Fzr1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fzr1
Entrez Gene ID	56371
Full Name	fizzy and cell division cycle 20 related 1
Synonyms	AW108046,Cdh1,FZR,FZR2,Fyr,HCDH,HCDH1
General protein information	Preferred Names fizzy and cell division cycle 20 related 1 Names fizzy-related protein homolog cdh1/Hct1 homolog cell division cycle 20 related 1 fizzy/cell division cycle 20 related 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_019757.1	NP_062731.1	fizzy-related protein homolog

Pathways from BioSystems

Homologies

Homo sapiens (human)	FZR1	NP_057347.2
Canis lupus familiaris (dog)	FZR1	XP_005633132.1
Rattus norvegicus (Norway rat)	Fzr1	NP_001101544.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002114	XP_320924.5
Caenorhabditis elegans (roundworm)	fzr-1	NP_496075.1
Kluyveromyces lactis	KLLA0A08822g	XP_451387.1
Oryza sativa (rice)	Os01g0972900	NP_001045543.1
Mus musculus (house mouse)	Fzr1	NP_062731.1
Drosophila melanogaster (fruit fly)	rap	NP_524852.2
Eremothecium gossypii	AGOS_AFL007C	NP_985541.2
Schizosaccharomyces pombe (fission yeast)	srw1	NP_594674.1
Magnaporthe oryzae (rice blast fungus)	MGG_06892	XP_003709620.1
Xenopus tropicalis (tropical clawed frog)	fzr1	NP_001120001.1
	FZR1	XP_001117911.2
Bos taurus (cattle)	FZR1	NP_001032698.1
Gallus gallus (chicken)	CDH1-A	NP_001265019.1
Danio rerio (zebrafish)	fzr1	NP_956547.1
Saccharomyces cerevisiae (baker's yeast)	CDH1	NP_011512.1
Arabidopsis thaliana (thale cress)	FZR3	NP_196888.2
Neurospora crassa	NCU01269	XP_960747.1

Gene Ontology
Bibliography

Related articles in PubMed

Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1.
Garz?n J, Rodr?guez R, Kong Z, Chabes A, Rodr?guez-Acebes S, M?ndez J, Moreno S, Garc?a-Higuera I
Oncogene36(42)5808-5818(2017 Oct)

The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.
Ha K, Ma C, Lin H, Tang L, Lian Z, Zhao F, Li JM, Zhen B, Pei H, Han S, Malumbres M, Jin J, Chen H, Zhao Y, Zhu Q, Zhang P
Nature communications815751(2017 Jun)

New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer's Disease.
Fuchsberger T, Lloret A, Vi?a J
International journal of molecular sciences18(5)(2017 May)

APC/C
Rattani A, Ballesteros Mejia R, Roberts K, Roig MB, Godwin J, Hopkins M, Eguren M, Sanchez-Pulido L, Okaz E, Ogushi S, Wolna M, Metson J, Pend?s AM, Malumbres M, Nov?k B, Herbert M, Nasmyth K
Current biology : CB27(10)1462-1476.e5(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

loss of Cdh1 leads to increased and extended S phase progression possibly due to the upregulation of cyclin D1.
Title: APC

results suggest that reduction of FZR1 increases therapeutic sensitivity of B-ALL and that transient rather than tonic inhibition of FZR1 may be a therapeutic strategy.
Title: FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.

Both catalytic and non-catalytic APC/C-Fzr1/Cdh1-mediated activities of PTEN are required for stalk cells' proliferative arrest. Findings implicate the PTEN-APC/C-Fzr1/Cdh1 hub in angiogenesis.
Title: PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.

Loss of APC/C(FZR1) activity in the male germline led to both a mitotic and a meiotic testicular defect resulting in infertility due to the absence of mature spermatozoa.
Title: The APC/C activator FZR1 is essential for meiotic prophase I in mice.

Fzr1 is a surprisingly essential gene involved in the establishment of a single spindle from the two pronuclei in 1-cell embryos as well as being involved in the maintenance of genomic integrity during the mitotic divisions of early mammalian embryos.
Title: The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development.

The following Fzr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fzr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19660	NM_019757.1 Latest version!	Mus musculus fizzy and cell division cycle 20 related 1 (Fzr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fzr1 ( NM_019757.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062731.1 Mus musculus fizzy and cell division cycle 20 related 1 (Fzr1), mRNA.

