Lpar2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lpar2
Entrez Gene ID	53978
Full Name	lysophosphatidic acid receptor 2
Synonyms	Edg4,IPA2,LPA2
General protein information	Preferred Names lysophosphatidic acid receptor 2 Names lysophosphatidic acid receptor 2 LPA receptor 2 LPA-2 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4 lysophosphatidic acid receptor Edg-4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 B3.3\|8 33.91 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_020028.3	NP_064412.2	lysophosphatidic acid receptor 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Lpar2	NP_001102579.1
Bos taurus (cattle)	LPAR2	NP_001179164.1
Danio rerio (zebrafish)	lpar2b	NP_001032783.1
Xenopus tropicalis (tropical clawed frog)	lpar2	NP_001007475.1
Mus musculus (house mouse)	Lpar2	NP_064412.2
Homo sapiens (human)	LPAR2	NP_004711.2
Pan troglodytes (chimpanzee)	LPAR2	XP_001143951.2
	LPAR2	XP_002801189.1
Canis lupus familiaris (dog)	LPAR2	XP_541918.2
Gallus gallus (chicken)	LPAR2	NP_001108553.1

Gene Ontology
Bibliography

Related articles in PubMed

Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways.
Vogt J, Kirischuk S, Unichenko P, Schl?ter L, Pelosi A, Endle H, Yang JW, Schmarowski N, Cheng J, Thalman C, Strauss U, Prokudin A, Bharati BS, Aoki J, Chun J, Lutz B, Luhmann HJ, Nitsch R
Cerebral cortex (New York, N.Y. : 1991)27(1)131-145(2017 Jan)

Lysophosphatidic acid-induced vascular neointimal formation in mouse carotid arteries is mediated by the matricellular protein CCN1/Cyr61.
Hao F, Zhang F, Wu DD, An D, Shi J, Li G, Xu X, Cui MZ
American journal of physiology. Cell physiology311(6)C975-C984(2016 Dec)

PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/?1-Integrin Signaling.
Liu X, Huai J, Endle H, Schl?ter L, Fan W, Li Y, Richers S, Yurugi H, Rajalingam K, Ji H, Cheng H, Rister B, Horta G, Baumgart J, Berger H, Laube G, Schmitt U, Schmeisser MJ, Boeckers TM, Tenzer S, Vlachos A, Deller T, Nitsch R, Vogt J
Developmental cell38(3)275-90(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pharmacologic activation of LPA2 attenuates Th2-driven allergic airway inflammation in a mouse model of asthma.
Title: Novel Inhibitory Effect of a Lysophosphatidic Acid 2 Agonist on Allergen-Driven Airway Inflammation.

These findings identify ATX and LPA2 as radiation-regulated genes that appear to play a physiological role in DNA repair.
Title: The autotaxin-LPA2 GPCR axis is modulated by ?-irradiation and facilitates DNA damage repair.

Lysophosphatidic acid gradients induce a spatiotemporally restricted decrease in the mobility of LPA receptor 2 (LPA2) on chemotactic fibroblasts.
Title: Asymmetrical macromolecular complex formation of lysophosphatidic acid receptor 2 (LPA2) mediates gradient sensing in fibroblasts.

Lysophosphatidic acid signals through LPA2 receptors and Galphaq proteins of cultured proximal tubule cells to transactivate latent TGF-beta in a Rho/Rho-kinase and alphavbeta6 integrin-dependent manner.
Title: Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G?q-mediated Rho and ?v?6 integrin-dependent activation of TGF-?.

these findings identify LPA acting via lpa2 as a novel negative regulatory pathway that inhibits DC activation and allergic airway inflammation.
Title: Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.

The following Lpar2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lpar2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11706	NM_020028.3 Latest version!	Mus musculus lysophosphatidic acid receptor 2 (Lpar2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lpar2 ( NM_020028.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064412.2 Mus musculus lysophosphatidic acid receptor 2 (Lpar2), mRNA.

