Hils1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hils1
Entrez Gene ID	54388
Full Name	histone H1-like protein in spermatids 1
Synonyms	H1.9,TISP64
General protein information	Preferred Names histone H1-like protein in spermatids 1 Names spermatid-specific linker histone H1-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 D
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is expressed in nuclei of late maturing spermatids. [provided by RefSeq, Nov 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_018792.2	NP_061262.1	spermatid-specific linker histone H1-like protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC615867	XP_002695949.1
Mus musculus (house mouse)	Hils1	NP_061262.1
Rattus norvegicus (Norway rat)	Hils1	NP_001103035.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of H1 linker histones in mammalian development and stem cell differentiation.
Pan C, Fan Y
Biochimica et biophysica acta1859(3)496-509(2016 Mar)

A unified phylogeny-based nomenclature for histone variants.
Talbert PB, Ahmad K, Almouzni G, Ausi? J, Berger F, Bhalla PL, Bonner WM, Cande WZ, Chadwick BP, Chan SW, Cross GA, Cui L, Dimitrov SI, Doenecke D, Eirin-L?pez JM, Gorovsky MA, Hake SB, Hamkalo BA, Holec S, Jacobsen SE, Kamieniarz K, Khochbin S, Ladurner AG, Landsman D, Latham JA, Loppin B, Malik HS, Marzluff WF, Pehrson JR, Postberg J, Schneider R, Singh MB, Smith MM, Thompson E, Torres-Padilla ME, Tremethick DJ, Turner BM, Waterborg JH, Wollmann H, Yelagandula R, Zhu B, Henikoff S
Epigenetics & chromatin57(2012 Jun)

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Developmental cell17(6)836-48(2009 Dec)

Comparative analysis of testis protein evolution in rodents.
Turner LM, Chuong EB, Hoekstra HE
Genetics179(4)2075-89(2008 Aug)

Control of mouse hils1 gene expression during spermatogenesis: identification of regulatory element by transgenic mouse.
Iguchi N, Tanaka H, Yamada S, Nishimura H, Nishimune Y
Biology of reproduction70(5)1239-45(2004 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

318-base pair (bp) 5'-proximal region, corresponding to first 70-bp proximal TATA-less promoter, and 248 bp of 5'-untranslated region is sufficient to confer testis- and spermatid-specific transcription and posttranscriptional control of mouse hils1 gene.
Title: Control of mouse hils1 gene expression during spermatogenesis: identification of regulatory element by transgenic mouse.

Hils1 may play an important role in the structural changes of spermatid nuclei, such as nuclear condensation, and gene regulation of haploid germ cell differentiation.
Title: Isolation and characterization of a novel cDNA encoding a DNA-binding protein (Hils1) specifically expressed in testicular haploid germ cells.

HILS1 is implicated in chromatin remodeling during mammalian spermiogenesis.
Title: HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis.

The following Hils1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hils1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58380	NM_018792.2 Latest version!	Mus musculus histone H1-like protein in spermatids 1 (Hils1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hils1 ( NM_018792.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061262.1 Mus musculus histone H1-like protein in spermatids 1 (Hils1), mRNA.

Price & Availability↑

CloneID	OMu58380
Clone ID Related Accession (Same CDS sequence)	NM_018792.2
Accession Version	NM_018792.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	spermatid-specific linker histone H1-like protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL606480.11. On Jun 10, 2015 this sequence version replaced NM_018792.1. ##Evidence-Data-START## Transcript is intronless :: BC061119.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 22650316 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCAAA TGGTGGCTGG AGACCAAGAT GCCGGCACAC TGTGGGTCCC AAGCCAGAGT 
GAGAGTCAAA CTGAGTCCGA CATCAGTACC CAAAGCCTGC GGAAGCCCAC CATGTCGTAT 
GTGATTCTGA AGACTTTGGC TGACAAGCGG GTACATAATT GTGTGTCCCT TGCTACCTTG 
AAGAAAGCTG TGTCTATCAC AGGGTACAAT ATGACCCATA ACACCTGGCG CTTCAAGCGT 
GTGCTCCAGA ATCTACTCGA TAAAGGCATG ATCATGCATG TGACCTGCTG CAAGGGTGCC 
TCCGGCTCCC TCTGCCTGTG CAAGGAGCGG GCCCTCAAGT CCAACCACAG GGCCAAGAGA 
TGCCAGGACA GACAGAAGAG CCAGAAGCCT CAGAAGCCTG GGCAGCGTGA GTCTGAACCA 
TGCCAATTGC TACTAAGCTC CAAAAAGAAG AATGACCAGC TTTTCAAAGG AGTCCGTAGG 
GTGGCCAAAG GCAACCGCCA TTGCCATTAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061262.1
CDS	289..801
Translation	MAQMVAGDQDAGTLWVPSQSESQTESDISTQSLRKPTMSYVILKTLADKRVHNCVSLATLKKAVSITGYNMTHNTWRFKRVLQNLLDKGMIMHVTCCKGASGSLCLCKERALKSNHRAKRCQDRQKSQKPQKPGQRESEPCQLLLSSKKKNDQLFKGVRRVAKGNRHCHY

