Snx3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Snx3
Entrez Gene ID	54198
Full Name	sorting nexin 3
Synonyms	SDP3
General protein information	Preferred Names sorting nexin 3 Names sorting nexin-3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 B2\|10 22.89 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_017472.4	NP_059500.2	sorting nexin-3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SNX3	XP_855006.2
Rattus norvegicus (Norway rat)	Snx3	NP_001037748.1
Gallus gallus (chicken)	SNX3	NP_001006408.1
Danio rerio (zebrafish)	snx3	NP_001032183.1
Kluyveromyces lactis	KLLA0A03718g	XP_451164.1
Schizosaccharomyces pombe (fission yeast)	snx3	NP_596480.1
Neurospora crassa	NCU01914	XP_965545.1
Pan troglodytes (chimpanzee)	SNX3	XP_001149032.1
Bos taurus (cattle)	SNX3	NP_001073246.1
Mus musculus (house mouse)	Snx3	NP_059500.2
Eremothecium gossypii	AGOS_ADR390C	NP_984486.2
Magnaporthe oryzae (rice blast fungus)	MGG_02948	XP_003720759.1
Homo sapiens (human)	SNX3	NP_003786.1
	SNX3	XP_001094537.1
Saccharomyces cerevisiae (baker's yeast)	SNX3	NP_015002.3
Xenopus tropicalis (tropical clawed frog)	snx3	NP_989030.1

Gene Ontology
Bibliography

Related articles in PubMed

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

SNX3 recruits to phagosomes and negatively regulates phagocytosis in dendritic cells.
Chua RY, Wong SH
Immunology139(1)30-47(2013 May)

Snx3 regulates recycling of the transferrin receptor and iron assimilation.
Chen C, Garcia-Santos D, Ishikawa Y, Seguin A, Li L, Fegan KH, Hildick-Smith GJ, Shah DI, Cooney JD, Chen W, King MJ, Yien YY, Schultz IJ, Anderson H, Dalton AJ, Freedman ML, Kingsley PD, Palis J, Hattangadi SM, Lodish HF, Ward DM, Kaplan J, Maeda T, Ponka P, Paw BH
Cell metabolism17(3)343-52(2013 Mar)

Developmental expression of sorting nexin 3 in the mouse central nervous system.
Mizutani R, Nakamura K, Yokoyama S, Sanbe A, Kusakawa S, Miyamoto Y, Torii T, Asahara H, Okado H, Yamauchi J, Tanoue A
Gene expression patterns : GEP11(1-2)33-40(2011 Jan-Feb)

Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells.
Mizutani R, Yamauchi J, Kusakawa S, Nakamura K, Sanbe A, Torii T, Miyamoto Y, Tanoue A
Cellular signalling21(11)1586-94(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SNX3 negatively regulates phagocytosis in DC possibly by modulating recruitment of essential PI3P lipid-binding proteins of the phagocytic pathways, such as EEA1, to phagosomal membranes.
Title: SNX3 recruits to phagosomes and negatively regulates phagocytosis in dendritic cells.

Snx3 regulates recycling of the transferrin receptor and iron assimilation.
Title: Snx3 regulates recycling of the transferrin receptor and iron assimilation.

Snx3 mRNA is expressed during neural development and in adult neural tissues, suggesting that SNX3 may play an important role in the development and function of the central nervous system.
Title: Developmental expression of sorting nexin 3 in the mouse central nervous system.

SNX3 promotes neurite outgrowth even in the presence of serum and that its short basic C-terminal sequence, as well as the PX domain, binds to phosphatidylinositol monophosphates.
Title: Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells.

vasopressin-induced Usp10 deubiquitylates and stabilizes endogenous SNX3 and consequently promotes cell surface expression of ENaC
Title: Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3.

The following Snx3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Snx3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22503	NM_017472.4 Latest version!	Mus musculus sorting nexin 3 (Snx3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Snx3 ( NM_017472.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_059500.2 Mus musculus sorting nexin 3 (Snx3), mRNA.

