Htr3b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Htr3b
Entrez Gene ID	57014
Full Name	5-hydroxytryptamine (serotonin) receptor 3B
Synonyms	5-HT3B
General protein information	Preferred Names 5-hydroxytryptamine (serotonin) receptor 3B Names 5-hydroxytryptamine receptor 3B 5-HT3 receptor subunit B 5-HT3-B serotonin receptor 3B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A5.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_020274.4	NP_064670.1	5-hydroxytryptamine receptor 3B precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HTR3B	XP_522188.2
Danio rerio (zebrafish)	LOC571632	XP_700329.5
Xenopus tropicalis (tropical clawed frog)	htr3b	XP_004916568.1
Homo sapiens (human)	HTR3B	NP_006019.1
Mus musculus (house mouse)	Htr3b	NP_064670.1
Rattus norvegicus (Norway rat)	Htr3b	NP_071525.1
	HTR3B	XP_001085912.2
Canis lupus familiaris (dog)	HTR3B	XP_853967.1
Bos taurus (cattle)	HTR3B	XP_002693062.1

Gene Ontology
Bibliography

Related articles in PubMed

Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT
Bhattarai Y, Schmidt BA, Linden DR, Larson ED, Grover M, Beyder A, Farrugia G, Kashyap PC
American journal of physiology. Gastrointestinal and liver physiology313(1)G80-G87(2017 Jul)

5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival.
Lv J, Wang L, Gao Y, Ding YQ, Liu F
The Journal of experimental medicine214(2)529-545(2017 Feb)

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH
PloS one12(7)e0180682(2017)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

It was concluded that epithelial 5-HT3 receptor may function as a mediator of gut microbiota-driven change in intestinal secretion.
Title: Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT

Results indicate that vestibular ganglion cells express functional 5-HT3 receptor channels (with 5-HT3a and 5-HT3b subunits) and might play a modulatory role in the peripheral vestibular nervous system
Title: 5-HT(3) receptor expression in the mouse vestibular ganglion.

Both serotonin and granisetron bind to an AA binding site in the heteromeric 5-HT3AB receptor.
Title: Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor.

5-HT mediates enhanced neurogenic contractions of the mouse bladder muscle by an action at 5-HT(3) receptors. The presence of the 5-HT(3) receptor was confirmed by the expression of both 5-HT(3A) and 5-HT(3B) receptor subunits.
Title: Demonstration of 5-HT(3) receptor function and expression in the mouse bladder.

The 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells.(rat 5-Ht3B)
Title: Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells.

The following Htr3b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Htr3b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11986	NM_020274.4 Latest version!	Mus musculus 5-hydroxytryptamine (serotonin) receptor 3B (Htr3b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Htr3b ( NM_020274.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064670.1 Mus musculus 5-hydroxytryptamine (serotonin) receptor 3B (Htr3b), mRNA.

Price & Availability↑

CloneID	OMu11986
Clone ID Related Accession (Same CDS sequence)	NM_020274.4
Accession Version	NM_020274.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1314bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	5-hydroxytryptamine receptor 3B precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK085213.1. On Sep 19, 2009 this sequence version replaced NM_020274.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK085213.1, BC046990.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATTCTTC TGTGGTCCTG CCTCCTGGTG GCTGTAGTAG GTATCCTAGG TACAGCGACA 
CCTCAGCCTG GGAATTCTTC TCTGCACCGT CTCACCAGGC AGCTCTTACA ACAGTACCAC 
AAGGAGGTCA GACCAGTTTA CAACTGGGCT GAGGCCACCA CTGTCTACCT GGACCTTTGC 
GTCCATGCTG TATTGGATGT GGATGTGCAG AATCAAAAAT TAAAGACAAG CGTGTGGTAC 
CGAGAGGTTT GGAACGATGA GTTTTTGTCC TGGAACTCTA GTCTGTTCGA TGAGATTCAA 
GAGATCTCTC TCCCTCTCAG TGCCCTCTGG GCCCCTGATA TCATCATTAA TGAGTTTGTG 
GATGTTGAAA GATCTCCTGA CCTGCCCTAT GTATACGTGA ACTCTTCTGG CACCATTAGA 
AACCACAAGC CCATCCAGGT GGTCTCCGCA TGCAGTTTGC AGACATATGC TTTCCCCTTT 
GATATCCAGA ACTGCAGCCT CACCTTTAAT AGCATTCTGC ACACAGTGGA AGACATAGAC 
CTGGGCTTCC TGAGGAATAG AGAAGACATC GAGAATGACA AAAGGGCTTT TATGAATGAC 
AGTGAGTGGC AGCTTCTTTC TGTGTCCTCT ACTTACCACA TCCGGCAGAG CAGCGCTGGA 
GACTTCGCAC AGATTCGGTT CAACGTAGTG ATCCGCAGAT GTCCATTGGC CTACGTTGTG 
AGCCTCTTGA TACCTAGCAT CTTCCTGATG CTCGTGGACC TGGGAAGCTT CTACTTGCCC 
CCCAACTGCC GTGCAAGAAT TGTGTTCAAG ACCAATGTGC TGGTGGGCTA TACGGTCTTC 
AGGGTCAACA TGTCTGATGA AGTGCCAAGA AGTGCAGGGT GCACACCTCT GATTGGGGTC 
TTCTTTACCG TCTGCATGGC CCTCTTGGTT CTCAGTTTAT CCAAATCCAT CTTGCTGATC 
AAATTCCTCT ATGAGGAGCG GCACAGTGGG CAAGAACGGC CTCTTATGTG CCTTCAAGGC 
GACTCTGATG CCGAGGAGTC TAGATTGTAC CTCGGGGCTC CACGTGCTGA CGTCACAGAG 
TCCCCGGTCC ATCAGGAGCA TCGGGTCCCA TCAGATACTC TGAAGGATTT CTGGTTCCAG 
TTCCGGTCCA TCAACAACTC TCTTCGAACT CGGGATCAGA TTCACCAGAA GGAGGTGGAG 
TGGCTGGCCA TCCTGTATCG CTTTGATCAG CTGCTCTTCC GAATCTACCT TGCCGTGCTG 
GGGCTCTATA CCGTCACCTT ATGCTCTCTC TGGGCACTGT GGAGCAGAAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064670.1
CDS	206..1519
Translation	MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSVWYREVWNDEFLSWNSSLFDEIQEISLPLSALWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNREDIENDKRAFMNDSEWQLLSVSSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTPLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSGQERPLMCLQGDSDAEESRLYLGAPRADVTESPVHQEHRVPSDTLKDFWFQFRSINNSLRTRDQIHQKEVEWLAILYRFDQLLFRIYLAVLGLYTVTLCSLWALWSRM

