Set cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Set
Entrez Gene ID	56086
Full Name	SET nuclear oncogene
Synonyms	2610030F17Rik,5730420M11Rik,AA407739,I-2PP2A,StF-IT-1,TAF-I
General protein information	Preferred Names SET nuclear oncogene Names protein SET SET translocation phosphatase 2A inhibitor I2PP2A template-activating factor I
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 B

mRNA and Protein(s)

mRNA	Protein	Name
NM_023871.4	NP_076360.1	protein SET isoform 1
NM_001204875.1	NP_001191804.1	protein SET isoform 2

Pathways from BioSystems

Homologies

	SET	XP_002800022.1
Rattus norvegicus (Norway rat)	Set	NP_001012522.1
Arabidopsis thaliana (thale cress)	NRP2	NP_564063.1
Mus musculus (house mouse)	Set	NP_076360.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003598	XP_313356.4
Xenopus tropicalis (tropical clawed frog)	set	NP_989041.1
Pan troglodytes (chimpanzee)	SET	XP_003312347.1
Bos taurus (cattle)	SET	NP_001033653.1
Gallus gallus (chicken)	SET	NP_001025862.2
Danio rerio (zebrafish)	setb	NP_958876.1
Caenorhabditis elegans (roundworm)	spr-2	NP_001021333.1
Homo sapiens (human)	SET	NP_003002.2
Drosophila melanogaster (fruit fly)	Set	NP_650438.2
Arabidopsis thaliana (thale cress)	NRP1	NP_001031282.1
Oryza sativa (rice)	Os02g0576700	NP_001047218.1
Oryza sativa (rice)	Os04g0459700	NP_001052986.1
Canis lupus familiaris (dog)	SET	XP_851207.1

Gene Ontology
Bibliography

Related articles in PubMed

Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.
Krishnan S, Smits AH, Vermeulen M, Reinberg D
Molecular cell67(4)579-593.e6(2017 Aug)

Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice.
Dorard E, Gorisse-Hussonnois L, Guihenneuc-Jouyaux C, Albac C, Potier MC, Allinquant B
Neurobiology of aging4643-8(2016 Oct)

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode.
Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu WG, Qin J, Honig B, Gu W
Nature538(7623)118-122(2016 Oct)

Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.
Hu X, Garcia C, Fazli L, Gleave M, Vitek MP, Jansen M, Christensen D, Mulholland DJ
Scientific reports515182(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression.
Title: Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.

Presence of SET in the cytoplasm in Down Syndrome brains may play a role in the progression of the disease.
Title: Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice.

Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A) signaling axis in Pten protein (Pten) deficient castration resistant prostate cancer (CRPC) progression.
Title: Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.

SET protein was expressed in spermatogonia and spermatocytes; the highest level was mainly in haploid and tetraploid cells of the prepubertal and adult groups, and Leydig cells of the adult and ageing groups. There was a low expression in Sertoli cells.
Title: Expression of the SET protein in testes of mice at different developmental stages.

The presence of full-length SET in the neuronal cytoplasm is sufficient to impair PP2A methylation and activity, leading to tau hyperphosphorylation.
Title: Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.

The following Set gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Set cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02599	NM_001204875.1 Latest version!	Mus musculus SET nuclear oncogene (Set), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu15617	NM_023871.4 Latest version!	Mus musculus SET nuclear oncogene (Set), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Set ( NM_001204875.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001191804.1 Mus musculus SET nuclear oncogene (Set), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu02599
Clone ID Related Accession (Same CDS sequence)	NM_001204875.1
Accession Version	NM_001204875.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	protein SET isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ899734.1, AK019960.1 and BU756940.1. Transcript Variant: This variant (2) encodes the shorter isoform (2; also known as isoform beta). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK019960.1, SRR1660811.35255.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGCGC CGACGGCCAA AGCCAGTAAA AAGGAGCTCA ACTCCAATCA CGACGGGGCC 
GACGAGACCT CAGAAAAAGA ACAGCAAGAA GCAATTGAAC ATATTGATGA AGTACAAAAT 
GAAATAGACA GACTTAATGA ACAAGCCAGT GAGGAAATTT TGAAAGTAGA ACAAAAATAT 
AACAAACTCC GCCAACCATT TTTTCAGAAG AGGTCAGAAT TGATCGCCAA AATCCCAAAT 
TTTTGGGTAA CAACATTTGT CAACCATCCA CAAGTGTCTG CACTGCTTGG GGAGGAGGAC 
GAGGAGGCTC TGCATTATTT GACCAGAGTT GAAGTGACAG AATTTGAAGA CATTAAATCA 
GGTTACAGAA TAGATTTTTA TTTTGATGAA AATCCTTACT TTGAAAATAA AGTTCTCTCC 
AAAGAATTTC ATCTGAACGA GAGTGGTGAC CCGTCTTCAA AGTCCACCGA AATCAAATGG 
AAATCTGGAA AGGATTTGAC AAAACGCTCA AGTCAAACGC AAAATAAGGC CAGCAGGAAG 
AGGCAGCACG AAGAGCCAGA GAGCTTCTTT ACCTGGTTTA CTGACCATTC TGACGCAGGT 
GCTGATGAGT TAGGAGAGGT CATCAAAGAT GACATCTGGC CAAATCCCTT GCAGTACTAC 
CTGGTTCCCG ACATGGATGA TGAAGAAGGA GAGGCAGAAG ATGATGATGA CGACGACGAA 
GAGGAGGAGG GGCTGGAAGA TATTGATGAA GAAGGAGATG AGGATGAAGG TGAAGAAGAT 
GACGATGAGG ATGAAGGGGA GGAAGGAGAG GAGGACGAAG GCGAGGATGA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001191804.1
CDS	348..1181
Translation	MSAPTAKASKKELNSNHDGADETSEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEAEDDDDDDEEEEGLEDIDEEGDEDEGEEDDDEDEGEEGEEDEGEDD

