Cldn6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cldn6
Entrez Gene ID	54419
Full Name	claudin 6
Synonyms	AL024037
General protein information	Preferred Names claudin 6 Names claudin-6 skullin tight junction molecule claudin 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 A3.3
Summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is essential for blastocyst formation in preimplantation mouse embryos, and is invloved in and is crucial for the formation and maintenance of the epidermal permeability barrier. This gene is adjacent to another family member Cldn9 on chromosome 17. [provided by RefSeq, Aug 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_018777.4	NP_061247.1	claudin-6 precursor
XM_006524641.1	XP_006524704.1	claudin-6 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CLDN6	XP_523276.1
	CLDN6	XP_001088715.1
Mus musculus (house mouse)	Cldn6	NP_061247.1
Xenopus tropicalis (tropical clawed frog)	cldn6.1	NP_988873.1
Rattus norvegicus (Norway rat)	Cldn6	NP_001095834.1
Bos taurus (cattle)	CLDN6	NP_001192626.1
Homo sapiens (human)	CLDN6	NP_067018.2
Canis lupus familiaris (dog)	CLDN6	XP_547168.2
Danio rerio (zebrafish)	cldne	NP_571840.1
Danio rerio (zebrafish)	cldnd	NP_851295.1
Xenopus tropicalis (tropical clawed frog)	LOC100493413	XP_002941739.1

Gene Ontology
Bibliography

Related articles in PubMed

Cigarette smoke and decreased oxygen tension inhibit pulmonary claudin-6 expression.
Jimenez FR, Lewis JB, Belgique ST, Milner DC, Lewis AL, Dunaway TM, Egbert KM, Winden DR, Arroyo JA, Reynolds PR
Experimental lung research42(8-10)440-452(2016 Oct - Dec)

The expression profile of Claudin family members in the developing mouse lung and expression alterations resulting from exposure to secondhand smoke (SHS).
Lewis JB, Jimenez FR, Merrell BJ, Kimbler B, Arroyo JA, Reynolds PR
Experimental lung research1-12(2018 Jan)

Systems biology of facial development: contributions of ectoderm and mesenchyme.
Hooper JE, Feng W, Li H, Leach SM, Phang T, Siska C, Jones KL, Spritz RA, Hunter LE, Williams T
Developmental biology426(1)97-114(2017 06)

Up-Regulation of Claudin-6 in the Distal Lung Impacts Secondhand Smoke-Induced Inflammation.
Lewis JB, Milner DC, Lewis AL, Dunaway TM, Egbert KM, Albright SC, Merrell BJ, Monson TD, Broberg DS, Gassman JR, Thomas DB, Arroyo JA, Reynolds PR
International journal of environmental research and public health13(10)(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cldn6 was markedly decreased in the lungs of mice exposed to acute tobacco sm
Title: Cigarette smoke and decreased oxygen tension inhibit pulmonary claudin-6 expression.

These data reveal captivating information suggesting a role for Cldn6 in lungs exposed to tobacco smoke and suggest that further research is necessary in order to fully explain roles for tight junctional components such as Cldn6
Title: Up-Regulation of Claudin-6 in the Distal Lung Impacts Secondhand Smoke-Induced Inflammation.

Over-expression of Claudin 6 during embryogenesis delays lung morphogenesis.
Title: Conditional pulmonary over-expression of Claudin 6 during embryogenesis delays lung morphogenesis.

Cldn6 is expressed by pulmonary epithelium during lung organogenesis.
Title: Developmental lung expression and transcriptional regulation of claudin-6 by TTF-1, Gata-6, and FoxA2.

The Inv-Cldn6-CDelta206 transgenic mice displayed a developmental delay in epidermal permeability barrier formation, as shown by the expression of keratins and Cldns, and by X-Gal penetration assays.
Title: Involucrin-claudin-6 tail deletion mutant (CDelta206) transgenic mice: a model of delayed epidermal permeability barrier formation and repair.

The following Cldn6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cldn6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15573	NM_018777.4 Latest version!	Mus musculus claudin 6 (Cldn6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu15573	XM_006524641.1 Latest version!	Mus musculus claudin 6 (Cldn6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cldn6 ( NM_018777.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061247.1 Mus musculus claudin 6 (Cldn6), mRNA.

