Cxcl13 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcl13
Entrez Gene ID	55985
Full Name	chemokine (C-X-C motif) ligand 13
Synonyms	4631412M08Rik,ANGIE2,Angie,BCA-1,BLC,BLR1L,Scyb13
General protein information	Preferred Names chemokine (C-X-C motif) ligand 13 Names C-X-C motif chemokine 13 B lymphocyte chemoattractant CXC chemokine BLC small inducible cytokine subfamily B (Cys-X-Cys), member 13 small-inducible cytokine B13
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_018866.2	NP_061354.1	C-X-C motif chemokine 13 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cxcl13	NP_061354.1
Rattus norvegicus (Norway rat)	Cxcl13	NP_001017496.1
Homo sapiens (human)	CXCL13	NP_006410.1
Canis lupus familiaris (dog)	CXCL13	XP_850182.1
Bos taurus (cattle)	CXCL13	NP_001015576.1
	CXCL13	NP_001028052.1
Pan troglodytes (chimpanzee)	CXCL13	XP_001147148.1

Gene Ontology
Bibliography

Related articles in PubMed

Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis.
Onder L, M?rbe U, Pikor N, Novkovic M, Cheng HW, Hehlgans T, Pfeffer K, Becher B, Waisman A, R?licke T, Gommerman J, Mueller CG, Sawa S, Scandella E, Ludewig B
Immunity47(1)80-92.e4(2017 07)

Chemokine CXCL13 activates p38 MAPK in the trigeminal ganglion after infraorbital nerve injury.
Zhang Q, Zhu MD, Cao DL, Bai XQ, Gao YJ, Wu XB
Inflammation40(3)762-769(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High glucose could inhibit osteogenic differentiation of mesenchymal stem cells by lncRNA AK028326 mediated down-regulation of CXCL13 expression.
Title: High glucose prevents osteogenic differentiation of mesenchymal stem cells via lncRNA AK028326/CXCL13 pathway.

This study indicated that CXCL13 may be pathogenically involved in Clostridium difficile infection (CDI) and served as a potential new biomarker for diagnosis and prognosis in CDI.
Title: Chemokine CXCL13 expression was up-regulated in Clostridium difficile infection.

CXCL13 has a role in directing B-lymphocyte migration
Title: Quantitative analysis of B-lymphocyte migration directed by CXCL13.

CXCL13 and CXCR5 contribute to orofacial pain via ERK-mediated proinflammatory cytokines production.
Title: Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice.

Results from this study suggest blockade of CXCL13 and BAFFR together may be an effective therapeutic strategy in preventing salivary hypofunction and reducing autoantibody titers and sialadenitis in patients with Sjogren's syndrome
Title: Early BAFF receptor blockade mitigates murine Sj?gren's syndrome: Concomitant targeting of CXCL13 and the BAFF receptor prevents salivary hypofunction.

The following Cxcl13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcl13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19691	NM_018866.2 Latest version!	Mus musculus chemokine (C-X-C motif) ligand 13 (Cxcl13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcl13 ( NM_018866.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061354.1 Mus musculus chemokine (C-X-C motif) ligand 13 (Cxcl13), mRNA.

Price & Availability↑

CloneID	OMu19691
Clone ID Related Accession (Same CDS sequence)	NM_018866.2
Accession Version	NM_018866.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	C-X-C motif chemokine 13 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC146611.2. On Nov 17, 2006 this sequence version replaced NM_018866.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF044196.1, AK156025.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCTCA GCACAGCAAC GCTGCTTCTC CTCCTGGCCA GCTGCCTCTC TCCAGGCCAC 
GGTATTCTGG AAGCCCATTA CACAAACTTA AAATGTAGGT GTTCTGGAGT GATTTCAACT 
GTTGTCGGTC TAAACATCAT AGATCGGATT CAAGTTACGC CCCCTGGGAA TGGCTGCCCC 
AAAACTGAAG TTGTGATCTG GACCAAGATG AAGAAAGTTA TATGTGTGAA TCCTCGTGCC 
AAATGGTTAC AAAGATTATT AAGACATGTC CAAAGCAAAA GTCTGTCTTC AACTCCCCAA 
GCTCCAGTGA GTAAGAGAAG AGCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061354.1
CDS	33..362
Translation	MRLSTATLLLLLASCLSPGHGILEAHYTNLKCRCSGVISTVVGLNIIDRIQVTPPGNGCPKTEVVIWTKMKKVICVNPRAKWLQRLLRHVQSKSLSSTPQAPVSKRRAA

Target ORF information:

RefSeq Version	NM_018866.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-X-C motif) ligand 13 (Cxcl13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018866.2

ORF Insert Sequence:

ATGAGGCTCA GCACAGCAAC GCTGCTTCTC CTCCTGGCCA GCTGCCTCTC TCCAGGCCAC 
GGTATTCTGG AAGCCCATTA CACAAACTTA AAATGTAGGT GTTCTGGAGT GATTTCAACT 
GTTGTCGGTC TAAACATCAT AGATCGGATT CAAGTTACGC CCCCTGGGAA TGGCTGCCCC 
AAAACTGAAG TTGTGATCTG GACCAAGATG AAGAAAGTTA TATGTGTGAA TCCTCGTGCC 
AAATGGTTAC AAAGATTATT AAGACATGTC CAAAGCAAAA GTCTGTCTTC AACTCCCCAA 
GCTCCAGTGA GTAAGAGAAG AGCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis.
Immunity47(1)80-92.e4(2017 07)
Onder L,M?rbe U,Pikor N,Novkovic M,Cheng HW,Hehlgans T,Pfeffer K,Becher B,Waisman A,R?licke T,Gommerman J,Mueller CG,Sawa S,Scandella E,Ludewig B

Chemokine CXCL13 activates p38 MAPK in the trigeminal ganglion after infraorbital nerve injury.
Inflammation40(3)762-769(2017 Jun)
Zhang Q,Zhu MD,Cao DL,Bai XQ,Gao YJ,Wu XB