Adam21 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adam21
Entrez Gene ID	56622
Full Name	a disintegrin and metallopeptidase domain 21
Synonyms	Adam31
General protein information	Preferred Names a disintegrin and metallopeptidase domain 21 Names disintegrin and metalloproteinase domain-containing protein 21 a disintegrin and metalloprotease domain (ADAM) 21 disintegrin and metalloproteinase domain-containing protein 31
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 D1\|12 37.79 cM
Summary	This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. The encoded protein functions in the regulation of spermatogenesis in the testes and neurogenesis in the central nervous system. [provided by RefSeq, May 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_020330.5	NP_065063.1	disintegrin and metalloproteinase domain-containing protein 21 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ADAM21	XP_001145699.1
	ADAM21	XP_001105948.1
Bos taurus (cattle)	ADAM21	XP_005212148.1
Gallus gallus (chicken)	LOC100857840	NP_001264719.1
Homo sapiens (human)	ADAM21	NP_003804.2
Canis lupus familiaris (dog)	ADAM21	XP_005623648.1
Mus musculus (house mouse)	Adam21	NP_065063.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression analysis of the Adam21 gene in mouse testis.
Yi C, Woo JM, Han C, Oh JS, Park I, Lee B, Jin S, Choi H, Kwon JT, Cho BN, Kim DH, Cho C
Gene expression patterns : GEP10(2-3)152-8(2010 Feb-Mar)

SPARC is expressed by macroglia and microglia in the developing and mature nervous system.
Vincent AJ, Lau PW, Roskams AJ
Developmental dynamics : an official publication of the American Association of Anatomists237(5)1449-62(2008 May)

New quantitative trait loci that regulate wound healing in an intercross progeny from DBA/1J and 129 x 1/SvJ inbred strains of mice.
Masinde GL, Li R, Nguyen B, Yu H, Srivastava AK, Edderkaoui B, Wergedal JE, Baylink DJ, Mohan S
Functional & integrative genomics6(2)157-63(2006 Apr)

A disintegrin and metalloprotease 21 (ADAM21) is associated with neurogenesis and axonal growth in developing and adult rodent CNS.
Yang P, Baker KA, Hagg T
The Journal of comparative neurology490(2)163-79(2005 Sep)

Chromosomal mapping of Adam9, Adam15 and Adam21.
Seldin MF, Hirohata S, Apte SS
Matrix biology : journal of the International Society for Matrix Biology19(2)185-7(2000 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Adam21 gene produces two types of transcripts with different cellular localization in the mouse testis, and the production of these alternate transcripts is due to utilization of cell-type-specific promoters.
Title: Expression analysis of the Adam21 gene in mouse testis.

The following Adam21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adam21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11991	NM_020330.5 Latest version!	Mus musculus a disintegrin and metallopeptidase domain 21 (Adam21), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adam21 ( NM_020330.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_065063.1 Mus musculus a disintegrin and metallopeptidase domain 21 (Adam21), mRNA.

Price & Availability↑

CloneID	OMu11991
Clone ID Related Accession (Same CDS sequence)	NM_020330.5
Accession Version	NM_020330.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	disintegrin and metalloproteinase domain-containing protein 21 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK014827.2 and AV268091.1. On May 13, 2016 this sequence version replaced NM_020330.4. ##Evidence-Data-START## Transcript exon combination :: AK014827.2, BY714350.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849384 [ECO:0000348] ##Evidence-Data-END##