Target ORF information:

RefSeq Version	NM_018792.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus histone H1-like protein in spermatids 1 (Hils1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018792.2

ORF Insert Sequence:

ATGGCTCAAA TGGTGGCTGG AGACCAAGAT GCCGGCACAC TGTGGGTCCC AAGCCAGAGT 
GAGAGTCAAA CTGAGTCCGA CATCAGTACC CAAAGCCTGC GGAAGCCCAC CATGTCGTAT 
GTGATTCTGA AGACTTTGGC TGACAAGCGG GTACATAATT GTGTGTCCCT TGCTACCTTG 
AAGAAAGCTG TGTCTATCAC AGGGTACAAT ATGACCCATA ACACCTGGCG CTTCAAGCGT 
GTGCTCCAGA ATCTACTCGA TAAAGGCATG ATCATGCATG TGACCTGCTG CAAGGGTGCC 
TCCGGCTCCC TCTGCCTGTG CAAGGAGCGG GCCCTCAAGT CCAACCACAG GGCCAAGAGA 
TGCCAGGACA GACAGAAGAG CCAGAAGCCT CAGAAGCCTG GGCAGCGTGA GTCTGAACCA 
TGCCAATTGC TACTAAGCTC CAAAAAGAAG AATGACCAGC TTTTCAAAGG AGTCCGTAGG 
GTGGCCAAAG GCAACCGCCA TTGCCATTAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of H1 linker histones in mammalian development and stem cell differentiation.
Biochimica et biophysica acta1859(3)496-509(2016 Mar)
Pan C,Fan Y

A unified phylogeny-based nomenclature for histone variants.
Epigenetics & chromatin57(2012 Jun)
Talbert PB,Ahmad K,Almouzni G,Ausi? J,Berger F,Bhalla PL,Bonner WM,Cande WZ,Chadwick BP,Chan SW,Cross GA,Cui L,Dimitrov SI,Doenecke D,Eirin-L?pez JM,Gorovsky MA,Hake SB,Hamkalo BA,Holec S,Jacobsen SE,Kamieniarz K,Khochbin S,Ladurner AG,Landsman D,Latham JA,Loppin B,Malik HS,Marzluff WF,Pehrson JR,Postberg J,Schneider R,Singh MB,Smith MM,Thompson E,Torres-Padilla ME,Tremethick DJ,Turner BM,Waterborg JH,Wollmann H,Yelagandula R,Zhu B,Henikoff S

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Developmental cell17(6)836-48(2009 Dec)
Yokoyama S,Ito Y,Ueno-Kudoh H,Shimizu H,Uchibe K,Albini S,Mitsuoka K,Miyaki S,Kiso M,Nagai A,Hikata T,Osada T,Fukuda N,Yamashita S,Harada D,Mezzano V,Kasai M,Puri PL,Hayashizaki Y,Okado H,Hashimoto M,Asahara H

Comparative analysis of testis protein evolution in rodents.
Genetics179(4)2075-89(2008 Aug)
Turner LM,Chuong EB,Hoekstra HE

Control of mouse hils1 gene expression during spermatogenesis: identification of regulatory element by transgenic mouse.
Biology of reproduction70(5)1239-45(2004 May)
Iguchi N,Tanaka H,Yamada S,Nishimura H,Nishimune Y

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Hils1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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