Chst2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Chst2
Entrez Gene ID	54371
Full Name	carbohydrate sulfotransferase 2
Synonyms	AI428561,AW121776,C130041E03Rik,Chts2,GST-2,GlcNAc6ST,Gn6st
General protein information	Preferred Names carbohydrate sulfotransferase 2 Names carbohydrate sulfotransferase 2 N-acetylglucosamine 6-O-sulfotransferase 1 N-acetylglucosamine-6-O-sulfotransferase galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2 glcNAc6ST-1 gn6st-1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 E3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_018763.2	NP_061233.2	carbohydrate sulfotransferase 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	chst2b	XP_001923604.2
Homo sapiens (human)	CHST2	NP_004258.2
Pan troglodytes (chimpanzee)	CHST2	XP_516797.2
Xenopus tropicalis (tropical clawed frog)	chst2	NP_001017162.1
	CHST2	XP_001111792.1
Bos taurus (cattle)	CHST2	NP_001107241.1
Mus musculus (house mouse)	Chst2	NP_061233.2
Rattus norvegicus (Norway rat)	Chst2	XP_006243615.1
Danio rerio (zebrafish)	chst2a	NP_001073464.2
Canis lupus familiaris (dog)	CHST2	XP_005634706.1
Gallus gallus (chicken)	CHST2	XP_003641807.2

Gene Ontology
Bibliography

Related articles in PubMed

Role of MAdCAM-1-Expressing High Endothelial Venule-Like Vessels in Colitis Induced in Mice Lacking Sulfotransferases Catalyzing L-Selectin Ligand Biosynthesis.
Low S, Hirakawa J, Hoshino H, Uchimura K, Kawashima H, Kobayashi M
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society22155417753363(2018 Jan)

Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.
Zhang Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, Narentuya, Akatsu H, Nishitsuji K, Michikawa M, Wyss-Coray T, Kadomatsu K, Uchimura K
Proceedings of the National Academy of Sciences of the United States of America114(14)E2947-E2954(2017 Apr)

Keratan Sulfate Regulates the Switch from Motor Neuron to Oligodendrocyte Generation During Development of the Mouse Spinal Cord.
Hashimoto H, Ishino Y, Jiang W, Yoshimura T, Takeda-Uchimura Y, Uchimura K, Kadomatsu K, Ikenaka K
Neurochemical research41(1-2)450-62(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data indicate that keratan sulfate expression is closely associated with functional disturbance after spinal cord injury; N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice are a good model to investigate the roles of keratan sulfate in the CNS
Title: N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury.

the sulfotransferase GlcNAc6ST-2 is induced in mouse collagen-induced arthritis.
Title: Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis.

Essential function of N-acetylglucosamine-6-O-sulfotransferases 2 (GlcNAc6ST-2) in L-selectin ligand biosynthesis in high endothelial venules and its importance in immune surveillance was shown.
Title: N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules.

N-acetylglucosamine-6-O-sulfotransferases (GlcNAc6ST-1 and GlcNAc6ST-2) deficiency results in elimination of both peripheral node addressin and sialyl 6-sulfo Lewis X in high endothelial venules.
Title: A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules.

GlcNAc6ST-1 has a role in lymphocyte homing to Peyer's patches
Title: N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing.

The following Chst2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chst2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18819	NM_018763.2 Latest version!	Mus musculus carbohydrate sulfotransferase 2 (Chst2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$314.30 $449.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Chst2 ( NM_018763.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061233.2 Mus musculus carbohydrate sulfotransferase 2 (Chst2), mRNA.

