Acrbp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acrbp
Entrez Gene ID	54137
Full Name	proacrosin binding protein
Synonyms	OY-TES-1,sp32
General protein information	Preferred Names proacrosin binding protein Names acrosin-binding protein acrbp
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 F2

mRNA and Protein(s)

mRNA	Protein	Name
NM_016845.2	NP_058541.2	acrosin-binding protein isoform 1 precursor
NM_001127340.1	NP_001120812.1	acrosin-binding protein isoform 2 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Acrbp	NP_001020220.1
Pan troglodytes (chimpanzee)	ACRBP	NP_001233534.1
Bos taurus (cattle)	ACRBP	XP_002687915.1
Homo sapiens (human)	ACRBP	NP_115878.2
	ACRBP	XP_001107683.1
Mus musculus (house mouse)	Acrbp	NP_058541.2
Gallus gallus (chicken)	ACRBP	XP_004938169.1
Canis lupus familiaris (dog)	ACRBP	XP_534908.2

Gene Ontology
Bibliography

Related articles in PubMed

Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse.
Kanemori Y, Koga Y, Sudo M, Kang W, Kashiwabara S, Ikawa M, Hasuwa H, Nagashima K, Ishikawa Y, Ogonuki N, Ogura A, Baba T
Proceedings of the National Academy of Sciences of the United States of America113(26)E3696-705(2016 06)

Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse.
Kanemori Y, Ryu JH, Sudo M, Niida-Araida Y, Kodaira K, Takenaka M, Kohno N, Sugiura S, Kashiwabara S, Baba T
Biology of reproduction88(4)105(2013 Apr)

Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice.
Tardif S, Guyonnet B, Cormier N, Cornwall GA
Molecular human reproduction18(6)298-307(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ACRBP-null male mice showed a severely reduced fertility, because of malformation of the acrosome.
Title: Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse.

Two forms of Acrbp mRNA-wild-type Acrbp-W and variant Acrbp-V5 mRNAs-were generated by alternative splicing of Acrbp in the mouse.
Title: Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse.

Data suggest that the fertility defect in PCSK4 (proprotein convertase subtilisin/kexin type 4) knockout mice is due, in part, to altered processing/proteolysis of ACRBP as well as structural abnormalities in sperm heads and acrosomes.
Title: Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice.