ATGGAGTGCT TCATAATGTT AGGTGCAGAT GCTAGAACAC TCATGAGAGT CACTCTTTTG 
CTGCTCTGGC TTAAGGCACT TCCATCCCTT ATTGACCTCT CACAGACTGG GTCCACTCAA 
TACCTCAGTT CTCCAGAAGT AGTTATCCCT CTGAAGGTGA CCAGCAGGGC CAGGGGTGCA 
AAGAATTCAG AGTGGCTCTC CTATAGCCTT GTATTTGGTG GCCGTAGACA TGTTGTCCAT 
ATGCGAGTCA AGAAGCTGTT GGTTTCTACT CACATCCCTG TACTCACCTA CACAGAGGAA 
CACACCCCCC TCAGCGATTA CCCCTTTGTC CCTAGTGACT GTTACTATCA TGGTTATGTA 
GAGGGAGCCC TTGAGTCTTT AGTTGCTTTC AGTGCCTGCA ATGGGGGGTT GCAGGGAGTG 
TTACAAATGA ATGGCTTCTC TTATGAAATT GAACCTATCA AGCACTCTAG CACATTCGAG 
CACCTAGTCT ATACATTAAA TAATAACAAG ACACAATTTC CACCTATGCT ATGTAGTTTA 
ACGGAGAAGA GACTACTGTA CCAACCCTTT GGAGTTGAAG AGGCTAAGAA GTCAGCTATG 
AAGCAAAATT ATGGAAAACT GTGGCCCCAC ATGTGGTTTC TGGAGCTGGC TGTAGTGGTA 
GACTATGGTT TCTTCACTAA CGCTCAACAA AACTTGTCAA AGGTACGAGG AGATGTGGTT 
CTTGTTGTTA ACATGGTAGA TTCCATGTAC AAGCCGCTGG ATACTTATGT GACTTTGGTT 
GGCATCGAGA TTTGGAATCG AGGAAATGTT CTCCCAATGG AAAACATACA TCAGGTCTTA 
GAAGATTTTT CTCATTGGAA ACAAATCAGT CTTTCTCAGG TACATCATGA TGCAGCCCAT 
ATCTTCATTA GAAGCTCACT TATAAGTGTA CTTGGTATAG CCTACATTGC AGGAATATGT 
CGTCCTCCTC TTGATTGTGG AGTTGAAAAT TTCCAAGGGG ACGCCTGGTC TCTTTTTGCC 
AACACGGTGG CCCATGAGTT AGGCCATACT TTTGGTATGA AGCATGATGA GGAATCCTGC 
TCTTGTGGGA AAAGTGGTTG TGTCATGAGT ACTTTCAGAG TGCCAGCAGA GAGATTCACC 
AATTGCAGCT ATAGTGATTT TATGAAGACC ACTTTAAACC AAGGAACTTG TCTGTACAAT 
CATCCAAGAC CAGGGGCAGG TTTCCTGGTG AAGCGCTGTG GGAATGGTAT GGTTGAAAGT 
GAAGAAGAGT GTGACTGTGG ATCTGTACAG GAATGTGAGC AAGATCCCTG TTGTTTTCTT 
AACTGTACGC TGAGACCTGC AGCTGCTTGT AGTTTTGGGC TCTGTTGCAA AGACTGCAAA 
TTCATGCTCT TGGGGGAACT CTGTAGACCA AAGATCAATG AATGTGACCT TCCAGAATGG 