Price & Availability↑

CloneID	OMu15573
Clone ID Related Accession (Same CDS sequence)	NM_018777.4 , XM_006524641.1
Accession Version	NM_018777.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Mus musculus(house mouse)
Product	claudin-6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK010560.1, AK010682.1 and BU757997.1. On Aug 6, 2010 this sequence version replaced NM_018777.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050138.1, AK010560.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCTA CTGGTCTGCA AATCTTGGGG ATCGTCCTGA CCCTGCTTGG CTGGGTCAAC 
GCCCTGGTGT CCTGTGCCCT GCCCATGTGG AAGGTGACCG CCTTCATCGG CAACAGCATC 
GTCGTGGCCC AGATGGTGTG GGAGGGGCTG TGGATGTCCT GTGTGGTTCA GAGCACTGGC 
CAGATGCAGT GCAAGGTGTA TGACTCACTG TTGGCGCTGC CCCAGGACCT GCAGGCTGCC 
AGAGCCCTCT GTGTTGTCAC CCTCCTCATT GTCCTGCTTG GCCTGCTCGT GTACCTGGCT 
GGAGCCAAGT GCACTACCTG TGTGGAAGAT AGGAACTCCA AGTCTCGTCT GGTGCTCATC 
TCTGGCATCA TCTTTGTCAT TTCTGGGGTC CTGACGCTCA TTCCTGTCTG CTGGACTGCC 
CACTCTATCA TCCAGGACTT CTACAACCCC TTGGTGGCTG ATGCTCAAAA GCGGGAGCTG 
GGGGCCTCCC TCTACCTGGG CTGGGCAGCC TCAGGCCTTT TGCTGCTGGG TGGAGGGCTA 
CTATGCTGCG CCTGCTCTTC TGGAGGGACC CAGGGACCCA GACATTACAT GGCCTGCTAT 
TCTACATCTG TCCCACATTC TCGGGGACCC TCCGAATATC CCACCAAGAA TTATGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061247.1
CDS	124..783
Translation	MASTGLQILGIVLTLLGWVNALVSCALPMWKVTAFIGNSIVVAQMVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVVTLLIVLLGLLVYLAGAKCTTCVEDRNSKSRLVLISGIIFVISGVLTLIPVCWTAHSIIQDFYNPLVADAQKRELGASLYLGWAASGLLLLGGGLLCCACSSGGTQGPRHYMACYSTSVPHSRGPSEYPTKNYV

Target ORF information:

RefSeq Version	NM_018777.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus claudin 6 (Cldn6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018777.4

ORF Insert Sequence:

ATGGCCTCTA CTGGTCTGCA AATCTTGGGG ATCGTCCTGA CCCTGCTTGG CTGGGTCAAC 
GCCCTGGTGT CCTGTGCCCT GCCCATGTGG AAGGTGACCG CCTTCATCGG CAACAGCATC 
GTCGTGGCCC AGATGGTGTG GGAGGGGCTG TGGATGTCCT GTGTGGTTCA GAGCACTGGC 
CAGATGCAGT GCAAGGTGTA TGACTCACTG TTGGCGCTGC CCCAGGACCT GCAGGCTGCC 
AGAGCCCTCT GTGTTGTCAC CCTCCTCATT GTCCTGCTTG GCCTGCTCGT GTACCTGGCT 
GGAGCCAAGT GCACTACCTG TGTGGAAGAT AGGAACTCCA AGTCTCGTCT GGTGCTCATC 
TCTGGCATCA TCTTTGTCAT TTCTGGGGTC CTGACGCTCA TTCCTGTCTG CTGGACTGCC 
CACTCTATCA TCCAGGACTT CTACAACCCC TTGGTGGCTG ATGCTCAAAA GCGGGAGCTG 
GGGGCCTCCC TCTACCTGGG CTGGGCAGCC TCAGGCCTTT TGCTGCTGGG TGGAGGGCTA 
CTATGCTGCG CCTGCTCTTC TGGAGGGACC CAGGGACCCA GACATTACAT GGCCTGCTAT 
TCTACATCTG TCCCACATTC TCGGGGACCC TCCGAATATC CCACCAAGAA TTATGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cldn6 ( XM_006524641.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006524704.1 Mus musculus claudin 6 (Cldn6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu15573
Clone ID Related Accession (Same CDS sequence)	NM_018777.4 , XM_006524641.1
Accession Version	XM_006524641.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	claudin-6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCTA CTGGTCTGCA AATCTTGGGG ATCGTCCTGA CCCTGCTTGG CTGGGTCAAC 
GCCCTGGTGT CCTGTGCCCT GCCCATGTGG AAGGTGACCG CCTTCATCGG CAACAGCATC 
GTCGTGGCCC AGATGGTGTG GGAGGGGCTG TGGATGTCCT GTGTGGTTCA GAGCACTGGC 
CAGATGCAGT GCAAGGTGTA TGACTCACTG TTGGCGCTGC CCCAGGACCT GCAGGCTGCC 
AGAGCCCTCT GTGTTGTCAC CCTCCTCATT GTCCTGCTTG GCCTGCTCGT GTACCTGGCT 
GGAGCCAAGT GCACTACCTG TGTGGAAGAT AGGAACTCCA AGTCTCGTCT GGTGCTCATC 
TCTGGCATCA TCTTTGTCAT TTCTGGGGTC CTGACGCTCA TTCCTGTCTG CTGGACTGCC 
CACTCTATCA TCCAGGACTT CTACAACCCC TTGGTGGCTG ATGCTCAAAA GCGGGAGCTG 
GGGGCCTCCC TCTACCTGGG CTGGGCAGCC TCAGGCCTTT TGCTGCTGGG TGGAGGGCTA 
CTATGCTGCG CCTGCTCTTC TGGAGGGACC CAGGGACCCA GACATTACAT GGCCTGCTAT 
TCTACATCTG TCCCACATTC TCGGGGACCC TCCGAATATC CCACCAAGAA TTATGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006524704.1
CDS	77..736
Translation	MASTGLQILGIVLTLLGWVNALVSCALPMWKVTAFIGNSIVVAQMVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVVTLLIVLLGLLVYLAGAKCTTCVEDRNSKSRLVLISGIIFVISGVLTLIPVCWTAHSIIQDFYNPLVADAQKRELGASLYLGWAASGLLLLGGGLLCCACSSGGTQGPRHYMACYSTSVPHSRGPSEYPTKNYV

