Slc6a14 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc6a14
Entrez Gene ID	56774
Full Name	solute carrier family 6 (neurotransmitter transporter), member 14
Synonyms	1110007A17Rik,9030613J17Rik,ATB0plus,CATB0plus
General protein information	Preferred Names solute carrier family 6 (neurotransmitter transporter), member 14 Names sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) amino acid transporter ATB0+ colonic system B0+ amino acid transporter CATB0+ solute carrier family 6 member 14
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X A2

mRNA and Protein(s)

mRNA	Protein	Name
NM_020049.4	NP_064433.3	sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC6A14	NP_009162.1
Bos taurus (cattle)	SLC6A14	NP_001091931.1
Danio rerio (zebrafish)	slc6a14	XP_001923596.1
Rattus norvegicus (Norway rat)	Slc6a14	NP_001032633.1
Xenopus tropicalis (tropical clawed frog)	slc6a14.1	XP_002939712.2
Pan troglodytes (chimpanzee)	SLC6A14	XP_003317696.1
	SLC6A14	XP_001104391.1
Canis lupus familiaris (dog)	SLC6A14	XP_549207.2
Mus musculus (house mouse)	Slc6a14	NP_064433.3
Gallus gallus (chicken)	SLC6A14	XP_003641183.1

Gene Ontology
Bibliography

Related articles in PubMed

Di Paola M, Park AJ, Ahmadi S, Roach EJ, Wu YS, Struder-Kypke M, Lam JS, Bear CE, Khursigara CM
mBio8(6)(2017 Dec)

Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer.
Babu E, Bhutia YD, Ramachandran S, Gnanaprakasam JP, Prasad PD, Thangaraju M, Ganapathy V
The Biochemical journal469(1)17-23(2015 Jul)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.
Willnow T, Antignac C, Br?ndli A, Christensen E, Cox R, Davidson D, Davies J, Devuyst O, Eichele G, Hastie N, Verroust P, Schedl A, Meij I
Organogenesis2(2)42-7(2005 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These studies demonstrate that SLC6A14 is critical for the maintenance of amino acid nutrition and optimal mammalian target of rapamycin (mTOR) signalling in ER+ breast cancer
Title: Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer.

The following Slc6a14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc6a14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11912	NM_020049.4 Latest version!	Mus musculus solute carrier family 6 (neurotransmitter transporter), member 14 (Slc6a14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$377.30 $539.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc6a14 ( NM_020049.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064433.3 Mus musculus solute carrier family 6 (neurotransmitter transporter), member 14 (Slc6a14), mRNA.

