Prg3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prg3
Entrez Gene ID	53856
Full Name	proteoglycan 3
Synonyms	MBP2,MBPH
General protein information	Preferred Names proteoglycan 3 Names proteoglycan 3 eosinophil major basic protein 2 major basic protein 2 prg3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 D\|2 49.45 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006499901.1	XP_006499964.1	proteoglycan 3 isoform X1
NM_016914.2	NP_058610.1	proteoglycan 3 precursor

Pathways from BioSystems

Homologies

	PRG3	XP_001103106.1
Homo sapiens (human)	PRG3	NP_006084.2
Canis lupus familiaris (dog)	PRG3	XP_540613.3
Mus musculus (house mouse)	Prg3	NP_058610.1
Rattus norvegicus (Norway rat)	Prg3	NP_001099957.1
Pan troglodytes (chimpanzee)	PRG3	XP_521985.2

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

The transcription factor XBP1 is selectively required for eosinophil differentiation.
Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA, Weller PF, Glimcher LH
Nature immunology16(8)829-37(2015 Aug)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT
Human molecular genetics15(8)1329-41(2006 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Prg3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prg3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10723	NM_016914.2 Latest version!	Mus musculus proteoglycan 3 (Prg3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu10723	XM_006499901.1 Latest version!	Mus musculus proteoglycan 3 (Prg3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prg3 ( NM_016914.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058610.1 Mus musculus proteoglycan 3 (Prg3), mRNA.

Price & Availability↑

CloneID	OMu10723
Clone ID Related Accession (Same CDS sequence)	XM_006499901.1 , NM_016914.2
Accession Version	NM_016914.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	proteoglycan 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL935159.11. On Nov 17, 2006 this sequence version replaced NM_016914.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF202533.1, AK158110.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164140 [ECO:0000348] ##Evidence-Data-END##

ATGAAACAGC CCCTGATCCT GTCCTTTCTC CTGCTGGGGA TGGTTTCTGC TTTTCATCTG 
GAGACTGCTC ATCTGGAGAA TCCCAAGAGA GAGGAAAGCC TGAAGCAGGA AGCAGATGGT 
TCGAGGGAGC AAGGGAGAGA GTTGGCTCTG ACTCAAGAGA CAAAGCAGAC AGAGGGAGAG 
GAGGTTGAGG GTTCCCAACA CCAAGACATT TTTGAGGATG AGGAGGCAAT GGAGTCAGAT 
CCAGATGCCT TAAATAAGGA CTCTGCTTGC CCCAAGGAAG AGGACACAAC TCATTTTCAG 
GGAACTCCTG GGTGCAAGAG CTGCAACTAT GTGCTGGTGA GGACTCCCGA GACATTTGAT 
AAGGCTCAGA GAGTCTGCAG GAGATGCTAC CGAGGCAACC TTGCTTCCGT CCACAGTTAT 
AGTTTCAACT ACCAAATTCA GAACTTGGCC AGGAAGATCA ATCAGTCCAT CGTCTGGATT 
GGAGGCATCC TCAGGGGATG GTTCTGGAAG AAGTTTTGCT GGATGGATGG GAGCTGCTGG 
GATTTTGGAT ACTGGGCCCC AGGGCAGCCT GGGAGTGGGG GAGGACACTG TGTGACTCTG 
TGTACCAAAG GGGGCCATTG GCGAAGAGCT TCATGCAAAA GTCACCTGCC TTTCATCTGC 
TCCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058610.1
CDS	161..829
Translation	MKQPLILSFLLLGMVSAFHLETAHLENPKREESLKQEADGSREQGRELALTQETKQTEGEEVEGSQHQDIFEDEEAMESDPDALNKDSACPKEEDTTHFQGTPGCKSCNYVLVRTPETFDKAQRVCRRCYRGNLASVHSYSFNYQIQNLARKINQSIVWIGGILRGWFWKKFCWMDGSCWDFGYWAPGQPGSGGGHCVTLCTKGGHWRRASCKSHLPFICSF

Target ORF information:

RefSeq Version	NM_016914.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus proteoglycan 3 (Prg3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016914.2

ORF Insert Sequence:

