Glmp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Glmp
Entrez Gene ID	56700
Full Name	glycosylated lysosomal membrane protein
Synonyms	0610031J06Rik,AB027141,NCU-G1
General protein information	Preferred Names glycosylated lysosomal membrane protein Names glycosylated lysosomal membrane protein lysosomal protein NCU-G1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 F1

mRNA and Protein(s)

mRNA	Protein	Name
NM_020003.1	NP_064387.1	glycosylated lysosomal membrane protein precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	C7H1orf85	XP_854965.1
Homo sapiens (human)	C1orf85	NP_653181.1
Bos taurus (cattle)	C3H1orf85	NP_001098946.1
	LOC719468	XP_002801903.1
Danio rerio (zebrafish)	zgc:92308	NP_001004580.1
Pan troglodytes (chimpanzee)	C1H1orf85	XP_513881.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004431	XP_313717.5
Xenopus tropicalis (tropical clawed frog)	c1orf85	XP_002945116.2
Mus musculus (house mouse)	0610031J06Rik	NP_064387.1
Rattus norvegicus (Norway rat)	RGD1303130	NP_001004226.1
Gallus gallus (chicken)	LOC777136	XP_003643962.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased glucose utilization and decreased fatty acid metabolism in myotubes from Glmp(gt/gt) mice.
Kong XY, Feng YZ, Eftest?l E, Kase ET, Haugum H, Eskild W, Rustan AC, Thoresen GH
Archives of physiology and biochemistry122(1)36-45(2016)

Lack of the Lysosomal Membrane Protein, GLMP, in Mice Results in Metabolic Dysregulation in Liver.
Kong XY, Kase ET, Herskedal A, Schjalm C, Damme M, Nesset CK, Thoresen GH, Rustan AC, Eskild W
PloS one10(6)e0129402(2015)

Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells.
Kong XY, Nesset CK, Damme M, L?berg EM, L?bke T, M?hlen J, Andersson KB, Lorenzo PI, Roos N, Thoresen GH, Rustan AC, Kase ET, Eskild W
Disease models & mechanisms7(3)351-62(2014 Mar)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the importance of GLMP in skeletal muscle
Title: Increased glucose utilization and decreased fatty acid metabolism in myotubes from Glmp(gt/gt) mice.

Data indicate that increased flux of glucose, increased de novo lipogenesis and lipid accumulation were detected in lysosomal protein NCU-G1 (Glmp) gt/gt primary hepatocytes.
Title: Lack of the Lysosomal Membrane Protein, GLMP, in Mice Results in Metabolic Dysregulation in Liver.

Microscopic examination of liver sections revealed accumulation of autofluorescent lipofuscin and iron in Ncu-g1(gt/gt) Kupffer cells.
Title: Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells.

The lysosomal localization of the mouse orthologue of the human C1orf85 protein, which has been termed kidney-predominant protein NCU-G1, is demonstrated.
Title: NCU-G1 is a highly glycosylated integral membrane protein of the lysosome.

The following Glmp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Glmp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11820	NM_020003.1 Latest version!	Mus musculus glycosylated lysosomal membrane protein (Glmp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Glmp ( NM_020003.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064387.1 Mus musculus glycosylated lysosomal membrane protein (Glmp), mRNA.

Price & Availability↑

CloneID	OMu11820
Clone ID Related Accession (Same CDS sequence)	NM_020003.1
Accession Version	NM_020003.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	glycosylated lysosomal membrane protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB027142.1. ##Evidence-Data-START## Transcript exon combination :: AB027142.1, AK154340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGTTTCGCT GTTGGGGACC TCACTGGGGC TGGGTCCCCT GTGCCCCTAC CCCATGGCTC 
CTTTTGAGTC TACTTGTGTG TTCAGCTCCA TTTGGCCTGC AGGGAGAAGA GACTCGCCAG 
GTATCTATGG AGGTTATTTC CGGCTGGCCA AATCCACAGA ACCTGCTTCA TATTCGGGCA 
GTGGGCAGCA ACTCCACCCT GCACTATGTG TGGAGCAGCC TGGGGCCTCC AGCTGTGGTG 
CTGGTGGCCA CTAACACCAC TCAGAGTGTC CTGAGTGTCA ACTGGAGTCT CCTGCTGTCT 
CCCGATCCTG CTGGGGCCCT GATGGTGCTC CCCAAGAGCA GCATACAGTT TTCTTCTGCT 
CTCGTCTTCA CCAGGCTGCT TGAGTTTGAC AGCACCAATG CGTCCGAGGG GGCACAGCCT 
CCAGGAAAGC CATACCCTCC GTACTCCTTG GCCAAGTTCT CCTGGAACAA TATCACCAAC 
TCATTGGATC TTGCCAACCT GAGTGCCGAT TTTCAAGGCC GCCCTGTAGA TGATCCTACT 
GGAGCATTCG CCAATGGCAG CCTGACCTTC AAGGTCCAAG CCTTTTCTAG ATCTGGTCGA 
CCTGCTCAGC CCCCTCGCCT CCTGCACACA GCAGATGTCT GCCAGTTAGA AGTGGCCCTG 
GTTGGAGCTT CTCCTCGTGG AAACCATTCC CTATTTGGTC TAGAGGTAGC CACCTTGGGA 
CAGGGCCCTG ACTGCCCCTC AGTGAACGAA CGGAACTCCA TCGATGATGA ATATGCACCT 
GCCGTCTTCC AGCTGAACCA GCTGTTATGG GGCTCTTCTC CATCTGGCTT CATGCAATGG 
CGACCAGTGG CTTTCTCTGA GGAGGAGCGG GCCCGAGAAT CAGCCCTCCC CTGCCAGGCT 
TCCACTCTTC ACTCCACCTT GGCATCTTCT CTCCCTCATT CACCAATTGT TCAAGCCTTC 
TTCGGGTCCC AGAACAACTT CTGTGCCTTC AATCTGACCT TTGGGGCTCC CACGGGCCCT 
GGCTACTGGG ACCAATACTA CCTTTGCTGG TCAATGCTTC TGGGCATGGG CTTCCCTCCG 
GTGGATATCT TCTCTCCACT AGTCCTCGGA ATCATGGCGG TAGCCCTGGG AGCCCCAGGA 
CTCATGTTCC TGGGGGGAGG CCTATTTCTG CTGCTGCGCC ACAGGCGGTA TTCTGAGTAC 
CAGTCCATAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064387.1
CDS	60..1274
Translation	MFRCWGPHWGWVPCAPTPWLLLSLLVCSAPFGLQGEETRQVSMEVISGWPNPQNLLHIRAVGSNSTLHYVWSSLGPPAVVLVATNTTQSVLSVNWSLLLSPDPAGALMVLPKSSIQFSSALVFTRLLEFDSTNASEGAQPPGKPYPPYSLAKFSWNNITNSLDLANLSADFQGRPVDDPTGAFANGSLTFKVQAFSRSGRPAQPPRLLHTADVCQLEVALVGASPRGNHSLFGLEVATLGQGPDCPSVNERNSIDDEYAPAVFQLNQLLWGSSPSGFMQWRPVAFSEEERARESALPCQASTLHSTLASSLPHSPIVQAFFGSQNNFCAFNLTFGAPTGPGYWDQYYLCWSMLLGMGFPPVDIFSPLVLGIMAVALGAPGLMFLGGGLFLLLRHRRYSEYQSIN