Target ORF information:

RefSeq Version	NM_020274.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus 5-hydroxytryptamine (serotonin) receptor 3B (Htr3b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020274.4

ORF Insert Sequence:

ATGATTCTTC TGTGGTCCTG CCTCCTGGTG GCTGTAGTAG GTATCCTAGG TACAGCGACA 
CCTCAGCCTG GGAATTCTTC TCTGCACCGT CTCACCAGGC AGCTCTTACA ACAGTACCAC 
AAGGAGGTCA GACCAGTTTA CAACTGGGCT GAGGCCACCA CTGTCTACCT GGACCTTTGC 
GTCCATGCTG TATTGGATGT GGATGTGCAG AATCAAAAAT TAAAGACAAG CGTGTGGTAC 
CGAGAGGTTT GGAACGATGA GTTTTTGTCC TGGAACTCTA GTCTGTTCGA TGAGATTCAA 
GAGATCTCTC TCCCTCTCAG TGCCCTCTGG GCCCCTGATA TCATCATTAA TGAGTTTGTG 
GATGTTGAAA GATCTCCTGA CCTGCCCTAT GTATACGTGA ACTCTTCTGG CACCATTAGA 
AACCACAAGC CCATCCAGGT GGTCTCCGCA TGCAGTTTGC AGACATATGC TTTCCCCTTT 
GATATCCAGA ACTGCAGCCT CACCTTTAAT AGCATTCTGC ACACAGTGGA AGACATAGAC 
CTGGGCTTCC TGAGGAATAG AGAAGACATC GAGAATGACA AAAGGGCTTT TATGAATGAC 
AGTGAGTGGC AGCTTCTTTC TGTGTCCTCT ACTTACCACA TCCGGCAGAG CAGCGCTGGA 
GACTTCGCAC AGATTCGGTT CAACGTAGTG ATCCGCAGAT GTCCATTGGC CTACGTTGTG 
AGCCTCTTGA TACCTAGCAT CTTCCTGATG CTCGTGGACC TGGGAAGCTT CTACTTGCCC 
CCCAACTGCC GTGCAAGAAT TGTGTTCAAG ACCAATGTGC TGGTGGGCTA TACGGTCTTC 
AGGGTCAACA TGTCTGATGA AGTGCCAAGA AGTGCAGGGT GCACACCTCT GATTGGGGTC 
TTCTTTACCG TCTGCATGGC CCTCTTGGTT CTCAGTTTAT CCAAATCCAT CTTGCTGATC 
AAATTCCTCT ATGAGGAGCG GCACAGTGGG CAAGAACGGC CTCTTATGTG CCTTCAAGGC 
GACTCTGATG CCGAGGAGTC TAGATTGTAC CTCGGGGCTC CACGTGCTGA CGTCACAGAG 
TCCCCGGTCC ATCAGGAGCA TCGGGTCCCA TCAGATACTC TGAAGGATTT CTGGTTCCAG 
TTCCGGTCCA TCAACAACTC TCTTCGAACT CGGGATCAGA TTCACCAGAA GGAGGTGGAG 
TGGCTGGCCA TCCTGTATCG CTTTGATCAG CTGCTCTTCC GAATCTACCT TGCCGTGCTG 
GGGCTCTATA CCGTCACCTT ATGCTCTCTC TGGGCACTGT GGAGCAGAAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT
American journal of physiology. Gastrointestinal and liver physiology313(1)G80-G87(2017 Jul)
Bhattarai Y,Schmidt BA,Linden DR,Larson ED,Grover M,Beyder A,Farrugia G,Kashyap PC

5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival.
The Journal of experimental medicine214(2)529-545(2017 Feb)
Lv J,Wang L,Gao Y,Ding YQ,Liu F

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
PloS one12(7)e0180682(2017)
Sundberg JP,Dadras SS,Silva KA,Kennedy VE,Garland G,Murray SA,Sundberg BA,Schofield PN,Pratt CH

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Htr3b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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