ATGAAACAGC CCCTGATCCT GTCCTTTCTC CTGCTGGGGA TGGTTTCTGC TTTTCATCTG 
GAGACTGCTC ATCTGGAGAA TCCCAAGAGA GAGGAAAGCC TGAAGCAGGA AGCAGATGGT 
TCGAGGGAGC AAGGGAGAGA GTTGGCTCTG ACTCAAGAGA CAAAGCAGAC AGAGGGAGAG 
GAGGTTGAGG GTTCCCAACA CCAAGACATT TTTGAGGATG AGGAGGCAAT GGAGTCAGAT 
CCAGATGCCT TAAATAAGGA CTCTGCTTGC CCCAAGGAAG AGGACACAAC TCATTTTCAG 
GGAACTCCTG GGTGCAAGAG CTGCAACTAT GTGCTGGTGA GGACTCCCGA GACATTTGAT 
AAGGCTCAGA GAGTCTGCAG GAGATGCTAC CGAGGCAACC TTGCTTCCGT CCACAGTTAT 
AGTTTCAACT ACCAAATTCA GAACTTGGCC AGGAAGATCA ATCAGTCCAT CGTCTGGATT 
GGAGGCATCC TCAGGGGATG GTTCTGGAAG AAGTTTTGCT GGATGGATGG GAGCTGCTGG 
GATTTTGGAT ACTGGGCCCC AGGGCAGCCT GGGAGTGGGG GAGGACACTG TGTGACTCTG 
TGTACCAAAG GGGGCCATTG GCGAAGAGCT TCATGCAAAA GTCACCTGCC TTTCATCTGC 
TCCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Prg3 ( XM_006499901.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006499964.1 Mus musculus proteoglycan 3 (Prg3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu10723
Clone ID Related Accession (Same CDS sequence)	XM_006499901.1 , NM_016914.2
Accession Version	XM_006499901.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	proteoglycan 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAACAGC CCCTGATCCT GTCCTTTCTC CTGCTGGGGA TGGTTTCTGC TTTTCATCTG 
GAGACTGCTC ATCTGGAGAA TCCCAAGAGA GAGGAAAGCC TGAAGCAGGA AGCAGATGGT 
TCGAGGGAGC AAGGGAGAGA GTTGGCTCTG ACTCAAGAGA CAAAGCAGAC AGAGGGAGAG 
GAGGTTGAGG GTTCCCAACA CCAAGACATT TTTGAGGATG AGGAGGCAAT GGAGTCAGAT 
CCAGATGCCT TAAATAAGGA CTCTGCTTGC CCCAAGGAAG AGGACACAAC TCATTTTCAG 
GGAACTCCTG GGTGCAAGAG CTGCAACTAT GTGCTGGTGA GGACTCCCGA GACATTTGAT 
AAGGCTCAGA GAGTCTGCAG GAGATGCTAC CGAGGCAACC TTGCTTCCGT CCACAGTTAT 
AGTTTCAACT ACCAAATTCA GAACTTGGCC AGGAAGATCA ATCAGTCCAT CGTCTGGATT 
GGAGGCATCC TCAGGGGATG GTTCTGGAAG AAGTTTTGCT GGATGGATGG GAGCTGCTGG 
GATTTTGGAT ACTGGGCCCC AGGGCAGCCT GGGAGTGGGG GAGGACACTG TGTGACTCTG 
TGTACCAAAG GGGGCCATTG GCGAAGAGCT TCATGCAAAA GTCACCTGCC TTTCATCTGC 
TCCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006499964.1
CDS	177..845
Translation	MKQPLILSFLLLGMVSAFHLETAHLENPKREESLKQEADGSREQGRELALTQETKQTEGEEVEGSQHQDIFEDEEAMESDPDALNKDSACPKEEDTTHFQGTPGCKSCNYVLVRTPETFDKAQRVCRRCYRGNLASVHSYSFNYQIQNLARKINQSIVWIGGILRGWFWKKFCWMDGSCWDFGYWAPGQPGSGGGHCVTLCTKGGHWRRASCKSHLPFICSF

Target ORF information:

RefSeq Version	XM_006499901.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus proteoglycan 3 (Prg3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006499901.1

ORF Insert Sequence:

ATGAAACAGC CCCTGATCCT GTCCTTTCTC CTGCTGGGGA TGGTTTCTGC TTTTCATCTG 
GAGACTGCTC ATCTGGAGAA TCCCAAGAGA GAGGAAAGCC TGAAGCAGGA AGCAGATGGT 
TCGAGGGAGC AAGGGAGAGA GTTGGCTCTG ACTCAAGAGA CAAAGCAGAC AGAGGGAGAG 
GAGGTTGAGG GTTCCCAACA CCAAGACATT TTTGAGGATG AGGAGGCAAT GGAGTCAGAT 
CCAGATGCCT TAAATAAGGA CTCTGCTTGC CCCAAGGAAG AGGACACAAC TCATTTTCAG 
GGAACTCCTG GGTGCAAGAG CTGCAACTAT GTGCTGGTGA GGACTCCCGA GACATTTGAT 
AAGGCTCAGA GAGTCTGCAG GAGATGCTAC CGAGGCAACC TTGCTTCCGT CCACAGTTAT 
AGTTTCAACT ACCAAATTCA GAACTTGGCC AGGAAGATCA ATCAGTCCAT CGTCTGGATT 
GGAGGCATCC TCAGGGGATG GTTCTGGAAG AAGTTTTGCT GGATGGATGG GAGCTGCTGG 
GATTTTGGAT ACTGGGCCCC AGGGCAGCCT GGGAGTGGGG GAGGACACTG TGTGACTCTG 
TGTACCAAAG GGGGCCATTG GCGAAGAGCT TCATGCAAAA GTCACCTGCC TTTCATCTGC 
TCCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology17(1)25(2016 08)
Liu X,Jiao Y,Cao Y,Deng N,Ma Y,Hasty KA,Kang A,Chen H,Stuart JM,Gu W

The transcription factor XBP1 is selectively required for eosinophil differentiation.
Nature immunology16(8)829-37(2015 Aug)
Bettigole SE,Lis R,Adoro S,Lee AH,Spencer LA,Weller PF,Glimcher LH

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Human molecular genetics15(8)1329-41(2006 Apr)
Desai J,Shannon ME,Johnson MD,Ruff DW,Hughes LA,Kerley MK,Carpenter DA,Johnson DK,Rinchik EM,Culiat CT

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Prg3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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