B4galt5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	B4galt5
Entrez Gene ID	56336
Full Name	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
Synonyms	9430078I07Rik,AW049941,AW539721
General protein information	Preferred Names UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 Names beta-1,4-galactosyltransferase 5 UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5 b4Gal-T5 beta-1,4-GalT II beta-1,4-GalTase 5 beta-1,4-galactosyltransferase V beta4Gal-T5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 H3

mRNA and Protein(s)

mRNA	Protein	Name
NM_019835.2	NP_062809.2	beta-1,4-galactosyltransferase 5

Pathways from BioSystems

Homologies

Homo sapiens (human)	B4GALT5	NP_004767.1
Pan troglodytes (chimpanzee)	B4GALT5	XP_001167173.1
Caenorhabditis elegans (roundworm)	W02B12.11	NP_496449.1
	B4GALT5	XP_001103384.2
Danio rerio (zebrafish)	b4galt5	NP_001038797.1
Canis lupus familiaris (dog)	B4GALT5	XP_543044.4
Bos taurus (cattle)	B4GALT5	XP_002692400.2
Mus musculus (house mouse)	B4galt5	NP_062809.2
Xenopus tropicalis (tropical clawed frog)	b4galt6	NP_001016385.1
Gallus gallus (chicken)	B4GALT5	XP_417519.4

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivis?kk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ
Nature medicine20(10)1147-56(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results strongly indicate that the amounts of Lac-Cer synthesized by beta4GalT5 correlate with the tumorigenic potentials of malignantly transformed cells.
Title: Gene expression levels of ?4-galactosyltransferase 5 correlate with the tumorigenic potentials of B16-F10 mouse melanoma cells.

Data indicate that mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosylceramide synthase and lactosylceramide synthase showed marked reduction in tumor volume.
Title: Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model.

The expression of the beta-1,4-GalT V gene has been shown to be regulated by transcription factors Sp1 and Ets-1 in cancer cells.(review)
Title: [Regulation of human ?-1,4-galactosyltransferase V gene expression in cancer cells].

beta-1,4-galactosyltransferase V is involved in lactosylceramide biosynthesis
Title: Involvement of murine ?-1,4-galactosyltransferase V in lactosylceramide biosynthesis.

Loss of beta4Gal-T5 is associated with hematoma and defect in extra-embryonic development.
Title: Beta4-galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development.

The following B4galt5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the B4galt5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11344	NM_019835.2 Latest version!	Mus musculus UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 (B4galt5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

B4galt5 ( NM_019835.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062809.2 Mus musculus UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 (B4galt5), mRNA.

Price & Availability↑

CloneID	OMu11344
Clone ID Related Accession (Same CDS sequence)	NM_019835.2
Accession Version	NM_019835.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	beta-1,4-galactosyltransferase 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ134591.1, BE981379.1, AK151469.1 and AL591854.18. On Oct 13, 2006 this sequence version replaced NM_019835.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB004786.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCGCCC GCCGGGGGCT GCTGCGGCTG CCGCGCCGCT CGCTGCTCGC CGCGCTCTTC 
TTCTTCTCGC TGTCGTCCTC GCTGCTCTAC TTCGTCTATG TGGCGCCCGG CATAGTGAAC 
ACCTACCTCT TCATGGTGCA GGCTCAGGGC ATCCTACTGC GGGACAATGT GAGGACCATC 
GGTGCCCAGG TGTACGAGCA GGTGGTCCGC AGCGCCTATG CCAAGAGGAA CAGCAGCCTG 
AATGACTCAG ATTATCCTCT GGACTTGAAC CACAGTGAAG CCTTTCCCCC AACCACGACC 
TTTCTTCCTG AAGATTTCAC CTACTTTGCC AACCACCCTT GCCCAGAGAG GCTCCCTTCC 
ATGAAGGGCC CGATAGATAT AAACATGAGT GAGATCGCAA TGGACGATAT TCATGAGCTG 
TTCTCCAGAG ACCCGGCCAT TAAGCTCGGA GGGCACTGGA AGCCTGCAGA CTGTGTGCCT 
CGGTGGAAGG TGGCTATCCT CATCCCCTTC CGGAACCGCC ATGAGCACCT CCCGGTCCTC 
CTGAGACACC TGCTCCCCAT GCTTCAGCGC CAGCGCCTGC AGTTCGCCTT CTATGTGATC 
GAGCAAGTTG GCACCCAGCC CTTTAACCGA GCCATGCTTT TCAATGTTGG TTTTCAAGAA 
GCCATGAAGG ACTTGGATTG GGATTGTCTG ATCTTCCATG ACGTCGATCA CATACCTGAG 
AGTGACCGAA ACTACTATGG CTGCGGGCAG ATGCCCAGGC ACTTTGCAAC CAAGCTGGAC 
AAGTACATGT ACCTGCTGCC CTACACTGAG TTTTTTGGTG GCGTGAGCGG CCTGACTGTA 
GAACAGTTTC GGAAAATCAA TGGCTTTCCT AATGCCTTCT GGGGCTGGGG CGGAGAAGAT 
GACGACTTGT GGAACAGGGT ACAAAATGCA GGCTATTCTG TGAGCCGGCC AGAAGGGGAC 
ACAGGAAAAT ACAAGTCCAT TCCTCACCAC CATCGAGGAG AGGTCCAGTT TCTTGGCAGG 
TACGCTCTGC TGAGGAAGTC AAAGGAGCGG CAAGGACTGG ATGGCCTCAA CAACCTGAAC 
TACTCTGCGA ATGTCACGTA CGACGCCTTG TATAAAAACA TAACTGTCAA CTTGACACCC 
GAGCTGGCTC AGGTGACTGA GTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062809.2
CDS	147..1313
Translation	MRARRGLLRLPRRSLLAALFFFSLSSSLLYFVYVAPGIVNTYLFMVQAQGILLRDNVRTIGAQVYEQVVRSAYAKRNSSLNDSDYPLDLNHSEAFPPTTTFLPEDFTYFANHPCPERLPSMKGPIDINMSEIAMDDIHELFSRDPAIKLGGHWKPADCVPRWKVAILIPFRNRHEHLPVLLRHLLPMLQRQRLQFAFYVIEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGEVQFLGRYALLRKSKERQGLDGLNNLNYSANVTYDALYKNITVNLTPELAQVTEY