Target ORF information:

RefSeq Version	NM_001204875.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET nuclear oncogene (Set), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001204875.1

ORF Insert Sequence:

ATGTCTGCGC CGACGGCCAA AGCCAGTAAA AAGGAGCTCA ACTCCAATCA CGACGGGGCC 
GACGAGACCT CAGAAAAAGA ACAGCAAGAA GCAATTGAAC ATATTGATGA AGTACAAAAT 
GAAATAGACA GACTTAATGA ACAAGCCAGT GAGGAAATTT TGAAAGTAGA ACAAAAATAT 
AACAAACTCC GCCAACCATT TTTTCAGAAG AGGTCAGAAT TGATCGCCAA AATCCCAAAT 
TTTTGGGTAA CAACATTTGT CAACCATCCA CAAGTGTCTG CACTGCTTGG GGAGGAGGAC 
GAGGAGGCTC TGCATTATTT GACCAGAGTT GAAGTGACAG AATTTGAAGA CATTAAATCA 
GGTTACAGAA TAGATTTTTA TTTTGATGAA AATCCTTACT TTGAAAATAA AGTTCTCTCC 
AAAGAATTTC ATCTGAACGA GAGTGGTGAC CCGTCTTCAA AGTCCACCGA AATCAAATGG 
AAATCTGGAA AGGATTTGAC AAAACGCTCA AGTCAAACGC AAAATAAGGC CAGCAGGAAG 
AGGCAGCACG AAGAGCCAGA GAGCTTCTTT ACCTGGTTTA CTGACCATTC TGACGCAGGT 
GCTGATGAGT TAGGAGAGGT CATCAAAGAT GACATCTGGC CAAATCCCTT GCAGTACTAC 
CTGGTTCCCG ACATGGATGA TGAAGAAGGA GAGGCAGAAG ATGATGATGA CGACGACGAA 
GAGGAGGAGG GGCTGGAAGA TATTGATGAA GAAGGAGATG AGGATGAAGG TGAAGAAGAT 
GACGATGAGG ATGAAGGGGA GGAAGGAGAG GAGGACGAAG GCGAGGATGA TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Set ( NM_023871.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_076360.1 Mus musculus SET nuclear oncogene (Set), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu15617
Clone ID Related Accession (Same CDS sequence)	NM_023871.4
Accession Version	NM_023871.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	protein SET isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE331951.1, BC103791.1, AK019960.1 and BU756940.1. On Mar 11, 2011 this sequence version replaced NM_023871.3. Transcript Variant: This variant (1) encodes the longer isoform (1; also known as isoform alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK172327.1, BC018255.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCGA AGCGGCAGTC TGCGATCCTG CCTCAGCCCA AGAAACCCAG ACCGGCTGCT 
GCCCCGAAGC TGGAGGACAA GTCGGCCTCT CCCGGCCTGC CGAAGGGAGA AAAAGAACAG 
CAAGAAGCAA TTGAACATAT TGATGAAGTA CAAAATGAAA TAGACAGACT TAATGAACAA 
GCCAGTGAGG AAATTTTGAA AGTAGAACAA AAATATAACA AACTCCGCCA ACCATTTTTT 
CAGAAGAGGT CAGAATTGAT CGCCAAAATC CCAAATTTTT GGGTAACAAC ATTTGTCAAC 
CATCCACAAG TGTCTGCACT GCTTGGGGAG GAGGACGAGG AGGCTCTGCA TTATTTGACC 
AGAGTTGAAG TGACAGAATT TGAAGACATT AAATCAGGTT ACAGAATAGA TTTTTATTTT 
GATGAAAATC CTTACTTTGA AAATAAAGTT CTCTCCAAAG AATTTCATCT GAACGAGAGT 
GGTGACCCGT CTTCAAAGTC CACCGAAATC AAATGGAAAT CTGGAAAGGA TTTGACAAAA 
CGCTCAAGTC AAACGCAAAA TAAGGCCAGC AGGAAGAGGC AGCACGAAGA GCCAGAGAGC 
TTCTTTACCT GGTTTACTGA CCATTCTGAC GCAGGTGCTG ATGAGTTAGG AGAGGTCATC 
AAAGATGACA TCTGGCCAAA TCCCTTGCAG TACTACCTGG TTCCCGACAT GGATGATGAA 
GAAGGAGAGG CAGAAGATGA TGATGACGAC GACGAAGAGG AGGAGGGGCT GGAAGATATT 
GATGAAGAAG GAGATGAGGA TGAAGGTGAA GAAGATGACG ATGAGGATGA AGGGGAGGAA 
GGAGAGGAGG ACGAAGGCGA GGATGATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076360.1
CDS	177..1046
Translation	MAPKRQSAILPQPKKPRPAAAPKLEDKSASPGLPKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEAEDDDDDDEEEEGLEDIDEEGDEDEGEEDDDEDEGEEGEEDEGEDD