The following Acrbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acrbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10778	NM_016845.2 Latest version!	Mus musculus proacrosin binding protein (Acrbp), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$321.30 $459.00
OMu05914	NM_001127340.1 Latest version!	Mus musculus proacrosin binding protein (Acrbp), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acrbp ( NM_016845.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058541.2 Mus musculus proacrosin binding protein (Acrbp), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu10778
Clone ID Related Accession (Same CDS sequence)	NM_016845.2
Accession Version	NM_016845.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1623bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	acrosin-binding protein isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY099028.1 and AK132705.1. On May 14, 2008 this sequence version replaced NM_016845.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK132705.1, D17573.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGATGAATC TAGCTGCTGG CTTCCTTCTG ATGCTTCTGG AAGTGCTGCT CCTGCCTGGA 
ACACCTCTTT CCGCTGAGGA ATCTCCAGCC TCCACTCCAG GCAGCCCTCT CTCGTCCACT 
GAGTATGAAC GCTTCTTCGC CCTGCTGACC CCAACCTGGA AGGCAGAGAC CACCTGCCGC 
CTCCGTGCCA CCCACGGCTG CCGGAACCCC ACTCTCGTTC AGTTGGATCA ATATGAAAAC 
CACGGATTGG TACCAGATGG TGCTGTCTGC TCCGATCTCC CTTATGCTTC CTGGTTTGAG 
TCCTTCTGCC AGTTTGCTCA GTATCGTTGC TCCAACCATG TCTACTATGC CAAGAGGGTC 
CGGTGCTCCC AGCCCGTCTC CATCCTATCC CCCAACACTC TCAAGGAGGT GGAGTCTTCA 
GCAGAAGTTC CTCCCACTTC CATGACCACC CCCATTGTGT CCCATGCCAC AGCCACAGAA 
CACCAGGCCT TCCAGCCTTG GCCTGAGCGG CTCAACAACA ACGTGGAGGA GCTGCTGCAG 
TCATCCTTGT CCCTGGGAGG CAAGGACCAA CAGAGCAGTC GGAGACCAGG CCAGGAGCAG 
CGCAAGCAGG AGCAGATCCA AGAACATAAG CTAGAAGAAG CGCAGGAGCA AGAAGAGCAG 
GAAGAAGAGG AAGAGGAGGA GGAAGCCAAG CAGGAAGAGG GGCAGGGGAC AGAGGCGGGT 
CTGGAGTCAG TGTCCAGGCT GCAGTCAGAC TCAGAGCCCA AGTTTCAATC CCAGTCACTG 
TCTTCCAACC CGTCCTTCTT CACTCCCCGG GTCCGAGAGG TGGAGTCTGC TCCATTGATG 
ATGAAGAATA TCCAGGAGCT CATTCGGTCT GCCCAGGAAA TGGATGAAAT GAATGAACTG 
TATGATGACT CCTGGAGAAG CCAAAGCACT GGCAGCCTCC AGCAGCTGCC CCACATGGAG 
ACCCTGATGG TGCTATGCTA TTCCATTATG GAGAATACCT GCACCATGAC TCCCACAGCC 
AAGGCCTGGA GCTACATGGA GGAGGAGATC CTTGGCTTCG GGGATTCGGT GTGTGACAAT 
CTCGGAAGGC GACACACAGC TGCCTGTCCC CTCTGTGCAT TCTGCTCCCT GAAGCTGGAG 
CAGTGCCACA GTGAAGCCAG TGTGCTGCGC CAGAAGTGTG ACGCTTCCCA CAAGATACCC 
TTCATCAGCC CCTTGCTCTC AGCCCAGAGC ATATCCACGG GCAACCAGGC GAGGATCCCA 
GATAAAGGAC GATTTGCTGG GCTAGAAATG TACGGAGGAC TCAGCTCAGA GTTCTGGTGC 
AACCGGCTTG CTATGAAGGG CTGTGAAGAT GACCGAGTCT CCAACTGGCT CAAAGCTGAG 
TTCCTTAGCT TCCAGGAGGG GGATTTCCCC ACCAAGATTT GTGACACAAA CTATATCCAG 
TACCCAAACT ACTGTTCCTT CAAAAGCCAG CAGTGCCTGC TGAGAAACCA GAACAGAAAG 
ATGTCCCGCA TGAGGTGTAT GCTGAATGAG AGGTACAACG TGCTAAGCCT GGCTAAGAGC 
GAAGAGGTGA TCCTTCGATG GAGCCAAGAG TTTAGCACTT TGGCTATAGG CCAGTTTGGA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058541.2
CDS	84..1706
Translation	MMNLAAGFLLMLLEVLLLPGTPLSAEESPASTPGSPLSSTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPPTSMTTPIVSHATATEHQAFQPWPERLNNNVEELLQSSLSLGGKDQQSSRRPGQEQRKQEQIQEHKLEEAQEQEEQEEEEEEEEAKQEEGQGTEAGLESVSRLQSDSEPKFQSQSLSSNPSFFTPRVREVESAPLMMKNIQELIRSAQEMDEMNELYDDSWRSQSTGSLQQLPHMETLMVLCYSIMENTCTMTPTAKAWSYMEEEILGFGDSVCDNLGRRHTAACPLCAFCSLKLEQCHSEASVLRQKCDASHKIPFISPLLSAQSISTGNQARIPDKGRFAGLEMYGGLSSEFWCNRLAMKGCEDDRVSNWLKAEFLSFQEGDFPTKICDTNYIQYPNYCSFKSQQCLLRNQNRKMSRMRCMLNERYNVLSLAKSEEVILRWSQEFSTLAIGQFG

Target ORF information:

RefSeq Version	NM_016845.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus proacrosin binding protein (Acrbp), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016845.2

ORF Insert Sequence:

ATGATGAATC TAGCTGCTGG CTTCCTTCTG ATGCTTCTGG AAGTGCTGCT CCTGCCTGGA 
ACACCTCTTT CCGCTGAGGA ATCTCCAGCC TCCACTCCAG GCAGCCCTCT CTCGTCCACT 
GAGTATGAAC GCTTCTTCGC CCTGCTGACC CCAACCTGGA AGGCAGAGAC CACCTGCCGC 
CTCCGTGCCA CCCACGGCTG CCGGAACCCC ACTCTCGTTC AGTTGGATCA ATATGAAAAC 
CACGGATTGG TACCAGATGG TGCTGTCTGC TCCGATCTCC CTTATGCTTC CTGGTTTGAG 
TCCTTCTGCC AGTTTGCTCA GTATCGTTGC TCCAACCATG TCTACTATGC CAAGAGGGTC 
CGGTGCTCCC AGCCCGTCTC CATCCTATCC CCCAACACTC TCAAGGAGGT GGAGTCTTCA 
GCAGAAGTTC CTCCCACTTC CATGACCACC CCCATTGTGT CCCATGCCAC AGCCACAGAA 
CACCAGGCCT TCCAGCCTTG GCCTGAGCGG CTCAACAACA ACGTGGAGGA GCTGCTGCAG 
TCATCCTTGT CCCTGGGAGG CAAGGACCAA CAGAGCAGTC GGAGACCAGG CCAGGAGCAG 
CGCAAGCAGG AGCAGATCCA AGAACATAAG CTAGAAGAAG CGCAGGAGCA AGAAGAGCAG 
GAAGAAGAGG AAGAGGAGGA GGAAGCCAAG CAGGAAGAGG GGCAGGGGAC AGAGGCGGGT 
CTGGAGTCAG TGTCCAGGCT GCAGTCAGAC TCAGAGCCCA AGTTTCAATC CCAGTCACTG 
TCTTCCAACC CGTCCTTCTT CACTCCCCGG GTCCGAGAGG TGGAGTCTGC TCCATTGATG 
ATGAAGAATA TCCAGGAGCT CATTCGGTCT GCCCAGGAAA TGGATGAAAT GAATGAACTG 
TATGATGACT CCTGGAGAAG CCAAAGCACT GGCAGCCTCC AGCAGCTGCC CCACATGGAG 
ACCCTGATGG TGCTATGCTA TTCCATTATG GAGAATACCT GCACCATGAC TCCCACAGCC 
AAGGCCTGGA GCTACATGGA GGAGGAGATC CTTGGCTTCG GGGATTCGGT GTGTGACAAT 
CTCGGAAGGC GACACACAGC TGCCTGTCCC CTCTGTGCAT TCTGCTCCCT GAAGCTGGAG 
CAGTGCCACA GTGAAGCCAG TGTGCTGCGC CAGAAGTGTG ACGCTTCCCA CAAGATACCC 
TTCATCAGCC CCTTGCTCTC AGCCCAGAGC ATATCCACGG GCAACCAGGC GAGGATCCCA 
GATAAAGGAC GATTTGCTGG GCTAGAAATG TACGGAGGAC TCAGCTCAGA GTTCTGGTGC 
AACCGGCTTG CTATGAAGGG CTGTGAAGAT GACCGAGTCT CCAACTGGCT CAAAGCTGAG 
TTCCTTAGCT TCCAGGAGGG GGATTTCCCC ACCAAGATTT GTGACACAAA CTATATCCAG 
TACCCAAACT ACTGTTCCTT CAAAAGCCAG CAGTGCCTGC TGAGAAACCA GAACAGAAAG 
ATGTCCCGCA TGAGGTGTAT GCTGAATGAG AGGTACAACG TGCTAAGCCT GGCTAAGAGC 
GAAGAGGTGA TCCTTCGATG GAGCCAAGAG TTTAGCACTT TGGCTATAGG CCAGTTTGGA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Acrbp ( NM_001127340.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001120812.1 Mus musculus proacrosin binding protein (Acrbp), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu05914
Clone ID Related Accession (Same CDS sequence)	NM_001127340.1
Accession Version	NM_001127340.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 951bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Mus musculus(house mouse)
Product	acrosin-binding protein isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY099028.1, BM938496.1 and AV260707.2. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in a protein (isoform 2) with a shorter, distinct C-terminus when compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK076691.1, BC011079.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGATGAATC TAGCTGCTGG CTTCCTTCTG ATGCTTCTGG AAGTGCTGCT CCTGCCTGGA 
ACACCTCTTT CCGCTGAGGA ATCTCCAGCC TCCACTCCAG GCAGCCCTCT CTCGTCCACT 
GAGTATGAAC GCTTCTTCGC CCTGCTGACC CCAACCTGGA AGGCAGAGAC CACCTGCCGC 
CTCCGTGCCA CCCACGGCTG CCGGAACCCC ACTCTCGTTC AGTTGGATCA ATATGAAAAC 
CACGGATTGG TACCAGATGG TGCTGTCTGC TCCGATCTCC CTTATGCTTC CTGGTTTGAG 
TCCTTCTGCC AGTTTGCTCA GTATCGTTGC TCCAACCATG TCTACTATGC CAAGAGGGTC 
CGGTGCTCCC AGCCCGTCTC CATCCTATCC CCCAACACTC TCAAGGAGGT GGAGTCTTCA 
GCAGAAGTTC CTCCCACTTC CATGACCACC CCCATTGTGT CCCATGCCAC AGCCACAGAA 
CACCAGGCCT TCCAGCCTTG GCCTGAGCGG CTCAACAACA ACGTGGAGGA GCTGCTGCAG 
TCATCCTTGT CCCTGGGAGG CAAGGACCAA CAGAGCAGTC GGAGACCAGG CCAGGAGCAG 
CGCAAGCAGG AGCAGATCCA AGAACATAAG CTAGAAGAAG CGCAGGAGCA AGAAGAGCAG 
GAAGAAGAGG AAGAGGAGGA GGAAGCCAAG CAGGAAGAGG GGCAGGGGAC AGAGGCGGGT 
CTGGAGTCAG TGTCCAGGCT GCAGTCAGAC TCAGAGCCCA AGTTTCAATC CCAGTCACTG 
TCTTCCAACC CGTCCTTCTT CACTCCCCGG GTCCGAGAGG TGGAGTCTGC TCCATTGATG 
ATGAAGAATA TCCAGGAGCT CATTCGGTCT GCCCAGGAAA TGGATGAAAT GAATGAACTG 
TATGATGACT CCTGGAGAAG CCAAAGCACT GGCAGGTACA GGAAATTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001120812.1
CDS	84..1034
Translation	MMNLAAGFLLMLLEVLLLPGTPLSAEESPASTPGSPLSSTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPPTSMTTPIVSHATATEHQAFQPWPERLNNNVEELLQSSLSLGGKDQQSSRRPGQEQRKQEQIQEHKLEEAQEQEEQEEEEEEEEAKQEEGQGTEAGLESVSRLQSDSEPKFQSQSLSSNPSFFTPRVREVESAPLMMKNIQELIRSAQEMDEMNELYDDSWRSQSTGRYRKL

