Txn2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Txn2
Entrez Gene ID	56551
Full Name	thioredoxin 2
Synonyms	2510006J11Rik,AI788873,Trx2
General protein information	Preferred Names thioredoxin 2 Names thioredoxin, mitochondrial MTRX mt-Trx thioredoxin nuclear gene encoding mitochondrial protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_019913.5	NP_064297.1	thioredoxin, mitochondrial precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Txn2	NP_064297.1
Homo sapiens (human)	TXN2	NP_036605.2
Bos taurus (cattle)	TXN2	NP_776633.1
Rattus norvegicus (Norway rat)	Txn2	NP_445783.1
Gallus gallus (chicken)	TXN2	NP_001026581.1
Danio rerio (zebrafish)	txn2	NP_991204.1
Drosophila melanogaster (fruit fly)	CG8993	NP_647716.1
Anopheles gambiae (African malaria mosquito)	TRX2	XP_308583.2
Caenorhabditis elegans (roundworm)	trx-2	NP_001256207.1
Canis lupus familiaris (dog)	TXN2	XP_531748.3
Xenopus tropicalis (tropical clawed frog)	txn2	NP_001008161.1

Gene Ontology
Bibliography

Related articles in PubMed

Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.
Magarin M, Pohl T, Lill A, Schulz H, Blaschke F, Heuser A, Thierfelder L, Donath S, Drenckhahn JD
Journal of molecular and cellular cardiology971-14(2016 Aug)

Thidoredxin-2 overexpression fails to rescue chronic high calorie diet induced hippocampal dysfunction.
Liu Y, Yang Y, Dong H, Cutler RG, Strong R, Mattson MP
Experimental neurology275 Pt 1126-32(2016 Jan)

Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.
Pirson M, Knoops B
The Journal of comparative neurology523(17)2599-617(2015 Dec)

Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function.
Huang Q, Zhou HJ, Zhang H, Huang Y, Hinojosa-Kirschenbaum F, Fan P, Yao L, Belardinelli L, Tellides G, Giordano FJ, Budas GR, Min W
Circulation131(12)1082-97(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TRX-2 overexpression does not mitigate adverse effects of a high-calorie diet on synaptic plasticity
Title: Thidoredxin-2 overexpression fails to rescue chronic high calorie diet induced hippocampal dysfunction.

The ventral signal observed from early stages colocalized with motor neuron markers Isl1/2 and FoxP1 and the strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord.
Title: Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.

An essential role was identified for thioredoxin-2 in preserving cardiac function by suppressing mitochondrial reactive oxygen species.
Title: Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function.

The SirT1 regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase, catalase, peroxiredoxins 3 and 5, thioredoxin 2, thioredoxin reductase 2, and uncoupling protein 2.
Title: SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1? complex.

This study shows that both fructose and glucose-sweetened liquid consumption results in fatty liver and upregulated thioredoxin-2 expression.
Title: Hepatic oxidative stress in fructose-induced fatty liver is not caused by sulfur amino acid insufficiency.

The following Txn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Txn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16235	NM_019913.5 Latest version!	Mus musculus thioredoxin 2 (Txn2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Txn2 ( NM_019913.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064297.1 Mus musculus thioredoxin 2 (Txn2), mRNA.

Price & Availability↑

CloneID	OMu16235
Clone ID Related Accession (Same CDS sequence)	NM_019913.5
Accession Version	NM_019913.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	thioredoxin, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL583886.11. On Apr 29, 2007 this sequence version replaced NM_019913.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK010917.1, BC068182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCTCAGC GGCTCCTCCT GGGGAGGTTC CTGACCTCAG TCATCTCCAG GAAGCCTCCT 
CAGGGTGTGT GGGCTTCCCT CACCTCTAAG ACCCTGCAGA CCCCTCAGTA CAATGCTGGT 
GGTCTAACAG TAATGCCCAG CCCAGCCCGG ACAGTACACA CCACCAGAGT CTGTTTGACG 
ACCTTTAACG TCCAGGATGG ACCTGACTTT CAAGACAGAG TTGTCAACAG TGAGACACCA 
GTTGTTGTGG ACTTTCATGC ACAGTGGTGT GGCCCCTGCA AGATCCTAGG ACCGCGGCTA 
GAGAAGATGG TCGCCAAGCA GCACGGGAAG GTGGTCATGG CCAAAGTGGA CATTGACGAT 
CACACAGACC TTGCCATTGA ATATGAGGTG TCAGCTGTGC CTACCGTGCT AGCCATCAAG 
AACGGGGACG TGGTGGACAA GTTTGTGGGG ATCAAGGACG AGGACCAGCT AGAAGCCTTC 
CTGAAGAAGC TGATTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064297.1
CDS	89..589
Translation	MAQRLLLGRFLTSVISRKPPQGVWASLTSKTLQTPQYNAGGLTVMPSPARTVHTTRVCLTTFNVQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAIKNGDVVDKFVGIKDEDQLEAFLKKLIG

Target ORF information:

RefSeq Version	NM_019913.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus thioredoxin 2 (Txn2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019913.5

ORF Insert Sequence:

ATGGCTCAGC GGCTCCTCCT GGGGAGGTTC CTGACCTCAG TCATCTCCAG GAAGCCTCCT 
CAGGGTGTGT GGGCTTCCCT CACCTCTAAG ACCCTGCAGA CCCCTCAGTA CAATGCTGGT 
GGTCTAACAG TAATGCCCAG CCCAGCCCGG ACAGTACACA CCACCAGAGT CTGTTTGACG 
ACCTTTAACG TCCAGGATGG ACCTGACTTT CAAGACAGAG TTGTCAACAG TGAGACACCA 
GTTGTTGTGG ACTTTCATGC ACAGTGGTGT GGCCCCTGCA AGATCCTAGG ACCGCGGCTA 
GAGAAGATGG TCGCCAAGCA GCACGGGAAG GTGGTCATGG CCAAAGTGGA CATTGACGAT 
CACACAGACC TTGCCATTGA ATATGAGGTG TCAGCTGTGC CTACCGTGCT AGCCATCAAG 
AACGGGGACG TGGTGGACAA GTTTGTGGGG ATCAAGGACG AGGACCAGCT AGAAGCCTTC 
CTGAAGAAGC TGATTGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.
Journal of molecular and cellular cardiology971-14(2016 Aug)
Magarin M,Pohl T,Lill A,Schulz H,Blaschke F,Heuser A,Thierfelder L,Donath S,Drenckhahn JD

Thidoredxin-2 overexpression fails to rescue chronic high calorie diet induced hippocampal dysfunction.
Experimental neurology275 Pt 1126-32(2016 Jan)
Liu Y,Yang Y,Dong H,Cutler RG,Strong R,Mattson MP

Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.
The Journal of comparative neurology523(17)2599-617(2015 Dec)
Pirson M,Knoops B

Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function.
Circulation131(12)1082-97(2015 Mar)
Huang Q,Zhou HJ,Zhang H,Huang Y,Hinojosa-Kirschenbaum F,Fan P,Yao L,Belardinelli L,Tellides G,Giordano FJ,Budas GR,Min W