Price & Availability↑

CloneID	OMu19660
Clone ID Related Accession (Same CDS sequence)	NM_019757.1
Accession Version	NM_019757.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	fizzy-related protein homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF083809.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF083809.1, AK083686.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164140 [ECO:0000348] ##Evidence-Data-END##

ATGGACCAGG ACTATGAGCG AAGGCTCCTG CGGCAGATCA TCATCCAGAA TGAGAACACA 
GTGCCCTGTG TTTCAGAGAT GCGGAGAACC CTGACACCAG CCAACTCCCC AGTGTCTTCA 
CCCAGCAAGC ATGGTGACCG CTTCATCCCC TCGCGGGCCG GGGCCAACTG GAGCGTGAAC 
TTCCACAGGA TCAATGAAAA TGAGAAGTCC CCCAGCCAGA ACCGCAAAGC CAAGGACGCC 
ACCTCGGACA ATGGCAAAGA CGGCCTGGCC TACTCCGCAC TGCTGAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT TCAGGACCCA CAGACGGAGG ACCGGCGGCT GCAGCCGTCC 
ACACCAGAGC ACAAGGGGCT CTTTACGTAT TCCCTCAGCA GCAAGCGCTC GAGTCCAGAT 
GATGGCAATG ACGTGTCCCC ATACTCTCTG TCCCCCGTTA GCAACAAAAG TCAGAAGCTG 
CTGCGGTCAC CACGGAAGCC CACACGCAAG ATCTCTAAGA TTCCCTTCAA GGTGCTGGAC 
GCGCCAGAGC TTCAGGACGA CTTCTACCTC AACTTGGTGG ACTGGTCCTC CCTCAACGTG 
CTCAGCGTGG GGCTGGGCAC CTGCGTGTAC CTGTGGAGTG CATGCACCAG CCAGGTGACC 
CGGCTCTGTG ACCTCTCTGT AGAAGGGGAC TCAGTGACTT CCGTTGGCTG GTCTGAGCGG 
GGGAACTTGG TCGCAGTAGG TACACACAAG GGCTTCGTGC AGATCTGGGA CGCTGCTGCT 
GGGAAGAAGC TGTCCATGCT GGAGGGCCAC ACAGCACGAG TGGGGGCGCT GGCCTGGAAT 
GCTGACCAGT TGTCATCTGG TAGCCGTGAC CGCATGATCC TACAGCGGGA TATCCGCACA 
CCACCCCTGC AGTCAGAGCG GCGGCTGCAG GGCCACCGGC AGGAAGTGTG TGGCCTAAAG 
TGGTCCACAG ACCACCAGCT GCTTGCCTCG GGGGGCAATG ACAACAAGCT GCTCGTGTGG 
AACCACTCTA GTCTAAGCCC TGTGCAGCAG TATACGGAGC ACCTGGCAGC CGTGAAGGCT 
ATTGCCTGGT CCCCACACCA GCATGGACTG CTGGCATCTG GTGGTGGCAC GGCTGACCGC 
TGCATCCGAT TCTGGAACAC TCTGACAGGT CAGCCACTGC AGTGCATTGA CACAGGCTCA 
CAAGTGTGCA ACCTGGCCTG GTCCAAGCAC GCCAATGAGC TGGTGAGCAC ACATGGCTAC 
TCACAGAACC AGATCCTCGT GTGGAAGTAC CCGTCCCTTA CGCAGGTGGC CAAGCTCACT 
GGCCACTCAT ATCGTGTCCT CTACCTGGCC ATGTCCCCTG ATGGGGAGGC CATAGTCACC 
GGAGCTGGAG ATGAGACCCT GAGGTTCTGG AATGTCTTCA GCAAAACACG CTCTACAAAG 
GAATCTGTGT CTGTGCTCAA CCTCTTCACC CGGATCCGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062731.1
CDS	143..1624
Translation	MDQDYERRLLRQIIIQNENTVPCVSEMRRTLTPANSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEHKGLFTYSLSSKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNADQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR

Target ORF information:

RefSeq Version	NM_019757.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus fizzy and cell division cycle 20 related 1 (Fzr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019757.1

ORF Insert Sequence:

