Tdo2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tdo2
Entrez Gene ID	56720
Full Name	tryptophan 2,3-dioxygenase
Synonyms	AA407491,TDO,TO,chky
General protein information	Preferred Names tryptophan 2,3-dioxygenase Names tryptophan 2,3-dioxygenase TRPO tdo variant1 tdo variant2 tryptamin 2,3-dioxygenase tryptophan oxygenase tryptophan pyrrolase tryptophanase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_019911.2	NP_064295.2	tryptophan 2,3-dioxygenase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TDO2	XP_001140187.1
Rattus norvegicus (Norway rat)	Tdo2	NP_071798.1
Bos taurus (cattle)	TDO2	NP_001039778.1
Mus musculus (house mouse)	Tdo2	NP_064295.2
Danio rerio (zebrafish)	tdo2b	NP_956150.1
Danio rerio (zebrafish)	tdo2a	NP_001096086.1
Caenorhabditis elegans (roundworm)	C28H8.11	NP_498284.1
Xenopus tropicalis (tropical clawed frog)	tdo2	NP_001015733.1
Gallus gallus (chicken)	TDO2	XP_420377.3
Drosophila melanogaster (fruit fly)	v	NP_511113.1
Canis lupus familiaris (dog)	TDO2	XP_532700.2
Anopheles gambiae (African malaria mosquito)	T23O_ANOGA	XP_312204.2
Homo sapiens (human)	TDO2	NP_005642.1

Gene Ontology
Bibliography

Related articles in PubMed

Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation.
Zhong W, Gao L, Zhou Z, Lin H, Chen C, Huang P, Huang W, Zhou C, Huang S, Nie L, Liu Y, Chen Y, Zhou D, Lv Z
Oncotarget8(25)40486-40500(2017 Jun)

n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
Rajamani K, Liu JW, Wu CH, Chiang IT, You DH, Lin SY, Hsieh DK, Lin SZ, Harn HJ, Chiou TW
Neuropharmacology117434-446(2017 May)

Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency.
Ferreira P, Shin I, Sosova I, Dornevil K, Jain S, Dewey D, Liu F, Liu A
Molecular genetics and metabolism120(4)317-324(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 and Sirt7) and enzymes in NAD biosynthetic pathway (Tdo2 and Nnmt); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 and Nnmt may serve as markers of HFD consumption. (Tdo2 = tryptophan 2,3-dioxygenase; Nnmt = nicotinamide N-methyltransferase)
Title: Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding.

Findings suggest non-redundant neurophysiological roles for indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2 and tryptophan 2,3-dioxygenase in modulating brain activities and metabolism.
Title: Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function.

both TDO and IDO biosynthesize nicotinamide from D-tryptophan and L-tryptophan in mice
Title: Contributions of tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase to the conversion of D-tryptophan to nicotinamide analyzed by using tryptophan 2,3-dioxygenase-knockout mice.

Data indicate that tryptophan 2,3-dioxygenase (Tdo2) may play an important role during mouse decidualization and be regulated by estrogen, progesterone, and cAMP.
Title: Differential expression and regulation of Tdo2 during mouse decidualization.

Endometrial expression of TDO in epithelial and stromal cells is regulated by HOXA10. Expression level of TDO influences infiltration of T-cells into endometrial stroma and thus may influence embryo viability.
Title: Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling.

The following Tdo2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tdo2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17612	NM_019911.2 Latest version!	Mus musculus tryptophan 2,3-dioxygenase (Tdo2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tdo2 ( NM_019911.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064295.2 Mus musculus tryptophan 2,3-dioxygenase (Tdo2), mRNA.

Price & Availability↑

CloneID	OMu17612
Clone ID Related Accession (Same CDS sequence)	NM_019911.2
Accession Version	NM_019911.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1221bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	tryptophan 2,3-dioxygenase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC018390.1. On Jun 19, 2003 this sequence version replaced NM_019911.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC018390.1, AK132271.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386 [ECO:0000348] ##Evidence-Data-END##

