Cxcl11 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcl11
Entrez Gene ID	56066
Full Name	chemokine (C-X-C motif) ligand 11
Synonyms	Cxc11,H174,I-tac,Ip9,Itac,Scyb11,Scyb9b,b-R1,betaR1
General protein information	Preferred Names chemokine (C-X-C motif) ligand 11 Names C-X-C motif chemokine 11 interferon-inducible T-cell alpha chemoattractant small inducible cytokine subfamily B (Cys-X-Cys), member 11 small-inducible cytokine B11
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_019494.1	NP_062367.1	C-X-C motif chemokine 11 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.
Sierro F, Biben C, Mart?nez-Mu?oz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, Harvey RP, Mart?nez-A C, Mackay CR, Mackay F
Proceedings of the National Academy of Sciences of the United States of America104(37)14759-64(2007 Sep)

Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5.
Smith JB, Wadleigh DJ, Xia YR, Mar RA, Herschman HR, Lusis AJ
Immunogenetics54(8)599-603(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis
Title: Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.

very low doses of CXCL11 rapidly suppress signs of EAE in C57BL/6 mice lacking functional CXCL11.
Title: CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

Data indicate that epidermis-derived I-TAC (Cxcl11) triggers a sustained Th2-response that determines the outcome of a complex immunological process.
Title: Epidermal expression of I-TAC (Cxcl11) instructs adaptive Th2-type immunity.

Analysis of genes within the Listr1 locus identified a frameshift mutation in the Cxcl11 gene of the C57BL/6 strain that prevents production of the mature chemokine CXCL11.
Title: Listr1 locus regulates innate immunity against Listeria monocytogenes infection in the mouse liver possibly through Cxcl11 polymorphism.

Cxcl10 and cxcl11 are new hair-specific transcriptional targets of ectodysplasin, and they indicates involvement of chemokines in hair development.
Title: Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development.

The following Cxcl11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcl11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22030	NM_019494.1 Latest version!	Mus musculus chemokine (C-X-C motif) ligand 11 (Cxcl11), transcript variant 1, coding, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcl11 ( NM_019494.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062367.1 Mus musculus chemokine (C-X-C motif) ligand 11 (Cxcl11), transcript variant 1, coding, mRNA.

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CloneID	OMu22030
Clone ID Related Accession (Same CDS sequence)	NM_019494.1
Accession Version	NM_019494.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	C-X-C motif chemokine 11 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF179872.1. On Sep 25, 2009 this sequence version replaced XM_903598.2. Transcript Variant: This variant (1, coding) represents the shorter transcript but encodes the functional protein. This variant, which is based on a transcript from the BALB/c mouse strain, includes a 1-nt insertion in the 5'-most exon compared to the reference genome sequence, which represents a null mutant allele (C57BL/6 strain). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF179872.1, AK040051.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 17804806 ##RefSeq-Attributes-END##

ATGAACAGGA AGGTCACAGC CATAGCCCTG GCTGCGATCA TCTGGGCCAC AGCTGCTCAA 
GGCTTCCTTA TGTTCAAACA GGGGCGCTGT CTTTGCATCG GCCCCGGGAT GAAAGCCGTC 
AAAATGGCAG AGATCGAGAA AGCTTCTGTA ATTTACCCGA GTAACGGCTG CGACAAAGTT 
GAAGTGATTG TTACTATGAA GGCTCATAAA CGACAAAGGT GCCTGGACCC CAGATCCAAG 
CAAGCTCGCC TCATAATGCA GGCAATAGAA AAAAAGAATT TTTTAAGGCG TCAAAACATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062367.1
CDS	64..366
Translation	MNRKVTAIALAAIIWATAAQGFLMFKQGRCLCIGPGMKAVKMAEIEKASVIYPSNGCDKVEVIVTMKAHKRQRCLDPRSKQARLIMQAIEKKNFLRRQNM

Target ORF information:

RefSeq Version	NM_019494.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-X-C motif) ligand 11 (Cxcl11), transcript variant 1, coding, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019494.1

ORF Insert Sequence:

ATGAACAGGA AGGTCACAGC CATAGCCCTG GCTGCGATCA TCTGGGCCAC AGCTGCTCAA 
GGCTTCCTTA TGTTCAAACA GGGGCGCTGT CTTTGCATCG GCCCCGGGAT GAAAGCCGTC 
AAAATGGCAG AGATCGAGAA AGCTTCTGTA ATTTACCCGA GTAACGGCTG CGACAAAGTT 
GAAGTGATTG TTACTATGAA GGCTCATAAA CGACAAAGGT GCCTGGACCC CAGATCCAAG 
CAAGCTCGCC TCATAATGCA GGCAATAGAA AAAAAGAATT TTTTAAGGCG TCAAAACATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.
Proceedings of the National Academy of Sciences of the United States of America104(37)14759-64(2007 Sep)
Sierro F,Biben C,Mart?nez-Mu?oz L,Mellado M,Ransohoff RM,Li M,Woehl B,Leung H,Groom J,Batten M,Harvey RP,Mart?nez-A C,Mackay CR,Mackay F

Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5.
Immunogenetics54(8)599-603(2002 Nov)
Smith JB,Wadleigh DJ,Xia YR,Mar RA,Herschman HR,Lusis AJ

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Cxcl11 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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