Target ORF information:

RefSeq Version	XM_006524641.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus claudin 6 (Cldn6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006524641.1

ORF Insert Sequence:

ATGGCCTCTA CTGGTCTGCA AATCTTGGGG ATCGTCCTGA CCCTGCTTGG CTGGGTCAAC 
GCCCTGGTGT CCTGTGCCCT GCCCATGTGG AAGGTGACCG CCTTCATCGG CAACAGCATC 
GTCGTGGCCC AGATGGTGTG GGAGGGGCTG TGGATGTCCT GTGTGGTTCA GAGCACTGGC 
CAGATGCAGT GCAAGGTGTA TGACTCACTG TTGGCGCTGC CCCAGGACCT GCAGGCTGCC 
AGAGCCCTCT GTGTTGTCAC CCTCCTCATT GTCCTGCTTG GCCTGCTCGT GTACCTGGCT 
GGAGCCAAGT GCACTACCTG TGTGGAAGAT AGGAACTCCA AGTCTCGTCT GGTGCTCATC 
TCTGGCATCA TCTTTGTCAT TTCTGGGGTC CTGACGCTCA TTCCTGTCTG CTGGACTGCC 
CACTCTATCA TCCAGGACTT CTACAACCCC TTGGTGGCTG ATGCTCAAAA GCGGGAGCTG 
GGGGCCTCCC TCTACCTGGG CTGGGCAGCC TCAGGCCTTT TGCTGCTGGG TGGAGGGCTA 
CTATGCTGCG CCTGCTCTTC TGGAGGGACC CAGGGACCCA GACATTACAT GGCCTGCTAT 
TCTACATCTG TCCCACATTC TCGGGGACCC TCCGAATATC CCACCAAGAA TTATGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cigarette smoke and decreased oxygen tension inhibit pulmonary claudin-6 expression.
Experimental lung research42(8-10)440-452(2016 Oct - Dec)
Jimenez FR,Lewis JB,Belgique ST,Milner DC,Lewis AL,Dunaway TM,Egbert KM,Winden DR,Arroyo JA,Reynolds PR

The expression profile of Claudin family members in the developing mouse lung and expression alterations resulting from exposure to secondhand smoke (SHS).
Experimental lung research1-12(2018 Jan)
Lewis JB,Jimenez FR,Merrell BJ,Kimbler B,Arroyo JA,Reynolds PR

Systems biology of facial development: contributions of ectoderm and mesenchyme.
Developmental biology426(1)97-114(2017 06)
Hooper JE,Feng W,Li H,Leach SM,Phang T,Siska C,Jones KL,Spritz RA,Hunter LE,Williams T

Up-Regulation of Claudin-6 in the Distal Lung Impacts Secondhand Smoke-Induced Inflammation.
International journal of environmental research and public health13(10)(2016 10)
Lewis JB,Milner DC,Lewis AL,Dunaway TM,Egbert KM,Albright SC,Merrell BJ,Monson TD,Broberg DS,Gassman JR,Thomas DB,Arroyo JA,Reynolds PR

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Cldn6 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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