Slc1a4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc1a4
Entrez Gene ID	55963
Full Name	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Synonyms	ASCT-1,ASCT1,AW045657,SATT
General protein information	Preferred Names solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 Names neutral amino acid transporter A alanine/serine/cysteine/threonine transporter 1 solute carrier family 1 member 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 A3.1\|11 12.97 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_018861.3	NP_061349.3	neutral amino acid transporter A

Pathways from BioSystems

Homologies

	SLC1A4	XP_001087755.2
Canis lupus familiaris (dog)	SLC1A4	XP_538511.4
Bos taurus (cattle)	SLC1A4	NP_001075046.1
Mus musculus (house mouse)	Slc1a4	NP_061349.3
Rattus norvegicus (Norway rat)	Slc1a4	NP_942058.1
Gallus gallus (chicken)	SLC1A4	XP_001232900.3
Homo sapiens (human)	SLC1A4	NP_003029.2
Pan troglodytes (chimpanzee)	SLC1A4	XP_001166088.1
Danio rerio (zebrafish)	slc1a4	NP_001002513.2
Xenopus tropicalis (tropical clawed frog)	slc1a4	NP_001096391.1

Gene Ontology
Bibliography

Related articles in PubMed

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, ?estan N, Gage FH, Lein ES
Development (Cambridge, England)140(22)4633-44(2013 Nov)

Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis.
Sch?fer M, D?tsch S, auf dem Keller U, Navid F, Schwarz A, Johnson DA, Johnson JA, Werner S
Genes & development24(10)1045-58(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results demonstrate injury-induced changes in Phgdh and ASCT1 expression.
Title: Expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase (Phgdh) and neutral amino acid transporter ASCT1 following an excitotoxic lesion in the mouse hippocampus.

either Phgdh or ASCT1 is provided to each segment of renal tubules, suggesting that metabolic interplay mediated by L-serine biosynthesis and supply may exist in the kidney
Title: Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney.

results strongly suggest that combinations of amino acid sequence changes and N-linked oligosaccharides in a critical carboxyl-terminal region of extracellular loop 2 (ECL2) control retroviral utilization of both the ASCT1 and ASCT2 receptors
Title: N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions.

ASCT1 expression was gradually downregulated in neuronal populations during late embryonic and neonatal periods, whereas its high expression was transmitted to radial glial cells and then to astrocytes; ASCT1 appears regulated to meet metabolic demands
Title: Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries.

used as receptor by HERV-W Env glycoprotein when their sites for N-glycosylation are eliminated by mutagenesis
Title: The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors.

The following Slc1a4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc1a4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11076	NM_018861.3 Latest version!	Mus musculus solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (Slc1a4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$314.30 $449.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc1a4 ( NM_018861.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061349.3 Mus musculus solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (Slc1a4), mRNA.