Target ORF information:

RefSeq Version	NM_019835.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 (B4galt5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019835.2

ORF Insert Sequence:

ATGCGCGCCC GCCGGGGGCT GCTGCGGCTG CCGCGCCGCT CGCTGCTCGC CGCGCTCTTC 
TTCTTCTCGC TGTCGTCCTC GCTGCTCTAC TTCGTCTATG TGGCGCCCGG CATAGTGAAC 
ACCTACCTCT TCATGGTGCA GGCTCAGGGC ATCCTACTGC GGGACAATGT GAGGACCATC 
GGTGCCCAGG TGTACGAGCA GGTGGTCCGC AGCGCCTATG CCAAGAGGAA CAGCAGCCTG 
AATGACTCAG ATTATCCTCT GGACTTGAAC CACAGTGAAG CCTTTCCCCC AACCACGACC 
TTTCTTCCTG AAGATTTCAC CTACTTTGCC AACCACCCTT GCCCAGAGAG GCTCCCTTCC 
ATGAAGGGCC CGATAGATAT AAACATGAGT GAGATCGCAA TGGACGATAT TCATGAGCTG 
TTCTCCAGAG ACCCGGCCAT TAAGCTCGGA GGGCACTGGA AGCCTGCAGA CTGTGTGCCT 
CGGTGGAAGG TGGCTATCCT CATCCCCTTC CGGAACCGCC ATGAGCACCT CCCGGTCCTC 
CTGAGACACC TGCTCCCCAT GCTTCAGCGC CAGCGCCTGC AGTTCGCCTT CTATGTGATC 
GAGCAAGTTG GCACCCAGCC CTTTAACCGA GCCATGCTTT TCAATGTTGG TTTTCAAGAA 
GCCATGAAGG ACTTGGATTG GGATTGTCTG ATCTTCCATG ACGTCGATCA CATACCTGAG 
AGTGACCGAA ACTACTATGG CTGCGGGCAG ATGCCCAGGC ACTTTGCAAC CAAGCTGGAC 
AAGTACATGT ACCTGCTGCC CTACACTGAG TTTTTTGGTG GCGTGAGCGG CCTGACTGTA 
GAACAGTTTC GGAAAATCAA TGGCTTTCCT AATGCCTTCT GGGGCTGGGG CGGAGAAGAT 
GACGACTTGT GGAACAGGGT ACAAAATGCA GGCTATTCTG TGAGCCGGCC AGAAGGGGAC 
ACAGGAAAAT ACAAGTCCAT TCCTCACCAC CATCGAGGAG AGGTCCAGTT TCTTGGCAGG 
TACGCTCTGC TGAGGAAGTC AAAGGAGCGG CAAGGACTGG ATGGCCTCAA CAACCTGAAC 
TACTCTGCGA ATGTCACGTA CGACGCCTTG TATAAAAACA TAACTGTCAA CTTGACACCC 
GAGCTGGCTC AGGTGACTGA GTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
Nature medicine20(10)1147-56(2014 Oct)
Mayo L,Trauger SA,Blain M,Nadeau M,Patel B,Alvarez JI,Mascanfroni ID,Yeste A,Kivis?kk P,Kallas K,Ellezam B,Bakshi R,Prat A,Antel JP,Weiner HL,Quintana FJ

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B4galt5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

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