ATGGACCAGG ACTATGAGCG AAGGCTCCTG CGGCAGATCA TCATCCAGAA TGAGAACACA 
GTGCCCTGTG TTTCAGAGAT GCGGAGAACC CTGACACCAG CCAACTCCCC AGTGTCTTCA 
CCCAGCAAGC ATGGTGACCG CTTCATCCCC TCGCGGGCCG GGGCCAACTG GAGCGTGAAC 
TTCCACAGGA TCAATGAAAA TGAGAAGTCC CCCAGCCAGA ACCGCAAAGC CAAGGACGCC 
ACCTCGGACA ATGGCAAAGA CGGCCTGGCC TACTCCGCAC TGCTGAAGAA TGAGCTGCTG 
GGTGCCGGCA TCGAGAAGGT TCAGGACCCA CAGACGGAGG ACCGGCGGCT GCAGCCGTCC 
ACACCAGAGC ACAAGGGGCT CTTTACGTAT TCCCTCAGCA GCAAGCGCTC GAGTCCAGAT 
GATGGCAATG ACGTGTCCCC ATACTCTCTG TCCCCCGTTA GCAACAAAAG TCAGAAGCTG 
CTGCGGTCAC CACGGAAGCC CACACGCAAG ATCTCTAAGA TTCCCTTCAA GGTGCTGGAC 
GCGCCAGAGC TTCAGGACGA CTTCTACCTC AACTTGGTGG ACTGGTCCTC CCTCAACGTG 
CTCAGCGTGG GGCTGGGCAC CTGCGTGTAC CTGTGGAGTG CATGCACCAG CCAGGTGACC 
CGGCTCTGTG ACCTCTCTGT AGAAGGGGAC TCAGTGACTT CCGTTGGCTG GTCTGAGCGG 
GGGAACTTGG TCGCAGTAGG TACACACAAG GGCTTCGTGC AGATCTGGGA CGCTGCTGCT 
GGGAAGAAGC TGTCCATGCT GGAGGGCCAC ACAGCACGAG TGGGGGCGCT GGCCTGGAAT 
GCTGACCAGT TGTCATCTGG TAGCCGTGAC CGCATGATCC TACAGCGGGA TATCCGCACA 
CCACCCCTGC AGTCAGAGCG GCGGCTGCAG GGCCACCGGC AGGAAGTGTG TGGCCTAAAG 
TGGTCCACAG ACCACCAGCT GCTTGCCTCG GGGGGCAATG ACAACAAGCT GCTCGTGTGG 
AACCACTCTA GTCTAAGCCC TGTGCAGCAG TATACGGAGC ACCTGGCAGC CGTGAAGGCT 
ATTGCCTGGT CCCCACACCA GCATGGACTG CTGGCATCTG GTGGTGGCAC GGCTGACCGC 
TGCATCCGAT TCTGGAACAC TCTGACAGGT CAGCCACTGC AGTGCATTGA CACAGGCTCA 
CAAGTGTGCA ACCTGGCCTG GTCCAAGCAC GCCAATGAGC TGGTGAGCAC ACATGGCTAC 
TCACAGAACC AGATCCTCGT GTGGAAGTAC CCGTCCCTTA CGCAGGTGGC CAAGCTCACT 
GGCCACTCAT ATCGTGTCCT CTACCTGGCC ATGTCCCCTG ATGGGGAGGC CATAGTCACC 
GGAGCTGGAG ATGAGACCCT GAGGTTCTGG AATGTCTTCA GCAAAACACG CTCTACAAAG 
GAATCTGTGT CTGTGCTCAA CCTCTTCACC CGGATCCGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1.
Oncogene36(42)5808-5818(2017 Oct)
Garz?n J,Rodr?guez R,Kong Z,Chabes A,Rodr?guez-Acebes S,M?ndez J,Moreno S,Garc?a-Higuera I

The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.
Nature communications815751(2017 Jun)
Ha K,Ma C,Lin H,Tang L,Lian Z,Zhao F,Li JM,Zhen B,Pei H,Han S,Malumbres M,Jin J,Chen H,Zhao Y,Zhu Q,Zhang P

New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer's Disease.
International journal of molecular sciences18(5)(2017 May)
Fuchsberger T,Lloret A,Vi?a J

APC/C
Current biology : CB27(10)1462-1476.e5(2017 May)
Rattani A,Ballesteros Mejia R,Roberts K,Roig MB,Godwin J,Hopkins M,Eguren M,Sanchez-Pulido L,Okaz E,Ogushi S,Wolna M,Metson J,Pend?s AM,Malumbres M,Nov?k B,Herbert M,Nasmyth K

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Fzr1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報