Price & Availability↑

CloneID	OMu11076
Clone ID Related Accession (Same CDS sequence)	NM_018861.3
Accession Version	NM_018861.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1599bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	neutral amino acid transporter A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK140866.1 and BC052733.1. On Jul 18, 2009 this sequence version replaced NM_018861.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK140866.1, SRR1660817.181359.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGAGAAGA GCGGCGAGAC CAACGGCTAC CTCGACGGCA CCCAGGCAGA GCCTGCGGCC 
GGGCCCCGAA CGCCCGAGAC GGCGATGGGC AAATCGCAGC GCTGTGCTAG CTTTTTTCGG 
CGCCACGCGC TGGTGCTGCT CACCGTGTCG GGAGTGTTGG TGGGTGCCGG CATGGGCGCG 
GCGCTGAGGG GGCTGCAGCT CACCCGCACC CAGATCACTT ACCTGGCCTT CCCGGGCGAG 
ATGCTGCTCC GCATGCTGCG CATGATCATC CTGCCGCTGG TGGTTTGCAG CCTGGTGTCG 
GGAGCCGCCT CCCTGGATGC CAGCTCCCTC GGGCGTCTGG GTGGCATCGC TGTTGCTTAC 
TTCGGCCTCA CCACGCTGAG CGCCTCGGCT CTCGCCGTTG CTCTGGCGTT CATCATCAAG 
CCAGGGGCGG GCGCGCAGAC CCTCCAGTCC AGCAGCCTGG GGCTGGAGAA CTCAGGGCCT 
CCTCCGGTCT CCAAAGAGAC AGTGGACTCT TTCCTCGATT TACTCAGAAA CCTGTTCCCT 
TCCAATCTTG TGGTTGCCGC ATTCACTACG TCTGCAACCG ATTACACAGT GGTGACCCAT 
AACACCAGCT CGGGGAACGT GACCAAAGAG AAGATCCCCG TTGTAACAGA TGTGGAAGGG 
ATGAACATTT TAGGTCTCGT CCTTTTTGCC CTGGTGTTAG GAGTGGCTCT AAAGAAGCTA 
GGCCCCGAGG GAGAAGACCT CATCCGATTC TTCAATTCCT TCAATGAGGC CACAATGGTG 
CTGGTGTCAT GGATCATGTG GTATGTTCCT ATAGGCATCA TGTTCCTGAT CGGAAGCAAG 
ATTGTAGAAA TGAAGGACAT CGTCATGCTG GTGACCAGTC TCGGGAAATA CATCTTCGCA 
TCTATGCTGG GCCATGTCAT CCACGGAGGA ATTGTCCTGC CTCTTGTGTA TTTTGCTTTC 
ACAAGGAAAA ACCCGTTCAC GTTCCTCCTG GGCCTCCTCA CCCCATTTGC GACAGCTTTT 
GCGACCTGTT CCAGCTCAGC AACCCTTCCG TCTATGATGA AGTGCATTGA GGAGAACAAT 
GGTGTAGACA AGAGGATCAG CAGGTTCATC CTCCCCATTG GGGCCACGGT CAACATGGAC 
GGAGCAGCCA TCTTCCAGTG TGTGGCCGCA GTGTTCATTG CCCAGCTCAA CAACGTAGAC 
CTGAACGCAG GACAGATTTT CACCATTCTA GTGACTGCCA CGGCATCCAG TGTTGGAGCA 
GCAGGTGTGC CGGCTGGGGG TGTCCTCACA ATTGCCATCA TCTTGGAGGC CATTGGATTG 
CCCACACATG ACCTCTCTCT GATCCTGGCT GTGGACTGGA TTGTGGACCG GACCACCACT 
GTGGTGAATG TGGAAGGGGA TGCCCTGGGA GCGGGGATCC TCAACCACCT GAATCAGAAG 
GTAGTGAAGA AAGGTGAGCA GGAGCTACAA GAAGTGAAGG TGGAAGCCAT TCCCAATTCC 
AAGTCTGAGG AGGAGACGTC GCCTCTGGTG ACACACCAGA ACCCAGCAGG CCCTGTGGCC 
ATTGCTCCTG AACTTGAATC CAAGGAGTCA GTGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061349.3
CDS	242..1840
Translation	MEKSGETNGYLDGTQAEPAAGPRTPETAMGKSQRCASFFRRHALVLLTVSGVLVGAGMGAALRGLQLTRTQITYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASSLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGAGAQTLQSSSLGLENSGPPPVSKETVDSFLDLLRNLFPSNLVVAAFTTSATDYTVVTHNTSSGNVTKEKIPVVTDVEGMNILGLVLFALVLGVALKKLGPEGEDLIRFFNSFNEATMVLVSWIMWYVPIGIMFLIGSKIVEMKDIVMLVTSLGKYIFASMLGHVIHGGIVLPLVYFAFTRKNPFTFLLGLLTPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVDLNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLSLILAVDWIVDRTTTVVNVEGDALGAGILNHLNQKVVKKGEQELQEVKVEAIPNSKSEEETSPLVTHQNPAGPVAIAPELESKESVL

Target ORF information:

RefSeq Version	NM_018861.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (Slc1a4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018861.3

ORF Insert Sequence:

ATGGAGAAGA GCGGCGAGAC CAACGGCTAC CTCGACGGCA CCCAGGCAGA GCCTGCGGCC 
GGGCCCCGAA CGCCCGAGAC GGCGATGGGC AAATCGCAGC GCTGTGCTAG CTTTTTTCGG 
CGCCACGCGC TGGTGCTGCT CACCGTGTCG GGAGTGTTGG TGGGTGCCGG CATGGGCGCG 
GCGCTGAGGG GGCTGCAGCT CACCCGCACC CAGATCACTT ACCTGGCCTT CCCGGGCGAG 
ATGCTGCTCC GCATGCTGCG CATGATCATC CTGCCGCTGG TGGTTTGCAG CCTGGTGTCG 
GGAGCCGCCT CCCTGGATGC CAGCTCCCTC GGGCGTCTGG GTGGCATCGC TGTTGCTTAC 
TTCGGCCTCA CCACGCTGAG CGCCTCGGCT CTCGCCGTTG CTCTGGCGTT CATCATCAAG 
CCAGGGGCGG GCGCGCAGAC CCTCCAGTCC AGCAGCCTGG GGCTGGAGAA CTCAGGGCCT 
CCTCCGGTCT CCAAAGAGAC AGTGGACTCT TTCCTCGATT TACTCAGAAA CCTGTTCCCT 
TCCAATCTTG TGGTTGCCGC ATTCACTACG TCTGCAACCG ATTACACAGT GGTGACCCAT 
AACACCAGCT CGGGGAACGT GACCAAAGAG AAGATCCCCG TTGTAACAGA TGTGGAAGGG 
ATGAACATTT TAGGTCTCGT CCTTTTTGCC CTGGTGTTAG GAGTGGCTCT AAAGAAGCTA 
GGCCCCGAGG GAGAAGACCT CATCCGATTC TTCAATTCCT TCAATGAGGC CACAATGGTG 
CTGGTGTCAT GGATCATGTG GTATGTTCCT ATAGGCATCA TGTTCCTGAT CGGAAGCAAG 
ATTGTAGAAA TGAAGGACAT CGTCATGCTG GTGACCAGTC TCGGGAAATA CATCTTCGCA 
TCTATGCTGG GCCATGTCAT CCACGGAGGA ATTGTCCTGC CTCTTGTGTA TTTTGCTTTC 
ACAAGGAAAA ACCCGTTCAC GTTCCTCCTG GGCCTCCTCA CCCCATTTGC GACAGCTTTT 
GCGACCTGTT CCAGCTCAGC AACCCTTCCG TCTATGATGA AGTGCATTGA GGAGAACAAT 
GGTGTAGACA AGAGGATCAG CAGGTTCATC CTCCCCATTG GGGCCACGGT CAACATGGAC 
GGAGCAGCCA TCTTCCAGTG TGTGGCCGCA GTGTTCATTG CCCAGCTCAA CAACGTAGAC 
CTGAACGCAG GACAGATTTT CACCATTCTA GTGACTGCCA CGGCATCCAG TGTTGGAGCA 
GCAGGTGTGC CGGCTGGGGG TGTCCTCACA ATTGCCATCA TCTTGGAGGC CATTGGATTG 
CCCACACATG ACCTCTCTCT GATCCTGGCT GTGGACTGGA TTGTGGACCG GACCACCACT 
GTGGTGAATG TGGAAGGGGA TGCCCTGGGA GCGGGGATCC TCAACCACCT GAATCAGAAG 
GTAGTGAAGA AAGGTGAGCA GGAGCTACAA GAAGTGAAGG TGGAAGCCAT TCCCAATTCC 
AAGTCTGAGG AGGAGACGTC GCCTCTGGTG ACACACCAGA ACCCAGCAGG CCCTGTGGCC 
ATTGCTCCTG AACTTGAATC CAAGGAGTCA GTGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Development (Cambridge, England)140(22)4633-44(2013 Nov)
Miller JA,Nathanson J,Franjic D,Shim S,Dalley RA,Shapouri S,Smith KA,Sunkin SM,Bernard A,Bennett JL,Lee CK,Hawrylycz MJ,Jones AR,Amaral DG,?estan N,Gage FH,Lein ES

Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis.
Genes & development24(10)1045-58(2010 May)
Sch?fer M,D?tsch S,auf dem Keller U,Navid F,Schwarz A,Johnson DA,Johnson JA,Werner S

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Slc1a4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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