Pdlim1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pdlim1
Entrez Gene ID	54132
Full Name	PDZ and LIM domain 1 (elfin)
Synonyms	CLP36,Clim1,mClim1
General protein information	Preferred Names PDZ and LIM domain 1 (elfin) Names PDZ and LIM domain protein 1 C-terminal LIM domain protein 1 LIM domain protein CLP-36 carboxyl terminal LIM domain protein 1 elfin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_016861.4	NP_058557.2	PDZ and LIM domain protein 1

Pathways from BioSystems

Homologies

	PDLIM1	XP_001099155.1
Bos taurus (cattle)	PDLIM1	NP_001030532.1
Gallus gallus (chicken)	PDLIM1	XP_426503.4
Danio rerio (zebrafish)	pdlim1	NP_001017870.1
Pan troglodytes (chimpanzee)	PDLIM1	XP_001153448.1
Mus musculus (house mouse)	Pdlim1	NP_058557.2
Xenopus tropicalis (tropical clawed frog)	pdlim1	NP_988930.1
Homo sapiens (human)	PDLIM1	NP_066272.1
Rattus norvegicus (Norway rat)	Pdlim1	NP_059061.1
Canis lupus familiaris (dog)	PDLIM1	XP_534974.4

Gene Ontology
Bibliography

Related articles in PubMed

Suppressor of fused controls cerebellar neuronal differentiation in a manner modulated by GLI3 repressor and Fgf15.
Kim JJ, Jiwani T, Erwood S, Loree J, Rosenblum ND
Developmental dynamics : an official publication of the American Association of Anatomists247(1)156-169(2018 Jan)

Lacking of palladin leads to multiple cellular events changes which contribute to NTD.
Tan J, Chen XJ, Shen CL, Zhang HX, Tang LY, Lu SY, Wu WT, Kuang Y, Fei J, Wang ZG
Neural development12(1)4(2017 Mar)

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

Autophagy regulates spermatid differentiation via degradation of PDLIM1.
Shang Y, Wang H, Jia P, Zhao H, Liu C, Liu W, Song Z, Xu Z, Yang L, Wang Y, Li W
Autophagy12(9)1575-92(2016 Sep)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

autophagy regulates cytoskeleton organization mainly via degradation of PDLIM1 to facilitate the differentiation of spermatids
Title: Autophagy regulates spermatid differentiation via degradation of PDLIM1.

Data show an inhibitory function of CLP-36 in GPVI immunoreceptor tyrosine-based activation motif signaling and as a key regulator of arterial thrombosis.
Title: CLP36 is a negative regulator of glycoprotein VI signaling in platelets.

The LIM-homeodomain-related genes Lmo4 and Clim1 are initially expressed by both CPN and subcerebral PN in layer V, and only during mid to late differentiation does expression of Lmo4 and Clim1 become largely segregated into distinct neuronal subtypes.
Title: Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development.

Clim1 protein plays an important role in the homeostasis of corneal epithelium and hair follicles.
Title: Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells.

The following Pdlim1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pdlim1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21079	NM_016861.4 Latest version!	Mus musculus PDZ and LIM domain 1 (elfin) (Pdlim1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pdlim1 ( NM_016861.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058557.2 Mus musculus PDZ and LIM domain 1 (elfin) (Pdlim1), mRNA.

Price & Availability↑

CloneID	OMu21079
Clone ID Related Accession (Same CDS sequence)	NM_016861.4
Accession Version	NM_016861.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	PDZ and LIM domain protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK158992.1, AK076285.1 and AF053367.2. On Oct 25, 2007 this sequence version replaced NM_016861.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF053367.2, AK146399.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGACCACCC AGCAGATTGT TCTCCAGGGC CCGGGTCCCT GGGGTTTCCG CCTCGTGGGC 
GGCAAGGACT TCGAACAACC TCTCGCCATT TCCCGGGTCA CTCCCGGAAG CAAGGCTGCT 
ATAGCGAATT TATGTATTGG AGATTTAATC ACAGCCATCG ATGGGGAAGA TACCAGCAGC 
ATGACACACT TGGAAGCTCA GAACAAAATC AAGGGCTGCG CAGACAACAT GACGCTCACA 
GTATCCAGGT CTGAACAGAA GATTTGGTCT CCTCTAGTGA CCGAGGAGGG GAAACGTCAT 
CCCTACAAGA TGAATTTAGC GTCGGAACCC CAAGAAGTCC TGCACATAGG AAGTGCCCAC 
AACCGAAGTG CCATGCCATT TACTGCCTCA CCTGCTCCCA GCACCCGGGT CATCACAAAC 
CAGTACAACA GCCCAACTGG CCTCTACTCA TCCGAAAACA TCTCTAACTT CAACAATGCT 
GTGGAGTCGA AGACCTCAGC CAGTGGGGAG GAGGCGAACA GCAGGCCCGT GGTTCAGCCT 
CATCCCTCCG GCAGCCTTAT CATTGACAAG GACTCTGAAG TTTACAAGAT GCTTCAGGAG 
AAGCAAGAAT TAAACGAGCC CCCCAAACAG TCCACATCCT TCCTGGTTCT GCAGGAGATC 
CTGGAGTCAG ATGGGAAAGG GGATCCCAAC AAGCCATCAG GATTTAGAAG TGTTAAAGCT 
CCAGTCACCA AAGTGGCTGC ATCTGTTGGA AATGCTCAGA AGCTGCCCAT CTGTGACAAA 
TGTGGAACTG GTATTGTTGG TGTGTTTGTG AAGCTGAGGG ATCACCATCG CCACCCTGAA 
TGCTATGTGT GCACCGACTG TGGCATCAAC CTGAAACAGA AGGGCCATTT CTTTGTAGAG 
GATCAGATCT ACTGTGAAAA GCATGCCCGG GAGCGGGTCA CTCCGCCTGA GGGCTACGAT 
GTGGTCACAG TGTTCCGCGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058557.2
CDS	176..1159
Translation	MTTQQIVLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAAIANLCIGDLITAIDGEDTSSMTHLEAQNKIKGCADNMTLTVSRSEQKIWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSAMPFTASPAPSTRVITNQYNSPTGLYSSENISNFNNAVESKTSASGEEANSRPVVQPHPSGSLIIDKDSEVYKMLQEKQELNEPPKQSTSFLVLQEILESDGKGDPNKPSGFRSVKAPVTKVAASVGNAQKLPICDKCGTGIVGVFVKLRDHHRHPECYVCTDCGINLKQKGHFFVEDQIYCEKHARERVTPPEGYDVVTVFRE

