Avpr1a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Avpr1a
Entrez Gene ID	54140
Full Name	arginine vasopressin receptor 1A
Synonyms	AVPR,Avpr1,V1a,V1aR
General protein information	Preferred Names arginine vasopressin receptor 1A Names vasopressin V1a receptor AVPR V1a V1a arginine vasopressin receptor antidiuretic hormone receptor 1a vascular/hepatic-type arginine vasopressin receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 D2
Summary	This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_016847.2	NP_058543.2	vasopressin V1a receptor

Pathways from BioSystems

Homologies

	AVPR1A	XP_001116798.2
Canis lupus familiaris (dog)	AVPR1A	NP_001185587.1
Danio rerio (zebrafish)	LOC571591	XP_700287.2
Homo sapiens (human)	AVPR1A	NP_000697.1
Mus musculus (house mouse)	Avpr1a	NP_058543.2
Gallus gallus (chicken)	AVPR1A	NP_001103908.1
Caenorhabditis elegans (roundworm)	CELE_T07D10.2	NP_493193.1
Pan troglodytes (chimpanzee)	AVPR1A	XP_003952184.1
Rattus norvegicus (Norway rat)	Avpr1a	NP_444178.2
Caenorhabditis elegans (roundworm)	F14F4.1	NP_510477.1
Bos taurus (cattle)	AVPR1A	NP_001098460.1
Danio rerio (zebrafish)	avpr1b	XP_683692.1
Xenopus tropicalis (tropical clawed frog)	avpr1a	XP_002931664.1

Gene Ontology
Bibliography

Related articles in PubMed

Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues.
Yao S, Bergan J, Lanjuin A, Dulac C
eLife6(2017 Dec)

Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function.
Berthon A, Faucz FR, Espiard S, Drougat L, Bertherat J, Stratakis CA
Human molecular genetics26(18)3495-3507(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that cryptochrome Cry1 and Cry2 expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP) receptor signaling is required to impose circuit-level circadian function.
Title: Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling.

The results suggest that vasopressin receptor is required for conditioned effects of an ethanol-associated social stimulus
Title: Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice.

Transaortic constriction decreased heart function and betaAR density. It increased V1AR expression. V1AR decreased cardiomyocyte betaAR ligand affinity, betaAR-induced calcium signaling and cAMP in a Gq protein-independent/G protein receptor kinase-dependent way.
Title: ?-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling.

Oxytocin inhibits ASICs through V1A receptors in sensory neurons modulating nociception and pain.
Title: Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons.

Local over-expression of the AVP receptor V1a enhances regeneration of atrophic muscle.
Title: Local overexpression of V1a-vasopressin receptor enhances regeneration in tumor necrosis factor-induced muscle atrophy.

The following Avpr1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Avpr1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15138	NM_016847.2 Latest version!	Mus musculus arginine vasopressin receptor 1A (Avpr1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Avpr1a ( NM_016847.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058543.2 Mus musculus arginine vasopressin receptor 1A (Avpr1a), mRNA.

Price & Availability↑

CloneID	OMu15138
Clone ID Related Accession (Same CDS sequence)	NM_016847.2
Accession Version	NM_016847.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	vasopressin V1a receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D49730.1. On Jul 23, 2003 this sequence version replaced NM_016847.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D49730.1, BC024149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAGTTTCC CGCGAGGCTC CCACGATCTG CCCGCGGGCA ACTCCAGCCC GTGGTGGCCT 
CTGACCACCG AGGGCGCCAA CAGCAGCCGG GAAGCAGCTG GGCTCGGGGA AGGCGGCAGC 
CCGCCGGGGG ACGTACGCAA CGAGGAGCTG GCGAAGCTGG AGGTTACCGT GCTGGCGGTG 
ATTTTCGTGG TGGCCGTGCT GGGTAATAGC AGTGTGCTGC TGGCGCTGCA TCGCACGCCA 
CGCAAGACAT CCCGCATGCA TCTCTTCATC CGACACCTCA GCCTGGCAGA CCTGGCGGTC 
GCCTTCTTCC AAGTGTTACC ACAGCTGTGC TGGGACATCA CCTACCGCTT CCGCGGGCCG 
GACTGGCTGT GCCGGGTGGT GAAGCACTTG CAGGTGTTTG CCATGTTCGC ATCTTCCTAC 
ATGCTGGTGG TGATGACGGC TGACCGCTAC ATCGCCGTGT GCCACCCGCT CAAGACCCTG 
CAGCAGCCCG CGCGCCGCTC GCGCCTCATG ATCGCCGCCT CTTGGGGGCT GAGTTTCGTT 
CTGAGCATAC CACAGTACTT TATCTTCTCT GTGATCGAAT TTGAGGTGAA CAATGGCACC 
AAAGCCCAAG ATTGCTGGGC TACCTTCATC CCGCCCTGGG GTACCCGTGC CTACGTGACC 
TGGATGACCA GCGGGGTCTT CGTGGTACCC GTGATCATCT TGGGTACCTG CTATGGCTTC 
ATCTGTTACC ACATCTGGCG CAATGTCCGA GGGAAGACAG CATCGCGACA GAGCAAAGGC 
GGCAAGGGCT CTGGGGAAGC CGCGGGTCCC TTCCACAAGG GGCTTCTGGT CACGCCTTGT 
GTCAGCAGCG TGAAGAGCAT TTCCCGTGCC AAGATCCGCA CAGTGAAGAT GACCTTTGTG 
ATTGTAAGCG CCTACATCCT CTGCTGGACA CCTTTCTTCA TCGTCCAGAT GTGGTCAGTC 
TGGGATACCA ATTTCGTTTG GACCGATTCC GAAAACCCTT CCACCACGAT CACGGCGTTA 
CTGGCTTCCT TGAACAGCTG CTGCAACCCG TGGATCTACA TGTTTTTTAG TGGTCATCTC 
CTACAAGATT GTGTCCAGAG CTTCCCATGC TGCCAAAGCA TAGCGCAGAA ATTCGCCAAG 
GATGACTCGG ATAGCATGAG CCGGAGACAG ACATCTTATT CTAACAACCG AAGCCCAACA 
AACAGCACTG GGACGTGGAA GGATTCACCT AAATCTTCAA AGTCCATCAG ATTTATCCCT 
GTCTCCACTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058543.2
CDS	307..1578
Translation	MSFPRGSHDLPAGNSSPWWPLTTEGANSSREAAGLGEGGSPPGDVRNEELAKLEVTVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASSYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAASWGLSFVLSIPQYFIFSVIEFEVNNGTKAQDCWATFIPPWGTRAYVTWMTSGVFVVPVIILGTCYGFICYHIWRNVRGKTASRQSKGGKGSGEAAGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWTPFFIVQMWSVWDTNFVWTDSENPSTTITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCQSIAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGTWKDSPKSSKSIRFIPVST

Target ORF information:

RefSeq Version	NM_016847.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus arginine vasopressin receptor 1A (Avpr1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016847.2

ORF Insert Sequence:

ATGAGTTTCC CGCGAGGCTC CCACGATCTG CCCGCGGGCA ACTCCAGCCC GTGGTGGCCT 
CTGACCACCG AGGGCGCCAA CAGCAGCCGG GAAGCAGCTG GGCTCGGGGA AGGCGGCAGC 
CCGCCGGGGG ACGTACGCAA CGAGGAGCTG GCGAAGCTGG AGGTTACCGT GCTGGCGGTG 
ATTTTCGTGG TGGCCGTGCT GGGTAATAGC AGTGTGCTGC TGGCGCTGCA TCGCACGCCA 
CGCAAGACAT CCCGCATGCA TCTCTTCATC CGACACCTCA GCCTGGCAGA CCTGGCGGTC 
GCCTTCTTCC AAGTGTTACC ACAGCTGTGC TGGGACATCA CCTACCGCTT CCGCGGGCCG 
GACTGGCTGT GCCGGGTGGT GAAGCACTTG CAGGTGTTTG CCATGTTCGC ATCTTCCTAC 
ATGCTGGTGG TGATGACGGC TGACCGCTAC ATCGCCGTGT GCCACCCGCT CAAGACCCTG 
CAGCAGCCCG CGCGCCGCTC GCGCCTCATG ATCGCCGCCT CTTGGGGGCT GAGTTTCGTT 
CTGAGCATAC CACAGTACTT TATCTTCTCT GTGATCGAAT TTGAGGTGAA CAATGGCACC 
AAAGCCCAAG ATTGCTGGGC TACCTTCATC CCGCCCTGGG GTACCCGTGC CTACGTGACC 
TGGATGACCA GCGGGGTCTT CGTGGTACCC GTGATCATCT TGGGTACCTG CTATGGCTTC 
ATCTGTTACC ACATCTGGCG CAATGTCCGA GGGAAGACAG CATCGCGACA GAGCAAAGGC 
GGCAAGGGCT CTGGGGAAGC CGCGGGTCCC TTCCACAAGG GGCTTCTGGT CACGCCTTGT 
GTCAGCAGCG TGAAGAGCAT TTCCCGTGCC AAGATCCGCA CAGTGAAGAT GACCTTTGTG 
ATTGTAAGCG CCTACATCCT CTGCTGGACA CCTTTCTTCA TCGTCCAGAT GTGGTCAGTC 
TGGGATACCA ATTTCGTTTG GACCGATTCC GAAAACCCTT CCACCACGAT CACGGCGTTA 
CTGGCTTCCT TGAACAGCTG CTGCAACCCG TGGATCTACA TGTTTTTTAG TGGTCATCTC 
CTACAAGATT GTGTCCAGAG CTTCCCATGC TGCCAAAGCA TAGCGCAGAA ATTCGCCAAG 
GATGACTCGG ATAGCATGAG CCGGAGACAG ACATCTTATT CTAACAACCG AAGCCCAACA 
AACAGCACTG GGACGTGGAA GGATTCACCT AAATCTTCAA AGTCCATCAG ATTTATCCCT 
GTCTCCACTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues.
eLife6(2017 Dec)
Yao S,Bergan J,Lanjuin A,Dulac C

Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function.
Human molecular genetics26(18)3495-3507(2017 Sep)
Berthon A,Faucz FR,Espiard S,Drougat L,Bertherat J,Stratakis CA

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Avpr1a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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