Price & Availability↑

CloneID	OMu11706
Clone ID Related Accession (Same CDS sequence)	NM_020028.3
Accession Version	NM_020028.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-12
Organism	Mus musculus(house mouse)
Product	lysophosphatidic acid receptor 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC064676.1 and AC158564.7. On May 27, 2006 this sequence version replaced NM_020028.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC064676.1, BC060131.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCAGT GCTACTACAA CGAGACCATC GGCTTTTTCT ATAATAACAG CGGCAAGGAG 
CTCAGCCTTC ACTGGCGCCC CAAAGATGTG GTGGTGGTGG CCCTGGGGCT GACAGTCAGT 
GTGCTGGTAT TGCTGACCAA TCTGCTGGTT ATTGCAGCCA TCGCCTCCAA CCGACGCTTC 
CACCAGCCCA TATACTACCT GCTTGGCAAC TTGGCTGCGG CTGACCTCTT CGCTGGCATG 
GCCTACCTCT TCCTCATGTT CCATACTGGC CCACGCACTG CCAGGCTCTC CATCAAAGGC 
TGGTTCCTGC GACAGGGCCT GCTGGACACC AGCCTCACGG CGTCAGTGGC CACACTGCTG 
GCCATCGCTG TGGAACGGCA CCGCAGTGTG ATGGCGGTAC AGCTACACAG CCGCCTGCCC 
CGGGGCCGTG TGGTCACACT CATCGTGGGT GTGTGGGCGG CTGCACTGGG TCTGGGGTTG 
CTACCTGCAC ACTTCTGGCA CTGCCTCTGT GACTTGGACA GTTGCTCACG CATGGTGCCC 
CTGTTCAGCC GCTCCTACTT GGCTGCGTGG GCCCTATCCA GCCTGCTTGT CTTCCTACTC 
ATGGTAGCTG TCTACACACG AATTTTCTTC TATGTGCGTA GACGGGTGGA ACGCATGGCG 
GAGCACGTCA GCTGCCATCC CCGCTACCGA GAGACCACAC TCAGCCTAGT CAAGACGGTT 
GTCATCATTC TGGGGGCATT TGTGGTGTGC TGGACACCGG GCCAGGTGGT GCTGCTCCTG 
GATGGCCTGG ACTGTAAGTC CTGCAACGTT CTGGCTGTGG AGAAGTACTT CCTGCTCCTG 
GCTGAGGCCA ACTCACTGGT CAATGCAGTG GTATATTCCT GCCGAGATGC TGAGATGCGC 
CGCACCTTCC GCCGCCTTCT CTGCTGCATG TGTCTCCGCT GGTCCAGCCA CAAGTCTGCC 
CGTTACTCAG CTTCTGCCCA GACGGGTGCC AGCACGCGGA TCATGCTTCC TGAGAATGGC 
CGCCCACTGA TGGACTCCAC CCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064412.2
CDS	157..1203
Translation	MGQCYYNETIGFFYNNSGKELSLHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGMAYLFLMFHTGPRTARLSIKGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVTLIVGVWAAALGLGLLPAHFWHCLCDLDSCSRMVPLFSRSYLAAWALSSLLVFLLMVAVYTRIFFYVRRRVERMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLDCKSCNVLAVEKYFLLLAEANSLVNAVVYSCRDAEMRRTFRRLLCCMCLRWSSHKSARYSASAQTGASTRIMLPENGRPLMDSTL

Target ORF information:

RefSeq Version	NM_020028.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus lysophosphatidic acid receptor 2 (Lpar2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020028.3

ORF Insert Sequence:

ATGGGCCAGT GCTACTACAA CGAGACCATC GGCTTTTTCT ATAATAACAG CGGCAAGGAG 
CTCAGCCTTC ACTGGCGCCC CAAAGATGTG GTGGTGGTGG CCCTGGGGCT GACAGTCAGT 
GTGCTGGTAT TGCTGACCAA TCTGCTGGTT ATTGCAGCCA TCGCCTCCAA CCGACGCTTC 
CACCAGCCCA TATACTACCT GCTTGGCAAC TTGGCTGCGG CTGACCTCTT CGCTGGCATG 
GCCTACCTCT TCCTCATGTT CCATACTGGC CCACGCACTG CCAGGCTCTC CATCAAAGGC 
TGGTTCCTGC GACAGGGCCT GCTGGACACC AGCCTCACGG CGTCAGTGGC CACACTGCTG 
GCCATCGCTG TGGAACGGCA CCGCAGTGTG ATGGCGGTAC AGCTACACAG CCGCCTGCCC 
CGGGGCCGTG TGGTCACACT CATCGTGGGT GTGTGGGCGG CTGCACTGGG TCTGGGGTTG 
CTACCTGCAC ACTTCTGGCA CTGCCTCTGT GACTTGGACA GTTGCTCACG CATGGTGCCC 
CTGTTCAGCC GCTCCTACTT GGCTGCGTGG GCCCTATCCA GCCTGCTTGT CTTCCTACTC 
ATGGTAGCTG TCTACACACG AATTTTCTTC TATGTGCGTA GACGGGTGGA ACGCATGGCG 
GAGCACGTCA GCTGCCATCC CCGCTACCGA GAGACCACAC TCAGCCTAGT CAAGACGGTT 
GTCATCATTC TGGGGGCATT TGTGGTGTGC TGGACACCGG GCCAGGTGGT GCTGCTCCTG 
GATGGCCTGG ACTGTAAGTC CTGCAACGTT CTGGCTGTGG AGAAGTACTT CCTGCTCCTG 
GCTGAGGCCA ACTCACTGGT CAATGCAGTG GTATATTCCT GCCGAGATGC TGAGATGCGC 
CGCACCTTCC GCCGCCTTCT CTGCTGCATG TGTCTCCGCT GGTCCAGCCA CAAGTCTGCC 
CGTTACTCAG CTTCTGCCCA GACGGGTGCC AGCACGCGGA TCATGCTTCC TGAGAATGGC 
CGCCCACTGA TGGACTCCAC CCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways.
Cerebral cortex (New York, N.Y. : 1991)27(1)131-145(2017 Jan)
Vogt J,Kirischuk S,Unichenko P,Schl?ter L,Pelosi A,Endle H,Yang JW,Schmarowski N,Cheng J,Thalman C,Strauss U,Prokudin A,Bharati BS,Aoki J,Chun J,Lutz B,Luhmann HJ,Nitsch R

Lysophosphatidic acid-induced vascular neointimal formation in mouse carotid arteries is mediated by the matricellular protein CCN1/Cyr61.
American journal of physiology. Cell physiology311(6)C975-C984(2016 Dec)
Hao F,Zhang F,Wu DD,An D,Shi J,Li G,Xu X,Cui MZ

PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/?1-Integrin Signaling.
Developmental cell38(3)275-90(2016 08)
Liu X,Huai J,Endle H,Schl?ter L,Fan W,Li Y,Richers S,Yurugi H,Rajalingam K,Ji H,Cheng H,Rister B,Horta G,Baumgart J,Berger H,Laube G,Schmitt U,Schmeisser MJ,Boeckers TM,Tenzer S,Vlachos A,Deller T,Nitsch R,Vogt J

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Lpar2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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