Nupr1 cDNA ORF clone, Mus musculus(house mouse)

Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke.
Lucitti JL, Sealock R, Buckley BK, Zhang H, Xiao L, Dudley AC, Faber JE
Stroke47(12)3022-3031(2016 Dec)

Nupr1 acts as a gene modifier of the effect of Kras(G12D)-induced senescence by regulating Dnmt1 expression and consequently genome-wide levels of DNA methylation.
Title: Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.

Hepatitis B virus X (HBx) protein can modulate NUPR1 expression through the Smad4 pathway and NUPR1 has a role in hepatocellular carcinoma progression.
Title: Hepatitis B virus X promotes hepatocellular carcinoma development via nuclear protein 1 pathway.

Data indicate that heat shock protein 70 (Hsp70) is higher in nuclear protein 1 (Nupr1+/-) haplodeficient mice, concomitant with improved insulin sensitivity.
Title: Reduced nuclear protein 1 expression improves insulin sensitivity and protects against diet-induced glucose intolerance through up-regulation of heat shock protein 70.

data shows that p8 deficiency increases ROS and subsequently the expression of anti-oxidative enzymes, such as HO-1, suggesting an involvement in the anti-oxidative defense.
Title: P8 deficiency increases cellular ROS and induces HO-1.

p8 has no impact on the cellular composition of the adaptive and innate immune systems in noninflammatory conditions. However, it may limit apoptosis and maintain homeostasis of the immune reaction during acute pancreatitis.
Title: p8 Deficiency causes siderosis in spleens and lymphocyte apoptosis in acute pancreatitis.