TGCAATGGAA CATCTCACCA GTGCCCAGAA GATGGATATG TACAGGATGG GGTCCCCTGT 
GGTGCCGGTG CCTACTGCTA TCAAAAGCAG TGTAATAACC ATGACCAACA GTGCAGGGAG 
ATTTTTGGCA AAGGTGCAAG AAGCGCATCT CATAATTGCT ATAAAGAAAT CAACTTACAA 
GGAAACAGGT TTGGCCATTG TGGCACAGAT GGCACAGTAT TCCTAAAATG CAGAATGTCA 
GATGTGTTTT GTGGGAAAGT CCACTGTGAA AATGTAGAAG ACATTCACCA TCCCCAGGCT 
CCTTATGTTT TGCAGAACAT TTATGCCAAT GGTATCACCT GCTGGAGTAC TGGCCATTGT 
TTGGGGATGG GTGTGCCTGA TGTTGGTGAA GTGAAAGATG GCACCACCTG TGGAGTAGGA 
AAGATCTGCC TACACAAGAA GTGTGTCAGT CTGTCTGTCC TTTCAAATGC TTGCCTTCCT 
GAGACTTGTA ATAGGAAGGG GGTCTGTAAT AACAAGCATC ACTGTCACTG TGACTATGGG 
TGGTCCCCGC CTTTCTGCCT GCACAGAGGT TATGGAGGTA GTATTGACAG TGGTCCAACA 
TCTCAAAAAA GAAGAGTCAT TATCACTGTC CTGTCAATAA CTGTGCCTGT TTTATCCATC 
CTAATTTGTC TGCTCATAGC TGGGCTTTAT AGAATATATT GTAAAATACC TTCTGGTCCC 
AAAGAGACTA AGGCCTCTTC ACCAGGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065063.1
CDS	509..2698
Translation	MECFIMLGADARTLMRVTLLLLWLKALPSLIDLSQTGSTQYLSSPEVVIPLKVTSRARGAKNSEWLSYSLVFGGRRHVVHMRVKKLLVSTHIPVLTYTEEHTPLSDYPFVPSDCYYHGYVEGALESLVAFSACNGGLQGVLQMNGFSYEIEPIKHSSTFEHLVYTLNNNKTQFPPMLCSLTEKRLLYQPFGVEEAKKSAMKQNYGKLWPHMWFLELAVVVDYGFFTNAQQNLSKVRGDVVLVVNMVDSMYKPLDTYVTLVGIEIWNRGNVLPMENIHQVLEDFSHWKQISLSQVHHDAAHIFIRSSLISVLGIAYIAGICRPPLDCGVENFQGDAWSLFANTVAHELGHTFGMKHDEESCSCGKSGCVMSTFRVPAERFTNCSYSDFMKTTLNQGTCLYNHPRPGAGFLVKRCGNGMVESEEECDCGSVQECEQDPCCFLNCTLRPAAACSFGLCCKDCKFMLLGELCRPKINECDLPEWCNGTSHQCPEDGYVQDGVPCGAGAYCYQKQCNNHDQQCREIFGKGARSASHNCYKEINLQGNRFGHCGTDGTVFLKCRMSDVFCGKVHCENVEDIHHPQAPYVLQNIYANGITCWSTGHCLGMGVPDVGEVKDGTTCGVGKICLHKKCVSLSVLSNACLPETCNRKGVCNNKHHCHCDYGWSPPFCLHRGYGGSIDSGPTSQKRRVIITVLSITVPVLSILICLLIAGLYRIYCKIPSGPKETKASSPG