Price & Availability↑

CloneID	OMu11912
Clone ID Related Accession (Same CDS sequence)	NM_020049.4
Accession Version	NM_020049.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1917bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL807250.9 and BC129908.1. On Jul 18, 2009 this sequence version replaced NM_020049.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF320226.1, BC129908.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAGAT TGAAGTGCCC GAACTTCTTC AAGTGCAGAC AGAAGGAGAA AGTGACAGCT 
TCATCCGAGA ACTTCCATGT TGGTGAAAAT GATGAAAATC AGGAACGTGG TAACTGGTCC 
AAAAAGTCAG ATTATCTTCT TTCCATGGTT GGCTATGCAG TGGGATTGGG CAATGTGTGG 
AGATTCCCAT ATCTGACCTA CACCAATGGC GGAGGTGCTT TCTTGATACC CTATGCAATC 
ATGCTAGCAT TGGCTGGTCT GCCTTTGTTC TTTCTGGAAT GTTCACTGGG ACAATTTGCT 
AGCTTAGGTC CAGTTTCAGT TTGGAGGATT TTGCCACTGT TTCAAGGTGT GGGAATCACG 
ATGGTCCTGA TATCCGTTTT TGTGGCAATC TATTATAATG TCATAATTGC CTACAGCCTT 
TACTACTTGT TTGCTTCTTT TCAAAGTGTA TTGCCGTGGG CAAATTGTTC TTCTTGGGCA 
GACGAAAACT GTAGCAGAAC ACCAATAGTA ACTGGCTGTA ATGTGAGCAT AGGGGCAGGA 
GAGATGTTTA TGAATATAAG CTGGGTAAAT ACCAACAATC TCACCTGCTT GAATGGTAGT 
GAAGTTTTTC GGCCAGGACA ACTTCCCAGT GAACAGTATT GGGATAAAGT GACACTTCAG 
AGGTCAAGTG GAATGGATGA AACTGGAGTT GTTGTGTGGT ATTTAGCACT TTGCCTTCTT 
CTGGCTTGGC TCATAGTTGG AGCAGCACTG TTTAAAGGAA TCAAATCCTC TGGCAAGGTG 
GTATATTTTA CAGCTCTTTT CCCATATGTG GTCCTTCTCA TTCTGTTAAT ACGAGGTGCA 
ACTTTGGAGG GTGCATCAAA AGGCATTTCA TATTACATTG GAGCACAGTC AAATTTTACA 
AAACTAAGAG AAGCTGAGGT CTGGAAGGAT GCTGCCACTC AGATATTTTA TTCCCTTTCT 
GTGGCTTGGG GTGGCCTAGT GGCTCTGTCA TCTTACAACA AGTTCAACAA CAACTGTTAC 
TCTGATGCCA TTATAGTTTG CTTGACAAAC TGCCTCACTA GTGTGTTTGC TGGATTTGCT 
ATATTTTCTA TTCTGGGACA CATGGCTCAT ATATCTGGAA AAGAAGTCTC TCAAGTTGTA 
AAATCAGGAT TTGACTTGGC ATTCATTGCC TATCCTGAAG CTCTAGCTCA ACTCCCAGCT 
GGTCCATTCT GGTCCATATT ATTTTTCTTC ATGCTTTTAA CATTGGGCCT TGATTCTCAG 
TTTGCTTCTA TTGAAACAAT TACAACAACA TTTCAAGATT TGTTTCCCAA AGCAATGAAA 
CGCATGAGGG TTCCTATAAC TTTGGGATGC TGCTTGATTT TGTTTCTCCT TGGCCTCCTC 
TGTGTGACTC AGGCTGGAAT TTACTGGGTT CATTTGATTG ATCACTTCTG TGCTGGATGG 
GGAATTTTAA TTGCTGCTAT CTTGGAAATT GCAGGAATCA TCTGGATTTA TGGAGGAAAT 
AGATTCATTG AAGATATAGA AATGATGATT GGAGCAAAAA GATGGATATT CTGGCTTTGG 
TGGAGAGCTT GCTGGTTTGT CATCACTCCT ATTCTGTTGT CTGCAATTCT AGTCTGGTCA 
CTGGTGAAAT TTCACAGACC TGATTATGCT GATATTCCAT ATCCTGACTG GGGAGTTGCT 
CTTGGCTGGT GTATGATCAT TTTCTGCATT ATTTGGATAC CAATTATGGC TATCATAAAA 
ATAGTTCAGG CAGAAGGAAA CATACTTCAG CGTATCATAA GCTGCTGTAG ACCAGCTTCG 
AACTGGGGTC CATACCTGGA AAAACATCGT GGGGAGAGAT ACAGAGACAT GGCTGAACCT 
GCAAAGGAGA CTGACCACGA AATACCTACT ATTAGTGGCA GTACAAAACC AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064433.3
CDS	249..2165
Translation	MDRLKCPNFFKCRQKEKVTASSENFHVGENDENQERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISVFVAIYYNVIIAYSLYYLFASFQSVLPWANCSSWADENCSRTPIVTGCNVSIGAGEMFMNISWVNTNNLTCLNGSEVFRPGQLPSEQYWDKVTLQRSSGMDETGVVVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFNNNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPAGPFWSILFFFMLLTLGLDSQFASIETITTTFQDLFPKAMKRMRVPITLGCCLILFLLGLLCVTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWIFWLWWRACWFVITPILLSAILVWSLVKFHRPDYADIPYPDWGVALGWCMIIFCIIWIPIMAIIKIVQAEGNILQRIISCCRPASNWGPYLEKHRGERYRDMAEPAKETDHEIPTISGSTKPE

Target ORF information:

RefSeq Version	NM_020049.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 6 (neurotransmitter transporter), member 14 (Slc6a14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020049.4

ORF Insert Sequence:

ATGGACAGAT TGAAGTGCCC GAACTTCTTC AAGTGCAGAC AGAAGGAGAA AGTGACAGCT 
TCATCCGAGA ACTTCCATGT TGGTGAAAAT GATGAAAATC AGGAACGTGG TAACTGGTCC 
AAAAAGTCAG ATTATCTTCT TTCCATGGTT GGCTATGCAG TGGGATTGGG CAATGTGTGG 
AGATTCCCAT ATCTGACCTA CACCAATGGC GGAGGTGCTT TCTTGATACC CTATGCAATC 
ATGCTAGCAT TGGCTGGTCT GCCTTTGTTC TTTCTGGAAT GTTCACTGGG ACAATTTGCT 
AGCTTAGGTC CAGTTTCAGT TTGGAGGATT TTGCCACTGT TTCAAGGTGT GGGAATCACG 
ATGGTCCTGA TATCCGTTTT TGTGGCAATC TATTATAATG TCATAATTGC CTACAGCCTT 
TACTACTTGT TTGCTTCTTT TCAAAGTGTA TTGCCGTGGG CAAATTGTTC TTCTTGGGCA 
GACGAAAACT GTAGCAGAAC ACCAATAGTA ACTGGCTGTA ATGTGAGCAT AGGGGCAGGA 
GAGATGTTTA TGAATATAAG CTGGGTAAAT ACCAACAATC TCACCTGCTT GAATGGTAGT 
GAAGTTTTTC GGCCAGGACA ACTTCCCAGT GAACAGTATT GGGATAAAGT GACACTTCAG 
AGGTCAAGTG GAATGGATGA AACTGGAGTT GTTGTGTGGT ATTTAGCACT TTGCCTTCTT 
CTGGCTTGGC TCATAGTTGG AGCAGCACTG TTTAAAGGAA TCAAATCCTC TGGCAAGGTG 
GTATATTTTA CAGCTCTTTT CCCATATGTG GTCCTTCTCA TTCTGTTAAT ACGAGGTGCA 
ACTTTGGAGG GTGCATCAAA AGGCATTTCA TATTACATTG GAGCACAGTC AAATTTTACA 
AAACTAAGAG AAGCTGAGGT CTGGAAGGAT GCTGCCACTC AGATATTTTA TTCCCTTTCT 
GTGGCTTGGG GTGGCCTAGT GGCTCTGTCA TCTTACAACA AGTTCAACAA CAACTGTTAC 
TCTGATGCCA TTATAGTTTG CTTGACAAAC TGCCTCACTA GTGTGTTTGC TGGATTTGCT 
ATATTTTCTA TTCTGGGACA CATGGCTCAT ATATCTGGAA AAGAAGTCTC TCAAGTTGTA 
AAATCAGGAT TTGACTTGGC ATTCATTGCC TATCCTGAAG CTCTAGCTCA ACTCCCAGCT 
GGTCCATTCT GGTCCATATT ATTTTTCTTC ATGCTTTTAA CATTGGGCCT TGATTCTCAG 
TTTGCTTCTA TTGAAACAAT TACAACAACA TTTCAAGATT TGTTTCCCAA AGCAATGAAA 
CGCATGAGGG TTCCTATAAC TTTGGGATGC TGCTTGATTT TGTTTCTCCT TGGCCTCCTC 
TGTGTGACTC AGGCTGGAAT TTACTGGGTT CATTTGATTG ATCACTTCTG TGCTGGATGG 
GGAATTTTAA TTGCTGCTAT CTTGGAAATT GCAGGAATCA TCTGGATTTA TGGAGGAAAT 
AGATTCATTG AAGATATAGA AATGATGATT GGAGCAAAAA GATGGATATT CTGGCTTTGG 
TGGAGAGCTT GCTGGTTTGT CATCACTCCT ATTCTGTTGT CTGCAATTCT AGTCTGGTCA 
CTGGTGAAAT TTCACAGACC TGATTATGCT GATATTCCAT ATCCTGACTG GGGAGTTGCT 
CTTGGCTGGT GTATGATCAT TTTCTGCATT ATTTGGATAC CAATTATGGC TATCATAAAA 
ATAGTTCAGG CAGAAGGAAA CATACTTCAG CGTATCATAA GCTGCTGTAG ACCAGCTTCG 
AACTGGGGTC CATACCTGGA AAAACATCGT GGGGAGAGAT ACAGAGACAT GGCTGAACCT 
GCAAAGGAGA CTGACCACGA AATACCTACT ATTAGTGGCA GTACAAAACC AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

mBio8(6)(2017 Dec)
Di Paola M,Park AJ,Ahmadi S,Roach EJ,Wu YS,Struder-Kypke M,Lam JS,Bear CE,Khursigara CM

Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer.
The Biochemical journal469(1)17-23(2015 Jul)
Babu E,Bhutia YD,Ramachandran S,Gnanaprakasam JP,Prasad PD,Thangaraju M,Ganapathy V

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.
Organogenesis2(2)42-7(2005 Apr)
Willnow T,Antignac C,Br?ndli A,Christensen E,Cox R,Davidson D,Davies J,Devuyst O,Eichele G,Hastie N,Verroust P,Schedl A,Meij I

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Slc6a14 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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