Price & Availability↑

CloneID	OMu18819
Clone ID Related Accession (Same CDS sequence)	NM_018763.2
Accession Version	NM_018763.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1593bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Mus musculus(house mouse)
Product	carbohydrate sulfotransferase 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ172365.1, BM947059.1, BM950407.1, BC051963.1, BU701895.1, AK048226.1, AK034634.1 and AW121776.1. On or before Aug 8, 2008 this sequence version replaced XM_001471695.1, NM_018763.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051963.1, AB011451.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCGCA GCTCGCCGCG AGCTCTGCCC CCCGGTGCGC TTCCCCGGCC GCTGCCGGCC 
GCGCCTGCCG CCGTGCAGCG GGCCCTGCTC CCGCCGTGGC CCCGGCGCGC AGGACGCCGC 
TGGCCTGCGT CCCCGCTCGG GATGAAGGTA TTTCGCAGGA AGGCGCTGGT GCTGTGCGCG 
GGCTATGCAC TGCTACTGGT GCTCACGATG CTCAACCTCT TGGACTACAA GTGGCATAAA 
GAGCCGCTGC AGCAGTGCAA CCCCGACGGG CCTCTGGGTG CCGCGGTAGG GGCGGCCGGG 
GCCGGCTGGG GACGGCCGGG GTCGCCTCCT GCAGCGCCAC CCCGCGCTCA CTCTCGCATG 
GACCCCCGCA CCCCGTACCG CCCTCCTGCC GCGGGCGTGG GGGCAGTTCC CGCAGCCGCG 
GCTGGGAGTG CAGGAGCTGC GGCCTCTCTG GGCAATGCTA CTCGAGGCAC CAGGGGTGGA 
GGGGACAAGC GGCAGTTGGT GTATGTGTTC ACCACGTGGC GCTCGGGCTC GTCCTTCTTC 
GGTGAGCTCT TCAACCAGAA CCCTGAGGTG TTCTTCCTCT ATGAGCCTGT GTGGCACGTG 
TGGCAAAAAC TGTACCCCGG GGACGCCGTT TCCCTGCAGG GGGCAGCGCG GGACATGCTG 
AGCGCTCTCT ACCGCTGCGA TCTTTCGGTT TTCCAGCTGT ATAGCCCCGC AGGCAGTGGG 
GGGCGCAACC TCACCACTCT GGGCATCTTT GGGGCAGCCA CTAACAAGGT GGTATGCTCC 
TCGCCACTCT GTCCTGCCTA CCGCAAGGAG GTCGTCGGAC TGGTGGACGA CCGCGTGTGC 
AAAAAGTGCC CACCTCAACG CCTGGCACGC TTCGAGGAGG AGTGTCGCAA GTACCGCACG 
CTGGTTATCA AGGGCGTGCG GGTCTTCGAT GTGGCTGTGT TGGCGCCGCT GCTTAAAGAT 
CCAGCCTTGG ACCTCAAGGT CATCCACCTA GTACGTGATC CTCGTGCTGT TGCCAGCTCC 
CGCATCCGCT CGCGTCACGG CCTCATCCGG GAAAGCCTAC AGGTGGTGCG AAGCCGGGAT 
CCAAGAGCCC ACCGCATGCC CTTCCTGGAG GCTGCTGGCC ACAAGCTTGG TGCCAAGAAG 
GAGGGTATGG GTGGCCCAGC AGACTACCAC GCTCTGGGTG CAATGGAGGT CATCTGCAAC 
AGTATGGCCA AGACGCTGCA AACAGCCCTG CAGCCTCCTG ACTGGCTGCA GGGACACTAC 
TTGGTGGTGA GGTACGAGGA TCTGGTGGGA GACCCCGTTA AGACCCTACG GAGGGTATAT 
GACTTTGTGG GGCTGCTGGT GAGTCCCGAA ATGGAGCAGT TTGCCCTGAA CATGACCAGT 
GGTTCGGGCT CCTCCTCCAA GCCTTTCGTG GTGTCAGCTC GCAATGCCAC TCAGGCCGCC 
AATGCCTGGC GGACCGCGCT CACCTTCCAG CAGATCAAAC AGGTGGAGGA GTTTTGCTAC 
CAGCCCATGG CCGTGCTGGG CTATGAGCGG GTTAACAGTC CTGAGGAGGT CAAAGACCTC 
AGCAAGACCT TGCTCAGGAA GCCCCGGCTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061233.2
CDS	877..2469
Translation	MSRSSPRALPPGALPRPLPAAPAAVQRALLPPWPRRAGRRWPASPLGMKVFRRKALVLCAGYALLLVLTMLNLLDYKWHKEPLQQCNPDGPLGAAVGAAGAGWGRPGSPPAAPPRAHSRMDPRTPYRPPAAGVGAVPAAAAGSAGAAASLGNATRGTRGGGDKRQLVYVFTTWRSGSSFFGELFNQNPEVFFLYEPVWHVWQKLYPGDAVSLQGAARDMLSALYRCDLSVFQLYSPAGSGGRNLTTLGIFGAATNKVVCSSPLCPAYRKEVVGLVDDRVCKKCPPQRLARFEEECRKYRTLVIKGVRVFDVAVLAPLLKDPALDLKVIHLVRDPRAVASSRIRSRHGLIRESLQVVRSRDPRAHRMPFLEAAGHKLGAKKEGMGGPADYHALGAMEVICNSMAKTLQTALQPPDWLQGHYLVVRYEDLVGDPVKTLRRVYDFVGLLVSPEMEQFALNMTSGSGSSSKPFVVSARNATQAANAWRTALTFQQIKQVEEFCYQPMAVLGYERVNSPEEVKDLSKTLLRKPRL

Target ORF information:

RefSeq Version	NM_018763.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus carbohydrate sulfotransferase 2 (Chst2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018763.2

ORF Insert Sequence:

ATGAGCCGCA GCTCGCCGCG AGCTCTGCCC CCCGGTGCGC TTCCCCGGCC GCTGCCGGCC 
GCGCCTGCCG CCGTGCAGCG GGCCCTGCTC CCGCCGTGGC CCCGGCGCGC AGGACGCCGC 
TGGCCTGCGT CCCCGCTCGG GATGAAGGTA TTTCGCAGGA AGGCGCTGGT GCTGTGCGCG 
GGCTATGCAC TGCTACTGGT GCTCACGATG CTCAACCTCT TGGACTACAA GTGGCATAAA 
GAGCCGCTGC AGCAGTGCAA CCCCGACGGG CCTCTGGGTG CCGCGGTAGG GGCGGCCGGG 
GCCGGCTGGG GACGGCCGGG GTCGCCTCCT GCAGCGCCAC CCCGCGCTCA CTCTCGCATG 
GACCCCCGCA CCCCGTACCG CCCTCCTGCC GCGGGCGTGG GGGCAGTTCC CGCAGCCGCG 
GCTGGGAGTG CAGGAGCTGC GGCCTCTCTG GGCAATGCTA CTCGAGGCAC CAGGGGTGGA 
GGGGACAAGC GGCAGTTGGT GTATGTGTTC ACCACGTGGC GCTCGGGCTC GTCCTTCTTC 
GGTGAGCTCT TCAACCAGAA CCCTGAGGTG TTCTTCCTCT ATGAGCCTGT GTGGCACGTG 
TGGCAAAAAC TGTACCCCGG GGACGCCGTT TCCCTGCAGG GGGCAGCGCG GGACATGCTG 
AGCGCTCTCT ACCGCTGCGA TCTTTCGGTT TTCCAGCTGT ATAGCCCCGC AGGCAGTGGG 
GGGCGCAACC TCACCACTCT GGGCATCTTT GGGGCAGCCA CTAACAAGGT GGTATGCTCC 
TCGCCACTCT GTCCTGCCTA CCGCAAGGAG GTCGTCGGAC TGGTGGACGA CCGCGTGTGC 
AAAAAGTGCC CACCTCAACG CCTGGCACGC TTCGAGGAGG AGTGTCGCAA GTACCGCACG 
CTGGTTATCA AGGGCGTGCG GGTCTTCGAT GTGGCTGTGT TGGCGCCGCT GCTTAAAGAT 
CCAGCCTTGG ACCTCAAGGT CATCCACCTA GTACGTGATC CTCGTGCTGT TGCCAGCTCC 
CGCATCCGCT CGCGTCACGG CCTCATCCGG GAAAGCCTAC AGGTGGTGCG AAGCCGGGAT 
CCAAGAGCCC ACCGCATGCC CTTCCTGGAG GCTGCTGGCC ACAAGCTTGG TGCCAAGAAG 
GAGGGTATGG GTGGCCCAGC AGACTACCAC GCTCTGGGTG CAATGGAGGT CATCTGCAAC 
AGTATGGCCA AGACGCTGCA AACAGCCCTG CAGCCTCCTG ACTGGCTGCA GGGACACTAC 
TTGGTGGTGA GGTACGAGGA TCTGGTGGGA GACCCCGTTA AGACCCTACG GAGGGTATAT 
GACTTTGTGG GGCTGCTGGT GAGTCCCGAA ATGGAGCAGT TTGCCCTGAA CATGACCAGT 
GGTTCGGGCT CCTCCTCCAA GCCTTTCGTG GTGTCAGCTC GCAATGCCAC TCAGGCCGCC 
AATGCCTGGC GGACCGCGCT CACCTTCCAG CAGATCAAAC AGGTGGAGGA GTTTTGCTAC 
CAGCCCATGG CCGTGCTGGG CTATGAGCGG GTTAACAGTC CTGAGGAGGT CAAAGACCTC 
AGCAAGACCT TGCTCAGGAA GCCCCGGCTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of MAdCAM-1-Expressing High Endothelial Venule-Like Vessels in Colitis Induced in Mice Lacking Sulfotransferases Catalyzing L-Selectin Ligand Biosynthesis.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society22155417753363(2018 Jan)
Low S,Hirakawa J,Hoshino H,Uchimura K,Kawashima H,Kobayashi M

Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.
Proceedings of the National Academy of Sciences of the United States of America114(14)E2947-E2954(2017 Apr)
Zhang Z,Takeda-Uchimura Y,Foyez T,Ohtake-Niimi S,Narentuya,Akatsu H,Nishitsuji K,Michikawa M,Wyss-Coray T,Kadomatsu K,Uchimura K

Keratan Sulfate Regulates the Switch from Motor Neuron to Oligodendrocyte Generation During Development of the Mouse Spinal Cord.
Neurochemical research41(1-2)450-62(2016 Feb)
Hashimoto H,Ishino Y,Jiang W,Yoshimura T,Takeda-Uchimura Y,Uchimura K,Kadomatsu K,Ikenaka K

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Chst2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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