Target ORF information:

RefSeq Version	NM_001127340.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus proacrosin binding protein (Acrbp), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127340.1

ORF Insert Sequence:

ATGATGAATC TAGCTGCTGG CTTCCTTCTG ATGCTTCTGG AAGTGCTGCT CCTGCCTGGA 
ACACCTCTTT CCGCTGAGGA ATCTCCAGCC TCCACTCCAG GCAGCCCTCT CTCGTCCACT 
GAGTATGAAC GCTTCTTCGC CCTGCTGACC CCAACCTGGA AGGCAGAGAC CACCTGCCGC 
CTCCGTGCCA CCCACGGCTG CCGGAACCCC ACTCTCGTTC AGTTGGATCA ATATGAAAAC 
CACGGATTGG TACCAGATGG TGCTGTCTGC TCCGATCTCC CTTATGCTTC CTGGTTTGAG 
TCCTTCTGCC AGTTTGCTCA GTATCGTTGC TCCAACCATG TCTACTATGC CAAGAGGGTC 
CGGTGCTCCC AGCCCGTCTC CATCCTATCC CCCAACACTC TCAAGGAGGT GGAGTCTTCA 
GCAGAAGTTC CTCCCACTTC CATGACCACC CCCATTGTGT CCCATGCCAC AGCCACAGAA 
CACCAGGCCT TCCAGCCTTG GCCTGAGCGG CTCAACAACA ACGTGGAGGA GCTGCTGCAG 
TCATCCTTGT CCCTGGGAGG CAAGGACCAA CAGAGCAGTC GGAGACCAGG CCAGGAGCAG 
CGCAAGCAGG AGCAGATCCA AGAACATAAG CTAGAAGAAG CGCAGGAGCA AGAAGAGCAG 
GAAGAAGAGG AAGAGGAGGA GGAAGCCAAG CAGGAAGAGG GGCAGGGGAC AGAGGCGGGT 
CTGGAGTCAG TGTCCAGGCT GCAGTCAGAC TCAGAGCCCA AGTTTCAATC CCAGTCACTG 
TCTTCCAACC CGTCCTTCTT CACTCCCCGG GTCCGAGAGG TGGAGTCTGC TCCATTGATG 
ATGAAGAATA TCCAGGAGCT CATTCGGTCT GCCCAGGAAA TGGATGAAAT GAATGAACTG 
TATGATGACT CCTGGAGAAG CCAAAGCACT GGCAGGTACA GGAAATTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse.
Proceedings of the National Academy of Sciences of the United States of America113(26)E3696-705(2016 06)
Kanemori Y,Koga Y,Sudo M,Kang W,Kashiwabara S,Ikawa M,Hasuwa H,Nagashima K,Ishikawa Y,Ogonuki N,Ogura A,Baba T

Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse.
Biology of reproduction88(4)105(2013 Apr)
Kanemori Y,Ryu JH,Sudo M,Niida-Araida Y,Kodaira K,Takenaka M,Kohno N,Sugiura S,Kashiwabara S,Baba T

Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice.
Molecular human reproduction18(6)298-307(2012 Jun)
Tardif S,Guyonnet B,Cormier N,Cornwall GA