Target ORF information:

RefSeq Version	NM_023871.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET nuclear oncogene (Set), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023871.4

ORF Insert Sequence:

ATGGCCCCGA AGCGGCAGTC TGCGATCCTG CCTCAGCCCA AGAAACCCAG ACCGGCTGCT 
GCCCCGAAGC TGGAGGACAA GTCGGCCTCT CCCGGCCTGC CGAAGGGAGA AAAAGAACAG 
CAAGAAGCAA TTGAACATAT TGATGAAGTA CAAAATGAAA TAGACAGACT TAATGAACAA 
GCCAGTGAGG AAATTTTGAA AGTAGAACAA AAATATAACA AACTCCGCCA ACCATTTTTT 
CAGAAGAGGT CAGAATTGAT CGCCAAAATC CCAAATTTTT GGGTAACAAC ATTTGTCAAC 
CATCCACAAG TGTCTGCACT GCTTGGGGAG GAGGACGAGG AGGCTCTGCA TTATTTGACC 
AGAGTTGAAG TGACAGAATT TGAAGACATT AAATCAGGTT ACAGAATAGA TTTTTATTTT 
GATGAAAATC CTTACTTTGA AAATAAAGTT CTCTCCAAAG AATTTCATCT GAACGAGAGT 
GGTGACCCGT CTTCAAAGTC CACCGAAATC AAATGGAAAT CTGGAAAGGA TTTGACAAAA 
CGCTCAAGTC AAACGCAAAA TAAGGCCAGC AGGAAGAGGC AGCACGAAGA GCCAGAGAGC 
TTCTTTACCT GGTTTACTGA CCATTCTGAC GCAGGTGCTG ATGAGTTAGG AGAGGTCATC 
AAAGATGACA TCTGGCCAAA TCCCTTGCAG TACTACCTGG TTCCCGACAT GGATGATGAA 
GAAGGAGAGG CAGAAGATGA TGATGACGAC GACGAAGAGG AGGAGGGGCT GGAAGATATT 
GATGAAGAAG GAGATGAGGA TGAAGGTGAA GAAGATGACG ATGAGGATGA AGGGGAGGAA 
GGAGAGGAGG ACGAAGGCGA GGATGATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.
Molecular cell67(4)579-593.e6(2017 Aug)
Krishnan S,Smits AH,Vermeulen M,Reinberg D

Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice.
Neurobiology of aging4643-8(2016 Oct)
Dorard E,Gorisse-Hussonnois L,Guihenneuc-Jouyaux C,Albac C,Potier MC,Allinquant B

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode.
Nature538(7623)118-122(2016 Oct)
Wang D,Kon N,Lasso G,Jiang L,Leng W,Zhu WG,Qin J,Honig B,Gu W

Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.
Scientific reports515182(2015 Nov)
Hu X,Garcia C,Fazli L,Gleave M,Vitek MP,Jansen M,Christensen D,Mulholland DJ

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Set cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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