Price & Availability↑

CloneID	OMu22503
Clone ID Related Accession (Same CDS sequence)	NM_017472.4
Accession Version	NM_017472.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	sorting nexin-3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK013183.1, DN176987.1 and AK007798.1. On Apr 2, 2008 this sequence version replaced NM_017472.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK007798.1, AK013183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGAGA CGGTAGCGGA CACCCGGCGG CTCATCACCA AGCCGCAGAA TCTGAATGAC 
GCCTACGGGC CGCCCAGCAA CTTCCTCGAG ATCGACGTGA GCAACCCGCA GACCGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACCTACGAG ATCAGGGTCA AGACAAATCT TCCTATCTTC 
AAGCTGAAGG AATCTACTGT TAGAAGAAGA TACAGTGACT TTGAGTGGCT TCGAAGTGAA 
CTAGAAAGAG AGAGCAAGGT TGTAGTTCCC CCACTCCCTG GGAAAGCATT TTTGCGGCAG 
CTTCCTTTTA GAGGAGACGA TGGAATATTT GATGACAATT TCATCGAGGA AAGGAAGCAA 
GGGCTGGAAC AGTTCATAAA CAAGGTCGCT GGTCATCCTC TGGCCCAGAA TGAACGTTGT 
CTTCACATGT TTTTACAGGA TGAAATTATA GATAAAAGCT ATACTCCATC TAAAATAAGA 
CATGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059500.2
CDS	278..766
Translation	MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Target ORF information:

RefSeq Version	NM_017472.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus sorting nexin 3 (Snx3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017472.4

ORF Insert Sequence:

ATGGCGGAGA CGGTAGCGGA CACCCGGCGG CTCATCACCA AGCCGCAGAA TCTGAATGAC 
GCCTACGGGC CGCCCAGCAA CTTCCTCGAG ATCGACGTGA GCAACCCGCA GACCGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACCTACGAG ATCAGGGTCA AGACAAATCT TCCTATCTTC 
AAGCTGAAGG AATCTACTGT TAGAAGAAGA TACAGTGACT TTGAGTGGCT TCGAAGTGAA 
CTAGAAAGAG AGAGCAAGGT TGTAGTTCCC CCACTCCCTG GGAAAGCATT TTTGCGGCAG 
CTTCCTTTTA GAGGAGACGA TGGAATATTT GATGACAATT TCATCGAGGA AAGGAAGCAA 
GGGCTGGAAC AGTTCATAAA CAAGGTCGCT GGTCATCCTC TGGCCCAGAA TGAACGTTGT 
CTTCACATGT TTTTACAGGA TGAAATTATA GATAAAAGCT ATACTCCATC TAAAATAAGA 
CATGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

SNX3 recruits to phagosomes and negatively regulates phagocytosis in dendritic cells.
Immunology139(1)30-47(2013 May)
Chua RY,Wong SH

Snx3 regulates recycling of the transferrin receptor and iron assimilation.
Cell metabolism17(3)343-52(2013 Mar)
Chen C,Garcia-Santos D,Ishikawa Y,Seguin A,Li L,Fegan KH,Hildick-Smith GJ,Shah DI,Cooney JD,Chen W,King MJ,Yien YY,Schultz IJ,Anderson H,Dalton AJ,Freedman ML,Kingsley PD,Palis J,Hattangadi SM,Lodish HF,Ward DM,Kaplan J,Maeda T,Ponka P,Paw BH

Developmental expression of sorting nexin 3 in the mouse central nervous system.
Gene expression patterns : GEP11(1-2)33-40(2011 Jan-Feb)
Mizutani R,Nakamura K,Yokoyama S,Sanbe A,Kusakawa S,Miyamoto Y,Torii T,Asahara H,Okado H,Yamauchi J,Tanoue A

Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells.
Cellular signalling21(11)1586-94(2009 Nov)
Mizutani R,Yamauchi J,Kusakawa S,Nakamura K,Sanbe A,Torii T,Miyamoto Y,Tanoue A

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Snx3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報