Target ORF information:

RefSeq Version	NM_020003.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus glycosylated lysosomal membrane protein (Glmp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020003.1

ORF Insert Sequence:

ATGTTTCGCT GTTGGGGACC TCACTGGGGC TGGGTCCCCT GTGCCCCTAC CCCATGGCTC 
CTTTTGAGTC TACTTGTGTG TTCAGCTCCA TTTGGCCTGC AGGGAGAAGA GACTCGCCAG 
GTATCTATGG AGGTTATTTC CGGCTGGCCA AATCCACAGA ACCTGCTTCA TATTCGGGCA 
GTGGGCAGCA ACTCCACCCT GCACTATGTG TGGAGCAGCC TGGGGCCTCC AGCTGTGGTG 
CTGGTGGCCA CTAACACCAC TCAGAGTGTC CTGAGTGTCA ACTGGAGTCT CCTGCTGTCT 
CCCGATCCTG CTGGGGCCCT GATGGTGCTC CCCAAGAGCA GCATACAGTT TTCTTCTGCT 
CTCGTCTTCA CCAGGCTGCT TGAGTTTGAC AGCACCAATG CGTCCGAGGG GGCACAGCCT 
CCAGGAAAGC CATACCCTCC GTACTCCTTG GCCAAGTTCT CCTGGAACAA TATCACCAAC 
TCATTGGATC TTGCCAACCT GAGTGCCGAT TTTCAAGGCC GCCCTGTAGA TGATCCTACT 
GGAGCATTCG CCAATGGCAG CCTGACCTTC AAGGTCCAAG CCTTTTCTAG ATCTGGTCGA 
CCTGCTCAGC CCCCTCGCCT CCTGCACACA GCAGATGTCT GCCAGTTAGA AGTGGCCCTG 
GTTGGAGCTT CTCCTCGTGG AAACCATTCC CTATTTGGTC TAGAGGTAGC CACCTTGGGA 
CAGGGCCCTG ACTGCCCCTC AGTGAACGAA CGGAACTCCA TCGATGATGA ATATGCACCT 
GCCGTCTTCC AGCTGAACCA GCTGTTATGG GGCTCTTCTC CATCTGGCTT CATGCAATGG 
CGACCAGTGG CTTTCTCTGA GGAGGAGCGG GCCCGAGAAT CAGCCCTCCC CTGCCAGGCT 
TCCACTCTTC ACTCCACCTT GGCATCTTCT CTCCCTCATT CACCAATTGT TCAAGCCTTC 
TTCGGGTCCC AGAACAACTT CTGTGCCTTC AATCTGACCT TTGGGGCTCC CACGGGCCCT 
GGCTACTGGG ACCAATACTA CCTTTGCTGG TCAATGCTTC TGGGCATGGG CTTCCCTCCG 
GTGGATATCT TCTCTCCACT AGTCCTCGGA ATCATGGCGG TAGCCCTGGG AGCCCCAGGA 
CTCATGTTCC TGGGGGGAGG CCTATTTCTG CTGCTGCGCC ACAGGCGGTA TTCTGAGTAC 
CAGTCCATAA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased glucose utilization and decreased fatty acid metabolism in myotubes from Glmp(gt/gt) mice.
Archives of physiology and biochemistry122(1)36-45(2016)
Kong XY,Feng YZ,Eftest?l E,Kase ET,Haugum H,Eskild W,Rustan AC,Thoresen GH

Lack of the Lysosomal Membrane Protein, GLMP, in Mice Results in Metabolic Dysregulation in Liver.
PloS one10(6)e0129402(2015)
Kong XY,Kase ET,Herskedal A,Schjalm C,Damme M,Nesset CK,Thoresen GH,Rustan AC,Eskild W

Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells.
Disease models & mechanisms7(3)351-62(2014 Mar)
Kong XY,Nesset CK,Damme M,L?berg EM,L?bke T,M?hlen J,Andersson KB,Lorenzo PI,Roos N,Thoresen GH,Rustan AC,Kase ET,Eskild W

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

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Glmp cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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