Target ORF information:

RefSeq Version	NM_020330.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus a disintegrin and metallopeptidase domain 21 (Adam21), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020330.5

ORF Insert Sequence:

ATGGAGTGCT TCATAATGTT AGGTGCAGAT GCTAGAACAC TCATGAGAGT CACTCTTTTG 
CTGCTCTGGC TTAAGGCACT TCCATCCCTT ATTGACCTCT CACAGACTGG GTCCACTCAA 
TACCTCAGTT CTCCAGAAGT AGTTATCCCT CTGAAGGTGA CCAGCAGGGC CAGGGGTGCA 
AAGAATTCAG AGTGGCTCTC CTATAGCCTT GTATTTGGTG GCCGTAGACA TGTTGTCCAT 
ATGCGAGTCA AGAAGCTGTT GGTTTCTACT CACATCCCTG TACTCACCTA CACAGAGGAA 
CACACCCCCC TCAGCGATTA CCCCTTTGTC CCTAGTGACT GTTACTATCA TGGTTATGTA 
GAGGGAGCCC TTGAGTCTTT AGTTGCTTTC AGTGCCTGCA ATGGGGGGTT GCAGGGAGTG 
TTACAAATGA ATGGCTTCTC TTATGAAATT GAACCTATCA AGCACTCTAG CACATTCGAG 
CACCTAGTCT ATACATTAAA TAATAACAAG ACACAATTTC CACCTATGCT ATGTAGTTTA 
ACGGAGAAGA GACTACTGTA CCAACCCTTT GGAGTTGAAG AGGCTAAGAA GTCAGCTATG 
AAGCAAAATT ATGGAAAACT GTGGCCCCAC ATGTGGTTTC TGGAGCTGGC TGTAGTGGTA 
GACTATGGTT TCTTCACTAA CGCTCAACAA AACTTGTCAA AGGTACGAGG AGATGTGGTT 
CTTGTTGTTA ACATGGTAGA TTCCATGTAC AAGCCGCTGG ATACTTATGT GACTTTGGTT 
GGCATCGAGA TTTGGAATCG AGGAAATGTT CTCCCAATGG AAAACATACA TCAGGTCTTA 
GAAGATTTTT CTCATTGGAA ACAAATCAGT CTTTCTCAGG TACATCATGA TGCAGCCCAT 
ATCTTCATTA GAAGCTCACT TATAAGTGTA CTTGGTATAG CCTACATTGC AGGAATATGT 
CGTCCTCCTC TTGATTGTGG AGTTGAAAAT TTCCAAGGGG ACGCCTGGTC TCTTTTTGCC 
AACACGGTGG CCCATGAGTT AGGCCATACT TTTGGTATGA AGCATGATGA GGAATCCTGC 
TCTTGTGGGA AAAGTGGTTG TGTCATGAGT ACTTTCAGAG TGCCAGCAGA GAGATTCACC 
AATTGCAGCT ATAGTGATTT TATGAAGACC ACTTTAAACC AAGGAACTTG TCTGTACAAT 
CATCCAAGAC CAGGGGCAGG TTTCCTGGTG AAGCGCTGTG GGAATGGTAT GGTTGAAAGT 
GAAGAAGAGT GTGACTGTGG ATCTGTACAG GAATGTGAGC AAGATCCCTG TTGTTTTCTT 
AACTGTACGC TGAGACCTGC AGCTGCTTGT AGTTTTGGGC TCTGTTGCAA AGACTGCAAA 
TTCATGCTCT TGGGGGAACT CTGTAGACCA AAGATCAATG AATGTGACCT TCCAGAATGG 
TGCAATGGAA CATCTCACCA GTGCCCAGAA GATGGATATG TACAGGATGG GGTCCCCTGT 
GGTGCCGGTG CCTACTGCTA TCAAAAGCAG TGTAATAACC ATGACCAACA GTGCAGGGAG 
ATTTTTGGCA AAGGTGCAAG AAGCGCATCT CATAATTGCT ATAAAGAAAT CAACTTACAA 
GGAAACAGGT TTGGCCATTG TGGCACAGAT GGCACAGTAT TCCTAAAATG CAGAATGTCA 
GATGTGTTTT GTGGGAAAGT CCACTGTGAA AATGTAGAAG ACATTCACCA TCCCCAGGCT 
CCTTATGTTT TGCAGAACAT TTATGCCAAT GGTATCACCT GCTGGAGTAC TGGCCATTGT 
TTGGGGATGG GTGTGCCTGA TGTTGGTGAA GTGAAAGATG GCACCACCTG TGGAGTAGGA 
AAGATCTGCC TACACAAGAA GTGTGTCAGT CTGTCTGTCC TTTCAAATGC TTGCCTTCCT 
GAGACTTGTA ATAGGAAGGG GGTCTGTAAT AACAAGCATC ACTGTCACTG TGACTATGGG 
TGGTCCCCGC CTTTCTGCCT GCACAGAGGT TATGGAGGTA GTATTGACAG TGGTCCAACA 
TCTCAAAAAA GAAGAGTCAT TATCACTGTC CTGTCAATAA CTGTGCCTGT TTTATCCATC 
CTAATTTGTC TGCTCATAGC TGGGCTTTAT AGAATATATT GTAAAATACC TTCTGGTCCC 
AAAGAGACTA AGGCCTCTTC ACCAGGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression analysis of the Adam21 gene in mouse testis.
Gene expression patterns : GEP10(2-3)152-8(2010 Feb-Mar)
Yi C,Woo JM,Han C,Oh JS,Park I,Lee B,Jin S,Choi H,Kwon JT,Cho BN,Kim DH,Cho C

SPARC is expressed by macroglia and microglia in the developing and mature nervous system.
Developmental dynamics : an official publication of the American Association of Anatomists237(5)1449-62(2008 May)
Vincent AJ,Lau PW,Roskams AJ

New quantitative trait loci that regulate wound healing in an intercross progeny from DBA/1J and 129 x 1/SvJ inbred strains of mice.
Functional & integrative genomics6(2)157-63(2006 Apr)
Masinde GL,Li R,Nguyen B,Yu H,Srivastava AK,Edderkaoui B,Wergedal JE,Baylink DJ,Mohan S

A disintegrin and metalloprotease 21 (ADAM21) is associated with neurogenesis and axonal growth in developing and adult rodent CNS.
The Journal of comparative neurology490(2)163-79(2005 Sep)
Yang P,Baker KA,Hagg T

Chromosomal mapping of Adam9, Adam15 and Adam21.
Matrix biology : journal of the International Society for Matrix Biology19(2)185-7(2000 May)
Seldin MF,Hirohata S,Apte SS

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Adam21 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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