGGTGCTG GGCGTCTACA CCTGGCCAAG CGGCAACACG 
TACCAAGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 
TGGGTGTACA AGGGCGAGTG GACGCACGGA TTTAAGGGGC GCTACGGGGT GCGGGAGTGC 
ACGGGCAACG GAGCCAAATA CGAAGGGACC TGGAGCAACG GACTGCAGGA TGGCTACGGC 
ACGGAGACCT ACTCGGATGG AGGAACGTAT CAGGGCCAAT GGGTTGGTGG CATGCGCCAG 
GGCTACGGTG TGCGGCAGAG TGTCCCTTAT GGCATGGCCG CAGTCATCCG TTCGCCCCTG 
AGGACCTCCA TCAACTCCCT GCGCAGCGAG CACACCAACG GGGCGGCACT GCACCCGGAC 
GCCTCCCCGG CAGTGGCCGG CAGTCCGGCC GTGTCCCGTG GTGGCTTCGT GCTGGTGGCC 
CACAGTGACT CGGAGATCCT CAAGAGCAAG AAGAAGGGAC TGTTCCGGCG CTCGCTGCTG 
AGCGGCCTGA AGCTACGCAA GTCTGAGTCC AAGAGCAGCC TGGCCAGCCA GCGCAGCAAG 
CAGAGCTCCT TCCGCAGCGA GGCCGGAATG AGCACCGTGA GCTCCACGGC CAGCGACATC 
CACTCCACCA TCAGCCTGGG CGAGGCCGAG GCTGAGCTGG CGGTCATTGA GGACGACATC 
GACGCCACTA CCACCGAGAC CTACGTGGGT GAATGGAAGA ACGACAAACG CTCGGGCTTC 
GGTGTGAGCC AGCGCTCGGA CGGGCTTAAG TATGAGGGCG AGTGGGTCAG CAACCGCCGG 
CATGGGTACG GGTGCATGAC TTTCCCCGAC GGCACCAAGG AGGAGGGGAA GTACAAGCAG 
AACGTGCTCG TGAGCGGCAA ACGCAAGAAT CTCATCCCGC TGCGTGCCAG CAAGATCCGG 
GAGAAGGTGG ACCGGGCCGT GGAGGCAGCC GAGAGGGCGG CCACCATCGC CAAGCAGAAA 
GCCGAGATCG CTGCGTCCAG GACCTCCCAC TCACGGGCCA AGGCTGAGGC AGCACTTACT 
GCGGCTCAGA AAGCCCAGGA GGAAGCGCGG ATCGCCAGGA TCACTGCCAA AGAGTTCTCT 
CCCTCCTTCC AGCACAGGGA AAACGGGCTT GAGTACCAGA GGCCAAAGCA CCAGATGTCC 
TGCGATGATA TCGAGGTGCT CTCCACCGGG ACACCCCTAC AGCAGGAGAG CCCCGAGCTG 
TACCGAAAGG GCACCACCCC TTCTGATCTG ACCCCTGACG ACAGTCCCCT GCAGAGCTTC 
CCCGCCAGCC CCACATCTAC CCCTCCGCCA GCTCCTGCCT CCAGGACCAA GATGGCCCAC 
TTCTCCAGGC AGGTCTCCGT GGACGAGGAG CGAAGCGGGG ACATCCAGAT GCTCCTCGAG 
GGCCGCGGAG GGGACTATGC CCGCAACAGC TGGGGCGAGG AGAAGGCTGG GGCCTCTAGG 
GGTATCCGCA GCGGTGCCCT ACGCAGCGGC CAGCCCACTG AGGACTTCCG CACCCGGGGC 
TCAGGCCACA AGCAGCCTGG GAACCCCAAG CCCCGGGAGC GGCGGACGGA GTCCCCCACC 
ACGTTCTCAT GGACTTCCCA CCACCGGGCA GGCAATCCCT GTTCTGGGGG CCCCAAGCTG 
CTAGAGCCAG ATGAGGAGCA GCTGAGCAAC TACAAGCTGG AGATGAAGCC CTTACTGAGG 
ATGGATGCCT GTCCACAGGA TACGCACCCA CAGAGACGGC GTCATAGCCG GGGTGCTGGG 
GGGGACAGGG GCTTCGGGCT ACAGAGACTG AGGTCCAAGT CCCAAAACAA GGAGAACCTT 
AGGCCAGCCT CCTCTGCAGA ACCCACGGTG CAGAAACTCG AGAGCCTGCG GCTGGGGGAC 
CGGCCCGAGC CCCGTCTGCT GCGTTGGGAC CTGACCTTCT CCCCACCCCA GAAGTCCCTG 
CCTGTTGCAC TCGAGTCTGA CGAGGAGACT GGAGATGAGC TCAAGTCCAG CACGGGCTCA 
GCTCCCATCT TGGTCGTCAT GGTGATCCTG CTCAACATTG GAGTCGCCAT TTTGTTTATT 
AACTTTTTCA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion.
Cell death & disease7(6)e2275(2016 Jun)
Li L,Pan ZF,Huang X,Wu BW,Li T,Kang MX,Ge RS,Hu XY,Zhang YH,Ge LJ,Zhu DY,Wu YL,Lou YJ

Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.
Biochemical and biophysical research communications363(3)835-9(2007 Nov)
Ikeda A,Miyazaki T,Kakizawa S,Okuno Y,Tsuchiya S,Myomoto A,Saito SY,Yamamoto T,Yamazaki T,Iino M,Tsujimoto G,Watanabe M,Takeshima H

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Molecular & cellular proteomics : MCP6(2)283-93(2007 Feb)
Munton RP,Tweedie-Cullen R,Livingstone-Zatchej M,Weinandy F,Waidelich M,Longo D,Gehrig P,Potthast F,Rutishauser D,Gerrits B,Panse C,Schlapbach R,Mansuy IM

Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.
Proceedings of the National Academy of Sciences of the United States of America103(28)10811-6(2006 Jul)
Moriguchi S,Nishi M,Komazaki S,Sakagami H,Miyazaki T,Masumiya H,Saito SY,Watanabe M,Kondo H,Yawo H,Fukunaga K,Takeshima H

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Molecular & cellular proteomics : MCP5(5)914-22(2006 May)
Trinidad JC,Specht CG,Thalhammer A,Schoepfer R,Burlingame AL

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Jph3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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