Ptges3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ptges3
Entrez Gene ID	56351
Full Name	prostaglandin E synthase 3
Synonyms	5730442A20Rik,Ptges,Tebp,cPGES,p23,sid3177
General protein information	Preferred Names prostaglandin E synthase 3 Names prostaglandin E synthase 3 cytosolic prostaglandin E2 synthase hsp90 co-chaperone p23 cochaperone progesterone receptor complex p23 prostaglandin E synthase 3 (cytosolic) sid 3177 telomerase binding protein, p23
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 D3

mRNA and Protein(s)

mRNA	Protein	Name
NM_019766.4	NP_062740.1	prostaglandin E synthase 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	PTGES3	NP_001269533.1
Pan troglodytes (chimpanzee)	PTGES3	NP_001233331.1
Bos taurus (cattle)	PTGES3	NP_001007807.2
Mus musculus (house mouse)	Gm9769	XP_003945448.2
Rattus norvegicus (Norway rat)	Ptges3	NP_001124461.1
Xenopus tropicalis (tropical clawed frog)	ptges3	NP_001007105.1
Mus musculus (house mouse)	Ptges3	NP_062740.1
Gallus gallus (chicken)	PTGES3	NP_001263235.1
Danio rerio (zebrafish)	ptges3a	NP_998335.1
	PTGES3	XP_001115388.1
Canis lupus familiaris (dog)	PTGES3	XP_005625578.1

Gene Ontology
Bibliography

Related articles in PubMed

Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23.
Madon-Simon M, Grad I, Bayo P, P?rez P, Picard D
PloS one12(6)e0180035(2017)

Identification of RNA-binding Proteins in Macrophages by Interactome Capture.
Liepelt A, Naarmann-de Vries IS, Simons N, Eichelbaum K, F?hr S, Archer SK, Castello A, Usadel B, Krijgsveld J, Preiss T, Marx G, Hentze MW, Ostareck DH, Ostareck-Lederer A
Molecular & cellular proteomics : MCP15(8)2699-714(2016 08)

The small co-chaperone p23 overexpressing transgenic mouse.
Zhang J, Spilman P, Chen S, Gorostiza O, Matalis A, Niazi K, Bredesen DE, Rao RV
Journal of neuroscience methods212(2)190-4(2013 Jan)

The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status.
Zelin E, Zhang Y, Toogun OA, Zhong S, Freeman BC
Molecular cell48(3)459-70(2012 Nov)

p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines.
Nguyen PM, Wang D, Wang Y, Li Y, Uchizono JA, Chan WK
Biochemical pharmacology84(6)838-50(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23; the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor, a paradigmatic Hsp90-p23 client protein, we investigated glucocorticoid signaling.
Title: Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23.

Results identified two proteins P23 and HCLS1, which were not known as RNA-binding proteins, exhibiting RNA-binding activity.
Title: Identification of RNA-binding Proteins in Macrophages by Interactome Capture.

we report the generation of transgenic mouse lines that overexpress wild-type p23 or uncleavable p23
Title: The small co-chaperone p23 overexpressing transgenic mouse.

Data support a model in which p23 and GCN5 regulate diverse multistep pathways by controlling the longevity of protein-DNA complexes.
Title: The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status.

p23 co-chaperone protects the aryl hydrocarbon receptor from degradation
Title: p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines.

The following Ptges3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptges3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15920	NM_019766.4 Latest version!	Mus musculus prostaglandin E synthase 3 (Ptges3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ptges3 ( NM_019766.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062740.1 Mus musculus prostaglandin E synthase 3 (Ptges3), mRNA.

Price & Availability↑

CloneID	OMu15920
Clone ID Related Accession (Same CDS sequence)	NM_019766.4
Accession Version	NM_019766.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	prostaglandin E synthase 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC131120.4. On Apr 29, 2007 this sequence version replaced NM_019766.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK077538.1, BC085264.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCCTG CTTCTGCAAA GTGGTACGAT CGAAGGGACT ATGTATTCAT TGAATTTTGT 
GTTGAAGACA GTAAAGATGT TAATGTAAAC TTTGAAAAAT CCAAACTTAC TTTCAGTTGT 
CTTGGAGGAA GCGATAATTT TAAGCATTTA AATGAAATTG ATCTTTTTCA TTGTATCGAT 
CCAAATGATT CCAAGCATAA AAGAACAGAC AGATCGATTT TATGTTGTTT GCGAAAAGGA 
GAATCCGGCC AGTCATGGCC TAGGTTAACA AAGGAAAGGG CAAAGCTTAA TTGGCTCAGT 
GTGGACTTCA ATAATTGGAA AGACTGGGAG GATGACTCAG ATGAAGACAT GTCGAATTTT 
GACCGTTTCT CTGAGATGAT GGATCACATG GGTGGTGATG AGGATGTAGA TTTACCAGAA 
GTAGATGGAG CAGATGATGA TTCACAAGAC AGTGATGATG AAAAGATGCC AGATCTGGAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062740.1
CDS	304..786
Translation	MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMDHMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE

Target ORF information:

RefSeq Version	NM_019766.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus prostaglandin E synthase 3 (Ptges3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019766.4

ORF Insert Sequence:

ATGCAGCCTG CTTCTGCAAA GTGGTACGAT CGAAGGGACT ATGTATTCAT TGAATTTTGT 
GTTGAAGACA GTAAAGATGT TAATGTAAAC TTTGAAAAAT CCAAACTTAC TTTCAGTTGT 
CTTGGAGGAA GCGATAATTT TAAGCATTTA AATGAAATTG ATCTTTTTCA TTGTATCGAT 
CCAAATGATT CCAAGCATAA AAGAACAGAC AGATCGATTT TATGTTGTTT GCGAAAAGGA 
GAATCCGGCC AGTCATGGCC TAGGTTAACA AAGGAAAGGG CAAAGCTTAA TTGGCTCAGT 
GTGGACTTCA ATAATTGGAA AGACTGGGAG GATGACTCAG ATGAAGACAT GTCGAATTTT 
GACCGTTTCT CTGAGATGAT GGATCACATG GGTGGTGATG AGGATGTAGA TTTACCAGAA 
GTAGATGGAG CAGATGATGA TTCACAAGAC AGTGATGATG AAAAGATGCC AGATCTGGAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23.
PloS one12(6)e0180035(2017)
Madon-Simon M,Grad I,Bayo P,P?rez P,Picard D

Identification of RNA-binding Proteins in Macrophages by Interactome Capture.
Molecular & cellular proteomics : MCP15(8)2699-714(2016 08)
Liepelt A,Naarmann-de Vries IS,Simons N,Eichelbaum K,F?hr S,Archer SK,Castello A,Usadel B,Krijgsveld J,Preiss T,Marx G,Hentze MW,Ostareck DH,Ostareck-Lederer A

The small co-chaperone p23 overexpressing transgenic mouse.
Journal of neuroscience methods212(2)190-4(2013 Jan)
Zhang J,Spilman P,Chen S,Gorostiza O,Matalis A,Niazi K,Bredesen DE,Rao RV

The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status.
Molecular cell48(3)459-70(2012 Nov)
Zelin E,Zhang Y,Toogun OA,Zhong S,Freeman BC

p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines.
Biochemical pharmacology84(6)838-50(2012 Sep)
Nguyen PM,Wang D,Wang Y,Li Y,Uchizono JA,Chan WK

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Ptges3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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