Target ORF information:

RefSeq Version	NM_016861.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus PDZ and LIM domain 1 (elfin) (Pdlim1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016861.4

ORF Insert Sequence:

ATGACCACCC AGCAGATTGT TCTCCAGGGC CCGGGTCCCT GGGGTTTCCG CCTCGTGGGC 
GGCAAGGACT TCGAACAACC TCTCGCCATT TCCCGGGTCA CTCCCGGAAG CAAGGCTGCT 
ATAGCGAATT TATGTATTGG AGATTTAATC ACAGCCATCG ATGGGGAAGA TACCAGCAGC 
ATGACACACT TGGAAGCTCA GAACAAAATC AAGGGCTGCG CAGACAACAT GACGCTCACA 
GTATCCAGGT CTGAACAGAA GATTTGGTCT CCTCTAGTGA CCGAGGAGGG GAAACGTCAT 
CCCTACAAGA TGAATTTAGC GTCGGAACCC CAAGAAGTCC TGCACATAGG AAGTGCCCAC 
AACCGAAGTG CCATGCCATT TACTGCCTCA CCTGCTCCCA GCACCCGGGT CATCACAAAC 
CAGTACAACA GCCCAACTGG CCTCTACTCA TCCGAAAACA TCTCTAACTT CAACAATGCT 
GTGGAGTCGA AGACCTCAGC CAGTGGGGAG GAGGCGAACA GCAGGCCCGT GGTTCAGCCT 
CATCCCTCCG GCAGCCTTAT CATTGACAAG GACTCTGAAG TTTACAAGAT GCTTCAGGAG 
AAGCAAGAAT TAAACGAGCC CCCCAAACAG TCCACATCCT TCCTGGTTCT GCAGGAGATC 
CTGGAGTCAG ATGGGAAAGG GGATCCCAAC AAGCCATCAG GATTTAGAAG TGTTAAAGCT 
CCAGTCACCA AAGTGGCTGC ATCTGTTGGA AATGCTCAGA AGCTGCCCAT CTGTGACAAA 
TGTGGAACTG GTATTGTTGG TGTGTTTGTG AAGCTGAGGG ATCACCATCG CCACCCTGAA 
TGCTATGTGT GCACCGACTG TGGCATCAAC CTGAAACAGA AGGGCCATTT CTTTGTAGAG 
GATCAGATCT ACTGTGAAAA GCATGCCCGG GAGCGGGTCA CTCCGCCTGA GGGCTACGAT 
GTGGTCACAG TGTTCCGCGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppressor of fused controls cerebellar neuronal differentiation in a manner modulated by GLI3 repressor and Fgf15.
Developmental dynamics : an official publication of the American Association of Anatomists247(1)156-169(2018 Jan)
Kim JJ,Jiwani T,Erwood S,Loree J,Rosenblum ND

Lacking of palladin leads to multiple cellular events changes which contribute to NTD.
Neural development12(1)4(2017 Mar)
Tan J,Chen XJ,Shen CL,Zhang HX,Tang LY,Lu SY,Wu WT,Kuang Y,Fei J,Wang ZG

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS genetics12(9)e1006355(2016 Sep)
Wu Y,Wei FY,Kawarada L,Suzuki T,Araki K,Komohara Y,Fujimura A,Kaitsuka T,Takeya M,Oike Y,Suzuki T,Tomizawa K

Autophagy regulates spermatid differentiation via degradation of PDLIM1.
Autophagy12(9)1575-92(2016 Sep)
Shang Y,Wang H,Jia P,Zhao H,Liu C,Liu W,Song Z,Xu Z,Yang L,Wang Y,Li W

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Pdlim1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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