ATGAGTGGGT GCCCGTTTGC AGGAAACAGT GTAGGATACA CTTTGAAAAA CGTATCTATG 
GAGGACAATG AAGAAGACAG AGCTCAAACT GGTGTAAACA GAGCCAGCAA AGGAGGACTT 
ATCTATGGCA ATTACTTGCA GTTGGAAAAG ATTTTGAATG CGCAAGAACT TCAGAGTGAA 
GTAAAAGGGA ACAAAATCCA TGACGAGCAC CTATTCATCA TAACTCATCA AGCTTATGAA 
CTTTGGTTTA AACAAATCCT CTGGGAACTA GATTCTGTTC GTGAAATCTT CCAAAATGGC 
CATGTCAGGG ATGAGAGGAA CATGCTCAAG GTGATAGCTC GGATGCATCG TGTGGTGGTC 
ATCTTCAAGC TCCTGGTACA GCAGTTCTCG GTTCTGGAAA CAATGACTGC TTTGGACTTC 
AATGACTTCA GAGAATACCT GTCTCCAGCA TCAGGCTTCC AGAGTCTACA GTTCCGGCTG 
CTGGAAAATA AGATTGGTGT TCTTCAGAGC TTGAGAGTCC CTTACAACAG GAAACACTAT 
CGTGATAACT TTGGAGGAGA CTACAATGAG CTGTTGCTGA AATCAGAGCA GGAGCAGACG 
CTGTTGCAGC TGGTGGAGGC ATGGCTGGAA AGAACACCTG GTTTAGAGCC AAATGGATTT 
AATTTCTGGG GAAAGTTTGA AAAAAATATC TTGAAAGGCC TGGAAGAAGA ATTTCTAAGG 
ATTCAGGCTA AAACCGACTC TGAAGAAAAA GAGGAACAGA TGGCAGAGTT CCGGAAGCAG 
AAGGAGGTGC TGCTCTGCTT GTTTGATGAG AAGCGTCATG ACTACCTTCT GAGTAAAGGT 
GAACGACGAC TGTCATACCG TGCACTCCAG GGAGCACTGA TGATATATTT TTACAGGGAG 
GAGCCTCGAT TCCAGGTCCC TTTCCAGCTG CTGACCTCAC TTATGGACAT TGACACGCTC 
ATGACCAAAT GGAGATATAA TCATGTGTGC ATGGTGCACA GAATGCTGGG CACCAAGGCT 
GGCACTGGGG GATCCTCAGG CTATCATTAC CTGCGTTCAA CTGTGAGCGA CAGGTACAAG 
GTTTTTGTGG ATTTATTTAA CCTCTCAACA TATCTGGTTC CCAGACACTG GGTACCAAAG 
ATGAATCCGA TCATTCACAA ATTCCTTTAC ACAGCCGAGT ACAGTGACAG CTCTTACTTC 
AGCAGCGATG AATCGGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064295.2
CDS	36..1256
Translation	MSGCPFAGNSVGYTLKNVSMEDNEEDRAQTGVNRASKGGLIYGNYLQLEKILNAQELQSEVKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVIARMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNFGGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPNGFNFWGKFEKNILKGLEEEFLRIQAKTDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGTKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLVPRHWVPKMNPIIHKFLYTAEYSDSSYFSSDESD

Target ORF information:

RefSeq Version	NM_019911.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus tryptophan 2,3-dioxygenase (Tdo2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019911.2

ORF Insert Sequence:

ATGAGTGGGT GCCCGTTTGC AGGAAACAGT GTAGGATACA CTTTGAAAAA CGTATCTATG 
GAGGACAATG AAGAAGACAG AGCTCAAACT GGTGTAAACA GAGCCAGCAA AGGAGGACTT 
ATCTATGGCA ATTACTTGCA GTTGGAAAAG ATTTTGAATG CGCAAGAACT TCAGAGTGAA 
GTAAAAGGGA ACAAAATCCA TGACGAGCAC CTATTCATCA TAACTCATCA AGCTTATGAA 
CTTTGGTTTA AACAAATCCT CTGGGAACTA GATTCTGTTC GTGAAATCTT CCAAAATGGC 
CATGTCAGGG ATGAGAGGAA CATGCTCAAG GTGATAGCTC GGATGCATCG TGTGGTGGTC 
ATCTTCAAGC TCCTGGTACA GCAGTTCTCG GTTCTGGAAA CAATGACTGC TTTGGACTTC 
AATGACTTCA GAGAATACCT GTCTCCAGCA TCAGGCTTCC AGAGTCTACA GTTCCGGCTG 
CTGGAAAATA AGATTGGTGT TCTTCAGAGC TTGAGAGTCC CTTACAACAG GAAACACTAT 
CGTGATAACT TTGGAGGAGA CTACAATGAG CTGTTGCTGA AATCAGAGCA GGAGCAGACG 
CTGTTGCAGC TGGTGGAGGC ATGGCTGGAA AGAACACCTG GTTTAGAGCC AAATGGATTT 
AATTTCTGGG GAAAGTTTGA AAAAAATATC TTGAAAGGCC TGGAAGAAGA ATTTCTAAGG 
ATTCAGGCTA AAACCGACTC TGAAGAAAAA GAGGAACAGA TGGCAGAGTT CCGGAAGCAG 
AAGGAGGTGC TGCTCTGCTT GTTTGATGAG AAGCGTCATG ACTACCTTCT GAGTAAAGGT 
GAACGACGAC TGTCATACCG TGCACTCCAG GGAGCACTGA TGATATATTT TTACAGGGAG 
GAGCCTCGAT TCCAGGTCCC TTTCCAGCTG CTGACCTCAC TTATGGACAT TGACACGCTC 
ATGACCAAAT GGAGATATAA TCATGTGTGC ATGGTGCACA GAATGCTGGG CACCAAGGCT 
GGCACTGGGG GATCCTCAGG CTATCATTAC CTGCGTTCAA CTGTGAGCGA CAGGTACAAG 
GTTTTTGTGG ATTTATTTAA CCTCTCAACA TATCTGGTTC CCAGACACTG GGTACCAAAG 
ATGAATCCGA TCATTCACAA ATTCCTTTAC ACAGCCGAGT ACAGTGACAG CTCTTACTTC 
AGCAGCGATG AATCGGATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation.
Oncotarget8(25)40486-40500(2017 Jun)
Zhong W,Gao L,Zhou Z,Lin H,Chen C,Huang P,Huang W,Zhou C,Huang S,Nie L,Liu Y,Chen Y,Zhou D,Lv Z

n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
Neuropharmacology117434-446(2017 May)
Rajamani K,Liu JW,Wu CH,Chiang IT,You DH,Lin SY,Hsieh DK,Lin SZ,Harn HJ,Chiou TW

Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency.
Molecular genetics and metabolism120(4)317-324(2017 Apr)
Ferreira P,Shin I,Sosova I,Dornevil K,Jain S,Dewey D,Liu F,Liu A

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Tdo2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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